Cited by 123Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and Adiposity

Humans and mice display opposing patterns of “browning” gene expression in visceral and subcutaneous white adipose tissue depots

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Zuriaga, Maria A., Fuster, Jose J., Gokce, Noyan, Walsh, Kenneth·2017·Frontiers in Cardiovascular Medicine

Abstract

Visceral adiposity is much more strongly associated with cardiometabolic disease in humans than subcutaneous adiposity. Browning, the appearance of brown-like adipocytes in the white adipose tissue (WAT), has been shown to protect mice against metabolic dysfunction, suggesting the possibility of new therapeutic approaches to treat obesity and type 2 diabetes. In mice, subcutaneous WAT depots express higher levels of browning genes when compared with visceral WAT, further suggesting that differences in WAT browning could contribute to the differences in the pathogenicity of the two depots. However, the expression of browning genes in different WAT depots of human has not been characterized. Here, it is shown that the expression of browning genes is higher in visceral than in subcutaneous WAT in humans, a pattern that is opposite to what is observed in mice. These results suggest that caution should be applied in extrapolating the results of murine browning gene expression studies to human pathophysiology.

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Authors
Zuriaga, M. A., Fuster, J. J., Gokce, N., & Walsh, K.
Affiliations
Boston University (US)
Corresponding author
Walsh, Kenneth
Venue
Frontiers in Cardiovascular Medicine
Published
2017-05-05
Volume
4
Pages
27-27
ISSN
2297-055X (ISSN-L)
OpenAlex
W2611211925
Cited by
122
References
45
Citations by year
2026: 7 · 2025: 10 · 2024: 8 · 2023: 17 · 2022: 14 · 2021: 23 · 2020: 18 · 2019: 14 · 2018: 6 · 2017: 4
FWCI
8.50
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Cardiovascular Medicine (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Heart, Lung, and Blood Institute (HL120160, HL131006, HL132564, HL081587, HL126141)
  • National Institute on Aging (AG052160)
Topics
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords
white adipose tissue browning, visceral adipose tissue, subcutaneous adipose tissue, obesity, type 2 diabetes, cardiometabolic disease, brown adipocytes, adipose tissue depots

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