Cellular signaling in the aging immune system

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works

Inflamm‐aging: An Evolutionary Perspective on Immunosenescence

FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358 · see citing works

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

Ray, P. D., Huang, B.-W., & Tsuji, Y. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.01.008 · Cited by 4,373 · see citing works

Molecular mechanisms of T cell co-stimulation and co-inhibition

Chen, L., & Flies, D. B. (2013) · Nature Reviews Immunology · doi:10.1038/nri3405 · Cited by 3,114 · see citing works

T Cell Activation

Smith-Garvin, J. E., Koretzky, G. A., & Jordan, M. S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132706 · Cited by 2,144 · see citing works

Mitogen-activated protein kinases in innate immunity

Arthur, J. S. C., & Ley, S. C. (2013) · Nature reviews. Immunology · doi:10.1038/nri3495 · Cited by 1,866 · see citing works

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

Pearce, E. L., Poffenberger, M. C., Chang, C.-H., & Jones, R. G. (2013) · Science · doi:10.1126/science.1242454 · Cited by 1,363 · see citing works

Age-dependent dysregulation of innate immunity

Shaw, A. C., Goldstein, D. R., & Montgomery, R. R. (2013) · Nature Reviews Immunology · doi:10.1038/nri3547 · Cited by 1,061 · see citing works

Causes, consequences, and reversal of immune system aging

Montecino-Rodriguez, E., Berent-Maoz, B., & Dorshkind, K. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64096 · Cited by 793 · see citing works

Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

Youm, Y.-H., Grant, R. W., McCabe, L. R., Albarado, D. C., Nguyen, K. Y., Ravussin, A., Pistell, P., Newman, S., Carter, R., Laque, A., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.010 · Cited by 674 · see citing works

Aging, frailty and age-related diseases

Fülöp, T., Larbi, A., Witkowski, J. M., McElhaney, J. E., Loeb, M. B., Mitnitski, A., & Pawelec, G. (2010) · Biogerontology · doi:10.1007/s10522-010-9287-2 · Cited by 655 · see citing works

Free Radical Theory of Aging: An Update: Increasing the Functional Life Span

HARMAN, D. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1354.003 · Cited by 601 · see citing works

Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans

Solana, R., Tarazona, R., Gayoso, I., Lesur, O., Dupuis, G., & Fulop, T. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.008 · Cited by 567 · see citing works

The kinetic-segregation model: TCR triggering and beyond

Davis, S. J., & van der Merwe, P. A. (2006) · Nature Immunology · doi:10.1038/ni1369 · Cited by 562 · see citing works

Aging of the Immune System: How Much Can the Adaptive Immune System Adapt?

Weng, N. (2006) · Immunity · doi:10.1016/j.immuni.2006.05.001 · Cited by 476 · see citing works

TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways

Štefanová, I., Hemmer, B., Vergelli, M., Martin, R., Biddison, W. E., & Germain, R. N. (2003) · Nature Immunology · doi:10.1038/ni895 · Cited by 465 · see citing works

T cell receptor signalling networks: branched, diversified and bounded

Brownlie, R. J., & Zamoyska, R. (2013) · Nature Reviews Immunology · doi:10.1038/nri3403 · Cited by 453 · see citing works

Mechanisms of NOD-like Receptor-Associated Inflammasome Activation

Wen, H., Miao, E. A., & Ting, J. P. ‐. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.037 · Cited by 415 · see citing works

SHP‐1 and SHP‐2 in T cells: two phosphatases functioning at many levels

Lorenz, U. M. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00760.x · Cited by 370 · see citing works

Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence

Sapey, E., Greenwood, H., Walton, G., Mann, E., Love, A., Aaronson, N., Insall, R. H., Stockley, R. A., & Lord, J. M. (2014) · Blood · doi:10.1182/blood-2013-08-519520 · Cited by 358 · see citing works

Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity

Li, G., Yu, M., Lee, W.-W., Tsang, M., Krishnan, E., Weyand, C. M., & Goronzy, J. J. (2012) · Nature Medicine · doi:10.1038/nm.2963 · Cited by 349 · see citing works

Human T Cell Aging and the Impact of Persistent Viral Infections

Fülöp, T., Larbi, A., & Pawelec, G. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00271 · Cited by 347 · see citing works

