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Cited by 471

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

Guidelines for topical photodynamic therapy: update

Morton, C.A., McKenna, K.E., Rhodes, L.E., on behalf of the British Association of Dermatologists Therapy Guidelines and Audit Subcommittee and the British Photodermatology Group·2008·British Journal of Dermatology

Abstract

Multicentre randomized controlled studies now demonstrate high efficacy of topical photodynamic therapy (PDT) for actinic keratoses, Bowen's disease (BD) and superficial basal cell carcinoma (BCC), and efficacy in thin nodular BCC, while confirming the superiority of cosmetic outcome over standard therapies. Long-term follow-up studies are also now available, indicating that PDT has recurrence rates equivalent to other standard therapies in BD and superficial BCC, but with lower sustained efficacy than surgery in nodular BCC. In contrast, current evidence does not support the use of topical PDT for squamous cell carcinoma. PDT can reduce the number of new lesions developing in patients at high risk of skin cancer and may have a role as a preventive therapy. Case reports and small series attest to the potential of PDT in a wide range of inflammatory/infective dermatoses, although recent studies indicate insufficient evidence to support its use in psoriasis. There is an accumulating evidence base for the use of PDT in acne, while detailed study of an optimized protocol is still required. In addition to high-quality treatment site cosmesis, several studies observe improvements in aspects of photoageing. Management of treatment-related pain/discomfort is a challenge in a minority of patients, and the modality is otherwise well tolerated. Long-term studies provide reassurance over the safety of repeated use of PDT.

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Metadata

Authors
Morton, C. A., McKenna, K. E., Rhodes, L. E., & on behalf of the British Association of Dermatologists Therapy Guidelines and Audit Subcommittee and the British Photodermatology Group
Venue
British Journal of Dermatology
Published
2008-12
Volume
159
Issue
6
Pages
1245-1266
ISSN
  • 0007-0963 (ISSN-L)
  • 1365-2133
OpenAlex
W2052703448
Cited by
471
References
17
FWCI
32.63
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Guidelines for topical photodynamic therapy: update. https://app.cochat.ai/papers/10.1111/j.1365-2133.2008.08882.x
The paper
Morton, C. A., McKenna, K. E., Rhodes, L. E., & on behalf of the British Association of Dermatologists Therapy Guidelines and Audit Subcommittee and the British Photodermatology Group. (2008). Guidelines for topical photodynamic therapy: update. British Journal of Dermatology. https://doi.org/10.1111/j.1365-2133.2008.08882.x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.