Childhood poverty, immune cell aging, and African Americans' insulin resistance: A prospective study
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The present study investigated developmental pathways that can contribute to chronic disease among rural African Americans. With a sample of 342 African American youth (59% female) from the southeastern United States followed for nearly two decades (2001–2019), we examined the prospective association between family poverty during adolescence (ages 11–18) and insulin resistance (IR) in young adulthood (ages 25–29) as well as underlying biological and psychosocial mechanisms. Results indicated family poverty during adolescence forecast higher levels of IR in young adulthood, with accelerated immune cell aging at age 20 partially mediating this association. Serial mediational models confirmed the hypothesized pathway linking family poverty, perceived life chances, cellular aging, and IR. Findings provide empirical support for theorized developmental precursors of chronic disease.
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In a prospective longitudinal study of 342 Black individuals (59% women) from the southeastern US, childhood socioeconomic status predicted insulin resistance in young adulthood, such that every additional year living in poverty in childhood was associated with a 1.04-unit increase in HOMA-IR.
“Childhood socioeconomic status predicted insulin resistance in young adulthood, such that every additional year living in poverty in childhood was associated with a 1.04-unit increase in HOMA-IR.”
From The effects of sleep disruption on metabolism, hunger, and satiety, and the influence of psychosocial stress and exercise: A narrative review (2024) · cites this paper as [138]
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- Authors
- Barton, A. W., Yu, T., Gong, Q., Miller, G. E., Chen, E., & Brody, G. H.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- University of Georgia (US)
- Northwestern University (US)
- Corresponding author
- Barton, Allen W
- Venue
- Child Development
- Publisher
- Oxford University Press (OUP)
- Published
- 2022-08-30
- Volume
- 93
- Issue
- 5
- Pages
- 1616-1624
- ISSN
- 0009-3920 (ISSN-L)
- 1467-8624
- PMC
- PMC9427675
- OpenAlex
- W4281249286
- Cited by
- 8
- References
- 55
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 1
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Child Development (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD030588)
- National Institute on Drug Abuse (P50 DA051361)
- Topics
- Social Sciences › Health › Health disparities and outcomes
- Health Sciences › Health Professions › General Health Professions › Food Security and Health in Diverse Populations
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Keywords
- child poverty, household poverty, insulin resistance, cellular aging, African American youth, adolescence, early adulthood, chronic disease, developmental pathways, rural African Americans
- MeSH terms
- Child Poverty, Adolescent, Adult, Black or African American, Child, Female, Humans, Insulin Resistance, Male, Prospective Studies, Cellular Senescence, Young Adult
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