Signal transduction and functional changes in neutrophils with aging

Fülöp, T., Larbi, A., Douziech, N., Fortin, C. F., Guérard, K., Lesur, O., Khalil, A., & Dupuis, G. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00110.x · Cited by 331 · see citing works

Regulation of protein tyrosine phosphatases by reversible oxidation

Östman, A., Frijhoff, J., Sandin, Å., & Böhmer, F. (2011) · The Journal of Biochemistry · doi:10.1093/jb/mvr104 · Cited by 288 · see citing works

Beyond pattern recognition: five immune checkpoints for scaling the microbial threat

Blander, J. M., & Sander, L. E. (2012) · Nature reviews. Immunology · doi:10.1038/nri3167 · Cited by 286 · see citing works

Tailoring T-cell receptor signals by proximal negative feedback mechanisms

Acuto, O., Bartolo, V. D., & Michel, F. (2008) · Nature reviews. Immunology · doi:10.1038/nri2397 · Cited by 245 · see citing works

Reversible Senescence in Human CD4+CD45RA+CD27− Memory T Cells

Di Mitri, D., Azevedo, R. I., Henson, S. M., Libri, V., Riddell, N. E., Macaulay, R., Kipling, D., Soares, M. V. D., Battistini, L., & Akbar, A. N. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100978 · Cited by 231 · see citing works

Protein tyrosine phosphatases in lymphocyte activation and autoimmunity

Rhee, I., & Veillette, A. (2012) · Nature Immunology · doi:10.1038/ni.2246 · Cited by 229 · see citing works

T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice

Wiede, F., Shields, B. J., Chew, S., Kyparissoudis, K., van Vliet, C., Galić, S., Tremblay, M. L., Russell, S. M., Godfrey, D. I., & Tiganis, T. (2011) · Journal of Clinical Investigation · doi:10.1172/jci59492 · Cited by 225 · see citing works

Pattern recognition receptor function in neutrophils

Thomas, C. J., & Schroder, K. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.02.008 · Cited by 220 · see citing works

Dysregulation of human Toll-like receptor function in aging

Shaw, A. C., Panda, A., Joshi, S. R., Qian, F., Allore, H. G., & Montgomery, R. R. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2010.10.007 · Cited by 215 · see citing works

Properties of end-stage human T cells defined by CD45RA re-expression

Henson, S. M., Riddell, N. E., & Akbar, A. N. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.04.001 · Cited by 180 · see citing works

The Nonphagocytic NADPH Oxidase Duox1 Mediates a Positive Feedback Loop During T Cell Receptor Signaling

Kwon, J., Shatynski, K. E., Chen, H., Morand, S. C., Deken, X. D., Miot, F., Leto, T. L., & Williams, M. S. (2010) · Science Signaling · doi:10.1126/scisignal.2000976 · Cited by 139 · see citing works

Preferential oxidation of the second phosphatase domain of receptor-like PTP-α revealed by an antibody against oxidized protein tyrosine phosphatases

Persson, C., Sjöblom, T., Groen, A. J., Kappert, K., Engström, U., Hellman, U., Heldin, C., den Hertog, J., & Östman, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0304403101 · Cited by 139 · see citing works

Signaling pathways in aged T cells – A reflection of T cell differentiation, cell senescence and host environment

Goronzy, J. J., Li, G., Yu, M., & Weyand, C. M. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.003 · Cited by 134 · see citing works

Inhibition of Protein-tyrosine Phosphatases by Mild Oxidative Stresses Is Dependent on S-Nitrosylation

Barrett, D. M., Black, S. M., Todor, H., Schmidt‐Ullrich, R., Dawson, K. S., & Mikkelsen, R. B. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411523200 · Cited by 133 · see citing works

The role of the T cell in age-related inflammation

Macaulay, R., Akbar, A. N., & Henson, S. M. (2012) · AGE · doi:10.1007/s11357-012-9381-2 · Cited by 130 · see citing works

Age-associated alterations in the recruitment of signal-transduction proteins to lipid rafts in human T lymphocytes

Larbi, A., Douziech, N., Dupuis, G., Khalil, A., Pelletier, H., Guérard, K., & Fülöp, T. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0703319 · Cited by 126 · see citing works

Differential role of lipid rafts in the functions of CD4+ and CD8+ human T lymphocytes with aging

