The DOI matches its Crossref record; 209 of the 212 references it cites were found in a registry or an index.
Toward Ubiquitous Blood Pressure Monitoring via Pulse Transit Time: Theory and Practice
Open accessAbstract
Ubiquitous blood pressure (BP) monitoring is needed to improve hypertension detection and control and is becoming feasible due to recent technological advances such as in wearable sensing. Pulse transit time (PTT) represents a well-known potential approach for ubiquitous BP monitoring. The goal of this review is to facilitate the achievement of reliable ubiquitous BP monitoring via PTT. We explain the conventional BP measurement methods and their limitations; present models to summarize the theory of the PTT-BP relationship; outline the approach while pinpointing the key challenges; overview the previous work toward putting the theory to practice; make suggestions for best practice and future research; and discuss realistic expectations for the approach.
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“Models that require a single calibration cuff measurement are convenient but potentially less accurate than those that use multiple measurements to form a patient-specific calibration curve”
From Wearable Photoplethysmography for Cardiovascular Monitoring (2022) · cites this paper as [20]
In the citing paper
“Pulse wave propagation delay between the genders indicates baseline differences in arterial stiffness with women displaying lower degrees of pulse arrival latency delay indicating higher vascular stiffness [106,107].”
From Sources of inaccuracy in photoplethysmography for continuous cardiovascular monitoring (2021) · cites this paper as [106]
In the citing paper
“New devices that promise to change the current paradigm of hypertension monitoring use either inflating wristband cuffs (e.g., Omron HeartGuide, currently undergoing clinical testing) or optical pulse wave-based metrics of BP [75,76].”
From Wearables and the Medical Revolution (2018) · cites this paper as [76]
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Citations
Cites
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“The advantage of reflectance-mode PPG is that it is less restrictive in terms of measurement locations [66], [67], [69].”
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Non-invasive pulse wave velocity measurement in mice
Zakaria, H., & Hasimun, P. (2017) · International Seminar on Sensors, Instrumentation, Measurement and Metrology (ISSIMM) · doi:10.1109/issimm.2017.8124270 · Cited by 7
“PAT is the time duration from first reference time point (R-wave) to second reference time point (Foot of PPG) [12][13].”
BackgroundFeasibility of Noninvasive Blood Pressure Measurement using a Chest-worn Patch Sensor
Selvaraj, N., & Reddivari, H. (2018) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2018.8513211 · Cited by 7
“The univariate relationship between traditional finger based PTT and BP has been extensively reported [2].”
BackgroundMethodCuffless Blood Pressure Estimation for Activities of Daily Living
Landry, C., Hedge, E. T., Hughson, R. L., Peterson, S. D., & Arami, A. (2020) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc44109.2020.9175976 · Cited by 7
“Most existing models for cuffless BP monitoring only provide SBP and DBP estimations [8], [9], with a couple of noted exceptions that also enable the estimation of the mean arterial pressure (MAP) [10], [11] or the pulse pressure [12].”
Vascular reactivity characterized by PPG-derived pulse wave velocity
Julián, P. A., Kontaxis, S., Lázaro, J. M., Rapalis, A., Brazaitis, M., Marozas, V., Laguna, P., Bailón, R., & Gil, E. (2025) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2025.107641 · Cited by 6
Li, J., Zhang, H., Zhang, Z., Zhang, H., Yang, X., & Yang, J. (2025) · IEEE Transactions on Instrumentation and Measurement · doi:10.1109/tim.2025.3548805 · Cited by 6
“Due to complex physiological factors and multidimensional features of pulse waveforms, existing linear methods [35], [36] typically struggle to accurately predict blood pressure.”
Sensor for cardiovascular health status monitoring: A review
Petronienė, J. J., Vaičiūnas, G., Garbinčius, G., Dzedzickis, A., & Bučinskas, V. (2025) · Sensors and Actuators A Physical · doi:10.1016/j.sna.2025.116720 · Cited by 7
Conformal prediction quantifies wearable cuffless blood pressure with certainty
Shen, Z., Chakraborti, T., Banerji, C. R. S., & Ding, X. (2025) · Scientific Reports · doi:10.1038/s41598-025-09580-0 · Cited by 6
“However, DBP estimation consistently outperforms SBP estimation, aligning with findings from prior cuffless BP studies 21,30 .”
