The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Functional dysbiosis within the gut microbiota of patients with constipated‐irritable bowel syndrome
Abstract
Summary: Background: The role of the gut microbiota in patho‐physiology of irritable bowel syndrome (IBS) is suggested by several studies. However, standard cultural and molecular methods used to date have not revealed specific and consistent IBS‐related groups of microbes. Aim: To explore the constipated‐IBS (C‐IBS) gut microbiota using a function‐based approach. Methods: The faecal microbiota from 14 C‐IBS women and 12 sex‐match healthy subjects were examined through a combined strictly anaerobic cultural evaluation of functional groups of microbes and fluorescent in situ hybridisation (16S rDNA gene targeting probes) to quantify main groups of bacteria. Starch fermentation by C‐IBS and healthy faecal samples was evaluated in vitro. Results: In C‐IBS, the numbers of lactate‐producing and lactate‐utilising bacteria and the number of H 2‐consuming populations, methanogens and reductive acetogens, were at least 10‐fold lower (P < 0.05) compared with control subjects. Concomitantly, the number of lactate‐ and H 2‐utilising sulphate‐reducing population was 10 to 100 fold increased in C‐IBS compared with healthy subjects. The butyrate‐producing Roseburia – E. rectale group was in lower number (0.01 < P < 0.05) in C‐IBS than in control. C‐IBS faecal microbiota produced more sulphides and H 2 and less butyrate from starch fermentation than healthy ones. Conclusions: A major functional dysbiosis was observed in constipated‐irritable bowel syndrome gut microbiota, reflecting altered intestinal fermentation. Sulphate‐reducing population increased in the gut of C‐IBS and were accompanied by alterations in other microbial groups. This could be responsible for changes in the metabolic output and enhancement in toxic sulphide production which could in turn influence gut physiology and contribute to IBS pathogenesis.
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Cites
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Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults
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Review article: the role of butyrate on colonic function
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Dysbiosis of the faecal microbiota in patients with Crohn’s disease and their unaffected relatives
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Gastrointestinal microbiota in irritable bowel syndrome: present state and perspectives
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Intestinal microecology and quality of life in irritable bowel syndrome patients
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“riaceae was shown to be increased in C-IBS compared with healthy individuals also as previously shown.(9) Bifidobacteria are considered beneficial for the host(13) in particular as they can inhibit growth of potential pathogenic”
ResultThe economic impact of irritable bowel syndrome
Inadomi, J. M., Fennerty, M. B., & Bjorkman, D. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.t01-1-01736.x · Cited by 190
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Cited by
Gut Microbiota in Patients With Irritable Bowel Syndrome—A Systematic Review
Pittayanon, R., Lau, J. T., Yuan, Y., Leontiadis, G. I., Tse, F., Surette, M., & Moayyedi, P. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.03.049 · Cited by 719
Pathophysiology of irritable bowel syndrome
Holtmann, G. J., Ford, A. C., & Talley, N. J. (2016) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(16)30023-1 · Cited by 590
The Gut–Brain Axis and the Microbiome: Mechanisms and Clinical Implications
Osadchiy, V., Martin, C. R., & Mayer, E. A. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.10.002 · Cited by 555
Microbial pathways in colonic sulfur metabolism and links with health and disease
Carbonero, F., Benefiel, A. C., Alizadeh-Ghamsari, A. H., & Gaskins, H. R. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00448 · Cited by 544
Can probiotics modulate human disease by impacting intestinal barrier function?
Bron, P. A., Kleerebezem, M., Brummer, R.-J., Cani, P. D., Mercenier, A., MacDonald, T. T., Garcia-Ródenas, C. L., & Wells, J. M. (2017) · British Journal Of Nutrition · doi:10.1017/s0007114516004037 · Cited by 499
Metadata
- Authors
- Chassard, C., Dapoigny, M., Scott, K. P., Crouzet, L., Del'homme, C., Marquet, P., Martin, J. C., Pickering, G., Ardid, D., Eschalier, A., Dubray, C., Flint, H. J., & Bernalier‐Donadille, A.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2012-02-08
- Volume
- 35
- Issue
- 7
- Pages
- 828-838
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W2053176597
- Cited by
- 363
- References
- 14
- FWCI
- 8.71
- Type
- journal article
- Language
- en
- Open access
- closed
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