Humans and mice display opposing patterns of “browning” gene expression in visceral and subcutaneous white adipose tissue depots
Open accessAbstract
Visceral adiposity is much more strongly associated with cardiometabolic disease in humans than subcutaneous adiposity. Browning, the appearance of brown-like adipocytes in the white adipose tissue (WAT), has been shown to protect mice against metabolic dysfunction, suggesting the possibility of new therapeutic approaches to treat obesity and type 2 diabetes. In mice, subcutaneous WAT depots express higher levels of browning genes when compared with visceral WAT, further suggesting that differences in WAT browning could contribute to the differences in the pathogenicity of the two depots. However, the expression of browning genes in different WAT depots of human has not been characterized. Here, it is shown that the expression of browning genes is higher in visceral than in subcutaneous WAT in humans, a pattern that is opposite to what is observed in mice. These results suggest that caution should be applied in extrapolating the results of murine browning gene expression studies to human pathophysiology.
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Humans express more BAT-related genes in VAT, while mice express these genes in scAT to a greater degree.
“a recent study has determined that humans express more BAT-related genes in VAT, while mice express these genes in scAT to a greater degree [277].”
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- Authors
- Zuriaga, M. A., Fuster, J. J., Gokce, N., & Walsh, K.
- Affiliations
- Boston University (US)
- Corresponding author
- Walsh, Kenneth
- Venue
- Frontiers in Cardiovascular Medicine
- Publisher
- Frontiers Media SA
- Published
- 2017-05-05
- Volume
- 4
- Pages
- 27-27
- ISSN
- 2297-055X (ISSN-L)
- PMC
- PMC5418233
- OpenAlex
- W2611211925
- Cited by
- 122
- References
- 45
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 8 · 2023: 17 · 2022: 14 · 2021: 23 · 2020: 18 · 2019: 14 · 2018: 6 · 2017: 4
- FWCI
- 8.50
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Cardiovascular Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Heart, Lung, and Blood Institute (HL120160, HL131006, HL132564, HL081587, HL126141)
- National Institute on Aging (AG052160)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- white adipose tissue browning, visceral adipose tissue, subcutaneous adipose tissue, obesity, type 2 diabetes, cardiometabolic disease, brown adipocytes, adipose tissue depots
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