Estimating blood pressure using video-based PPG and deep learning
Zaza, G., Casalino, G., Caputo, S. L., & Castellano, G. (2025) · Image and Vision Computing · doi:10.1016/j.imavis.2025.105683 · Cited by 6
Integrating transfer learning with scalogram analysis for blood pressure estimation from PPG signals
Subramanian, S., Mishra, S., Patil, S., Kolekar, M. H., & Ortiz, F. (2025) · Scientific Reports · doi:10.1038/s41598-025-23350-y · Cited by 5
Artificial Intelligence-Driven Wearable Sensors for Cardiovascular Health Monitoring
Deng, H. T., Ma, B., Chen, G., Chi, J., Tong, J., Yu, F., Lü, B., Chen, Y., Zhao, C., Zhang, C., et al. (2026) · ACS Sensors · doi:10.1021/acssensors.5c04840 · Cited by 6
Poliński, A. (2023) · Physiological Measurement · doi:10.1088/1361-6579/acbf00 · Cited by 6
“In the last case, the tangent was calculated based on five points near themaximal slope using the least squares approach (Mukkamala et al 2015, Poliński et al 2021).”
MethodNocturnal Blood Pressure Estimation from Sleep Plethysmography Using Machine Learning
Yılmaz, G., Lyu, X., Ong, J. L., Ling, L. H., Penzel, T., Yeo, B. T. T., & Chee, M. W. L. (2023) · Sensors · doi:10.3390/s23187931 · Cited by 7
“A linear relationship between PAT/PTT and BP can be derived from explicit analytical models [9].”
BackgroundSecuring Pacemakers Using Runtime Monitors over Physiological Signals
Panda, A., Pinisetty, S., & Roop, P. S. (2024) · ACM Transactions on Embedded Computing Systems · doi:10.1145/3638286 · Cited by 6
MEMS Fingertip Strain Plethysmography for Cuffless Estimation of Blood Pressure
Shokouhmand, A., Jiang, X., Ayazi, F., & Ebadi, N. (2024) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2024.3372968 · Cited by 6
“Furthermore, the regression parameters are subject-specific, hindering the generalization of the model among subjects [9].”
BackgroundMethodZhao, J. F., Zhang, Q., Qin, C., Lu, T., Ning, Z., Guan, Q., & Ma, X. (2024) · International Joint Conference on Neural Networks (IJCNN) · doi:10.1109/ijcnn60899.2024.10649923 · Cited by 6
“Currently, much research employs prediction methods based on the Pulse Transit Time (PTT) [11], [12] or manual feature extraction [13], [14].”
MethodMarchi, B. D., Agovi, E., & Aliverti, A. (2024) · Information Systems Frontiers · doi:10.1007/s10796-024-10550-6 · Cited by 7
“According to the literature (Mukkamala et al., 2015), the optimal site for detecting the PPG signal using this method is the radial artery of the left arm.”
Guo, J., Wang, W., Zhang, J., Chen, H., Chen, R., Zhao, B., Xie, X., & Chen, D. (2024) · Journal of Lightwave Technology · doi:10.1109/jlt.2024.3515043 · Cited by 6
“In previous studies, PTT has been identified as a potential indicator for continuous, cuffless BP estimation [29].”
Zhou, Y., Shahrbabak, S. M., Bahrami, R., Rahman, F. N., Sanchez-Perez, J. A., Gazi, A. H., Inan, O. T., & Hahn, J. (2025) · Sensors · doi:10.3390/s25051371 · Cited by 6
“We repeated the above procedure to construct distinct SMVs pertaining to MNS and AVNS in order to compare and contrast their respective mechanism of action.”
A Self-Calibrated, Wearable Vital Sign Monitoring Device Enabled by Edge Computing
Jayathilake, M., Miller, M., Byfield, R., & Lin, J. (2025) · IEEE Sensors Journal · doi:10.1109/jsen.2025.3563830 · Cited by 6
“While photoplethysmogram (PPG) signals have been explored in various ways, three main methods have been used to correlate PPG and BP: pulse transit time (PTT) [5], pulse arrival time (PAT) [6], and pulse wave analysis (PWA) [7], along with pulse wave velocity (PWV) [8].”
Difference in Pulse Arrival Time at Forehead and at Finger as a Surrogate of Pulse Transit Time
Lázaro, J. M., Bailón, R., Laguna, P., Marozas, V., Rapalis, A., & Gil, E. (2016) · Computing in cardiology · doi:10.22489/cinc.2016.079-432 · Cited by 6
“This motivates the study of some alternatives to ECG for measuring the proximal point, including ballistocardiogram, seismocardiogram, and impedance cardiography [1].”
