Proteasome inhibition enhances the induction and impairs the maintenance of late-phase long-term potentiation

The molecular biology of memory storage: a dialogue between genes and synapses

Kandel, E. R. (2001) · Science · doi:10.1126/science.1067020 · Cited by 3,917 · see citing works

Synaptic tagging and long-term potentiation

Frey, U., & Morris, R. G. M. (1997) · Nature · doi:10.1038/385533a0 · Cited by 1,736 · cited 1× · see citing works

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

Fenteany, G., Standaert, R. F., Lane, W. S., Choi, S., Corey, E. J., & Schreiber, S. L. (1995) · Science · doi:10.1126/science.7732382 · Cited by 1,583 · see citing works

Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism

Tao, X., Finkbeiner, S., Arnold, D. B., Shaywitz, A. J., & Greenberg, M. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)81010-7 · Cited by 1,561 · see citing works

Regulation of translation initiation by FRAP/mTOR

Gingras, A.-C., Raught, B., & Sonenberg, N. (2001) · Genes & Development · doi:10.1101/gad.887201 · Cited by 1,545 · see citing works

An Overview of Real-Time Quantitative PCR: Applications to Quantify Cytokine Gene Expression

Giulietti, A., Overbergh, L., Valckx, D., Decallonne, B., Bouillon, R., & Mathieu, C. (2001) · Methods · doi:10.1006/meth.2001.1261 · Cited by 1,403 · see citing works

Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons

Frey, U., Huang, Y.-Y., & Kandel, E. R. (1993) · Science · doi:10.1126/science.8389057 · Cited by 1,218 · see citing works

Genetic Demonstration of a Role for PKA in the Late Phase of LTP and in Hippocampus-Based Long-Term Memory

Abel, T., Nguyen, P. V., Barad, M., Deuel, T. A. S., Kandel, E. R., & Bourtchouladze, R. (1997) · Cell · doi:10.1016/s0092-8674(00)81904-2 · Cited by 1,217 · see citing works

The physiology and pharmacology of hippocampal formation theta rhythms

Bland, B. H. (1986) · Progress in Neurobiology · doi:10.1016/0301-0082(86)90019-5 · Cited by 1,039 · see citing works

Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger.

O’Dell, T. J., Hawkins, R. D., Kandel, E. R., & Arancio, O. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11285 · Cited by 1,034 · see citing works

Using Antibodies: A Laboratory Manual

Harlow, E., & Lane, D. A. (1998) · Cited by 996 · see citing works

Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system

Ehlers, M. D. (2003) · Nature Neuroscience · doi:10.1038/nn1013 · Cited by 977 · see citing works

Dendritic Protein Synthesis, Synaptic Plasticity, and Memory

Sutton, M. A., & Schuman, E. M. (2006) · Cell · doi:10.1016/j.cell.2006.09.014 · Cited by 894 · see citing works

Requirement of a Critical Period of Transcription for Induction of a Late Phase of LTP

Nguyen, P. V., Abel, T., & Kandel, E. R. (1994) · Science · doi:10.1126/science.8066450 · Cited by 888 · see citing works

Translational Control by MAPK Signaling in Long-Term Synaptic Plasticity and Memory

Kelleher, R. J., Govindarajan, A., Jung, H.-Y., Kang, H., & Tonegawa, S. (2004) · Cell · doi:10.1016/s0092-8674(04)00115-1 · Cited by 845 · see citing works

Anisomycin, an inhibitor of protein synthesis, blocks late phases of LTP phenomena in the hippocampal CA1 region in vitro

Frey, U., Krug, M., Reymann, K. G., & Matthies, H. (1988) · Brain Research · doi:10.1016/0006-8993(88)90008-x · Cited by 806 · see citing works

A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus

Tang, S. J., Reis, G., Kang, H., Gingras, A.-C., Sonenberg, N., & Schuman, E. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012605299 · Cited by 734 · see citing works

Rapid and selective induction of BDNF expression in the hippocampus during contextual learning

Hall, J., Thomas, K. L., & Everitt, B. (2000) · Nature Neuroscience · doi:10.1038/75698 · Cited by 669 · see citing works

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.

Jefferies, H. B. J., Reinhard, C., Kozma, S. C., & Thomas, G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.10.4441 · Cited by 623 · see citing works

Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture.

Barco, A., Alarcon, J. M., & Kandel, E. (2002) · Cell · doi:10.1016/s0092-8674(02)00657-8 · Cited by 595 · see citing works

Induction of CRE-Mediated Gene Expression by Stimuli That Generate Long-Lasting LTP in Area CA1 of the Hippocampus

Impey, S., Mark, M., Villacres, E. C., Poser, S., Chavkin, C., & Storm, D. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80120-8 · Cited by 593 · see citing works

Translational Regulatory Mechanisms in Persistent Forms of Synaptic Plasticity

Kelleher, R. J., Govindarajan, A., & Tonegawa, S. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.013 · Cited by 592 · see citing works

OLFACTORY MEMORY FORMATION INDROSOPHILA: From Molecular to Systems Neuroscience

Davis, R. L. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135651 · Cited by 543 · see citing works

eIF2α Phosphorylation Bidirectionally Regulates the Switch from Short- to Long-Term Synaptic Plasticity and Memory

Costa‐Mattioli, M., Gobert, D., Stern, E., Gamache, K., Colina, R., Cuello, A. C., Sossin, W. S., Kaufman, R. J., Pelletier, J., Rosenblum, K., et al. (2007) · Cell · doi:10.1016/j.cell.2007.01.050 · Cited by 510 · see citing works

Changes in paired-pulse facilitation suggest presynaptic involvement in long-term potentiation

Schulz, P. E., Cook, E. P., & Johnston, D. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-09-05325.1994 · Cited by 460 · see citing works

Ubiquitin Hydrolase Uch-L1 Rescues β-Amyloid-Induced Decreases in Synaptic Function and Contextual Memory

