Cytomegalovirus infection induces the accumulation of short-lived, multifunctional CD4+ CD45RA+ CD27− T cells: the potential involvement of interleukin-7 in this process: IL-7 induces re-expression of CD45RA in CD4+ T cells
Open accessAbstract
The relative roles that ageing and lifelong cytomegalovirus (CMV) infection have in shaping naive and memory CD4+ T-cell repertoires in healthy older people is unclear. Using multiple linear regression analysis we found that age itself is a stronger predictor than CMV seropositivity for the decrease in CD45RA+ CD27+ CD4+ T cells over time. In contrast, the increase in CD45RA⁻ CD27⁻ and CD45RA+ CD27⁻ CD4+ T cells is almost exclusively the result of CMV seropositivity, with age alone having no significant effect. Furthermore, the majority of the CD45RA⁻ CD27⁻ and CD45RA+ CD27⁻ CD4+ T cells in CMV-seropositive donors are specific for this virus. CD45RA+ CD27⁻ CD4+ T cells have significantly reduced CD28, interleukin-7 receptor α (IL-7Rα) and Bcl-2 expression, Akt (ser473) phosphorylation and reduced ability to survive after T-cell receptor activation compared with the other T-cell subsets in the same donors. Despite this, the CD45RA+ CD27⁻ subset is as multifunctional as the CD45RA⁻ D27+ and CD45RA⁻ CD27⁻ CD4+ T-cell subsets, indicating that they are not an exhausted population. In addition, CD45RA+ CD27⁻ CD4+ T cells have cytotoxic potential as they express high levels of granzyme B and perforin. CD4+ memory T cells re-expressing CD45RA can be generated from the CD45RA⁻ CD27+ population by the addition of IL-7 and during this process these cells down-regulated expression of IL-7R and Bcl-2 and so resemble their counterparts in vivo. Finally we showed that the proportion of CD45RA+ CD27⁻ CD4+ T cells of multiple specificities was significantly higher in the bone marrow than the blood of the same individuals, suggesting that this may be a site where these cells are generated.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Unlike senescent fibroblasts, T cells with characteristics of senescence are prone to apoptosis in vitro.
“Unlike senescent fibroblasts however, T cells that have characteristics of senescence are prone to apoptosis in vitro [23, 28] although they may be induced to persist by appropriate signals such as growth factors in vivo [32].”
From Senescence of T Lymphocytes: Implications for Enhancing Human Immunity (2016) · cites this paper as [28]
Within primary human T cells, both CD4+ and CD8+ populations contain a subset of poorly proliferative cells with characteristics very similar to senescent fibroblasts.
“Within primary human T cells, in both CD4 + [23, 28, 29] and CD8 + [25, 30] populations, there is a subset of poorly proliferative cells that exhibit characteristics that are very similar to senescent fibroblasts (Fig. 1).”
From Senescence of T Lymphocytes: Implications for Enhancing Human Immunity (2016) · cites this paper as [28]
Senescent-like T cells can be identified by surface marker expression CD27-, CD28-, CD45RA+, KLRG1+, CD57+, which are characteristics of highly differentiated T cells.
“These cells can be identified by surface marker expression (CD27 - ,CD28 - , CD45RA + , KLRG1 + , CD57 + ) that are all characteristics of highly differentiated T cells [23, 28, 30, 31].”
From Senescence of T Lymphocytes: Implications for Enhancing Human Immunity (2016) · cites this paper as [28]
Compared to less differentiated populations, senescent T cells secrete high levels of inflammatory cytokines IFN-gamma and TNF-alpha after short term activation.
“In comparison to less differentiated populations, senescent T cells also secrete high levels of inflammatory cytokines such IFN and TNF after short term activation [28, 30, 50]”
From Senescence of T Lymphocytes: Implications for Enhancing Human Immunity (2016) · cites this paper as [28]
Undifferentiated T cells with relatively long telomeres are CD27+CD28+, while senescent T cells with the shortest telomeres are found within the CD27-CD28- population.
