Understanding the mechanisms of reversal of type 2 diabetes

Management of hyperglycemia in type 2 diabetes, 2018. A consensus report by the american diabetes association (ADA) and the european association for the study of diabetes (EASD)

Davies, M. J., D’Alessio, D. A., Fradkin, J., Kernan, W. N., Mathieu, C., Mingrone, G., Rossing, P., Tsapas, A., Wexler, D. J., & Buse, J. B. (2018) · Diabetes Care · doi:10.2337/dci18-0033 · Cited by 3,518 · see citing works

Glycemic Control With Diet, Sulfonylurea, Metformin, or Insulin in Patients With Type 2 Diabetes Mellitus<SUBTITLE>Progressive Requirement for Multiple Therapies (UKPDS 49)</SUBTITLE>

Turner, R. C. (1999) · JAMA · doi:10.1001/jama.281.21.2005 · Cited by 2,375 · see citing works

Who Would Have Thought It? An Operation Proves to Be the Most Effective Therapy for Adult-Onset Diabetes Mellitus

Pories, W. J., Swanson, M. S., MacDonald, K. G., Long, S. B., Morris, P. G., Brown, B. M., Barakat, H. A., deRamon, R. A., Israel, G., Dolezal, J. M., et al. (1995) · Annals of Surgery · doi:10.1097/00000658-199509000-00011 · Cited by 2,293 · see citing works

Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial

Lean, M. E., Leslie, W. S., Barnes, A. C., Brosnahan, N., Thom, G., McCombie, L., Peters, C., Zhyzhneuskaya, S., Al-Mrabeh, A., Hollingsworth, K. G., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(17)33102-1 · Cited by 2,095 · see citing works

Long-term weight loss maintenance

Wing, R. R., & Phelan, S. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.1.222s · Cited by 1,941 · see citing works

U.K. Prospective Diabetes Study 16: Overview of 6 Years' Therapy of Type II Diabetes: A Progressive Disease

U.K. Prospective Diabetes Study Group (1995) · Diabetes · doi:10.2337/diab.44.11.1249 · Cited by 1,923 · see citing works

Review of the key results from the Swedish Obese Subjects ( <scp>SOS</scp> ) trial – a prospective controlled intervention study of bariatric surgery

Sjöström, L. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12012 · Cited by 1,835 · see citing works

Banting Lecture 2001

McGarry, J. D. (2002) · Diabetes · doi:10.2337/diabetes.51.1.7 · Cited by 1,435 · see citing works

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

Talchai, C., Xuan, S., Lin, H. V., Sussel, L., & Accili, D. (2012) · Cell · doi:10.1016/j.cell.2012.07.029 · Cited by 1,415 · see citing works

Lipid-induced insulin resistance: unravelling the mechanism

Samuel, V. T., Petersen, K. F., & Shulman, G. I. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60408-4 · Cited by 1,189 · see citing works

Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol

Lim, E. L., Hollingsworth, K. G., Aribisala, B. S., Chen, M. J., Mathers, J. C., & Taylor, R. (2011) · Diabetologia · doi:10.1007/s00125-011-2204-7 · Cited by 1,164 · see citing works

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

Perry, R. J., Samuel, V. T., Petersen, K. F., & Shulman, G. I. (2014) · Nature · doi:10.1038/nature13478 · Cited by 1,136 · see citing works

Lipotoxicity in the Pathogenesis of Obesity-Dependent NIDDM: Genetic and Clinical Implications

Unger, R. H. (1995) · Diabetes · doi:10.2337/diab.44.8.863 · Cited by 1,100 · see citing works

Association of bariatric surgery with long-term remission of type 2 diabetes and with microvascular and macrovascular complications

Sjöström, L., Peltonen, M., Jacobson, P., Ahlin, S., Andersson-Assarsson, J., Anveden, Å., Bouchard, C., Carlsson, B., Karason, K., Lönroth, H., et al. (2014) · JAMA · doi:10.1001/jama.2014.5988 · Cited by 1,054 · see citing works

Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial

Lean, M. E. J., Leslie, W. S., Barnes, A. C., Brosnahan, N., Thom, G., McCombie, L., Peters, C., Zhyzhneuskaya, S., Al-Mrabeh, A., Hollingsworth, K. G., et al. (2019) · The Lancet Diabetes &amp; Endocrinology · doi:10.1016/s2213-8587(19)30068-3 · Cited by 981 · see citing works

Reversal of Nonalcoholic Hepatic Steatosis, Hepatic Insulin Resistance, and Hyperglycemia by Moderate Weight Reduction in Patients With Type 2 Diabetes

Petersen, K. F., Dufour, S., Befroy, D., Lehrke, M., Hendler, R. E., & Shulman, G. I. (2005) · Diabetes · doi:10.2337/diabetes.54.3.603 · Cited by 911 · see citing works

Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships.

Lee, Y., Hirose, H., Ohneda, M., Johnson, J. H., McGarry, J., & Unger, R. H. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.10878 · Cited by 832 · see citing works

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

Laybutt, D. R., Preston, A. M., Åkerfeldt, M. C., Kench, J. G., Busch, A. K., Biankin, A. V., & Biden, T. J. (2007) · Diabetologia · doi:10.1007/s00125-006-0590-z · Cited by 830 · see citing works

The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome

Petersen, K. F., Dufour, S., Savage, D. B., Bilz, S., Solomon, G., Yonemitsu, S., Cline, G. W., Befroy, D., Zemany, L., Kahn, B. B., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705408104 · Cited by 759 · see citing works

Pancreatic β‐cell mass in European subjects with type 2 diabetes

Rahier, J., Guiot, Y., Goebbels, R. M., Sempoux, C., & Henquin, J. C. (2008) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2008.00969.x · Cited by 756 · see citing works

Association of an intensive lifestyle intervention with remission of type 2 diabetes

Gregg, E. W., Chen, H., Wagenknecht, L. E., Clark, J. M., Delahanty, L. M., Bantle, J., Pownall, H. J., Johnson, K. C., Safford, M. M., Kitabchi, A. E., et al. (2012) · JAMA · doi:10.1001/jama.2012.67929 · Cited by 752 · see citing works

Overproduction of large VLDL particles is driven by increased liver fat content in man

Adiels, M., Taskinen, M.-R., Packard, C., Caslake, M. J., Soro-Paavonen, A., Westerbacka, J., Vehkavaara, S., Häkkinen, A., Olofsson, S.-O., Yki-Järvinen, H., et al. (2006) · Diabetologia · doi:10.1007/s00125-005-0125-z · Cited by 690 · see citing works

Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects

Gastaldelli, A., Cusi, K., Pettiti, M., Hardies, J., Miyazaki, Y., Berria, R., Buzzigoli, E., Sironi, A. M., Cersosimo, E., Ferrannini, E., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.068 · Cited by 629 · see citing works

Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance

Lotta, L. A., Gulati, P., Day, F. R., Payne, F., Ongen, H., van de Bunt, M., Gaulton, K. J., Eicher, J. D., Sharp, S. J., Luan, J., et al. (2016) · Nature Genetics · doi:10.1038/ng.3714 · Cited by 587 · see citing works

Nonalcoholic Fatty Liver Disease Is Independently Associated With an Increased Incidence of Cardiovascular Events in Type 2 Diabetic Patients

Targher, G., Bertolini, L., Rodella, S., Tessari, R., Zenari, L., Lippi, G., & Arcaro, G. (2007) · Diabetes Care · doi:10.2337/dc07-0349 · Cited by 575 · see citing works

Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes

Cinti, F., Bouchi, R., Kim-Muller, J. Y., Ohmura, Y., Sandoval, P. R., Masini, M., Marselli, L., Suleiman, M., Ratner, L. E., Marchetti, P., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2860 · Cited by 552 · see citing works

Type 2 Diabetes

Taylor, R. (2013) · Diabetes Care · doi:10.2337/dc12-1805 · Cited by 485 · see citing works

Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease

Luukkonen, P. K., Zhou, Y., Sädevirta, S., Leivonen, M., Arola, J., Orešič, M., Hyötyläinen, T., & Yki-Järvinen, H. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.01.002 · Cited by 461 · see citing works

Remission of human type 2 diabetes requires decrease in liver and pancreas fat content but is dependent upon capacity for β cell recovery

Taylor, R., Al-Mrabeh, A., Zhyzhneuskaya, S., Peters, C., Barnes, A. C., Aribisala, B. S., Hollingsworth, K. G., Mathers, J. C., Sattar, N., & Lean, M. E. J. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.07.003 · Cited by 450 · see citing works

Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy

Butler, A. E., Cao-Minh, L., Galasso, R., Rizza, R. A., Corradin, A., Cobelli, C., & Butler, P. C. (2010) · Diabetologia · doi:10.1007/s00125-010-1809-6 · Cited by 435 · see citing works

Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients.