Gong, B., Cao, Z., Zheng, P., Vitolo, O. V., Liu, S., Staniszewski, A., Moolman, D. L., Zhang, H., Shelanski, M. L., & Arancio, O. (2006) · Cell · doi:10.1016/j.cell.2006.06.046 · Cited by 424 · see citing works

Translational control of hippocampal synaptic plasticity and memory by the eIF2α kinase GCN2

Costa-Mattioli, M., Gobert, D., Harding, H., Herdy, B., Azzi, M., Bruno, M., Bidinosti, M., Mamou, C. B., Marcinkiewicz, E., Yoshida, M., et al. (2005) · Nature · doi:10.1038/nature03897 · Cited by 421 · see citing works

Increasing Numbers of Synaptic Puncta during Late-Phase LTP

Bozdagi, O., Shan, W., Tanaka, H., Benson, D. L., & Huntley, G. W. (2000) · Neuron · doi:10.1016/s0896-6273(00)00100-8 · Cited by 373 · see citing works

Mechanistic Studies on the Inactivation of the Proteasome by Lactacystin

Dick, L. R., Cruikshank, A. A., Grenier, L., Melandri, F. D., Nunes, S. L., & Stein, R. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.13.7273 · Cited by 369 · see citing works

Ubiquitin C-Terminal Hydrolase Is an Immediate-Early Gene Essential for Long-Term Facilitation in Aplysia

Hegde, A. N., Inokuchi, K., Pei, W., Casadio, A., Ghirardi, M., Chain, D. G., Martin, K. C., Kandel, E. R., & Schwartz, J. H. (1997) · Cell · doi:10.1016/s0092-8674(00)80188-9 · Cited by 356 · see citing works

Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins.

Terada, N., Patel, H. R., Takase, K., Kohno, K., Nairn, A. C., & Gelfand, E. W. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.24.11477 · Cited by 353 · see citing works

Signaling from synapse to nucleus: the logic behind the mechanisms

Deisseroth, K. A., Mermelstein, P. G., Xia, H., & Tsien, R. W. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00076-x · Cited by 350 · see citing works

Gene Expression Profiling of Facilitated L-LTP in VP16-CREB Mice Reveals that BDNF Is Critical for the Maintenance of LTP and Its Synaptic Capture

Barco, Á., Patterson, S., Alarcón, J. M., Gromova, P., Mata, M., Morozov, A., & Kandel, E. R. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.005 · Cited by 332 · see citing works

Regulation of hippocampal synaptic plasticity by cyclic AMP-dependent protein kinases

Nguyen, P., & Woo, N. H. (2003) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2003.12.003 · Cited by 324 · see citing works

Time-restricted role for dendritic activation of the mTOR-p70S6K pathway in the induction of late-phase long-term potentiation in the CA1

Cammalleri, M., Lütjens, R., Berton, F., King, A. R., Simpson, C., Francesconi, W., & Sanna, P. (2003) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.2336098100 · Cited by 314 · see citing works

A Balance of Protein Synthesis and Proteasome-Dependent Degradation Determines the Maintenance of LTP

Fonseca, R., Vabulas, R. M., Hartl, F. U., Bonhoeffer, T., & Nägerl, U. V. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.015 · Cited by 310 · see citing works

N‐methyl‐D‐aspartate receptor signaling results in Aurora kinase‐catalyzed CPEB phosphorylation and αCaMKII mRNA polyadenylation at synapses

Huang, Y.-S., Jung, M.-Y., Sarkissian, M., & Richter, J. (2002) · EMBO Journal · doi:10.1093/emboj/21.9.2139 · Cited by 290 · see citing works

Inducible Enhancement of Memory Storage and Synaptic Plasticity in Transgenic Mice Expressing an Inhibitor of ATF4 (CREB-2) and C/EBP Proteins

Chen, A. Y.-C., Muzzio, I. A., Malleret, G., Bartsch, D., Verbitsky, M., Pavlidis, P., Yonan, A. L., Vronskaya, S., Grody, M. B., Cepeda, I. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00501-4 · Cited by 276 · see citing works

Influence of actinomycin D, a RNA synthesis inhibitor, on long‐term potentiation in rat hippocampal neurons in vivo and in vitro.

Frey, U., Frey, S., Schollmeier, F., & Krug, M. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021179 · Cited by 273 · see citing works

A Role for the Proteasome in the Light Response of the Timeless Clock Protein

Naidoo, N. N., Song, W., Hunter-Ensor, M., & Sehgal, A. (1999) · Science · doi:10.1126/science.285.5434.1737 · Cited by 269 · see citing works

ATF4 Degradation Relies on a Phosphorylation-Dependent Interaction with the SCFβTrCPUbiquitin Ligase

Lassot, I., Ségéral, E., Berlioz‐Torrent, C., Durand, H., Groussin, L., Hai, T., Bénarous, R., & Margottin-Goguet, F. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.6.2192-2202.2001 · Cited by 254 · see citing works

Forskolin-Induced LTP in the CA1 Hippocampal Region Is NMDA Receptor Dependent

Otmakhov, N., Khibnik, L. A., Otmakhova, N. A., Carpenter, S. M., Riahi, S., Asrican, B., & Lisman, J. E. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00941.2003 · Cited by 254 · see citing works

Dopaminergic stimulation of local protein synthesis enhances surface expression of GluR1 and synaptic transmission in hippocampal neurons

Smith, W. B., Starck, S. R., Roberts, R. W., & Schuman, E. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.015 · Cited by 252 · see citing works

Maintenance of late-phase LTP is accompanied by PKA-dependent increase in AMPA receptor synthesis

Nayak, A., Zastrow, D. J., Lickteig, R. L., Zahniser, N. R., & Browning, M. D. (1998) · Nature · doi:10.1038/29305 · Cited by 229 · see citing works

Regulatory subunits of cAMP-dependent protein kinases are degraded after conjugation to ubiquitin: a molecular mechanism underlying long-term synaptic plasticity.