“While undifferentiated T cells that have relatively long telomeres are CD27 + CD28 + , senescent T cells with the shortest telomeres are found within the CD27 - CD28 - population [22, 28, 34, 54].”
From Senescence of T Lymphocytes: Implications for Enhancing Human Immunity (2016) · cites this paper as [28]
For T cells in peripheral blood, there is a correlation between the sequential loss of costimulatory receptors on the cell surface and the progressive loss of telomeres.
“For T cells in peripheral blood, there is a correlation between the sequential loss of costimulatory receptors on the cell surface and the progressive loss of telomeres.”
From Senescence of T Lymphocytes: Implications for Enhancing Human Immunity (2016) · cites this paper as [28]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections
Appay, V., Dunbar, P. R., Callan, M. F. C., Klenerman, P., Gillespie, G. M. A., Papagno, L., Ogg, G. S., King, A., Lechner, F., Spina, C. A., et al. (2002) · Nature Medicine · doi:10.1038/nm0402-379 · Cited by 1,556 · see citing works
Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15
Zhang, X. M., Sun, S., Hwang, I., Tough, D. F., & Sprent, J. (1998) · Immunity · doi:10.1016/s1074-7613(00)80564-6 · Cited by 1,248 · see citing works
Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo
Tough, D. F., Borrow, P., & Sprent, J. (1996) · Science · doi:10.1126/science.272.5270.1947 · Cited by 1,081 · see citing works
Skewed maturation of memory HIV-specific CD8 T lymphocytes
Champagne, P., Ogg, G. S., King, A. S., Knabenhans, C., Ellefsen, K., Nobile, M., Appay, V., Rizzardi, G. P., Fleury, S., Lipp, M., et al. (2001) · Nature · doi:10.1038/35065118 · Cited by 1,002 · see citing works
Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells.
Akbar, A. N., Terry, L. A., Timms, A., Beverley, P. C. L., & Janossy, G. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.140.7.2171 · Cited by 921 · see citing works
Self-citationPhenotype and function of human T lymphocyte subsets: Consensus and issues
Appay, V., van Lier, R. A. W., Sallusto, F., & Roederer, M. (2008) · Cytometry Part A · doi:10.1002/cyto.a.20643 · Cited by 729 · see citing works
Geginat, J., Lanzavecchia, A., & Sallusto, F. (2003) · Blood · doi:10.1182/blood-2002-11-3577 · Cited by 604 · see citing works
Geginat, J., Sallusto, F., & Lanzavecchia, A. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.12.1711 · Cited by 533 · see citing works
Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections.
Nikolich-Žugich, J. (2008) · Nature reviews. Immunology · doi:10.1038/nri2318 · Cited by 463 · see citing works
Gillespie, G. M. A., Wills, M. R., Appay, V., O’Callaghan, C. A., Murphy, M., Smith, N. T., Sissons, P., Rowland‐Jones, S., Bell, J. I., & Moss, P. A. H. (2000) · Journal of Virology · doi:10.1128/jvi.74.17.8140-8150.2000 · Cited by 419 · see citing works
Saule, P., Trauet, J., Dutriez, V., Lekeux, V., Dessaint, J., & Labalette, M. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.11.001 · Cited by 369 · see citing works
Professional Memory CD4+ T Lymphocytes Preferentially Reside and Rest in the Bone Marrow
Tokoyoda, K., Zehentmeier, S., Hegazy, A. N., Albrecht, I., Grün, J. R., Löhning, M., & Radbruch, A. (2009) · Immunity · doi:10.1016/j.immuni.2009.03.015 · Cited by 352 · see citing works
Khan, N., Hislop, A. D., Gudgeon, N. H., Cobbold, M., Khanna, R., Nayak, L., Rickinson, A. B., & Moss, P. A. H. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.12.7481 · Cited by 351 · see citing works
CD8 T cell dysfunction during chronic viral infection
Shin, H., & Wherry, E. J. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.06.004 · Cited by 346 · see citing works
The Yellow Fever Virus Vaccine Induces a Broad and Polyfunctional Human Memory CD8+ T Cell Response
Akondy, R. S., Monson, N. D., Miller, J. D., Edupuganti, S., Teuwen, D. E., Wu, H. G., Quyyumi, F. F., Garg, S., Altman, J. D., del Rı́o, C., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803903 · Cited by 345 · see citing works
Immunosenescence: what does it mean to health outcomes in older adults?
