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Cited by 104Sleep and Work-Related FatigueCircadian rhythm and melatoninSleep and Wakefulness Research

Sleep timing may modulate the effect of sleep loss on testosterone

Schmid, Sebastian M., Hallschmid, Manfred, Jauch‐Chara, Kamila, Lehnert, Hendrik, Schultes, Bernd·2012·Clinical Endocrinology
DOI 10.1111/j.1365-2265.2012.04419.x
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Abstract

BACKGROUND: Sleep loss has been shown to reduce secretory activity of the pituitary-gonadal axis in men, but the determinants of this effect are unknown. OBJECTIVE: To discriminate the effects of sleep duration and sleep timing on serum concentrations of luteinizing hormone (LH), testosterone (T) and prolactin (PRL). METHODS: Fifteen young, healthy men (27·1 ± 1·3 years; BMI, 22·9 ± 0·3 kg/m(2) ) were examined in a condition of sleep time restriction to 4 h (bedtime, 02:45 -07:00 h) for two consecutive nights and in a control condition of 8 h regular sleep (bedtime, 22:45-07:00 h). After the second night, serum concentrations of LH, T and PRL were monitored over a 15-h period. In addition, these hormones were measured in serum samples obtained in a further experiment in eight healthy men (24·5 ± 1·1 years; BMI, 23·7 ± 0·6 kg/m(2) ) in the morning after one night of total sleep deprivation, of 4·5 h sleep (bedtime, 22:30-03:30 h), and of regular 7 h sleep (bedtime, 22:30-06:00 h). RESULTS: Serum LH, T and PRL concentrations showed characteristic diurnal variations across the 15-h period without any differences between the 4- and 8-h sleep conditions. However, total sleep deprivation and 4·5 h of sleep restricted to the first night-half markedly decreased morning T and PRL concentrations (both P ≤ 0·05). CONCLUSION: Collectively, our data suggest that the effect of sleep restriction on pituitary-gonadal secretory activity may be modulated by sleep timing. While sleep loss in the early part of the night does not affect T and PRL, early awakening and wakefulness during the second part of the night reduces morning circulating T and PRL concentrations.

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Crossref · 10.1111/j.1365-2265.2012.04419.x

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  • Sleep loss and lower sleep duration are associated with lower morning, afternoon, and 24-h testosterone.

    “When epidemiological and interventional studies are considered collectively, sleep loss and lower sleep duration are associated with lower morning, afternoon and 24-h testosterone; as well as higher afternoon, but not morning or 24-h cortisol.”

    From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [43]

  • All in-laboratory studies when collectively examined show that sleep restriction decreases testosterone.

    “All studies when collectively examined show that sleep restriction decreases testosterone.”

    From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [43]

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Authors
Schmid, S. M., Hallschmid, M., Jauch‐Chara, K., Lehnert, H., & Schultes, B.
Affiliations
University of Lübeck (DE)
Corresponding author
Schmid, Sebastian M.
ORCID
Venue
Clinical Endocrinology
Publisher
Wiley
Published
2012-10-05
Volume
77
Issue
5
Pages
749-754
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1111/j.1365-2265.2012.04419.x
OpenAlex
W2063639466
Cited by
104
References
6
Citations by year
2026: 1 · 2025: 6 · 2024: 4 · 2023: 9 · 2022: 7 · 2021: 14 · 2020: 10 · 2019: 12 · 2018: 10 · 2017: 9 · 2016: 7 · 2015: 9 · 2014: 3 · 2013: 2
FWCI
6.01
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
sleep timing, sleep deprivation, sleep restriction, total sleep deprivation, testosterone, luteinizing hormone, prolactin, pituitary-gonadal axis, diurnal variation, early morning awakening, nocturnal wakefulness
MeSH terms
Adult, Humans, Sleep Initiation and Maintenance Disorders, Luteinizing Hormone, Male, Prolactin, Sleep, Sleep Deprivation, Testosterone, Wakefulness

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