Ryysy, L., Häkkinen, A. M., Goto, T., Vehkavaara, S., Westerbacka, J., Halavaara, J., & Yki-Järvinen, H. (2000) · Diabetes · doi:10.2337/diabetes.49.5.749 · Cited by 431 · see citing works

Very low-calorie diet and 6 months of weight stability in type 2 diabetes: pathophysiological changes in responders and nonresponders

Steven, S., Hollingsworth, K. G., Al-Mrabeh, A., Avery, L., Aribisala, B., Caslake, M., & Taylor, R. (2016) · Diabetes Care · doi:10.2337/dc15-1942 · Cited by 418 · see citing works

High Expression Rates of Human Islet Amyloid Polypeptide Induce Endoplasmic Reticulum Stress–Mediated β-Cell Apoptosis, a Characteristic of Humans With Type 2 but Not Type 1 Diabetes

Huang, C.-J., Lin, C., Haataja, L., Gurlo, T., Butler, A. E., Rizza, R. A., & Butler, P. C. (2007) · Diabetes · doi:10.2337/db07-0197 · Cited by 417 · see citing works

Mechanisms of Disease: hepatic steatosis in type 2 diabetes—pathogenesis and clinical relevance

Roden, M. (2006) · Nature Clinical Practice Endocrinology &#38 Metabolism · doi:10.1038/ncpendmet0190 · Cited by 404 · see citing works

Pancreatic β Cell Dedifferentiation in Diabetes and Redifferentiation following Insulin Therapy

Wang, Z., York, N., Nichols, C. G., & Remedi, M. S. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.010 · Cited by 404 · see citing works

Pancreatic Fat Content and β-Cell Function in Men With and Without Type 2 Diabetes

Tushuizen, M. E., Bunck, M. C. M., Pouwels, P. J. W., Bontemps, S., van Waesberghe, J. H. T., Schindhelm, R. K., Mari, A., Heine, R. J., & Diamant, M. (2007) · Diabetes Care · doi:10.2337/dc07-0326 · Cited by 402 · see citing works

Glucolipotoxicity of the pancreatic beta cell

Poitout, V., Amyot, J., Semache, M., Zarrouki, B., Hagman, D., & Fontés, G. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.08.006 · Cited by 382 · see citing works

Mechanisms of Recovery From Type 2 Diabetes After Malabsorptive Bariatric Surgery

Guidone, C., Manco, M., Valera-Mora, E., Iaconelli, A., Gniuli, D., Mari, A., Nanni, G., Castagneto, M., Calvani, M., & Mingrone, G. (2006) · Diabetes · doi:10.2337/db06-0068 · Cited by 367 · see citing works

Pathogenesis of type 2 diabetes: tracing the reverse route from cure to cause

Taylor, R. (2008) · Diabetologia · doi:10.1007/s00125-008-1116-7 · Cited by 352 · see citing works

Effects of weight loss on mechanisms of hyperglycemia in obese non-insulin-dependent diabetes mellitus

Henry, R. R., Wallace, P., & Olefsky, J. M. (1986) · Diabetes · doi:10.2337/diab.35.9.990 · Cited by 325 · see citing works

Relative effects of calorie restriction and weight loss in noninsulin- dependent diabetes mellitus

Kelley, D. E. (1993) · Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.77.5.1287 · Cited by 303 · see citing works

Specific hepatic sphingolipids relate to insulin resistance, oxidative stress, and inflammation in nonalcoholic steatohepatitis