McElhaney, J. E., & Effros, R. B. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.05.023 · Cited by 340 · see citing works
Akbar, A. N., Borthwick, N., Salmon, M., Gombert, W. M., Bofill, M., Shamsadeen, N., Pilling, D., Pett, S. L., Grundy, J. E., & Janossy, G. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.2.427 · Cited by 336 · see citing works
Self-citationInterleukin 15 Controls both Proliferation and Survival of a Subset of Memory-Phenotype CD8+ T Cells
Judge, A. D., Zhang, X. M., Fujii, H., Surh, C. D., & Sprent, J. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020772 · Cited by 331 · see citing works
Kannanganat, S., Ibegbu, C., Chennareddi, L. S., Robinson, H. L., & Amara, R. R. (2007) · Journal of Virology · doi:10.1128/jvi.00228-07 · Cited by 304 · see citing works
Fletcher, J. M., Vukmanovic-Stejic, M., Dunne, P. J., Birch, K. E., Cook, J. E., Jackson, S. E., Salmon, M., Rustin, M. H., & Akbar, A. N. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.12.8218 · Cited by 296 · see citing works
Self-citationChronic herpesvirus reactivation occurs in aging
Stowe, R., KOZLOVA, E., Yetman, D. L., Walling, D. M., Goodwin, J. S., & Glaser, R. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.01.005 · Cited by 279 · see citing works
Down-Regulation of CD28 Expression by TNF-α
Bryl, E., Vallejo, A. N., Weyand, C. M., & Goronzy, J. J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.6.3231 · Cited by 264 · see citing works
Henson, S. M., Franzese, O., Macaulay, R., Libri, V., Azevedo, R. I., Kiani-Alikhan, S., Plunkett, F. J., Masters, J. E., Jackson, S., Griffiths, S. J., et al. (2009) · Blood · doi:10.1182/blood-2009-01-199588 · Cited by 262 · see citing works
Self-citationChidrawar, S. M., Khan, N., Wei, W., McLarnon, A., Smith, N., Nayak, L., & Moss, P. A. H. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2008.03785.x · Cited by 244 · see citing works
Messaoudi, I., LeMaoult, J., Guevara-Patino, J. A., Metzner, B. M., & Nikolich‐Žugich, J. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040437 · Cited by 243 · see citing works
Memory T cell homeostasis and senescence during aging
Akbar, A. N., & Fletcher, J. M. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.07.019 · Cited by 225 · see citing works
Self-citationPlunkett, F. J., Franzese, O., Finney, H. M., Fletcher, J. M., Belaramani, L. L., Salmon, M., Dokal, I., Webster, D., Lawson, A. D. G., & Akbar, A. N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.12.7710 · Cited by 222 · see citing works
Self-citationBiomarkers of human immunosenescence: impact of cytomegalovirus infection
Derhovanessian, E., Larbi, A., & Pawelec, G. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.05.012 · Cited by 220 · see citing works
IL-7-Dependent Extrathymic Expansion of CD45RA+ T Cells Enables Preservation of a Naive Repertoire
Soares, M. V. D., Soares, D., Borthwick, N., Maini, M. K., Janossy, G., Salmon, M., & Akbar, A. N. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.11.5909 · Cited by 216 · see citing works
Self-citationGamadia, L. E., Rentenaar, R. J., Baars, P. A., Remmerswaal, E. B. M., Surachno, S., Weel, J. F. L., Toebes, M., Schumacher, T. N., ten Berge, I. J. M., & van Lier, R. A. W. (2001) · Blood · doi:10.1182/blood.v98.3.754 · Cited by 215 · see citing works
Pourgheysari, B., Khan, N., Best, D., Bruton, R., Nayak, L., & Moss, P. A. H. (2007) · Journal of Virology · doi:10.1128/jvi.01262-06 · Cited by 214 · see citing works
Interleukin 7 production and function in stromal cell-dependent B cell development.