Hegde, A. N., Goldberg, A. L., & Schwartz, J. H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.16.7436 · Cited by 215 · see citing works

Brief theta-burst stimulation induces a transcription-dependent late phase of LTP requiring cAMP in area CA1 of the mouse hippocampus.Preprint

Nguyen, P., & Kandel, E. R. (1997) · Learning & Memory · doi:10.1101/lm.4.2.230 · Cited by 215 · see citing works

Ubiquitin-Mediated Proteasome Activity Is Required for Agonist-Induced Endocytosis of GluRs

Patrick, G. N., Bingol, B., Weld, H. A., & Schuman, E. M. (2003) · Current Biology · doi:10.1016/j.cub.2003.10.028 · Cited by 205 · see citing works

Mechanisms for Generating the Autonomous cAMP-Dependent Protein Kinase Required for Long-Term Facilitation in Aplysia

Chain, D. G., Casadio, A., Schacher, S., Hegde, A. N., Valbrun, M., Yamamoto, N., Goldberg, A. L., Bartsch, D., Kandel, E. R., & Schwartz, J. H. (1999) · Neuron · doi:10.1016/s0896-6273(00)80686-8 · Cited by 186 · see citing works

The Anaphase-Promoting Complex Regulates the Abundance of GLR-1 Glutamate Receptors in the Ventral Nerve Cord of C. elegans

Juo, P., & Kaplan, J. M. (2004) · Current Biology · doi:10.1016/j.cub.2004.11.010 · Cited by 164 · see citing works

Involvement of Protein Synthesis and Degradation in Long-Term Potentiation of Schaffer Collateral CA1 Synapses

Karpova, A., Mikhaylova, M., Thomas, U., Knöpfel, T., & Behnisch, T. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4573-05.2006 · Cited by 162 · see citing works

Ubiquitin and the synapse

Hegde, A. N., & DiAntonio, A. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn961 · Cited by 158 · see citing works

Protein serine/threonine phosphatases in neuronal plasticity and disorders of learning and memory

Mansuy, I. M., & Shenolikar, S. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.10.004 · Cited by 151 · see citing works

Neuronal activity determines the protein synthesis dependence of long-term potentiation

Fonseca, R., Nägerl, U. V., & Bonhoeffer, T. (2006) · Nature Neuroscience · doi:10.1038/nn1667 · Cited by 150 · see citing works

Neuronal Activity Increases the Phosphorylation of the Transcription Factor cAMP Response Element-binding Protein (CREB) in Rat Hippocampus and Cortex

Moore, A. N., Waxham, M. N., & Dash, P. K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.24.14214 · Cited by 144 · see citing works

Ubiquitin-proteasome-mediated local protein degradation and synaptic plasticity

Hegde, A. N. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.05.005 · Cited by 141 · see citing works

The Ubiquitin Proteasome System Functions as an Inhibitory Constraint on Synaptic Strengthening

Zhao, Y., Hegde, A. N., & Martin, K. C. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00332-4 · Cited by 136 · see citing works

Proteasome Activity Is Required for Anthrax Lethal Toxin To Kill Macrophages

Tang, G., & Leppla, S. H. (1999) · Infection and Immunity · doi:10.1128/iai.67.6.3055-3060.1999 · Cited by 118 · see citing works

Induction and maintenance of late‐phase long‐term potentiation in isolated dendrites of rat hippocampal CA1 pyramidal neurones

Vickers, C. A., Dickson, K. S., & Wyllie, D. J. A. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.092924 · Cited by 116 · see citing works

Postsynaptic signaling networks: Cellular cogwheels underlying long-term plasticity

Blitzer, R. D., Iyengar, R., & Landau, E. M. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.02.031 · Cited by 115 · see citing works

Adenylyl Cyclase Activation Modulates Activity-Dependent Changes in Synaptic Strength and Ca2+/Calmodulin-Dependent Kinase II Autophosphorylation

Makhinson, M., Chotiner, J. K., Watson, J. B., & O’Dell, T. J. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-07-02500.1999 · Cited by 110 · see citing works

Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2

Yoshida, M., Yoshida, K., Kozlov, G., Lim, N. S., Crescenzo, G. D., Pang, Z., Berlanga, J. J., Kahvejian, A., Gehring, K., Wing, S. S., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601079 · Cited by 108 · see citing works

Development of hippocampal long-term potentiation is reduced by recently introduced calpain inhibitors

del Cerro, S., Larson, J., Oliver, M. W., & LYNCH, G. S. (1990) · Brain Research · doi:10.1016/0006-8993(90)90660-4 · Cited by 104 · see citing works

Calpain inhibitors block long-term potentiation

Denny, J. B., Polan-Curtain, J. L., Ghuman, A., Wayner, M. J., & Armstrong, D. L. (1990) · Brain Research · doi:10.1016/0006-8993(90)90148-5 · Cited by 101 · see citing works

Protein synthesis‐dependent LTP in isolated dendrites of CA1 pyramidal cells

Cracco, J., Serrano, P., Moskowitz, S. I., Bergold, P., & Sacktor, T. (2005) · Hippocampus · doi:10.1002/hipo.20078 · Cited by 101 · see citing works

Proteasome Inhibition Triggers Activity-Dependent Increase in the Size of the Recycling Vesicle Pool in Cultured Hippocampal Neurons

Willeumier, K., Pulst, S. M., & Schweizer, F. E. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1684-06.2006 · Cited by 98 · see citing works

Protein kinase A activity is required for the budding of constitutive transport vesicles from the trans-Golgi network

Muñiz, M., Martín, M. E., Hidalgo, J., & Velasco, A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14461 · Cited by 96 · see citing works

Proteasome inhibition induces reversible impairments in protein synthesis

Ding, Q., Dimayuga, E. R., Markesbery, W. R., & Keller, J. N. (2006) · The FASEB Journal · doi:10.1096/fj.05-5495com · Cited by 94 · see citing works

Ubiquitination and Proteasome-dependent Degradation of Human Eukaryotic Translation Initiation Factor 4E

Murata, T., & Shimotohno, K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600563200 · Cited by 81 · see citing works