BackgroundMethodPu, Y., Xie, X., Xiong, L., & Zhang, H. (2021) · Advances in transdisciplinary engineering · doi:10.3233/atde210241 · Cited by 6
“[11] proposed two arterial wall mechanics and wave propagation models in the artery.”
BackgroundChalumuri, Y. R., Kimball, J. P., Mousavi, A. S., Zia, J. S., Rolfes, C., Parreira, J. D., Inan, O. T., & Hahn, J. (2022) · Sensors · doi:10.3390/s22041336 · Cited by 6
“5–10 Hz for the PPG, which were chosen based on the best practices reported in the literature [28,29].”
MethodXu, Z., Sakagawa, T., Furui, A., Jomyo, S., Morita, M., Ando, M., & Tsuji, T. (2022) · IEEE Sensors Journal · doi:10.1109/jsen.2022.3165880 · Cited by 6
“2(a), the real-time QRS detection algorithm developed for feature extraction of ECG signals was used to detect the peak point of the pulse wave and the ECG in each heartbeat cycle [34].”
MethodToda, S., & Matsumura, K. (2023) · Sensors · doi:10.3390/s23073689 · Cited by 6
Park, S., Lee, S., Park, E., Lee, J., & Kim, I. Y. (2023) · Biomedical Engineering Letters · doi:10.1007/s13534-023-00284-w · Cited by 6
“PTT can be replaced by pulse arrival time (PAT), and most Seongryul Park and Seungjae Lee have contributed equally to this work. researchers have used PAT due to its convenience for measurement [5, 6].”
BackgroundSurapaneni, S. P., & Manikandan, M. S. (2023) · International Conference on Electronics, Computers and Artificial Intelligence (ECAI) · doi:10.1109/ecai58194.2023.10194077 · Cited by 6
“The PPG signal is acquired non-invasively by using a simple and low-cost optical sensing technique [2], [4], [5], wherein the”
BackgroundMethodSelvaraj, N. (2016) · IEEE Healthcare Innovations and Point of Care Technologies Conference (HI-POCT) · doi:10.1109/hic.2016.7797731 · Cited by 6
“com) physiological interventions, and their reliability as predictors of beat-to-beat NIBP for medical practice is dubious [2]– [6].”
BackgroundWearable Sensing of Left Ventricular Function
Inan, O. T. (2017) · Springer eBooks · doi:10.1007/978-3-319-51394-2_14 · Cited by 6
Nabeel, P. M., Karthik, S., Joseph, J., & Sivaprakasam, M. (2017) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2017.8037169 · Cited by 6
“The present cuffless BP methods using PWV are based on mathematical models requiring either subject or population specific calibration [1].”
MethodLi, Y., Li, S., & Deng, N. (2018) · International Journal of Distributed Sensor Networks · doi:10.1177/1550147718818738 · Cited by 6
Casanella, R., Khosrow-Khavar, F., Schmidt, S. E., Zanetti, J. M., & Tavakolian, K. (2019) · Series in bioengineering · doi:10.1007/978-981-10-5092-3_3 · Cited by 6
Personalized Nutrition: Customizing Your Diet for Better Health
McClements, D. J. (2019) · Springer eBooks · doi:10.1007/978-3-030-12995-8_8 · Cited by 6
Pulse Decomposition Analysis Techniques
Baruch, M. C. (2019) · Springer eBooks · doi:10.1007/978-3-030-24701-0_7 · Cited by 6
Evaluation of transit time-based models in wearable central aortic blood pressure estimation
Fierro, G., Armentano, R. L., & Silveira, F. (2020) · Biomedical Physics & Engineering Express · doi:10.1088/2057-1976/ab7a55 · Cited by 6
Nabeel, P. M., Kiran, V. R., Shah, M. I., Abhidev, V. V., Manoj, R., Sivaprakasam, M., & Joseph, J. (2021) · IEEE International Symposium on Medical Measurements and Applications (MeMeA) · doi:10.1109/memea52024.2021.9478737 · Cited by 6
Panula, T., Sirkiä, J., & Kaisti, M. (2021) · Computing in cardiology · doi:10.23919/cinc53138.2021.9662866 · Cited by 6
“A typical VUT system consists of a main unit similar to hospital patient monitors and a finger cuff device connected via communication cable and pneumatic tubing.”
MethodInfluentialHigh Sampling Rate Smartphone-PPG via Built-in Rolling Shutter Image Sensor
Rachim, V. P., Baek, J., Kim, Y. S., Kim, Y., & Park, S. (2022) · IEEE Internet of Things Journal · doi:10.1109/jiot.2022.3201910 · Cited by 6
“one of the emerging methods for PPG-derived physiological monitoring in mobile devices is related to the BP monitoring system [41], [44].”