Sudo, T., Ito, M., Ogawa, Y., Iizuka, M., Kodama, H., Kunisada, T., Hayashi, S., Ogawa, M., Sakai, K., & Nishikawa, S. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.170.1.333 · Cited by 210 · see citing works
Faint, J. M., Annels, N. E., Curnow, S. J., Shields, P., Pilling, D., Hislop, A. D., Wu, L., Akbar, A. N., Buckley, C. D., Moss, P. A. H., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.1.212 · Cited by 171 · see citing works
Self-citationWills, M. R., Carmichael, A., Weekes, M. P., Mynard, K., Okecha, G., Hicks, R., & Sissons, J. G. P. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.12.7080 · Cited by 167 · see citing works
Immunosenescence, autoimmunity, and rheumatoid arthritis
Weyand, C. M., Fulbright, J. W., & Goronzy, J. J. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00090-1 · Cited by 161 · see citing works
Cytomegalovirus Infection Reduces Telomere Length of the Circulating T Cell Pool
van de Berg, P. J. E. J., Griffiths, S. J., Yong, S.-L., Macaulay, R., Bemelman, F. J., Jackson, S., Henson, S. M., ten Berge, I. J. M., Akbar, A. N., & van Lier, R. A. W. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903442 · Cited by 157 · see citing works
Self-citationDunne, P. J., Faint, J. M., Gudgeon, N. H., Fletcher, J. M., Plunkett, F. J., Soares, M. V. D., Hislop, A. D., Annels, N. E., Rickinson, A. B., Salmon, M., et al. (2002) · Blood · doi:10.1182/blood-2002-01-0160 · Cited by 144 · see citing works
Self-citationBorthwick, N., Lowdell, M. W., Salmon, M., & Akbar, A. N. (2000) · International Immunology · doi:10.1093/intimm/12.7.1005 · Cited by 144 · see citing works
Self-citationWeinberger, B., Lazuardi, L., Weiskirchner, I., Keller, M., Neuner, C., Fischer, K.-H., Neuman, B., Würzner, R., & Grubeck‐Loebenstein, B. (2006) · Human Immunology · doi:10.1016/j.humimm.2006.10.019 · Cited by 138 · see citing works
Will telomere erosion lead to a loss of T-cell memory?
