High-fat diet acutely affects circadian organisation and eating behavior
Open accessAbstract
The organisation of timing in mammalian circadian clocks optimally coordinates behavior and physiology with daily environmental cycles. Chronic consumption of a high-fat diet alters circadian rhythms, but the acute effects on circadian organisation are unknown. To investigate the proximate effects of a high-fat diet on circadian physiology, we examined the phase relationship between central and peripheral clocks in mice fed a high-fat diet for 1 week. By 7 days, the phase of the liver rhythm was markedly advanced (by 5 h), whereas rhythms in other tissues were not affected. In addition, immediately upon consumption of a high-fat diet, the daily rhythm of eating behavior was altered. As the tissue rhythm of the suprachiasmatic nucleus was not affected by 1 week of high-fat diet consumption, the brain nuclei mediating the effect of a high-fat diet on eating behavior are likely to be downstream of the suprachiasmatic nucleus.
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A high-fat diet may alter the function of the circadian clock, with an altered period of the locomotor activity rhythm and changes in the rhythms of core clock genes in adipose and liver tissue.
“Even a high-fat diet may alter the function of the circadian clock, with an altered period of the locomotor activity rhythm and changes in the rhythms of the core clock genes in adipose and liver tissue [35–40,49].”
From Circadian control of glucose metabolism (2014) · cites this paper as [39]
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- Authors
- Pendergast, J. S., Branecky, K. L., Yang, W., Ellacott, K. L. J., Niswender, K. D., & Yamazaki, S.
- Affiliations
- Vanderbilt University (US)
- Montgomery Bell Academy Nashville TN USA
- Corresponding author
- Pendergast, Julie S.
- Yamazaki, Shin
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2013-01-21
- Volume
- 37
- Issue
- 8
- Pages
- 1350-1356
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- PMC
- PMC3645495
- OpenAlex
- W2075957423
- Cited by
- 198
- References
- 19
- Citations by year
- 2026: 8 · 2025: 18 · 2024: 22 · 2023: 11 · 2022: 11 · 2021: 19 · 2020: 13 · 2019: 21 · 2018: 18 · 2017: 14 · 2016: 12 · 2015: 8 · 2014: 14 · 2013: 8
- FWCI
- 7.57
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation
- Vanderbilt University
- National Institutes of Health
- Vanderbilt Digestive Diseases Research Center, Vanderbilt University Medical Center
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK085712, DK 20593, U24DK059637, U24DK076169, DK085712, P30DK058404, P30DK020593)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- high-fat diet, circadian rhythm, dietary habits, suprachiasmatic nucleus, peripheral clocks, central clock, meal timing
- MeSH terms
- Animals, Circadian Rhythm, Feeding Behavior, Luminescent Measurements, Male, Mice, Inbred C57BL, Motor Activity, Mice, Diet, High-Fat
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