Larbi, A., Dupuis, G., Khalil, A., Douziech, N., Fortin, C., & Fülöp, T. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2005.08.016 · Cited by 126 · see citing works

Cutting Edge: Fyn Is Essential for Tyrosine Phosphorylation of Csk-Binding Protein/Phosphoprotein Associated with Glycolipid-Enriched Microdomains in Lipid Rafts in Resting T Cells

Yasuda, K., Nagafuku, M., Shima, T., Okada, M., Yagi, T., Yamada, T., Minaki, Y., Kato, A., Tani‐ichi, S., Hamaoka, T., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.6.2813 · Cited by 126 · see citing works

The immunological synapse: a cause or consequence of T-cell receptor triggering?

Alarcón, B., Mestre, D., & Martínez, N. (2011) · Immunology · doi:10.1111/j.1365-2567.2011.03458.x · Cited by 120 · see citing works

Immunosenescence in vertebrates and invertebrates

Müller, L., Fülöp, T., & Pawelec, G. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-12 · Cited by 117 · see citing works

Involvement of SHP-1 Tyrosine Phosphatase in TCR-Mediated Signaling Pathways in Lipid Rafts

Kosugi, A., Sakakura, J., Yasuda, K., Ogata, M., & Hamaoka, T. (2001) · Immunity · doi:10.1016/s1074-7613(01)00146-7 · Cited by 113 · see citing works

Impairment of SHP-1 down-regulation in the lipid rafts of human neutrophils under GM-CSF stimulation contributes to their age-related, altered functions

Fortin, C. F., Larbi, A., Lesur, O., Douziech, N., & Fülöp, T. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0805481 · Cited by 112 · see citing works

Cytomegalovirus infection induces the accumulation of short-lived, multifunctional CD4+ CD45RA+ CD27− T cells: the potential involvement of interleukin-7 in this process: IL-7 induces re-expression of CD45RA in CD4+ T cells

Libri, V., Azevedo, R. I., Jackson, S. E., Di Mitri, D., Lachmann, R., Fuhrmann, S., Vukmanovic-Stejic, M., Yong, K., Battistini, L., Kern, F., et al. (2011) · Immunology · doi:10.1111/j.1365-2567.2010.03386.x · Cited by 111 · see citing works

Impact of age on T cell signaling: A general defect or specific alterations?

Larbi, A., Pawelec, G., Wong, S. C., Goldeck, D., Tai, J. J.-Y., & Fulop, T. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2010.09.008 · Cited by 108 · see citing works

Oxidative stress modulation and T cell activation

Larbi, A., Kempf, J., & Pawelec, G. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.05.004 · Cited by 102 · see citing works

Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age

Yu, M., Li, G., Lee, W.-W., Yuan, M., Cui, D., Weyand, C. M., & Goronzy, J. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109797109 · Cited by 102 · see citing works

Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity

Stanford, S. M., Rapini, N., & Bottini, N. (2012) · Immunology · doi:10.1111/j.1365-2567.2012.03591.x · Cited by 102 · see citing works

Neutrophil Extracellular Traps as Innate Immune Reaction against the Emerging Apicomplexan Parasite Besnoitia besnoiti

MuĂąoz-Caro, T., Hermosilla, C. R., Silva, L. M. R., Cortes, H. C. E., & Taubert, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091415 · Cited by 98 · see citing works

Aging and Neutrophils: There Is Still Much To Do

Fortin, C. F., McDonald, P. P., Lesur, O., & Fülöp, T. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0750 · Cited by 94 · see citing works

Molecular Mechanisms Involved in the Aging of the T-cell Immune Response

Moro‐García, M. A., Alonso‐Arias, R., & López‐Larrea, C. (2012) · Current Genomics · doi:10.2174/138920212803759749 · Cited by 85 · see citing works

Feedback Circuits Monitor and Adjust Basal Lck-Dependent Events in T Cell Receptor Signaling

Schoenborn, J. R., Tan, Y. X., Zhang, C., Shokat, K. M., & Weiss, A. (2011) · Science Signaling · doi:10.1126/scisignal.2001893 · Cited by 85 · see citing works

The role of the MAPK pathway alterations in GM-CSF modulated human neutrophil apoptosis with aging

