Cited by 77Autism Spectrum Disorder ResearchTryptophan and brain disordersGenetics and Neurodevelopmental Disorders

Inflammatory profiles in the BTBR mouse: how relevant are they to autism spectrum disorders?

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Careaga, Milo, Schwartzer, Jared, Ashwood, Paul·2015·Brain Behavior and Immunity

Abstract

Autism spectrum disorders (ASD) are a group of disorders characterized by core behavioral features including stereotyped interests, repetitive behaviors and impairments in communication and social interaction. In addition, widespread changes in the immune systems of individuals with ASD have been identified, in particular increased evidence of inflammation in the periphery and central nervous system. While the etiology of these disorders remains unclear, it appears that multiple gene and environmental factors are involved. The need for animal models paralleling the behavioral and immunological features of ASD is paramount to better understand the link between immune system dysregulation and behavioral deficits observed in these disorders. As such, the asocial BTBR mouse strain displays both ASD relevant behaviors and persistent immune dysregulation, providing a model system that has and continues to be instructive in understanding the complex nature of ASD.

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Authors
Careaga, M., Schwartzer, J., & Ashwood, P.
Affiliations
  • University of California, Davis (US)
  • Mount Holyoke College (US)
Corresponding author
Ashwood, Paul
Venue
Brain Behavior and Immunity
Publisher
Elsevier BV
Published
2015-01
Volume
43
Pages
11-16
ISSN
0889-1591 (ISSN-L)
OpenAlex
W2014225402
Cited by
77
References
64
Citations by year
2026: 2 · 2025: 6 · 2024: 9 · 2023: 10 · 2022: 8 · 2021: 7 · 2020: 7 · 2019: 5 · 2018: 7 · 2017: 7 · 2016: 5 · 2015: 4
FWCI
0.51
Type
journal article
Language
en
Open access
Locations
  • Brain Behavior and Immunity (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
National Institute of Mental Health (T32MH073124)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
autism spectrum disorder, BTBR mice, immune dysregulation, neuroinflammation, animal models of autism, asocial behavior, peripheral inflammation, behavioral deficits
MeSH terms
Animals, Child Development Disorders, Pervasive, Disease Models, Animal, Inflammation, Interpersonal Relations, Mice, Inbred Strains, Phenotype, Social Behavior, Mice

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