Cited by 78Smoking Behavior and CessationSubstance Abuse Treatment and OutcomesPrenatal Substance Exposure Effects

Increases in hyperactive-impulsive symptoms predict relapse among smokers in nicotine replacement therapy

Rukstalis, Margaret, Jepson, Christopher, Patterson, Freda, Lerman, Caryn·2005·Journal of Substance Abuse Treatment

Abstract

Inattention and hyperactive-impulsive symptoms have been associated with nicotine dependence. In an open-label randomized trial (N = 454) of transdermal nicotine versus nicotine nasal spray, we examined whether increases in inattention and hyperactive-impulsive symptoms measured by self-report in the first quit week predicted relapse at the end of 8 weeks of treatment (EOT). During the first quit week, 166 (37%) participants reported an increase whereas 288 (63%) reported no change/decrease in total symptoms; changes were not influenced by treatment type. In a logistic regression model of abstinence, an increase in total symptoms in the first quit week significantly reduced odds of abstinence at EOT (continuous change score: OR = 0.94, 95% CI = 0.91-0.98, p = .002; dichotomized change score: OR = 0.57, 95% CI = 0.37-0.87, p = .009). Early increases in inattention and hyperactive-impulsive symptoms following quit date during nicotine replacement therapy predicted relapse to smoking, suggesting that treatments targeting these symptoms in the first quit week may facilitate abstinence.

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Crossref · 10.1016/j.jsat.2005.02.002

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  • Subjective and performance measures of abstinence-induced cognitive deficits predict smoking cessation in clinical trials.

    “Subjective and performance measures of abstinence-induced cognitive deficits predict smoking cessation in clinical trials (17, 18).”

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Authors
Rukstalis, M., Jepson, C., Patterson, F., & Lerman, C.
Affiliations
University of Pennsylvania (US)
Corresponding author
Rukstalis, Margaret
Venue
Journal of Substance Abuse Treatment
Publisher
Elsevier BV
Published
2005-06
Volume
28
Issue
4
Pages
297-304
ISSN
0740-5472 (ISSN-L)
OpenAlex
W2158636445
Cited by
78
References
46
Citations by year
2025: 3 · 2024: 2 · 2023: 2 · 2021: 4 · 2019: 1 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 6 · 2014: 5 · 2013: 10 · 2012: 6
FWCI
3.00
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Substance Abuse Treatment (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Pfizer
  • National Cancer Institute (CA/DA 84718)
Topics
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords
hyperactive-impulsive symptoms, inattention, nicotine dependence, smoking relapse, nicotine replacement therapy, transdermal nicotine, nicotine nasal spray, smoking cessation, abstinence, symptom change
MeSH terms
Adult, Attention Deficit Disorder with Hyperactivity, Female, Humans, Impulsive Behavior, Male, Nicotine, Predictive Value of Tests, Recurrence, Smoking, Nicotinic Agonists

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