Akbar, A. N., Beverley, P. C. L., & Salmon, M. (2004) · Nature Reviews Immunology · doi:10.1038/nri1440 · Cited by 135 · see citing works
Self-citationVescovini, R., Telera, A. R., Fagnoni, F. F., Biasini, C., Medici, M. C., Valcavi, P., Pede, P. D., Lucchini, G., Zanlari, L., Passeri, G., et al. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.04.004 · Cited by 119 · see citing works
Direct measurement of T cell subset kinetics in vivo in elderly men and women
Wallace, D. L., Zhang, Y., Ghattas, H., Worth, A., Irvine, A., Bennett, A. R., Griffin, G. E., Beverley, P. C. L., Tough, D. F., & Macallan, D. C. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.3.1787 · Cited by 115 · see citing works
Reed, J. R., Vukmanovic-Stejic, M., Fletcher, J. M., Soares, M. V. D., Cook, J. E., Orteu, C. H., Jackson, S. E., Birch, K. E., Foster, G. R., Salmon, M., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040178 · Cited by 111 · see citing works
Self-citationWaller, E. C. P., McKinney, N., Hicks, R., Carmichael, A. J., Sissons, J. G. P., & Wills, M. R. (2007) · Blood · doi:10.1182/blood-2007-07-104604 · Cited by 90 · see citing works
Effect of ageing on CMV-specific CD8 T cells from CMV seropositive healthy donors
Pita‐López, M. L., Gayoso, I., DelaRosa, O., Casado, J. G., Alonso, C., Muñoz-Gomáriz, E., Tarazona, R., & Solana, R. (2009) · Immunity & Ageing · doi:10.1186/1742-4933-6-11 · Cited by 86 · see citing works
Wallace, D. L., Berard, M., Soares, M. V. D., Oldham, J. E., Cook, J. E., Akbar, A. N., Tough, D. F., & Beverley, P. C. L. (2006) · Immunology · doi:10.1111/j.1365-2567.2006.02429.x · Cited by 79 · see citing works
Self-citationGombert, W. M., Borthwick, N., Wallace, D. L., et al. (1996) · Immunology · doi:10.1046/j.1365-2567.1996.d01-759.x · Cited by 57 · see citing works
Dunne, P. J. (2005) · Blood · doi:10.1182/blood-2004-11-4469 · Cited by 53 · see citing works
Wherry, E. J., Becker, T. C., Boone, D. L., Murali‐Krishna, K., Ma, A. I., & Ahmed, R. (2002) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0757-4_22 · Cited by 47 · see citing works
Type 1 IFN Maintains the Survival of Anergic CD4+ T Cells
Lombardi, G., Dunne, P. J., Scheel‐Toellner, D., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.7.3782 · Cited by 45 · see citing works
CD45RA(bright)/CD11a(bright) CD8+ T cells: effector T cells.
Höflich, C., Döcke, W. ‐., Busch, A., Kern, F., & Volk, H. (1998) · International Immunology · doi:10.1093/intimm/10.12.1837 · Cited by 33 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- IL-7 induces re-expression of CD45RA in CD4 + T cells 13652567, 2011, 3, · DOI
- Pilling D, Akbar AN, Girdlestone J et al. Interferon-beta mediates stromal cell rescue of T cells from apoptosis. Eur J Immunol 1999; 29:1041-50.
Cited by
Sorted by citations
Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?
Akbar, A. N., & Henson, S. M. (2011) · Nature Reviews Immunology · doi:10.1038/nri2959 · Cited by 474 · see citing works
Self-citationWertheimer, A. M., Bennett, M. S., Park, B., Uhrlaub, J. L., Martinez, C., Pulko, V., Currier, N. L., Nikolich-Žugich, D., Kaye, J., & Nikolich-Žugich, J. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301721 · Cited by 352 · see citing works
Lanna, A., Henson, S. M., Escors, D., & Akbar, A. N. (2014) · Nature Immunology · doi:10.1038/ni.2981 · Cited by 328 · see citing works
Self-citationSenescence of T Lymphocytes: Implications for Enhancing Human Immunity
Akbar, A. N., Henson, S. M., & Lanna, A. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.09.002 · Cited by 285 · see citing works
Self-citationCellular signaling in the aging immune system
Fulop, T., Le Page, A., Fortin, C., Witkowski, J. M., Dupuis, G., & Larbi, A. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.05.007 · Cited by 158 · see citing works
Henson, S. M., Macaulay, R., Riddell, N. E., Nunn, C. J., & Akbar, A. N. (2015) · European Journal of Immunology · doi:10.1002/eji.201445312 · Cited by 146 · see citing works