Temporal spacing of synaptic stimulation critically modulates the dependence of LTP on cyclic AMP‐dependent protein kinase

Woo, N. H., Duffy, S. N., Abel, T., & Nguyen, P. V. (2003) · Hippocampus · doi:10.1002/hipo.10086 · Cited by 73 · see citing works

Ubiquitin‐proteasome‐mediated CREB repressor degradation during induction of long‐term facilitation

Upadhya, S. C., Smith, T. K., & Hegde, A. N. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02707.x · Cited by 73 · see citing works

New Roles for Ubiquitin in the Assembly and Function of Neuronal Circuits

Murphey, R. K., & Godenschwege, T. A. (2002) · Neuron · doi:10.1016/s0896-6273(02)00943-1 · Cited by 72 · see citing works

[25] Utilization of the inhibitor protein of adenosine cyclic monophosphate-dependent protein kinase, and peptides derived from it, as tools to study adenosine cyclic monophosphate-mediated cellular processes

Awalsh, D., & Glass, D. B. (1991) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(91)01027-y · Cited by 70 · see citing works

Multiplex semi-quantitative reverse transcriptase–polymerase chain reaction of low abundance neuronal mRNAs

Pernas-Alonso, R., Morelli, F., di Porzio, U., & Perrone‐Capano, C. (1999) · Brain Research Protocols · doi:10.1016/s1385-299x(99)00045-8 · Cited by 69 · see citing works

Postsynaptic Application of a Peptide Inhibitor of cAMP-Dependent Protein Kinase Blocks Expression of Long-Lasting Synaptic Potentiation in Hippocampal Neurons

Duffy, S. N., & Nguyen, P. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-04-01142.2003 · Cited by 67 · see citing works

Protein Synthesis Is Required for Synaptic Immunity to Depotentiation

Woo, N. H., & Nguyen, P. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-04-01125.2003 · Cited by 67 · see citing works

Multiplex Relative RT-PCR Method for Verification of Differential Gene Expression

Spencer, W. E., & Christensen, M. J. (1999) · BioTechniques · doi:10.2144/99275rr04 · Cited by 58 · see citing works

Expression mechanisms of long-term potentiation in the hippocampus.

Isaac, J., Oliet, S., Hjelmstad, G., Nicoll, R., & Malenka, R. (1996) · Journal of Physiology - Paris · doi:10.1016/s0928-4257(97)87901-6 · Cited by 51 · see citing works

Differential regulation of proteasome activity in the nucleus and the synaptic terminals

Upadhya, S. C., Ding, L., Smith, T. K., & Hegde, A. N. (2005) · Neurochemistry International · doi:10.1016/j.neuint.2005.11.003 · Cited by 45 · see citing works

Gene Expression in the Conversion of Early‐Phase to Late‐Phase Long‐Term Potentiation

Lee, P. R., Cohen, J. E., Becker, K. G., & Fields, R. D. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1342.023 · Cited by 44 · see citing works

Making memories last: the synaptic tagging and capture hypothesis

Redondo, R. L., & Morris, R. G. M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn2963 · Cited by 792 · see citing works

Regulation of hippocampal synaptic plasticity by BDNF

Leal, G., Afonso, P. M., Salazar, I. L., & Duarte, C. B. (2015) · Brain Research · doi:10.1016/j.brainres.2014.10.019 · Cited by 410 · see citing works

The right time to learn: Mechanisms and optimization of spaced learning

Smolen, P., Zhang, Y., & Byrne, J. H. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.18 · Cited by 326 · see citing works

Deconstruction for Reconstruction: The Role of Proteolysis in Neural Plasticity and Disease

Bingol, B., & Sheng, M. (2011) · Neuron · doi:10.1016/j.neuron.2010.11.006 · Cited by 275 · see citing works

Ubiquitination in postsynaptic function and plasticity

Mabb, A. M., & Ehlers, M. D. (2010) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100109-104129 · Cited by 255 · see citing works

Regulation of the proteasome by neuronal activity and calcium/calmodulin-dependent protein kinase II

Djakovic, S. N., Schwarz, L. A., Barylko, B., DeMartino, G. N., & Patrick, G. N. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.021956 · Cited by 236 · see citing works

Protein homeostasis and synaptic plasticity

Cajigas, I. J., Will, T. J., & Schuman, E. M. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.173 · Cited by 185 · see citing works

The roles of protein expression in synaptic plasticity and memory consolidation

Rosenberg, T., Gal-Ben-Ari, S., Dieterich, D. C., Kreutz, M. R., Ziv, N. E., Gundelfinger, E. D., & Rosenblum, K. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00086 · Cited by 165 · see citing works

The ubiquitin-proteasome pathway and synaptic plasticityPreprint

Hegde, A. N. (2010) · Learning & Memory · doi:10.1101/lm.1504010 · Cited by 151 · see citing works

A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal function

Ramachandran, K. V., & Margolis, S. S. (2017) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3389 · Cited by 144 · see citing works

Role of the ubiquitin–proteasome system in brain ischemia: Friend or foe?

Caldeira, M. V., Salazar, I. L., Curcio, M., Canzoniero, L. M. T., & Duarte, C. B. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.10.003 · Cited by 134 · see citing works

The ubiquitin–proteasome system as a critical regulator of synaptic plasticity and long-term memory formation

Jarome, T. J., & Helmstetter, F. J. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.03.009 · Cited by 133 · see citing works

Regulation of local translation at the synapse by BDNF

Santos, A. R., Comprido, D., & Duarte, C. B. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.08.004 · Cited by 122 · see citing works

Protein degradation and protein synthesis in long-term memory formation

Jarome, T. J., & Helmstetter, F. J. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00061 · Cited by 119 · see citing works

Phosphorylation of Rpt6 regulates synaptic strength in hippocampal neurons

Djakovic, S. N., Marquez-Lona, E. M., Jakawich, S. K., Wright, R., Chu, C., Sutton, M. A., & Patrick, G. N. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.4427-11.2012 · Cited by 112 · see citing works