Apostolopoulou, M., Gordillo, R., Koliaki, C., Gancheva, S., Jelenik, T., De Filippo, E., Herder, C., Markgraf, D., Jankowiak, F., Esposito, I., et al. (2018) · Diabetes Care · doi:10.2337/dc17-1318 · Cited by 284 · see citing works

Fat in the liver and insulin resistance

Yki‐Järvinen, H. (2005) · Annals of Medicine · doi:10.1080/07853890510037383 · Cited by 267 · see citing works

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

Brereton, M. F., Iberl, M., Shimomura, K., Zhang, Q., Adriaenssens, A. E., Proks, P., Spiliotis, I. I., Dace, W., Mattis, K. K., Ramracheya, R., et al. (2014) · Nature Communications · doi:10.1038/ncomms5639 · Cited by 259 · see citing works

Direct assessment of liver glycogen storage by 13C nuclear magnetic resonance spectroscopy and regulation of glucose homeostasis after a mixed meal in normal subjects.

Taylor, R., Magnusson, I., Rothman, D. L., Cline, G. W., Caumo, A., Cobelli, C., & Shulman, G. I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118379 · Cited by 258 · see citing works

Year-long weight loss treatment for obese patients with type II diabetes: Does including an intermittent very-low-calorie diet improve outcome?

Wing, R. R., Blair, E., Marcus, M., Epstein, L. H., & Harvey, J. (1994) · The American Journal of Medicine · doi:10.1016/0002-9343(94)90302-6 · Cited by 228 · see citing works

Pancreatic Ectopic Fat Is Characterized by Adipocyte Infiltration and Altered Lipid Composition

Pinnick, K. E., Collins, S., Londos, C., Gauguier, D., Clark, A., & Fielding, B. A. (2008) · Obesity · doi:10.1038/oby.2007.110 · Cited by 220 · see citing works

Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans

Sevastianova, K., Santos, A., Kotronen, A., Hakkarainen, A., Makkonen, J., Silander, K., Peltonen, M., Romeo, S., Lundbom, J., Lundbom, N., et al. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.038695 · Cited by 211 · see citing works

Ectopic Fat Storage in the Pancreas, Liver, and Abdominal Fat Depots: Impact on β-Cell Function in Individuals with Impaired Glucose Metabolism

van der Zijl, N. J., Goossens, G. H., Moors, C. C. M., van Raalte, D. H., Muskiet, M. H. A., Pouwels, P. J. W., Blaak, E. E., & Diamant, M. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1722 · Cited by 200 · see citing works

Predicting the Glycemic Response to Gastric Bypass Surgery in Patients With Type 2 Diabetes

Dixon, J. B., Chuang, L., Chong, K., Chen, S., Lambert, G. W., Straznicky, N. E., Lambert, É., & Lee, W. (2012) · Diabetes Care · doi:10.2337/dc12-0779 · Cited by 198 · see citing works

Acute compensatory eating following exercise is associated with implicit hedonic wanting for food

Finlayson, G., Bryant, E. J., Blundell, J. E., & King, N. A. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.02.002 · Cited by 195 · see citing works

Normal weight individuals who develop Type 2 diabetes: the personal fat threshold

Taylor, R., & Holman, R. R. (2014) · Clinical Science · doi:10.1042/cs20140553 · Cited by 190 · see citing works

The relative contributions of different levels of overweight and obesity to the increased prevalence of diabetes in the United States: 1976–2004

Gregg, E. W., Cheng, Y. J., Narayan, K. M. V., Thompson, T. J., & Williamson, D. F. (2007) · Preventive Medicine · doi:10.1016/j.ypmed.2007.07.020 · Cited by 185 · see citing works

Type 2 Diabetes: The Pathologic Basis of Reversible β-Cell Dysfunction

White, M. G., Shaw, J. A. M., & Taylor, R. (2016) · Diabetes Care · doi:10.2337/dc16-0619 · Cited by 174 · see citing works

Loss of β-Cell Identity Occurs in Type 2 Diabetes and Is Associated With Islet Amyloid Deposits

Spijker, H. S., Song, H., Ellenbroek, J. H., Roefs, M. M., Engelse, M. A., Bos, E., Koster, A. J., Rabelink, T. J., HANSEN, B. C., Clark, A., et al. (2015) · Diabetes · doi:10.2337/db14-1752 · Cited by 172 · see citing works

