Cited by 16Neuroscience and Neural EngineeringNeural dynamics and brain functionEEG and Brain-Computer Interfaces

Spectral distribution of local field potential responses to electrical stimulation of the retina

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Wong, Yan T, Halupka, Kerry, Kameneva, Tatiana, Cloherty, Shaun L, Grayden, David B, Burkitt, Anthony N, Meffin, Hamish, Shivdasani, Mohit N·2016·Journal of Neural Engineering

Abstract

OBJECTIVE: Different frequency bands of the local field potential (LFP) have been shown to reflect neuronal activity occurring at varying cortical scales. As such, recordings of the LFP may offer a novel way to test the efficacy of neural prostheses and allow improvement of stimulation strategies via neural feedback. Here we use LFP measurements from visual cortex to characterize neural responses to electrical stimulation of the retina. We aim to show that the LFP is a viable signal that contains sufficient information to optimize the performance of sensory neural prostheses. APPROACH: Clinically relevant electrode arrays were implanted in the suprachoroidal space of one eye in four felines. LFPs were simultaneously recorded in response to stimulation of individual electrodes using penetrating microelectrode arrays from the visual cortex. The frequency response of each electrode was extracted using multi-taper spectral analysis and the uniqueness of the responses was determined via a linear decoder. MAIN RESULTS: We found that cortical LFPs are reliably modulated by electrical stimulation of the retina and that the responses are spatially localized. We further characterized the spectral distribution of responses, with maximum information being contained in the low and high gamma bands. Finally, we found that LFP responses are unique to a large range of stimulus parameters (∼40) with a maximum conveyable information rate of 6.1 bits. SIGNIFICANCE: These results show that the LFP can be used to validate responses to electrical stimulation of the retina and we provide the first steps towards using these responses to provide more efficacious stimulation strategies.

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Authors
Wong, Y. T., Halupka, K., Kameneva, T., Cloherty, S. L., Grayden, D. B., Burkitt, A. N., Meffin, H., & Shivdasani, M. N.
Affiliations
  • The University of Melbourne (AU)
  • Bionics Institute (AU)
  • National Vision Research Institute, Australian College of Optometry, Carlton, VIC 3053,
Corresponding author
Wong, Yan T
Venue
Journal of Neural Engineering
Published
2016-03-30
Volume
13
Issue
3
Pages
036003
ISSN
  • 1741-2552 (ISSN-L)
  • 1741-2560
OpenAlex
W2330926819
Cited by
16
References
56
Citations by year
2026: 1 · 2025: 1 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 1
FWCI
0.75
Type
journal article
Language
en
Open access
Locations
  • Journal of Neural Engineering (publishedVersion)
  • PubMed (publishedVersion)
  • RMIT Research Repository (RMIT University Library) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
  • Swinburne figshare (Swinburne University of Technology) (submittedVersion)
Funders
  • Australian Research Council (DP140104533)
  • Special Research Initiative (SRI) in Bionic Vision Science and Technology awarded to Bionic Vision Australia (SR1000005)
  • National Health and Medical Research Council Australia (GNT1063093)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
Keywords
local field potentials, visual cortex, neural prostheses, gamma band, spectral distribution, frequency response, linear decoder, information rate, feline model, neural feedback
MeSH terms
Algorithms, Animals, Cats, Electric Stimulation, Electrodes, Implanted, Evoked Potentials, Visual, Membrane Potentials, Microelectrodes, Prosthesis Design, Visual Cortex, Visual Prosthesis, Neural Prostheses

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