Cytosolic Proteostasis Networks of the Mitochondrial Stress Response

D'Amico, D. F., Sorrentino, V., & Auwerx, J. H. (2017) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2017.05.002 · Cited by 106 · see citing works

Ubiquitination Acutely Regulates Presynaptic Neurotransmitter Release in Mammalian Neurons

Rinetti, G. V., & Schweizer, F. E. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3712-09.2010 · Cited by 100 · see citing works

Role of ubiquitin–proteasome-mediated proteolysis in nervous system disease

Hegde, A. N., & Upadhya, S. C. (2010) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2010.07.006 · Cited by 96 · see citing works

Proteolysis, synaptic plasticity and memory

Hegde, A. N. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.09.003 · Cited by 91 · see citing works

The proteasome and its role in the nervous system

Türker, F., Cook, E. K., & Margolis, S. S. (2021) · Cell chemical biology · doi:10.1016/j.chembiol.2021.04.003 · Cited by 92 · see citing works

Scaffolding Proteins of the Post-synaptic Density Contribute to Synaptic Plasticity by Regulating Receptor Localization and Distribution: Relevance for Neuropsychiatric Diseases

Iasevoli, F., Tomasetti, C., & de Bartolomeis, A. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0886-y · Cited by 88 · see citing works

The proteasome: A key modulator of nervous system function, brain aging, and neurodegenerative disease

Davidson, K., & Pickering, A. M. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1124907 · Cited by 84 · see citing works

Defective proteostasis in Alzheimer’s disease

Cozachenco, D., Ribeiro, F. C., & Ferreira, S. T. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101862 · Cited by 82 · see citing works

Perturbed proteostasis in autism spectrum disorders

Louros, S. R., & Osterweil, E. K. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13723 · Cited by 79 · see citing works

Changes in mGlu5 Receptor-Dependent Synaptic Plasticity and Coupling to Homer Proteins in the Hippocampus of Ube3A Hemizygous Mice Modeling Angelman Syndrome

Pignatelli, M., Piccinin, S., Molinaro, G., Menna, L. D., Riozzi, B., Cannella, M., Motolese, M., Vetere, G., Catania, M. V., Battaglia, G., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1846-13.2014 · Cited by 77 · see citing works

Calpains and proteasomes mediate degradation of ryanodine receptors in a model of cardiac ischemic reperfusion

Pedrozo, Z., Sánchez, G., Torrealba, N., Valenzuela, R., Fernández, C., Hidalgo, C., Lavandero, S., & Donoso, P. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.12.005 · Cited by 76 · see citing works

Protein degradation and memory formation

Fioravante, D., & Byrne, J. H. (2010) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2010.11.002 · Cited by 75 · see citing works

Proteasome Modulates Positive and Negative Translational Regulators in Long-Term Synaptic Plasticity

Dong, C., Bach, S. V., Haynes, K. A., & Hegde, A. N. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3291-13.2014 · Cited by 71 · see citing works

Think locally: control of ubiquitin‐dependent protein degradation in neurons

Segref, A., & Hoppe, T. (2008) · EMBO Reports · doi:10.1038/embor.2008.229 · Cited by 71 · see citing works

BDNF-Induced Changes in the Expression of the Translation Machinery in Hippocampal Neurons: Protein Levels and Dendritic mRNA

Manadas, B. J., Santos, A. R., Szabadfi, K., Gomes, J. R., Garbis, S. D., Fountoulakis, M., & Duarte, C. B. (2009) · Journal of Proteome Research · doi:10.1021/pr900366x · Cited by 59 · see citing works

Protein degradation by the proteasome is required for synaptic tagging and the heterosynaptic stabilization of hippocampal late-phase long-term potentiation

Cai, F., Frey, J. U., Sanna, P. P., & Behnisch, T. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.032 · Cited by 59 · see citing works

Further evidence for an anti-inflammatory role of artesunate in experimental cerebral malaria

de Miranda, A. S., Brant, F., Rocha, N. P., Cisalpino, D., Rodrigues, D. H., Souza, D. G., Machado, F. S., Rachid, M. A., Teixeira, A. L., & Campos, A. C. (2013) · Malaria Journal · doi:10.1186/1475-2875-12-388 · Cited by 54 · see citing works

The effects of proteasomal inhibition on synaptic proteostasis

Hakim, V., Cohen, L. D., Zuchman, R., Ziv, T., & Ziv, N. E. (2016) · The EMBO Journal · doi:10.15252/embj.201593594 · Cited by 52 · see citing works

Reconsolidation and the regulation of plasticity: moving beyond memory

Bonin, R. P., & Koninck, Y. D. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.04.007 · Cited by 51 · see citing works

‘Tagging’ along memories in aging: Synaptic tagging and capture mechanisms in the aged hippocampus

Shetty, M. S., & Sajikumar, S. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.12.008 · Cited by 53 · see citing works

Forgetting of what was once learned: Exploring the role of postsynaptic ionotropic glutamate receptors on memory formation, maintenance, and decay

Sachser, R. M., Haubrich, J., Lunardi, P. S., & Alvares, L. D. O. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.07.015 · Cited by 52 · see citing works

Nucleus accumbens neurons exhibit synaptic scaling that is occluded by repeated dopamine pre‐exposure

Sun, X., & Wolf, M. E. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06852.x · Cited by 51 · see citing works

The Role of the Ubiquitin Proteasome System in Ischemia and Ischemic Tolerance

Meller, R. (2009) · The Neuroscientist · doi:10.1177/1073858408327809 · Cited by 52 · see citing works

GluN2B-Containing NMDA Receptors Regulate AMPA Receptor Traffic through Anchoring of the Synaptic Proteasome

Ferreira, J. S., Schmidt, J., Rio, P., Águas, R., Rooyakkers, A., Li, K. W., Smit, A. B., Craig, A. M., & Carvalho, A. L. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.3567-14.2015 · Cited by 50 · see citing works