Untitled work

Steven (2016) · doi:10.2337/dc15-0750 · Cited by 171 · see citing works

Exercise, appetite and weight management: understanding the compensatory responses in eating behaviour and how they contribute to variability in exercise-induced weight loss

King, N. A., Horner, K., Hills, A. P., Byrne, N. M., Wood, R. E., Bryant, E., Caudwell, P., Finlayson, G., Gibbons, C., Hopkins, M., et al. (2012) · British Journal of Sports Medicine · doi:10.1136/bjsm.2010.082495 · Cited by 169 · see citing works

Fat Accumulation in the Liver Is Associated with Defects in Insulin Suppression of Glucose Production and Serum Free Fatty Acids Independent of Obesity in Normal Men

Seppala-Lindroos, A. (2002) · Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.87.7.3023 · Cited by 168 · see citing works

Diabetic Retinopathy After Two Years of Intensified Insulin Treatment

(1988) · JAMA · doi:10.1001/jama.1988.03410010045032 · Cited by 161 · see citing works

Pancreatic Steatosis Demonstrated at MR Imaging in the General Population: Clinical Relevance

Kühn, J., Berthold, F., Mayerle, J. V., et al. (2015) · Radiology · doi:10.1148/radiol.15140446 · Cited by 157 · see citing works

Pancreatic Steatosis and Its Relationship to β-Cell Dysfunction in Humans

Szczepaniak, L. S., Victor, R. G., Mathur, R., Nelson, M. D., Szczepaniak, E. W., Tyer, N. M., Chen, Y. I., Unger, R. H., Bergman, R. N., & Lingvay, I. (2012) · Diabetes Care · doi:10.2337/dc12-0701 · Cited by 139 · see citing works

Serial Metabolic Measurements and Conversion to Type 2 Diabetes in the West of Scotland Coronary Prevention Study

Sattar, N., McConnachie, A., Ford, I., Gaw, A., Cleland, S. J., Forouhi, N. G., McFarlane, P., Shepherd, J., Cobbe, S., & Packard, C. (2007) · Diabetes · doi:10.2337/db06-1256 · Cited by 127 · see citing works

Rapid improvement in diabetes after gastric bypass surgery

Lingvay, I., Guth, E., Islam, A., & Livingston, E. (2013) · Diabetes Care · doi:10.2337/dc12-2316 · Cited by 116 · see citing works

Effect of the Look AHEAD Study Intervention on Medication Use and Related Cost to Treat Cardiovascular Disease Risk Factors in Individuals With Type 2 Diabetes

Redmon, J. B., Bertoni, A. G., Connelly, S., Feeney, P. A., Glasser, S. P., Glick, H. A., Greenway, F. L., Hesson, L. A., Lawlor, M. S., Montez, M. G., et al. (2010) · Diabetes Care · doi:10.2337/dc09-2090 · Cited by 115 · see citing works

Peroxisome Proliferator–Activated Receptor α Improves Pancreatic Adaptation to Insulin Resistance in Obese Mice and Reduces Lipotoxicity in Human Islets

Lalloyer, F., Vandewalle, B., Percevault, F., Torpier, G., Kerr-Conte, J. A., Oosterveer, M. H., Paumelle, R., Fruchart, J., Kuipers, F., Pattou, F. N., et al. (2006) · Diabetes · doi:10.2337/db06-0016 · Cited by 115 · see citing works

Diabetic retinopathy after two years of intensified insulin treatment. Follow-up of the Kroc Collaborative Study

Bergenstal, R. M., Morse, P. H., Rubenstein, A. H., Jj, B., Bilous, R., Keen, H., Pickup, J. C., Viberti, G. C., Gosh, G., KOHNER, E. M., et al. (1988) · JAMA · Cited by 110 · see citing works

Stabilisation of diabetic retinopathy following simultaneous pancreas and kidney transplant

Pearce, I. (2000) · British Journal of Ophthalmology · doi:10.1136/bjo.84.7.736 · Cited by 108 · see citing works

β-Cell Dedifferentiation in Patients With T2D With Adequate Glucose Control and Nondiabetic Chronic Pancreatitis