Larbi, A., Douziech, N., Fortin, C. F., Linteau, A., Dupuis, G., & Fülöp, T. (2005) · Immunity & Ageing · doi:10.1186/1742-4933-2-6 · Cited by 79 · see citing works

Plasma membrane microdomains in aging and disease

Ohno‐Iwashita, Y., Shimada, Y., Hayashi, M., & Inomata, M. (2010) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/j.1447-0594.2010.00600.x · Cited by 68 · see citing works

Direct correlation of glutathione and ascorbate and their dependence on age and season in human lymphocytes

Lenton, K. J., Therriault, H., Cantin, A. M., Fülöp, T., Payette, H., & Wagner, J. R. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.5.1194 · Cited by 67 · see citing works

SHP-1 in T Cells Limits the Production of CD8 Effector Cells without Impacting the Formation of Long-Lived Central Memory Cells

Fowler, C., Pao, L. I., Blattman, J. N., & Greenberg, P. D. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001362 · Cited by 59 · see citing works

Free Radicals and Antioxidants: How to Reestablish Redox Homeostasis in Chronic Diseases?

Bocci, V. A., & Valacchi, G. (2013) · Current Medicinal Chemistry · doi:10.2174/0929867311320270005 · Cited by 53 · see citing works

Low‐Grade Inflammation with Aging Has Consequences for T‐Lymphocyte Signaling

Larbi, A., Dupuis, G., Douziech, N., Khalil, A., & Fülöp, T. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1329.016 · Cited by 50 · see citing works

Multipoint Binding of the SLP-76 SH2 Domain to ADAP Is Critical for Oligomerization of SLP-76 Signaling Complexes in Stimulated T Cells

Coussens, N. P., Hayashi, R., Brown, P. H., Balagopalan, L., Balbo, A., Akpan, I. O., Houtman, J. C. D., Barr, V. A., Schuck, P., Appella, E., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00410-13 · Cited by 49 · see citing works

The role of membrane rafts in Lck transport, regulation and signalling in T-cells

Ventimiglia, L. N., & Alonso, M. A. (2013) · Biochemical Journal · doi:10.1042/bj20130468 · Cited by 47 · see citing works

Control of Immune Responses by Trafficking Cell Surface Proteins, Vesicles and Lipid Rafts to and from the Immunological Synapse

Taner, S. B., Önfelt, B., Pirinen, N. J., McCann, F. E., Magee, A. I., & Davis, D. M. (2004) · Traffic · doi:10.1111/j.1600-0854.2004.00214.x · Cited by 44 · see citing works

Downregulation of inhibitory SRC homology 2 domain-containing phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly

Le Page, A., Fortin, C., Garneau, H., Allard, N., Tsvetkova, K., Tan, C. T. Y., Larbi, A., Dupuis, G., & Fülöp, T. (2014) · Cell Communication and Signaling · doi:10.1186/1478-811x-12-2 · Cited by 44 · see citing works

Reversal of functional defects in highly differentiated young and old CD8 T cells by PDL blockade

Henson, S. M., Macaulay, R., Franzese, O., & Akbar, A. N. (2012) · Immunology · doi:10.1111/j.1365-2567.2011.03550.x · Cited by 42 · see citing works

Free radicals and redox signalling in T-cells during chronic inflammation and ageing

Griffiths, H. R., Dunston, C. R., Bennett, S. J., Grant, M. M., Phillips, D. C., & Kitas, G. D. (2011) · Biochemical Society Transactions · doi:10.1042/bst0391273 · Cited by 42 · see citing works

T cell receptor-mediated activation is a potent inducer of macroautophagy in human CD8(+)CD28(+) T cells but not in CD8(+)CD28(-) T cells

Arnold, C. R., Pritz, T., Brunner, S., Knabb, C., Salvenmoser, W., Holzwarth, B., Thedieck, K., & Grubeck-Loebenstein, B. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.01.018 · Cited by 42 · see citing works

Age-related changes in cAMP and cGMP levels during phagocytosis in human polymorphonuclear leukocytes

Füöp, T., Fóris, G., & Leovey, A. (1984) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(84)90048-4 · Cited by 38 · see citing works

Lipid rafts in lymphocyte activation

Pizzo, P., & Viola, A. (2004) · Microbes and Infection · doi:10.1016/j.micinf.2004.02.017 · Cited by 37 · see citing works