Loss of F-box Only Protein 2 (Fbxo2) Disrupts Levels and Localization of Select NMDA Receptor Subunits, and Promotes Aberrant Synaptic Connectivity

Atkin, G., Moore, S. J., Lü, Y., Nelson, R. F., Tipper, N., Rajpal, G., Hunt, J. F. V., Tennant, W., Hell, J. W., Murphy, G. G., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3013-14.2015 · Cited by 46 · see citing works

On the transition from reconsolidation to extinction of contextual fear memories

Cassini, L. F., Flavell, C. R., Amaral, O. B., & Lee, J. L. C. (2017) · Learning & Memory · doi:10.1101/lm.045724.117 · Cited by 47 · see citing works

Differential Role of the Proteasome in the Early and Late Phases of BDNF-Induced Facilitation of LTP

Santos, A. R., Mele, M., Vaz, S. H., Kellermayer, B., Grimaldi, M., Colino-Oliveira, M., Rombo, D. M., Comprido, D., Sebastião, A. M., & Duarte, C. B. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4521-14.2015 · Cited by 40 · see citing works

The Ubiquitin–Proteasome System Is Necessary for Long-Term Synaptic Depression inAplysia

Fioravante, D., Liu, R.-Y., & Byrne, J. H. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2139-08.2008 · Cited by 43 · see citing works

Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD

Sydow, A., Hochgräfe, K., Könen, S., Cadinu, D., Matenia, D., Petrova, O. M., Joseph, M., Dennissen, F. J. A., & Mandelkow, E. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0281-z · Cited by 42 · see citing works

The ubiquitin-specific protease 14 (USP14) is a critical regulator of long-term memory formationPreprint

Jarome, T. J., Kwapis, J. L., Hallengren, J. J., Wilson, S. M., & Helmstetter, F. J. (2013) · Learning & Memory · doi:10.1101/lm.032771.113 · Cited by 41 · see citing works

Local ubiquitin-proteasome-mediated proteolysis and long-term synaptic plasticity

Hegde, A. N., Haynes, K. A., Bach, S. V., & Beckelman, B. C. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00096 · Cited by 40 · see citing works

Memory and the circadian system: Identifying candidate mechanisms by which local clocks in the brain may regulate synaptic plasticity

Hartsock, M. J., & Spencer, R. L. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.07.023 · Cited by 42 · see citing works

Neuronal membrane proteasomes regulate neuronal circuit activity in vivo and are required for learning-induced behavioral plasticity

He, H., Ahsan, A., Bera, R., McLain, N. J., Faulkner, R. L., Ramachandran, K. V., Margolis, S. S., & Cline, H. T. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2216537120 · Cited by 39 · see citing works

CB1-receptor-mediated inhibitory LTD triggers presynaptic remodeling via protein synthesis and ubiquitination

Monday, H. R., Bourdenx, M., Jordan, B. A., & Castillo, P. E. (2020) · eLife · doi:10.7554/elife.54812 · Cited by 38 · see citing works

The proteasome and epigenetics: zooming in on histone modifications

Bach, S. V., & Hegde, A. N. (2016) · BioMolecular Concepts · doi:10.1515/bmc-2016-0016 · Cited by 38 · see citing works

Mechanisms governing the reactivation-dependent destabilization of memories and their role in extinction

Flavell, C. R., Lambert, E. A., Winters, B. D., & Bredy, T. W. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00214 · Cited by 36 · see citing works

ATF4: a Novel Potential Therapeutic Target for Alzheimer’s Disease

Wei, N., Zhu, L., & Liu, D. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8970-8 · Cited by 36 · see citing works

The diversity of linkage-specific polyubiquitin chains and their role in synaptic plasticity and memory formation

Musaus, M., Navabpour, S., & Jarome, T. J. (2020) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2020.107286 · Cited by 36 · see citing works

An essential postsynaptic role for the ubiquitin proteasome system in slow homeostatic synaptic plasticity in cultured hippocampal neurons

Jakawich, S. K., Neely, R., Djakovic, S. N., Patrick, G. N., & Sutton, M. A. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.09.061 · Cited by 36 · see citing works

Recent insights on principles of synaptic protein degradation

Cohen, L. D., & Ziv, N. E. (2017) · F1000Research · doi:10.12688/f1000research.10599.1 · Cited by 35 · see citing works

The ubiquitin-proteasome system and learning-dependent synaptic plasticity – A 10 year update

Patrick, M. B., Omar, N., Werner, C. T., Mitra, S., & Jarome, T. J. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105280 · Cited by 35 · see citing works

The relationship between protein synthesis and protein degradation in object recognition memory

Furini, C. R. G., Myskiw, J. D. C., Schmidt, B. E., Zinn, C. G., Peixoto, P. B., Pereira, L. D., & Izquierdo, I. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.07.038 · Cited by 33 · see citing works

Synaptic proteasome is inhibited in Alzheimer’s disease models and associates with memory impairment in mice

Ribeiro, F. C., Cozachenco, D., Heimfarth, L., Fortuna, J. T. S., de Freitas, G. B., de Sousa, J. M., Alves‐Leon, S. V., Leite, R. E. P., Suemoto, C. K., Grinberg, L. T., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-05511-9 · Cited by 32 · see citing works

HECT‐type E3 ubiquitin ligases in nerve cell development and synapse physiology

Ambrozkiewicz, M. C., & Kawabe, H. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.05.009 · Cited by 31 · see citing works

Two waves of proteasome-dependent protein degradation in the hippocampus are required for recognition memory consolidation

Figueiredo, L. S., Dornelles, A. D. S., Petry, F. D. S., Falavigna, L., Dargél, V. A., Köbe, L. M., Aguzzoli, C. S., Roesler, R., & Schröder, N. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.02.005 · Cited by 31 · see citing works

Temporal phases of long-term potentiation (LTP): myth or fact?