MethodInfluentialBresch, E., Schmitt, L., Matteis, D. D., & Muehlsteff, J. (2016) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2016.7591666 · Cited by 6
“We have been following the pulse wave velocity (PWV) methodology towards unobtrusive ABP measurement, since sensor embodiments are small and light weight and offer potentially comfortable quasi-continuous and non-invasive ABP measurements [1-5].”
MethodDesign a noninvasive digital blood pressure meter using high sensitivity pressure gauge MPX5050GP
Mujadin, A., & Kusuma, P. W. (2017) · International Symposium on Electronics and Smart Devices (ISESD) · doi:10.1109/isesd.2017.8253339 · Cited by 6
“The MAP can be seen after extracted the oscillation signal [4].”
BackgroundInfluentialXu, Y., Zhang, W., Wang, D., & Ping, P. (2018) · IEEE International Instrumentation and Measurement Technology Conference · doi:10.1109/i2mtc.2018.8409817 · Cited by 6
“To improve the performances of PTT-based cuff-less BP estimation method, the key point is the calibration model between PTT and BP [5].”
BackgroundMethodYang, C., Dong, Y., Chen, Y. J., & Tavassolian, N. (2019) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2019.2936414 · Cited by 6
“, they cannot effectively track immediate BP variations [4].”
InfluentialJanjua, G. M. W., Finlay, D., Guldenring, D., Haq, A. U., & McLaughlin, J. A. (2019) · IEEE Access · doi:10.1109/access.2019.2944212 · Cited by 6
Han, 杨. Y., Shihong, 王. W., Hao, 钟. Z., Leyang, 黄. H., Jianxin, 赵. Z., Lü, 吕. W., Zeyin, 毛. M., Anni, 邓. D., Yixuan, 石. S., Qin, 黄. H., et al. (2024) · Chinese Journal of Lasers · doi:10.3788/cjl231418 · Cited by 5
Wang, H., Yao, C., Liu, Z., Wang, X., Liu, Z., Zhang, T., Huang, X., Wang, L., Wang, Y., Xiao, G., et al. (2024) · Advanced Intelligent Systems · doi:10.1002/aisy.202400547 · Cited by 5
Video-based estimation of blood pressure
Dasari, A., Jeni, L. A., & Tucker, C. S. (2025) · PLoS ONE · doi:10.1371/journal.pone.0311654 · Cited by 5
“To estimate PWV, we compute Pulse Transit Time (PTT) [19], defined as the temporal delay between rPPG signals obtained from two regions at different distances from the heart (such as the face and the hand).”
Kim, M., Sung, M., Jung, J., Cho, S. P., Park, J., Soh, S., Joo, H., & Chung, K. S. (2026) · Sensors · doi:10.3390/s26020735 · Cited by 7
Lee, Y., Ko, D.-H., Son, M.-H., Yang, S.-H., & Um, J. (2024) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2024.3363134 · Cited by 5
Fassina, L., Muzio, F. P. L., Berboth, L., Otvos, J., Faragli, A., & Alogna, A. (2024) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-024-10546-2 · Cited by 5
Hong, S., Hsiao, C., & Coté, G. L. (2024) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2024.116793 · Cited by 5
A PMUT-Based Wearable Ultrasound System for Central Blood Pressure Monitoring
Yang, H. Z., Liu, H., Chen, J., Gao, X., Chen, C., Wang, Z., Zhang, X., Li, H., & Yin, F. (2024) · IEEE Ultrasonics, Ferroelectrics, and Frequency Control Joint Symposium (UFFC-JS) · doi:10.1109/uffc-js60046.2024.10793732 · Cited by 5
“However, upper arm sphygmo-manometers rely on cuffs, and the inflation and deflation process during measurement can cause patient discomfort, making them unsuitable for frequent or continuous blood pressure monitoring [7].”