Focal Adhesion Kinase Negatively Regulates Lck Function Downstream of the T Cell Antigen Receptor

Chapman, N. M., Connolly, S. F., Reinl, E. L., & Houtman, J. C. D. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301587 · Cited by 37 · see citing works

Reactive oxygen species regulate M-CSF-induced monocyte/macrophage proliferation through SHP1 oxidation

Choi, H. K., Kim, T. H., Jhon, G., & Lee, S. Y. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.05.017 · Cited by 34 · see citing works

Reduced oxygen tension results in reduced human T cell proliferation and increased intracellular oxidative damage and susceptibility to apoptosis upon activation

Larbi, A., Cabreiro, F., Zelba, H., Marthandan, S., Combet, E., Friguet, B., Petropoulos, I., Barnett, Y., & Pawelec, G. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.09.025 · Cited by 34 · see citing works

Aging, immunosenescence and membrane rafts: the lipid connection

Fülöp, T., Page, A. Y. L., Garneau, H., Azimi, N., Baëhl, S., Dupuis, G., Pawelec, G., & Larbi, A. (2012) · Longevity & Healthspan · doi:10.1186/2046-2395-1-6 · Cited by 34 · see citing works

APC, T Cells, and the Immune Synapse

Reichardt, P., Dornbach, B., & Gunzer, M. (2009) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-03858-7_12 · Cited by 33 · see citing works

The Immune System in the Elderly: A Fair Fight Against Diseases?

Larbi, A., Rymkiewicz, P. D., Vasudev, A., Low, I., Shadan, N. B., Mustafah, S., Ayyadhury, S., & Fülöp, T. (2013) · Aging Health · doi:10.2217/ahe.12.78 · Cited by 29 · see citing works

Vitamin E, signalosomes and gene expression in T cells

Molano, A., & Meydani, S. N. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.11.002 · Cited by 29 · see citing works

Do Membrane Rafts Contribute to Human Immunosenescence?

Tomoiu, A., Larbi, A., Fortin, C. F., Dupuis, G., & Fülöp, T. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1395.008 · Cited by 24 · see citing works

Reduced neutrophil superoxide production among healthy older adults in response to acute psychological stress

Khanfer, R., Carroll, D., Lord, J. M., & Phillips, A. C. (2012) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2012.09.013 · Cited by 20 · see citing works

Increased Mammalian Target of Rapamycin Complex 2 Signaling Promotes Age-Related Decline in CD4 T Cell Signaling and Function

Perkey, E., Fingar, D. C., Miller, R. A., & Garcia, G. G. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300750 · Cited by 19 · see citing works

Regulating naïve and memory CD8 T cell homeostasis – a role for protein tyrosine phosphatases

Pike, K. A., & Tremblay, M. L. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08587.x · Cited by 18 · see citing works

Aging of Cell Communication: Loss of Receptor Function

Robert, L., & Fülöp, T. (2014) · Interdisciplinary topics in gerontology and geriatrics · doi:10.1159/000358903 · Cited by 15 · see citing works

A specific type of membrane microdomains is involved in the maintenance and translocation of kinase active Lck to lipid rafts

Ballek, O., Broučková, A., Manning, J. E., & Filipp, D. (2012) · Immunology Letters · doi:10.1016/j.imlet.2012.01.001 · Cited by 12 · see citing works

Aging

Robert, L. (2014) · Interdisciplinary topics in gerontology and geriatrics · doi:10.1159/isbn.978-3-318-02653-5 · Cited by 10 · see citing works

Age-related changes in lck–Vav signaling pathways in mouse CD4 T cells

Garcia, G. G., & Miller, R. A. (2009) · Cellular Immunology · doi:10.1016/j.cellimm.2009.06.001 · Cited by 9 · see citing works

Attention: a key to collaboration between health providers and older adult patients

Morrow, D. G. (2013) · Aging Health · doi:10.2217/ahe.12.82 · Cited by 8 · see citing works

There is still much to do.

