Cited by 86Circadian rhythm and melatoninDietary Effects on HealthDiet, Metabolism, and Disease

Altered feeding differentially regulates circadian rhythms and energy metabolism in liver and muscle of rats

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Reznick, Jane, Preston, Elaine, Wilks, Donna L., Beale, Susan M., Turner, Nigel, Cooney, Gregory J.·2013·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Abstract

Energy metabolism follows a diurnal pattern responding to the light/dark cycle and food availability. This study investigated the impact of restricting feeding to the daylight hours and feeding a high fat diet on circadian clock (bmal1, dbp, tef and e4bp4) and metabolic (pepck, fas, ucp3, pdk4) gene expression and markers of energy metabolism in muscle and liver of rats. The results show that in chow-fed rats switched to daylight feeding, the peak diurnal expression of genes in liver was shifted by 6-12h while expression of these genes in muscle remained in a similar phase to rats feeding ad libitum. High fat feeding during the daylight hours had limited effect on clock gene expression in liver or muscle but shifted the peak expression of metabolic genes (pepck, fas) in liver by 6-12h. The differential effects of daylight feeding on gene and protein expression in muscle and liver were accompanied by an 8% reduction in whole body energy expenditure, a 20-30% increased glycogen content during the light phase in muscle of day-fed rats and increased adipose tissue deposition per gram food consumed. These data demonstrate that a mismatch of feeding and light/dark cycle disrupts tissue metabolism in muscle with significant consequences for whole body energy homeostasis.

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  • A differential shift of metabolically important organs such as liver and muscle might have profound effects on glucose metabolism.

    “Clearly a differential shift of metabolically important organs such as liver and muscle might also have profound effects on glucose metabolism [151].”

    From Circadian control of glucose metabolism (2014) · cites this paper as [151]

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Authors
Reznick, J., Preston, E., Wilks, D. L., Beale, S. M., Turner, N., & Cooney, G. J.
Affiliations
Garvan Institute of Medical Research (AU)
Corresponding author
Cooney, Gregory J.
Venue
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Publisher
Elsevier BV
Published
2013-01
Volume
1832
Issue
1
Pages
228-238
ISSN
0925-4439 (ISSN-L)
OpenAlex
W2089674063
Cited by
86
References
49
Citations by year
2025: 6 · 2024: 7 · 2023: 7 · 2022: 3 · 2021: 6 · 2020: 10 · 2019: 3 · 2018: 8 · 2017: 12 · 2016: 6 · 2015: 8 · 2014: 4 · 2013: 6
FWCI
2.57
Type
journal article
Language
en
Open access
Locations
  • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords
circadian rhythm, meal timing, high-fat diet, clock genes, Bmal1, DBP, Eragrostis tef, E4BP4, energy metabolism, liver, skeletal muscle, energy expenditure, glycogen, adipose tissue deposition, energy homeostasis, phosphoenolpyruvate carboxykinase, Fas, UCP3, PDK4
MeSH terms
Animals, Circadian Rhythm, Dietary Fats, Energy Metabolism, Gene Expression Regulation, Liver, Male, Rats, Wistar, Muscle, Skeletal, Rats, Period Circadian Proteins, Diet, High-Fat

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