Self-citationWeltevrede, M., Eilers, R., de Melker, H. E., & van Baarle, D. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.02.005 · Cited by 128 · see citing works
The characterization of varicella zoster virus-specific T cells in skin and blood during aging
Vukmanovic-Stejic, M., Sandhu, D., Seidel, J. A., Patel, N., Sobande, T. O., Agius, E., Jackson, S. E., Fuentes-Duculan, J., Suárez-Fariñas, M., Mabbott, N. A., et al. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.63 · Cited by 117 · see citing works
Self-citationDerhovanessian, E., Theeten, H., Hähnel, K., Van Damme, P., Cools, N., & Pawelec, G. (2013) · Vaccine · doi:10.1016/j.vaccine.2012.11.041 · Cited by 121 · see citing works
The role of senescent T cells in immunopathology
Covre, L. P., De Maeyer, R. P. H., Gomes, D. C. O., & Akbar, A. N. (2020) · Aging Cell · doi:10.1111/acel.13272 · Cited by 93 · see citing works
Self-citationImpact of Aging and Cytomegalovirus on Immunological Response to Influenza Vaccination and Infection
Merani, S., Pawelec, G., Kuchel, G. A., & McElhaney, J. E. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00784 · Cited by 74 · see citing works
Age-Associated Increase of Low-Avidity Cytomegalovirus-Specific CD8+ T Cells That Re-Express CD45RA
Griffiths, S. J., Riddell, N. E., Masters, J., Libri, V., Henson, S. M., Wertheimer, A., Wallace, D., Sims, S., Rivino, L., Larbi, A., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203267 · Cited by 82 · see citing works
Self-citationLanna, A., Coutavas, E., Levati, L., Seidel, J., Rustin, M. H. A., Henson, S. M., Akbar, A. N., & Franzese, O. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301409 · Cited by 62 · see citing works
Self-citationRiddell, N. E., Griffiths, S. J., Rivino, L., King, D. C. B., Teo, G. H., Henson, S. M., Cantisan, S., Solana, R., Kemeny, D. M., MacAry, P. A., et al. (2015) · Immunology · doi:10.1111/imm.12409 · Cited by 60 · see citing works
Self-citationZlamy, M., Almanzar, G., Parson, W., Schmidt, C., Leierer, J., Weinberger, B., Jeller, V., Unsinn, K., Eyrich, M., Würzner, R., et al. (2016) · Immunity & Ageing · doi:10.1186/s12979-016-0058-z · Cited by 29 · see citing works
- Authors
- Libri, V., Azevedo, R. I., Jackson, S. E., Di Mitri, D., Lachmann, R., Fuhrmann, S., Vukmanovic-Stejic, M., Yong, K., Battistini, L., Kern, F., Soares, M. V. D., & Akbar, A. N.
- Affiliations
- University College London (GB)
- Instituto de Medicina Molecular João Lobo Antunes (PT)
- Brighton and Sussex Medical School (GB)
- Fondazione Santa Lucia (IT)
- Corresponding author
- Akbar, Arne N.
- ORCID
- Venue
- Immunology
- Publisher
- Wiley
- Published
- 2011-01-07
- Volume
- 132
- Issue
- 3
- Pages
- 326-339
- ISSN
- 0019-2805 (ISSN-L)
- PMC
- PMC3044899
- OpenAlex
- W1942062259
- Cited by
- 111
- References
- 52
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 11 · 2023: 7 · 2022: 4 · 2021: 7 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 10 · 2016: 9 · 2015: 7 · 2014: 7 · 2013: 10 · 2012: 9
- FWCI
- 8.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- Directorate for Biological Sciences
- Biotechnology and Biological Sciences Research Council (BB/E019188/1)
- Fundação para a Ciência e a Tecnologia (POCI2010)
- Topics
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Keywords
- cytomegalovirus infection, CD4+ T cells, IL-7, CD127, T cell exhaustion, memory T cells, CD28, Bcl-2, Akt phosphorylation, granzyme B, perforin, bone marrow, T cell receptor specificity
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Cell Differentiation, Cell Separation, Cell Survival, Cytomegalovirus Infections, Flow Cytometry, Humans, Middle Aged, Signal Transduction, CD4-Positive T-Lymphocytes, Interleukin-7, T-Lymphocyte Subsets, Leukocyte Common Antigens, Tumor Necrosis Factor Receptor Superfamily, Member 7, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
