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The Roles of MAPK Cascades in Synaptic Plasticity and Memory in Aplysia: Facilitatory Effects and Inhibitory Constraints: Figure 1

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Sharma, Shiv K., Carew, Thomas J.·2004·Learning & Memory

Abstract

Synaptic plasticity is thought to contribute to memory formation. Serotonin-induced facilitation of sensory-motor (SN-MN) synapses in Aplysia is an extensively studied cellular analog of memory for sensitization. Serotonin, a modulatory neurotransmitter, is released in the CNS during sensitization training, and induces three temporally and mechanistically distinct phases of SN-MN synaptic facilitation. The role of protein kinase A and protein kinase C in SN-MN synaptic facilitation is well documented. Recently, it has become clear that mitogen-activated protein kinase (MAPK) cascades also play a critical role in SN-MN plasticity. Here, we summarize the roles of MAPK cascades in synaptic plasticity and memory for sensitization in Aplysia.

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  • The PKA and ERK cascades are necessary to induce long-term synaptic facilitation (LTF) in Aplysia.

    “Two biochemical cascades required for LTF are those that mediate activation of protein kinase A (PKA)12–15 and the MAP kinase isoform termed extracellular signal-regulated kinase (ERK)16–18.”

    From Computational design of enhanced learning protocols (2012) · cites this paper as [17]

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Authors
Sharma, S. K., & Carew, T. J.
Affiliations
University of California, Irvine (US)
Venue
Learning & Memory
Published
2004-07
Volume
11
Issue
4
Pages
373-378
ISSN
  • 1072-0502 (ISSN-L)
  • 1549-5485
OpenAlex
W1995725994
Cited by
95
References
68
Citations by year
2025: 2 · 2023: 3 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 8 · 2015: 1 · 2014: 8 · 2013: 7 · 2012: 9
Type
posted content
Language
en
Open access
Locations
  • Learning & Memory (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation (0049013)
  • National Institute of Mental Health (R01 MH-141083)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords
MAPK signaling, synaptic plasticity, memory formation, Aplysia, serotonin, sensitization, sensory-motor synapses, synaptic facilitation, protein kinase A, protein kinase C
MeSH terms
Animals, Aplysia, Association Learning, Conditioning, Psychological, Memory, Motor Neurons, Neuronal Plasticity, Neurons, Afferent, Serotonin, Synapses, Signal Transduction, Mitogen-Activated Protein Kinases, MAP Kinase Signaling System

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