Age‐related differences in working memory deficits during nicotine withdrawal
Open accessAbstract
Nicotine withdrawal is associated with subtle working memory deficits that predict subsequent relapse. We examined the neural substrates underlying these processes in treatment‐seeking smokers, and explored the moderating influence of age on abstinence‐induced alterations in brain activity and performance. Sixty‐three smokers participated in two blood oxygen level‐dependent (BOLD) functional magnetic resonance imaging scans while performing a visual N‐back task on two separate occasions: smoking as usual and after 24 hours of biochemically confirmed abstinence (order counterbalanced). Abstinence (versus smoking) led to reduced accuracy, slower median correct response time and reduced BOLD signal change in the three a priori regions of interest: medial frontal/cingulate gyrus and right and left dorsolateral prefrontal cortex. Significant age × session effects were found for BOLD signal change in all three regions, as well as for withdrawal and craving; for all measures, abstinence effects were attenuated in smokers aged ≥50 years compared with those <50 years old. These results suggest that abstinence effects on neurocognitive function may be more pronounced for younger smokers, and may indicate a new avenue for research exploring mechanisms underlying age differences in smoking cessation success.
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There are known impairments in cognitive abilities following ANE.
“Furthermore, there are known impairments in cognitive abilities [175–177].”
From Consequences of adolescent drug use (2023) · cites this paper as [177]
Nicotine has a myriad of harmful effects on adolescent development, mood, and behavior.
“nicotine has a myriad of harmful effects on adolescent development, mood, and behavior.”
From Consequences of adolescent drug use (2023) · cites this paper as [177]
The Introduction and Discussion address working-memory deficits and withdrawal symptoms during nicotine abstinence in smokers, not harmful effects of nicotine on adolescent development, mood, or behavior. The Methods describe participants aged 18–65; a search for adolescent and developmental effects found no passage addressing the claim. (LLM, conf=0.75)
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Neuroimaging Insights Into the Multifaceted Nature of the Nicotine Withdrawal Syndrome
Sutherland, M. T., Yanes, J. A., & Stein, E. A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802574-1.00018-1 · Cited by 1 · see citing works
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Memory Disorders and Addiction
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- Authors
- Falcone, M., Wileyto, E. P., Ruparel, K., Gerraty, R. T., LaPrate, L., Detre, J. A., Gur, R., Loughead, J., & Lerman, C.
- Affiliations
- University of Pennsylvania (US)
- Hospital of the University of Pennsylvania (US)
- Corresponding author
- Lerman, Caryn
- ORCID
- Venue
- Addiction Biology
- Publisher
- Wiley
- Published
- 2013-03-18
- Volume
- 19
- Issue
- 5
- Pages
- 907-917
- ISSN
- 1355-6215 (ISSN-L)
- 1369-1600
- PMC
- PMC3701751
- OpenAlex
- W1760408200
- Cited by
- 48
- References
- 53
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 8 · 2015: 7 · 2014: 7 · 2013: 4
- FWCI
- 6.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Addiction Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Pfizer
- GlaxoSmithKline
- National Institutes of Health
- National Institute on Drug Abuse (R01DA026849)
- National Cancer Institute (P30CA016520, P50CA143187)
- National Institute of General Medical Sciences (T32GM008076)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- nicotine withdrawal, working memory, age differences, smoking cessation, abstinence, craving, dorsolateral prefrontal cortex, cingulate gyrus, medial frontal cortex, n-back task, neurocognitive function, relapse
- MeSH terms
- Adolescent, Adult, Age Factors, Aged, Female, Humans, Magnetic Resonance Imaging, Male, Memory Disorders, Memory, Short-Term, Middle Aged, Psychomotor Performance, Smoking, Substance Withdrawal Syndrome, Tobacco Use Disorder, Smoking Cessation, Prefrontal Cortex, Young Adult
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