Abbas, A.-K., Villers, A., & Ris, L. (2015) · Reviews in the Neurosciences · doi:10.1515/revneuro-2014-0072 · Cited by 29 · see citing works

Brain-derived neurotrophic factor and the course of experimental cerebral malaria

Linares, M., Marín‐García, P., Pérez-Benavente, S., Sánchez‐Nogueiro, J., Puyet, A., Bautista, J. M., & Díez, A. (2012) · Brain Research · doi:10.1016/j.brainres.2012.10.040 · Cited by 30 · see citing works

Roles of the ubiquitin proteasome system in the effects of drugs of abuse

Massaly, N., Francès, B., & Moulédous, L. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00099 · Cited by 29 · see citing works

The effects of proteasome on baseline and methamphetamine-dependent dopamine transmission

Limanaqi, F., Biagioni, F., Busceti, C. L., Ryskalin, L., & Fornai, F. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.05.008 · Cited by 29 · see citing works

A role of protein degradation in memory consolidation after initial learning and extinction learning in the honeybee (Apis mellifera)Preprint

Felsenberg, J., Dombrowski, V., & Eisenhardt, D. (2012) · Learning & Memory · doi:10.1101/lm.026245.112 · Cited by 28 · see citing works

Ubiquitin-Proteasome System Inhibition Promotes Long-Term Depression and Synaptic Tagging/Capture

Li, Q., Körte, M., & Sajikumar, S. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv084 · Cited by 29 · see citing works

Involvement of Protein Degradation by the Ubiquitin Proteasome System in Opiate Addictive Behaviors

Massaly, N., Dahan, L., Baudonnat, M., Hovnanian, C., Rekik, K., Solinas, M., David, V., Pech, S., Zajac, J., Roullet, P., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.217 · Cited by 28 · see citing works

Balanced actions of protein synthesis and degradation in memory formationPreprint

Park, H., & Kaang, B. (2019) · Learning & Memory · doi:10.1101/lm.048785.118 · Cited by 26 · see citing works

NGF-Dependent Changes in Ubiquitin Homeostasis Trigger Early Cholinergic Degeneration in Cellular and Animal AD-Model

Latina, V., Caioli, S., Zona, C., Ciotti, M. T., Borreca, A., Calissano, P., & Amadoro, G. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00487 · Cited by 26 · see citing works

The Role of Proteases in Hippocampal Synaptic Plasticity: Putting Together Small Pieces of a Complex Puzzle

Salazar, I. L., Caldeira, M. V., Curcio, M., & Duarte, C. B. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1752-5 · Cited by 25 · see citing works

Recent developments in transcriptional and translational regulation underlying long-term synaptic plasticity and memoryPreprint

Hegde, A., & Smith, S. G. (2019) · Learning & memory (Cold Spring Harbor, N.Y.) · doi:10.1101/lm.048769.118 · Cited by 19 · see citing works

Degradation of Transcriptional Repressor ATF4 during Long-Term Synaptic Plasticity

Smith, S. G., Haynes, K. A., & Hegde, A. N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228543 · Cited by 23 · see citing works

Keeping synapses in shape: degradation pathways in the healthy and aging brain

Kuijpers, M. (2022) · Neuronal Signaling · doi:10.1042/ns20210063 · Cited by 22 · see citing works

Dynamics of Hippocampal Protein Expression During Long-term Spatial Memory Formation

Borovok, N., Nesher, E., Levin, Y., Reichenstein, M., Pinhasov, A., & Michaelevski, I. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m115.051318 · Cited by 21 · see citing works

Females, but not males, require protein degradation in the hippocampus for contextual fear memory formationPreprint

Martin, K., Musaus, M., Navabpour, S., Gustin, A., Ray, W. K., Helm, R. F., & Jarome, T. J. (2021) · Learning & Memory · doi:10.1101/lm.053429.121 · Cited by 23 · see citing works

Autophagy and mitophagy at the synapse and beyond: implications for learning, memory and neurological disorders

Lu, J., Florio, D. N. D., Boya, P., Maday, S., Springer, W., & Chu, C. T. (2025) · Autophagy · doi:10.1080/15548627.2025.2581217 · Cited by 21 · see citing works

mAChR-dependent decrease in proteasome activity in the gustatory cortex is necessary for novel taste learning

Rosenberg, T., Elkobi, A., & Rosenblum, K. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.07.029 · Cited by 19 · see citing works

Proteomic analysis of hippocampal proteins in acrylamide-exposed Wistar rats

Nagashima, D., Zhang, L., Kitamura, Y., Ichihara, S., Watanabe, E., Zong, C., Yamano, Y., Sakurai, T., Oikawa, S., & Ichihara, G. (2019) · Archives of Toxicology · doi:10.1007/s00204-019-02484-9 · Cited by 18 · see citing works

Regulation of aberrant proteasome activity re‐establishes plasticity and long‐term memory in an animal model of Alzheimer's disease

Krishna‐K, K., Baby, N., Raghuraman, R., Navakkode, S., Behnisch, T., & Sajikumar, S. (2020) · The FASEB Journal · doi:10.1096/fj.201902844rr · Cited by 18 · see citing works

Distinct roles of Bdnf I and Bdnf IV transcript variant expression in hippocampal neurons

Bach, S. V., Bauman, A. J., Hosein, D., Tuscher, J. J., Ianov, L., Greathouse, K. M., Henderson, B. W., Herskowitz, J. H., Martinowich, K., & Day, J. J. (2024) · Hippocampus · doi:10.1002/hipo.23600 · Cited by 17 · see citing works

Building up and knocking down: An emerging role for epigenetics and proteasomal degradation in systems consolidation

Walters, B. J., & Zovkic, I. B. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.005 · Cited by 17 · see citing works

Proteasome and Autophagy-Mediated Impairment of Late Long-Term Potentiation (l-LTP) after Traumatic Brain Injury in the Somatosensory Cortex of Mice

Feldmann, L. K., Prieult, F. L., Felzen, V., Thal, S. C., Engelhard, K., Behl, C., & Mittmann, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20123048 · Cited by 17 · see citing works

Proteasome regulates transcription-favoring histone methylation, acetylation and ubiquitination in long-term synaptic plasticity

