The Roles of MAPK Cascades in Synaptic Plasticity and Memory in Aplysia: Facilitatory Effects and Inhibitory Constraints: Figure 1
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Synaptic plasticity is thought to contribute to memory formation. Serotonin-induced facilitation of sensory-motor (SN-MN) synapses in Aplysia is an extensively studied cellular analog of memory for sensitization. Serotonin, a modulatory neurotransmitter, is released in the CNS during sensitization training, and induces three temporally and mechanistically distinct phases of SN-MN synaptic facilitation. The role of protein kinase A and protein kinase C in SN-MN synaptic facilitation is well documented. Recently, it has become clear that mitogen-activated protein kinase (MAPK) cascades also play a critical role in SN-MN plasticity. Here, we summarize the roles of MAPK cascades in synaptic plasticity and memory for sensitization in Aplysia.
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The PKA and ERK cascades are necessary to induce long-term synaptic facilitation (LTF) in Aplysia.
“Two biochemical cascades required for LTF are those that mediate activation of protein kinase A (PKA)12–15 and the MAP kinase isoform termed extracellular signal-regulated kinase (ERK)16–18.”
From Computational design of enhanced learning protocols (2012) · cites this paper as [17]
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- Authors
- Sharma, S. K., & Carew, T. J.
- Affiliations
- University of California, Irvine (US)
- Venue
- Learning & Memory
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2004-07
- Volume
- 11
- Issue
- 4
- Pages
- 373-378
- ISSN
- 1072-0502 (ISSN-L)
- 1549-5485
- OpenAlex
- W1995725994
- Cited by
- 95
- References
- 68
- Citations by year
- 2025: 2 · 2023: 3 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 8 · 2015: 1 · 2014: 8 · 2013: 7 · 2012: 9
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Learning & Memory (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (0049013)
- National Institute of Mental Health (R01 MH-141083)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- MAPK signaling, synaptic plasticity, memory formation, Aplysia, serotonin, sensitization, sensory-motor synapses, synaptic facilitation, protein kinase A, protein kinase C
- MeSH terms
- Animals, Aplysia, Association Learning, Conditioning, Psychological, Memory, Motor Neurons, Neuronal Plasticity, Neurons, Afferent, Serotonin, Synapses, Signal Transduction, Mitogen-Activated Protein Kinases, MAP Kinase Signaling System
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