Inflammatory profiles in the BTBR mouse: how relevant are they to autism spectrum disorders?
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Autism spectrum disorders (ASD) are a group of disorders characterized by core behavioral features including stereotyped interests, repetitive behaviors and impairments in communication and social interaction. In addition, widespread changes in the immune systems of individuals with ASD have been identified, in particular increased evidence of inflammation in the periphery and central nervous system. While the etiology of these disorders remains unclear, it appears that multiple gene and environmental factors are involved. The need for animal models paralleling the behavioral and immunological features of ASD is paramount to better understand the link between immune system dysregulation and behavioral deficits observed in these disorders. As such, the asocial BTBR mouse strain displays both ASD relevant behaviors and persistent immune dysregulation, providing a model system that has and continues to be instructive in understanding the complex nature of ASD.
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The BTBR mouse has been shown to display a pro-inflammatory phenotype that is thought to contribute to the development of ASD-like behavior.
“Indeed, the BTBR mouse has been shown to display a pro-inflammatory phenotype that is thought to contribute to the development of ASD-like behavior (Careaga et al., 2015; Heo et al., 2011; Onore et al., 2013).”
From Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism (2017) · cites this paper as Careaga et al., 2015
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- Authors
- Careaga, M., Schwartzer, J., & Ashwood, P.
- Affiliations
- University of California, Davis (US)
- Mount Holyoke College (US)
- Corresponding author
- Ashwood, Paul
- Venue
- Brain Behavior and Immunity
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 43
- Pages
- 11-16
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC4776653
- OpenAlex
- W2014225402
- Cited by
- 77
- References
- 64
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 9 · 2023: 10 · 2022: 8 · 2021: 7 · 2020: 7 · 2019: 5 · 2018: 7 · 2017: 7 · 2016: 5 · 2015: 4
- FWCI
- 0.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Mental Health (T32MH073124)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, BTBR mice, immune dysregulation, neuroinflammation, animal models of autism, asocial behavior, peripheral inflammation, behavioral deficits
- MeSH terms
- Animals, Child Development Disorders, Pervasive, Disease Models, Animal, Inflammation, Interpersonal Relations, Mice, Inbred Strains, Phenotype, Social Behavior, Mice
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