Bach, S. V., Tacon, P. R., Morgan, J. W., & Hegde, A. N. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.02.029 · Cited by 17 · see citing works

The Rates of Protein Synthesis and Degradation Account for the Differential Response of Neurons to Spaced and Massed Training Protocols

Naqib, F., Farah, C. A., Pack, C. C., & Sossin, W. S. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002324 · Cited by 17 · see citing works

The Drosophila LC8 homolog cut up specifies the axonal transport of proteasomes

Kreko‐Pierce, T., & Eaton, B. A. (2017) · Journal of Cell Science · doi:10.1242/jcs.207027 · Cited by 16 · see citing works

Orthogonal approaches required to measure proteasome composition and activity in mammalian brain tissue

Türker, F., Bharadwaj, R. A., Kleinman, J. E., Weinberger, D. R., Hyde, T. M., White, C. J., Williams, D. W., & Margolis, S. S. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104811 · Cited by 16 · see citing works

Chronic over‐expression of ubiquitin impairs learning, reduces synaptic plasticity, and enhances GRIA receptor turnover in mice

Vaden, J. H., Tian, T. M., Golf, S. R., McLean, J. W., Wilson, J. A., & Wilson, S. M. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14630 · Cited by 15 · see citing works

Target Proteins in the Dorsal Hippocampal Formation Sustain the Memory-Enhancing and Neuroprotective Effects of Ginkgo biloba

Gaiardo, R. B., Abreu, T. F., Tashima, A. K., Telles, M. M., & Cerutti, S. M. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01533 · Cited by 15 · see citing works

Neuronal membrane proteasome-derived peptides modulate NMDAR-dependent neuronal signaling to promote changes in gene expression

Türker, F., Brennan, A. M., & Margolis, S. S. (2023) · Molecular Biology of the Cell · doi:10.1091/mbc.e23-06-0218 · Cited by 14 · see citing works

Involvement of ubiquitination in Alzheimer’s disease

Lin, N., Gao, X., Li, X., & Chu, W.-M. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1459678 · Cited by 14 · see citing works

Two inhibitors of the ubiquitin proteasome system enhance long-term memory formation upon olfactory conditioning in the honeybee (Apis mellifera)

Felsenberg, J., Dyck, Y. F. K., Kloß, A., Dahlmann, B., Klötzel, P.-M., & Eisenhardt, D. (2014) · Journal of Experimental Biology · doi:10.1242/jeb.108142 · Cited by 14 · see citing works

Changes in the expression of collapsin response mediator protein‐2 during synaptic plasticity in the mouse hippocampus

Kadoyama, K., Matsuura, K., Nakamura‐Hirota, T., Takano, M., Otani, M., & Matsuyama, S. (2015) · Journal of Neuroscience Research · doi:10.1002/jnr.23626 · Cited by 14 · see citing works

A Putative Role for Ubiquitin-Proteasome Signaling in Estrogenic Memory Regulation

Beamish, S. B., & Frick, K. M. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.807215 · Cited by 14 · see citing works

Persistent Long-Term Facilitation at an Identified Synapse Becomes Labile with Activation of Short-Term Heterosynaptic Plasticity

Hu, J., & Schacher, S. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0098-14.2014 · Cited by 13 · see citing works

The role of 19S proteasome associated deubiquitinases in activity-dependent hippocampal synaptic plasticity

Yun, D., Zhuang, Y., Kreutz, M. R., & Behnisch, T. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.01.043 · Cited by 13 · see citing works

Proteolytic Degradation of Hippocampal STEP61 in LTP and Learning

Saavedra, A., Ballesteros, J. J., Tyebji, S., Martínez‐Torres, S., Blázquez, G., López‐Hidalgo, R., Azkona, G., Alberch, J., Martín, E. D., & Pérez‐Navarro, E. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1170-1 · Cited by 13 · see citing works

Evidence that melatonin downregulates Nedd4-1 E3 ligase and its role in cellular survival

Yalçın, E., Beker, M. Ç., Türkseven, Ş., Çağlayan, B., Gürel, B., Kılıç, Ü., Çağlayan, A. B., Cakmak, R. K., Baykal, A. T., Keleştemur, T., et al. (2019) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2019.114686 · Cited by 13 · see citing works

Emerging roles for integrated stress response signaling in homeostasis

Nandakumar, S., Grmai, L., & Vasudevan, D. (2025) · FEBS Journal · doi:10.1111/febs.70166 · Cited by 12 · see citing works

Persistent Associative Plasticity at an Identified Synapse Underlying Classical Conditioning Becomes Labile with Short-Term Homosynaptic Activation

Hu, J., & Schacher, S. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2034-15.2015 · Cited by 12 · see citing works

Rapid ATF4 Depletion Resets Synaptic Responsiveness after cLTP

Amar, F., Corona, C., Husson, J., Liu, J., Shelanski, M. L., & Greene, L. A. (2021) · eNeuro · doi:10.1523/eneuro.0239-20.2021 · Cited by 12 · see citing works

Proteasome Modulates Positive and Negative Translational Regulators in Long-Term Synaptic Plasticity

Dong, C., Bach, S. V., Haynes, K. A., & Hegde, A. N. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3291-13.2014 · Cited by 71 · see citing works

Memories of the Proteasome

Ray, L. B. (2006) · Science s STKE · doi:10.1126/stke.3582006tw363

PROTEASOME REGULATES TRANSCRIPTION AND TRANSLATION IN LONG-TERM SYNAPTIC PLASTICITY

Bach, S. (2015) · WakeSpace Scholarship (Wake Forest University)

Protein degradation by the proteasome is required for synaptic tagging and the heterosynaptic stabilization of hippocampal late-phase long-term potentiation

Cai, F., Frey, J. U., Sanna, P. P., & Behnisch, T. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.032 · Cited by 59 · see citing works

The Role of Ubiquitin-Proteasome-Mediated Proteolysis in Long-term Synaptic Plasticity

Haynes, K. A. (2015) · WakeSpace Scholarship (Wake Forest University)