Sun, J., Ni, Q., Xie, J., Xu, M., Zhang, J., Kuang, J., Wang, Y., Ning, G., & Wang, Q. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-00968 · Cited by 104 · see citing works

Expression of Mesenchymal and α-Cell Phenotypic Markers in Islet β-Cells in Recently Diagnosed Diabetes

White, M. G., Marshall, H. L., Rigby, R., et al. (2013) · Diabetes Care · doi:10.2337/dc13-0705 · Cited by 102 · see citing works

Differences in pancreatic volume, fat content, and fat density measured by multidetector-row computed tomography according to the duration of diabetes

Lim, S. K., Bae, J. H., Chun, E. J., Kim, H., Kim, S. Y., Kim, K. M., Choi, S. H., Park, K. S., Florez, J. C., & Jang, H. C. (2014) · Acta Diabetologica · doi:10.1007/s00592-014-0581-3 · Cited by 99 · see citing works

Natural History of Pancreatic Islet B‐Cell Function in Type 2 Diabetes Mellitus Studied over Six Years by Homeostasis Model Assessment

Rudenski, A. S., Hadden, D. R., Atkinson, A. B., Kennedy, L., Matthews, D. R., Merrett, J. D., Pockaj, B. A., & Turner, R. C. (1988) · Diabetic Medicine · doi:10.1111/j.1464-5491.1988.tb00938.x · Cited by 97 · see citing works

Short-term progression of cardiometabolic risk factors in relation to age at type 2 diabetes diagnosis: a longitudinal observational study of 100,606 individuals from the Swedish National Diabetes Register

Steinarsson, A. O., Rawshani, A., Guðbjörnsdóttir, S., Franzén, S., Svensson, A., & Sattar, N. A. (2018) · Diabetologia · doi:10.1007/s00125-017-4532-8 · Cited by 94 · see citing works

Quantification of intrapancreatic fat in type 2 diabetes by MRI

Al-Mrabeh, A. H., Hollingsworth, K. G., Steven, S., TINIAKOS, D. G., & Taylor, R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174660 · Cited by 92 · see citing works

Mechanisms by which a Very-Low-Calorie Diet Reverses Hyperglycemia in a Rat Model of Type 2 Diabetes

Perry, R. J., Peng, L., Cline, G. W., Wang, Y., Rabin-Court, A., Song, J. D., Zhang, D., Zhang, X., Nozaki, Y., Dufour, S., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.10.004 · Cited by 89 · see citing works

Individual variability in compensatory eating following acute exercise in overweight and obese women

Hopkins, M., Blundell, J. E., & King, N. A. (2013) · British Journal of Sports Medicine · doi:10.1136/bjsports-2012-091721 · Cited by 82 · see citing works

Beating type 2 diabetes into remission

McCombie, L., Leslie, W., Taylor, R., Kennon, B., Sattar, N., & Lean, M. E. J. (2017) · BMJ · doi:10.1136/bmj.j4030 · Cited by 81 · see citing works

Regulation of endogenous glucose production after a mixed meal in type 2 diabetes

Singhal, P., Caumo, A., Carey, P. E., Cobelli, C., & Taylor, R. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00424.2001 · Cited by 80 · see citing works

Clinical management of type 2 diabetes in south Asia

Misra, A., Sattar, N. A., Tandon, N., Shrivastava, U., Vikram, N. K., Khunti, K. K., & Hills, A. P. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(18)30199-2 · Cited by 79 · see citing works

Pioglitazone Decreases Fasting and Postprandial Endogenous Glucose Production in Proportion to Decrease in Hepatic Triglyceride Content

Balasubramanian, R., Gerrard, J., Man, C. D., Firbank, M., Lane, A. P., English, P. T., Cobelli, C., & Taylor, R. (2008) · Diabetes · doi:10.2337/db07-1828 · Cited by 76 · see citing works

Calorie restriction and not glucagon‐like peptide‐1 explains the acute improvement in glucose control after gastric bypass in Type 2 diabetes

Steven, S., Hollingsworth, K. G., Small, P. K., Woodcock, S. A., Pucci, A., Aribasala, B., Al‐Mrabeh, A., Batterham, R. L., & Taylor, R. (2016) · Diabetic Medicine · doi:10.1111/dme.13257 · Cited by 71 · see citing works