A Novel Wearable Device for Continuous Blood Pressure Monitoring Utilizing Strain Gauge Technology
McMurray, J. P., DeVries, A., Frazee, K. P., Sizemore, B., Branan, K. L., Jennings, R., & Coté, G. L. (2025) · Biosensors · doi:10.3390/bios15070413 · Cited by 6
Dhillon, M. S., & Banet, M. J. (2019) · Springer eBooks · doi:10.1007/978-3-030-24701-0_5 · Cited by 5
Cuffless Blood Pressure Monitoring and the Advent of a New Era in Medicine and Society
Avolio, A. P., Shirbani, F., Tan, I., & Butlin, M. (2019) · Springer eBooks · doi:10.1007/978-3-030-24701-0_1 · Cited by 5
Zhang, P., Liu, C., Chen, H., & Liu, J. (2020) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2020.2979249 · Cited by 5
“At the second level of the TOP strategy, an indirect parameter estimation can then learn to project the subjects’ physiologic parameters to the optimal TF parameters estimated at the first level of the TOP strategy, as we assume that coefficient B and time delay Δt are related to these physiologic parameters according…”
BackgroundFinnegan, E., Davidson, S. M., Harford, M., Jorge, J., & Villarroel, M. (2021) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc46164.2021.9629883 · Cited by 5
“PEP has been shown to be a large proportion of PAT (10-35%) and has been suggested to be a significant limitation to SBP estimation using PAT [5].”
BackgroundMethodInfluentialA Hardware-based Lightweight ANN for Real-time Wearable Blood Pressure Estimation
Zhang, J., Li, J., Jiang, Y., Wang, K., Guo, R., Ma, Y., & Qin, Y. (2022) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc48229.2022.9871215 · Cited by 5
“PPG waveform analysis is a potential approach for achieving continuous, non-invasive, and cuff-less BP measurement [4].”
MethodRadial artery pulse wave estimation by compressed sensing measurements of wrist bio-impedance
Kromka, J., Šaliga, J., Kováč, O., Vito, L. D., Picariello, F., & Tudosa, I. (2023) · Measurement · doi:10.1016/j.measurement.2023.113174 · Cited by 5
Zhou, Y., Parreira, J. D., Shahrbabak, S. M., Sanchez-Perez, J. A., Rahman, F. N., Gazi, A. H., Inan, O. T., & Hahn, J. (2024) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2024.3453121 · Cited by 5
“…physio-markers are plausibly explainable: (i) PTT and PAT are inversely proportional to diastolic and systolic BP in acute settings, respectively [32]; (ii) PEP is inversely proportional to cardiac contractility and thus to SV [34], [35]; (iii) PPG amplitude at the extremity locations is…”
Non-invasive monitoring of pulmonary artery pressure at the bedside
Proença, M., Braun, F., Muntané, E., Solà, J., Adler, A., Lemay, M., Thiran, J., & Rimoldi, S. F. (2016) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2016.7591662 · Cited by 5
“An acceptable approximation is to use the R-wave peak of the ECG as surrogate timing reference: the PTT is approximated by the so-called pulse arrival time (PAT) [11].”
MethodQuantifying the effects of blood pressure changes on ballistocardiogram signals
Javaid, A. Q., Töreyin, H., & Inan, O. T. (2017) · Signal Processing and Communications Applications Conference (SIU) · doi:10.1109/siu.2017.7960423 · Cited by 5
“The PTT-BP relationship has been extensively studied in existing literature [7].”
BackgroundPredicting High Blood Pressure Using Decision Tree-Based Algorithm
Nimmala, S., Ramadevi, Y., Naik, N. S., & Cheruku, R. (2018) · Advances in intelligent systems and computing · doi:10.1007/978-981-10-8569-7_6 · Cited by 5
A Meta-Analysis of Pulse Arrival Time Based Blood Pressure Estimation
Poliński, A., Pietrewicz, M., Kocejko, T., Bujnowski, A., Rumiński, J., & Wtorek, J. (2018) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2018.8513605 · Cited by 6
“There are also variety of methods for estimating these points (see for example [19], [20]).”
Wood, K. N., Greaves, D. K., & Hughson, R. L. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00317.2019 · Cited by 5
Pulse Wave Velocity Techniques
Li, J. (2019) · Springer eBooks · doi:10.1007/978-3-030-24701-0_6 · Cited by 5
Dash, A. K., Jain, K., Ghosh, N., Patra, A., & Choudhury, A. D. (2019) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2019.8856583 · Cited by 5
“Review articles on BP monitoring using PAT and other physiological parameters can be found in [6], [10].”
BackgroundMethodA Machine Learning Enabled Wireless Intracranial Brain Deformation Sensing System
Islam, S., Shah, V., Gidde, S. T. R., Hutapea, P., Song, S. H., Picone, J., & Kim, A. (2020) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2020.2990071 · Cited by 5
“TBI depends heavily on blood pressure [9], [10], cerebrospinal fluid (CSF), or intracranial pressure (ICP).”
