Increases in hyperactive-impulsive symptoms predict relapse among smokers in nicotine replacement therapy
Abstract
Inattention and hyperactive-impulsive symptoms have been associated with nicotine dependence. In an open-label randomized trial (N = 454) of transdermal nicotine versus nicotine nasal spray, we examined whether increases in inattention and hyperactive-impulsive symptoms measured by self-report in the first quit week predicted relapse at the end of 8 weeks of treatment (EOT). During the first quit week, 166 (37%) participants reported an increase whereas 288 (63%) reported no change/decrease in total symptoms; changes were not influenced by treatment type. In a logistic regression model of abstinence, an increase in total symptoms in the first quit week significantly reduced odds of abstinence at EOT (continuous change score: OR = 0.94, 95% CI = 0.91-0.98, p = .002; dichotomized change score: OR = 0.57, 95% CI = 0.37-0.87, p = .009). Early increases in inattention and hyperactive-impulsive symptoms following quit date during nicotine replacement therapy predicted relapse to smoking, suggesting that treatments targeting these symptoms in the first quit week may facilitate abstinence.
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Subjective and performance measures of abstinence-induced cognitive deficits predict smoking cessation in clinical trials.
“Subjective and performance measures of abstinence-induced cognitive deficits predict smoking cessation in clinical trials (17, 18).”
From Varenicline improves mood and cognition during smoking abstinence (2009) · cites this paper as [18]
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- Authors
- Rukstalis, M., Jepson, C., Patterson, F., & Lerman, C.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Rukstalis, Margaret
- Venue
- Journal of Substance Abuse Treatment
- Publisher
- Elsevier BV
- Published
- 2005-06
- Volume
- 28
- Issue
- 4
- Pages
- 297-304
- ISSN
- 0740-5472 (ISSN-L)
- OpenAlex
- W2158636445
- Cited by
- 78
- References
- 46
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 2 · 2021: 4 · 2019: 1 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 6 · 2014: 5 · 2013: 10 · 2012: 6
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Substance Abuse Treatment (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Pfizer
- National Cancer Institute (CA/DA 84718)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- hyperactive-impulsive symptoms, inattention, nicotine dependence, smoking relapse, nicotine replacement therapy, transdermal nicotine, nicotine nasal spray, smoking cessation, abstinence, symptom change
- MeSH terms
- Adult, Attention Deficit Disorder with Hyperactivity, Female, Humans, Impulsive Behavior, Male, Nicotine, Predictive Value of Tests, Recurrence, Smoking, Nicotinic Agonists
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