CoChat
Sign Up
Cited by 9Neuroscience and Neural EngineeringNeural dynamics and brain functionEEG and Brain-Computer Interfaces

Local field potential phase modulates neural responses to intracortical electrical stimulation

Allison-Walker, Timothy John, Ann Hagan, Maureen, Chiang Price, Nicholas Seow, Tat Wong, Yan·2020·2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
DOI 10.1109/embc44109.2020.9176186
Open this paper in CoChat — free account

Abstract

Cortical visual prostheses could one day help restore sight to the blind by targeting the visual cortex with electrical stimulation. However, power consumption and limited spatial resolution impose limits on performance, while large amounts of electrical charge sometimes necessary to evoke phosphenes can cause seizures. Here, we propose the use of the local field potential as a control signal for the timing of stimulation to reduce charge requirements. In Sprague-Dawley rats, visual cortex was electrically stimulated at random times, and neural responses recorded. Electrical stimulation at specific phases of the local field potential required smaller amounts of charge to elicit spikes than naïve stimulation. Incorporating this into prosthesis design could improve their safety and efficacy.

Integrity signals

Registry

Crossref · 10.1109/embc44109.2020.9176186

Cites

22 of 22 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Pre-stimulus activity influences both neural responses and perceptual thresholds.

    “Additionally, pre-stimulus activity has been shown to influence both neural responses and perceptual thresholds [42, 44–46].”

    From Deep Learning–Based Control of Electrically Evoked Activity in Human Visual Cortex (2025) · cites this paper as [45]

  • Preliminary studies in rats show that it is possible to use the information from the local field potentials (LFPs) as control signals to specify the precise timing of stimulation to reduce charge requirements.

    “Some preliminary studies in rats support this point of view and show that it is possible to use the information from the local field potentials (LFPs) as control signals to specify the precise timing of stimulation to reduce charge requirements (Allison-Walker et al., 2020).”

    From Toward a personalized closed-loop stimulation of the visual cortex: Advances and challenges (2022) · cites this paper as Allison-Walker et al., 2020

  • LFP phase-dependent response to stimulation has been reported in experiments in rats and using non-invasive transcranial magnetic stimulation (TMS) in sighted humans.

    “This has been reported in experiments in rats (Allison-Walker et al., 2020) and using non-invasive transcranial magnetic stimulation (TMS) in sighted humans (Dugue et al., 2011), but the feasibility of LFP phase-locked stimulation with intracortical electrodes in humans still remains unexplored.”

    From Toward a personalized closed-loop stimulation of the visual cortex: Advances and challenges (2022) · cites this paper as Allison-Walker et al., 2020

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Allison-Walker, T. J., Ann Hagan, M., Chiang Price, N. S., & Tat Wong, Y.
Affiliations
Monash University (AU)
Venue
2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
Publisher
IEEE
Published
2020-07
Volume
2020
Pages
3521-3524
ISSN
2375-7477 (ISSN-L)
DOI
10.1109/embc44109.2020.9176186
OpenAlex
W3082055087
Cited by
9
References
22
Citations by year
2026: 1 · 2025: 2 · 2023: 1 · 2022: 3 · 2021: 2
FWCI
5.76
Type
conference paper
Language
en
Open access
closed
Licence
Locations
  • Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
Keywords
local field potentials, cortical visual prosthesis, visual cortex, stimulation timing, phosphenes, seizure risk, neural responses, rat model
MeSH terms
Animals, Electric Stimulation, Evoked Potentials, Visual, Phosphenes, Visual Cortex, Rats, Sprague-Dawley, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review