BackgroundMulti-source Multi-frequency Bio-impedance Measurement Method for Localized Pulse Wave Monitoring
Ibrahim, B., Talukder, A., & Jafari, R. (2020) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc44109.2020.9176495 · Cited by 5
“Previous studies showed that cuffless BP can be estimated from features extracted from the arterial pulse signal at the wrist based on the morphology of the pulse signal and pulse transit time (PTT) which is the time delay between the pulse signal between two points along the artery [4-6].”
BackgroundFrom sleep medicine to medicine during sleep–a clinical perspective
Bar, N., Sobel, J., Penzel, T., Shamay, Y., & Behar, J. A. (2021) · Physiological Measurement · doi:10.1088/1361-6579/abf47c · Cited by 5
Noncontact Monitoring of Relative Changes in Blood Pressure Using Microwave Radar Sensors
Suzuki, S. V., Sun, G., Hoshiga, M., Kotani, K., & Asao, T. (2022) · Journal of Biomedical Science and Engineering · doi:10.4236/jbise.2022.151006 · Cited by 5
Wu, Y., Geng, X., Xu, Z., & Ni, X. (2022) · Nature and Science of Sleep · doi:10.2147/nss.s370334 · Cited by 5
“BP value can be obtained for each beat.(20) Since the sleep stage score is based on 30 seconds, BP”
BackgroundMethods of Contactless Blood Pressure Measurement
Bajraktari, F., Liu, J., & Pott, P. P. (2022) · Current Directions in Biomedical Engineering · doi:10.1515/cdbme-2022-1112 · Cited by 5
“It is inversely related to the BP [12].”
BackgroundPulse arrival time measurement with coffee provocation
Ahmaniemi, T., Rajala, S., Lindholm, H. J., & Taipalus, T. (2017) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2017.8036810 · Cited by 5
“Firstly, satisfactory correlation of PAT or PWV with blood pressure seems to be apply only to systolic blood pressure [5], which may be insufficient for cardiac monitoring applications.”
BackgroundInfluentialBlood Pressure Estimation using Arterial Diameter: Exploring Different Machine Learning Methods
Poojitha, U. P., Ram, K., Nabeel, P. M., Kiran, R. V., Joseph, J., & Sivaprakasam, M. (2020) · IEEE International Symposium on Medical Measurements and Applications (MeMeA) · doi:10.1109/memea49120.2020.9137234 · Cited by 5
“The need for cuff-less BP measurement is growing due to its applicability as wearable, clinical importance and non-invasiveness [2], [3].”
BackgroundMethodGuang, Z., Wang, Z., Hou, F., Wan, Z., Feng, C., Yu, M. Y., Wang, J., & Wang, H. (2021) · Review of Scientific Instruments · doi:10.1063/5.0037661 · Cited by 5
Zhang, P., Qiu, Q., & Zhou, Y. (2018) · Australasian Physical & Engineering Sciences in Medicine · doi:10.1007/s13246-018-0652-9 · Cited by 5
Noninvasive method to validate the variability of blood pressure during arrhythmias
Watanabe, T., Hoshide, S., & Kario, K. (2021) · Hypertension Research · doi:10.1038/s41440-021-00835-7 · Cited by 5
“cardiography monitoring to the maximum pulse wave in the peripheral arteries was defined as the conventional pulse transit time (cPTT) [5, 6], and this time variable has been used in a novel cuffless form of continuous BP monitoring.”
MethodPracticalBP: Continuous Cuffless Blood Pressure Monitoring with Only One Record for Calibration
Li, C., Junyao, P., Hu, Q., Chen, L., Huang, Y., Wu, S., Cheng, W., & Zhang, Q. (2025) · Proceedings of the ACM on Interactive Mobile Wearable and Ubiquitous Technologies · doi:10.1145/3749486 · Cited by 5
“This type of work is based on the Moens-Korteweg equation and Hughes Equation [40, 45] to model blood vessels and blood flow, and it is found that BP has a strong correlation with pulse wave transmission velocity.”
Cuffless Blood Pressure Monitoring Devices: Technical Foundations and Clinical Implications
Parati, G., Ochoa, J. E., Abreu, A. B. A., Brouwers, S., Bruno, R. M., Caiani, E. G., Casado-Arroyo, R., Cluitmans, M. J. M., Davos, C. H., LUCIA, R. D., et al. (2026) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwag058 · Cited by 5
Calibration‐free blood pressure estimation based on a convolutional neural network
Cho, J.-W., Shin, H., & Choi, A. (2023) · Psychophysiology · doi:10.1111/psyp.14480 · Cited by 4
Evaluation of Wearable Head BCG for PTT Measurement in Blood Pressure Intervention
Wang, W., Zhu, L., Morshed, M. B., Rahman, M. M., Bae, J., & Kuang, J. (2025) · IEEE International Conference on Acoustics Speech and Signal Processing · doi:10.1109/icassp49660.2025.10890732 · Cited by 4
“Pulse transit time (PTT), the time interval taken for pulse wave to travel from proximal to distal sites through the aorta tree, is well recognized to closely relate to BP through the pulse wave transition theory [1].”