Population response to information on reversibility of Type 2 diabetes

Steven, S., Lim, E. L., & Taylor, R. (2013) · Diabetic Medicine · doi:10.1111/dme.12116 · Cited by 70 · see citing works

Morphology of the pancreas in type 2 diabetes: effect of weight loss with or without normalisation of insulin secretory capacity

Al-Mrabeh, A. H., Hollingsworth, K. G., Steven, S., & Taylor, R. (2016) · Diabetologia · doi:10.1007/s00125-016-3984-6 · Cited by 65 · see citing works

Reversal of type 2 diabetes after bariatric surgery is determined by the degree of achieved weight loss in both short- and long-duration diabetes

Steven, S., Carey, P. E., Small, P. K., & Taylor, R. (2015) · Diabetic Medicine · doi:10.1111/dme.12567 · Cited by 55 · see citing works

Reversibility of metabolic and morphological changes associated with chronic exposure of pancreatic islet β‐cells to fatty acids

Pinnick, K., Neville, M., Clark, A., & Fielding, B. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22445 · Cited by 55 · see citing works

Can type 2 diabetes be reversed and how can this best be achieved? James Lind Alliance research priority number one

Taylor, R., & Barnes, A. C. (2018) · Diabetic Medicine · doi:10.1111/dme.13851 · Cited by 38 · see citing works

Long-term progression of retinopathy after initiation of insulin therapy in Type�2 diabetes: an observational study

Arun, C. S., Pandit, R., & Taylor, R. (2004) · Diabetologia · doi:10.1007/s00125-004-1473-9 · Cited by 37 · see citing works

Diabetes Case Studies: Real Problems, Practical Solutions

Suzi Kochar, M., Janice L. Gilden, M., Shazli Azmi, M., et al. (2015) · American Diabetes Association eBooks · doi:10.2337/9781580405713 · Cited by 8 · see citing works

Cardiovascular risk in diabetes mellitus: Epidemiology, assessment and prevention

Wong, N. D., & Sattar, N. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00877-z · Cited by 495 · see citing works

Effect of intensive lifestyle intervention on bodyweight and glycaemia in early type 2 diabetes (DIADEM-I): an open-label, parallel-group, randomised controlled trial

Taheri, S., Zaghloul, H., Chagoury, O., Elhadad, S., Ahmed, S. H., El Khatib, N., Amona, R. A., El Nahas, K., Suleiman, N., Alnaama, A., et al. (2020) · The Lancet Diabetes &amp; Endocrinology · doi:10.1016/s2213-8587(20)30117-0 · Cited by 393 · see citing works

Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities

Opazo-Ríos, L., Mas, S., Marín-Royo, G., Mezzano, S., Gómez-Guerrero, C., Moreno, J. A., & Egido, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072632 · Cited by 363 · see citing works

Efficacy and safety of co-administered once-weekly cagrilintide 2·4 mg with once-weekly semaglutide 2·4 mg in type 2 diabetes: a multicentre, randomised, double-blind, active-controlled, phase 2 trial

Frias, J. P., Deenadayalan, S., Erichsen, L., Knop, F. K., Lingvay, I., Macura, S., Mathieu, C., Pedersen, S. D., & Davies, M. (2023) · The Lancet · doi:10.1016/s0140-6736(23)01163-7 · Cited by 334 · see citing works

Impact of remission from type 2 diabetes on long-term health outcomes: findings from the Look AHEAD study

Gregg, E. W., Chen, H., Bancks, M. P., Manalac, R., Maruthur, N., Munshi, M., Wing, R., & for the Look AHEAD Research Group (2024) · Diabetologia · doi:10.1007/s00125-023-06048-6 · Cited by 87 · see citing works

Therapy of Type 2 Diabetes

Landgraf, R., Aberle, J., Birkenfeld, A. L., Gallwitz, B., Kellerer, M., Klein, H., Müller-Wieland, D., Nauck, M. A., Reuter, H.-M., & Siegel, E. (2019) · Experimental and Clinical Endocrinology &amp; Diabetes · doi:10.1055/a-1018-9106 · Cited by 62 · see citing works

Dietary weight-management for type 2 diabetes remissions in South Asians: the South Asian diabetes remission randomised trial for proof-of-concept and feasibility (STANDby)

Sattar, N., Welsh, P., Leslie, W. S., Thom, G., McCombie, L., Brosnahan, N., Richardson, J., Gill, J. M. R., Crawford, L., & Lean, M. E. J. (2023) · The Lancet Regional Health - Southeast Asia · doi:10.1016/j.lansea.2022.100111 · Cited by 58 · see citing works

First-phase insulin secretion: can its evaluation direct therapeutic approaches?