Zeng, Y., Zhu, Y., Song, X., Wang, Q., Yang, J., & Wang, W. (2025) · IEEE Internet of Things Journal · doi:10.1109/jiot.2025.3557771 · Cited by 4
“Prior research has estimated BP using PAT that incorporates the preejection period (PEP) and PTT [41].”
An Explainable and Formal Framework for Hypertension Monitoring Using ECG and PPG
Panda, A., Anand, A., Pinisetty, S., & Roop, P. S. (2024) · IEEE Embedded Systems Letters · doi:10.1109/les.2024.3443449 · Cited by 4
“2) is a good indicator of BP [15].”
Berkebile, J. A., Inan, O. T., & Beach, P. A. (2025) · Frontiers in Network Physiology · doi:10.3389/fnetp.2025.1543838 · Cited by 4
Zhu, L., Morshed, M. B., Hahn, J., Rahman, M. M., & Desai, S. A. (2025) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc58623.2025.11254380 · Cited by 4
“It is highly sensitive to changes in arterial stiffness and BP, making it a widely pursued biomarker for cuffless BP monitoring [8], [9].”
Solà, J., Vybornova, A., Braun, F., Proença, M., Delgado-Gonzalo, R., Ferrario, D., Verjus, C., Bertschi, M., Pierrel, N., & Schoettker, N. (2017) · World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany · doi:10.1007/978-981-10-5122-7_216 · Cited by 4
Ubiquitous blood pressure monitoring using EEG and PPG signals
Lu, Y., Peng, H., Zhao, J., Deng, Z., Huang, Z., Zhang, J., Deng, J., Wang, Z., & Wei, C. (2017) · ACM International Joint Conference on Pervasive and Ubiquitous Computing (UbiComp) · doi:10.1145/3123024.3123187 · Cited by 5
“The relationship between PTT and blood pressure has been studied by many researchers (for examples, see comprehensive review[3].”
BackgroundInfluentialSeo, J., Sodini, C. G., & Lee, H.-S. (2018) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2018.8513259 · Cited by 4
“the strain because the central arterial compliance is negligibly affected by the autonomic nervous control [17].”
BackgroundChen, K., Zhang, X., Zou, Q., & Wang, X. (2020) · International Conference on Intelligent Transportation, Big Data & Smart City (ICITBS) · doi:10.1109/icitbs49701.2020.00196 · Cited by 4
“As can be seen from table, for SBP and DBP estimated from proposed method and the contrast method[5][13], BP estimation with the new proposed method agreed with those”
BackgroundMethodValidation of Pulse Transit Time Based Blood Pressure Estimation on Atrial Fibrillation Patients
Chen, Y., Huang, S., Wang, T., & Ma, T. (2020) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc44109.2020.9176221 · Cited by 4
“PTT-BP relationship has been widely investigated [3, 4], and current PTT-BP relationship is under the following assumptions: (1) vessel properties including ρ, γ, and the ratio of h to d remain constant; (2) wave reflection interference is absent[5].”
BackgroundGuo, M., Ni, H., & Chen, A. Q. (2020) · ACM International Joint Conference on Pervasive and Ubiquitous Computing (UbiComp) · doi:10.1145/3410530.3414398 · Cited by 4
“Including Systolic Time (ST), Diastolic Time (DT), and the other intervals between different positions on the PPG; c) Personal profile features, user's information is closely related to physical conditions such as gender, age, BMI, etc., It is worth mentioning that the PTT in OfficeBP is caused by the difference in di…”
BackgroundInfluentialPulse Arrival Time Is Associated With Hemorrhagic Volume in a Porcine Model: A Pilot Study
Booth, G. J., Cole, J., Geiger, P., Adams, J., Barnhill, J., & Hughey, S. B. (2021) · Military Medicine · doi:10.1093/milmed/usab069 · Cited by 4
Shao, J., Shi, P. A., & Hu, S. (2021) · Journal of Sensors · doi:10.1155/2021/8868083 · Cited by 4
“microcirculation, rather than a simple tube [4].”
BackgroundMethodInfluentialCamera-based blood pressure monitoring
Natarajan, K., Yavarimanesh, M., Wang, W., & Mukkamala, R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822281-2.00014-7 · Cited by 4
Blood pressure wave propagation—a multisensor setup for cerebral autoregulation studies
Zienkiewicz, A., Favre, M., Ferdinando, H., Iring-Sanchez, S., Serrador, J. M., & Myllylä, T. (2021) · Physiological Measurement · doi:10.1088/1361-6579/ac3629 · Cited by 4
“Ononehand, PTTestimation along the central arteries seems to bepromising, because of the central arterial wall properties and little interference causedbywave reflection (Mukkamala et al2015).”
BackgroundMethodInfluentialAntognoli, L., Panni, L., Cosoli, G., & Scalise, L. (2023) · IEEE International Workshop on Metrology for Living Environment (MetroLivEnv) · doi:10.1109/metrolivenv56897.2023.10164071 · Cited by 3
“the point with the maximum gradient on the rising edge of the PPG [24].”
BackgroundInfluentialA comparative analysis of reflective and transmissive PPG sensor in pulse acquisition system
Sukesh Rao, M., Hegde, R. B., & Bangera, S. C. (2023) · International Conference on Computer, Electronics & Electrical Engineering & their Applications (IC2E3) · doi:10.1109/ic2e357697.2023.10262473 · Cited by 4
“Several study has been made to find the accuracy and stability of heart rate (HR) determined from the PPG signal with discrete BPM values and found essential differences according to the finger and type of PPG sensor used [4], [6], [7], [9], [10], [17]–[19].”
BackgroundMethodFingertip Strain Plethysmography: Representation of Pulse Information based on Vascular Vibration
Shokouhmand, A., Ayazi, F., & Ebadi, N. (2023) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc40787.2023.10340340 · Cited by 4
“As a result, the reflected light has lower density compared to the transmitted light [5].”
BackgroundA Novel Indicator for Cuff-Less Blood Pressure Estimation Based on Photoplethysmography
Jiang, H., Miao, F., Gao, M., Hong, X., He, Q., Ma, H., & Li, Y. (2016) · Lecture notes in computer science · doi:10.1007/978-3-319-48335-1_13 · Cited by 4
Video-based Photoplethysmography and Machine Learning Algorithms to Achieve Pulse Wave Velocity
Souza, P. H. D. B., Souza, I. M. B., Alcalá, S. G. S., Vitorino, P. V. D. O., da Rocha, A. F., & Barbosa, T. M. G. D. A. (2021) · International Journal of Biotech Trends and Technology · doi:10.14445/22490183/ijbtt-v11i1p602 · Cited by 4
Raju, S. M. T. U., Dipto, S. A., Hossain, M. I., Chowdhury, M. A. S., Haque, F., Nashrah, A. T., Nishan, A., Ahmad, A., Chowdhury, M. Z., & Hashem, M. M. A. (2023) · Research Square · doi:10.21203/rs.3.rs-2624386/v1 · Cited by 4
Metadata
- Authors
- Mukkamala, R., Hahn, J.-O., Inan, O. T., Mestha, L. K., Kim, C.-S., Toreyin, H., & Kyal, S.
- Affiliations
- Michigan State University (US)
- University of Maryland, College Park (US)
- Georgia Institute of Technology (US)
- Palo Alto Research Center (US)
- Corresponding author
- Mukkamala, Ramakrishna
- Venue
- IEEE Transactions on Biomedical Engineering
- Published
- 2015-08
- Volume
- 62
- Issue
- 8
- Pages
- 1879-1901
- ISSN
- 0018-9294 (ISSN-L)
- 1558-2531
- PMC
- PMC4515215
- OpenAlex
- W2294418644
- Cited by
- 935
- References
- 212
- Citations by year
- 2026: 92 · 2025: 93 · 2024: 96 · 2023: 89 · 2022: 93 · 2021: 87 · 2020: 84 · 2019: 92 · 2018: 83 · 2017: 71 · 2016: 50 · 2015: 4
- FWCI
- 34.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- IEEE Transactions on Biomedical Engineering (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Biomedical Imaging and Bioengineering
- National Institutes of Health (U01 EB018818)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Non-Invasive Vital Sign Monitoring
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- blood pressure monitoring, pulse transit time, ubiquitous health monitoring, wearable sensors, hypertension detection, non-invasive blood pressure estimation
- MeSH terms
- Blood Pressure, Blood Pressure Determination, Clothing, Equipment Design, Humans, Signal Processing, Computer-Assisted, Pulse Wave Analysis
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