Di Giuseppe, G., Ciccarelli, G., Soldovieri, L., Capece, U., Cefalo, C. M. A., Moffa, S., Nista, E. C., Brunetti, M., Cinti, F., Gasbarrini, A., et al. (2023) · Trends in Endocrinology &amp; Metabolism · doi:10.1016/j.tem.2023.02.001 · Cited by 46 · see citing works

Insulin resistance and metabolic flexibility as drivers of liver and cardiac disease in T2DM

Colosimo, S., Mitra, S. K., Chaudhury, T., & Marchesini, G. (2023) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2023.111016 · Cited by 38 · see citing works

High Circulating Triglycerides Are Most Commonly a Marker of Ectopic Fat Accumulation: Connecting the Clues to Advance Lifestyle Interventions

Sattar, N., McGuire, D. K., & Gill, J. M. R. (2022) · Circulation · doi:10.1161/circulationaha.122.060411 · Cited by 19 · see citing works

Therapy of Type 2 Diabetes

Landgraf, R., Aberle, J., Birkenfeld, A. L., Gallwitz, B., Kellerer, M., Klein, H., Müller-Wieland, D., Nauck, M. A., Wiesner, T., & Siegel, E. (2022) · Experimental and Clinical Endocrinology &amp; Diabetes · doi:10.1055/a-1624-3449 · Cited by 12 · see citing works

Genetic evidence strongly supports managing weight and blood pressure in addition to glycemic control in preventing vascular complications in people with type 2 diabetes

Ahmed, A., Amin, H., Drenos, F., Sattar, N., & Yaghootkar, H. (2023) · Diabetes Care · doi:10.2337/dc23-0855 · Cited by 10 · see citing works

Clinical utility of liver function tests for resolution of metabolic dysfunction-associated steatotic liver disease after weight loss in the Diabetes Remission Clinical Trial

Zhyzhneuskaya, S. V., Al‐Mrabeh, A. H., Peters, C., Barnes, A. C., Hollingsworth, K. G., Welsh, P., Sattar, N., Lean, M. E. J., & Taylor, R. (2025) · Diabetic Medicine · doi:10.1111/dme.15462 · Cited by 6 · see citing works

Comprehensive Long-Term Changes in Cardiovascular Risk Biomarkers With Tirzepatide

Sattar, N., Linetzky, B., Ruotolo, G., Verma, S., Sourij, H., Wang, H., Vanderman, K., Wilson, J. M., Griffin, R. M., Stefanski, A., et al. (2026) · JACC · doi:10.1016/j.jacc.2026.04.044 · Cited by 5 · see citing works

DETERMINING QUALITY REQUIREMENTS AT THE UNIVERSITIES TO IMPROVE THE QUALITY OF EDUCATION

Mustafa, N. H., Kelesbayev, D., & Alibekova, Z. D. (2018) · The Journal of Economic Research & Business Administration · doi:10.26577/be-2018-2-2141

Susquehanna Chorale Spring Concert "Roots and Wings"

Hawkins, D. (2017)

Genentech taps Affimed’s antibodies

Cross, R. (2018) · C&EN Global Enterprise · doi:10.1021/cen-09635-buscon15

KOMPLIKASI REGIONAL ANESTESI PADA PEDIATRIK

Sari, D. (2023) · Jurnal Komplikasi Anestesi · doi:10.22146/jka.v5i1.7322

Enxerto livre de arteria epigastrica inferior: avaliacao hemodinamica e angiografica pre e pos-operatoria

Dib, A., Puig, L. B., Salvadori, D., et al. (1988) · Arquivos Brasileiros de Cardiologia