Shribman, S. (2010) · PubMed · Cited by 4 · see citing works

Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

Fulop, T., Larbi, A., Dupuis, G., Le Page, A., Frost, E. H., Cohen, A. A., Witkowski, J. M., & Franceschi, C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01960 · Cited by 1,364 · see citing works

Immunology of aging: the birth of inflammaging

Fulop, T., Larbi, A., Pawelec, G., Khalil, A., Cohen, A. A., Hirokawa, K., Witkowski, J. M., & Franceschi, C. (2021) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-021-08899-6 · Cited by 464 · see citing works

Aging of the immune system: Focus on inflammation and vaccination

Pinti, M., Appay, V., Campisi, J., Frasca, D., Fülöp, T., Sauce, D., Larbi, A., Weinberger, B., & Cossarizza, A. (2016) · European Journal of Immunology · doi:10.1002/eji.201546178 · Cited by 439 · see citing works

Aging and the immune system: An overview

Akha, A. A. S. (2018) · Journal of Immunological Methods · doi:10.1016/j.jim.2018.08.005 · Cited by 389 · see citing works

Successful and Maladaptive T Cell Aging

Goronzy, J. J., & Weyand, C. M. (2017) · Immunity · doi:10.1016/j.immuni.2017.03.010 · Cited by 362 · see citing works

The integration of inflammaging in age-related diseases

Fülöp, T., Witkowski, J. M., Olivieri, F., & Larbi, A. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2018.09.003 · Cited by 356 · see citing works

Mitochondrial Dysfunction in Alzheimer’s Disease and the Rationale for Bioenergetics Based Therapies

Onyango, I. G., Dennis, J., & Khan, S. M. (2016) · Aging and Disease · doi:10.14336/ad.2015.1007 · Cited by 260 · see citing works

Remodeling of the Immune Response With Aging: Immunosenescence and Its Potential Impact on COVID-19 Immune Response

Cunha, L. L., Perazzio, S. F., Azzi, J., Cravedi, P., & Riella, L. V. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01748 · Cited by 239 · see citing works

Immune System Dysfunction in the Elderly

Eduardo Fuentes, Q., FUENTES, M., Alarcón, M. A., & Palomo, I. F. (2017) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201720160487 · Cited by 234 · see citing works

Serum copper to zinc ratio: Relationship with aging and health status

Malavolta, M., Piacenza, F., Basso, A., Giacconi, R., Costarelli, L., & Mocchegiani, E. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.01.004 · Cited by 227 · see citing works

An evidence-based update on the pharmacological activities and possible molecular targets of Lycium barbarum polysaccharides

Zhou, S.-F., Jiang, C., Zhou, Z.-W., Hu, S., He, L., Xue-wen, F., He, Z., Sun, T., Zhang, X., Gu, L., et al. (2014) · Drug Design Development and Therapy · doi:10.2147/dddt.s72892 · Cited by 214 · see citing works

Plasma levels of danger-associated molecular patterns are associated with immune suppression in trauma patients

Timmermans, K., Kox, M., Vaneker, M., van den Berg, M. P., John, A. T., van Laarhoven, A., van der Hoeven, H., Scheffer, G. J., & Pickkers, P. (2016) · Intensive Care Medicine · doi:10.1007/s00134-015-4205-3 · Cited by 184 · see citing works

Zinc deficiency enhanced inflammatory response by increasing immune cell activation and inducing IL6 promoter demethylation

Wong, C. P., Rinaldi, N. A., & Ho, E. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400761 · Cited by 174 · see citing works

Novel findings in neutrophil biology and their impact on cardiovascular disease

Bonaventura, A., Montecucco, F., Dallegri, F., Carbone, F., Lüscher, T. F., Camici, G. G., & Liberale, L. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz084 · Cited by 173 · see citing works

From inflamm-aging to immune-paralysis: a slippery slope during aging for immune-adaptation

Fülöp, T., Dupuis, G., Baëhl, S., Page, A. Y. L., Bourgade, K., Frost, E. H., Witkowski, J. M., Pawelec, G., Larbi, A., & Cunnane, S. C. (2015) · Biogerontology · doi:10.1007/s10522-015-9615-7 · Cited by 161 · see citing works

Modeling Influenza Virus Infection: A Roadmap for Influenza Research

Boianelli, A., Nguyễn, V. K., Ebensen, T., Schulze, K., Wilk, E., Sharma, N., Stegemann‐Koniszewski, S., Bruder, D., Toapanta, F. R., Guzmán, C. A., et al. (2015) · Viruses · doi:10.3390/v7102875 · Cited by 152 · see citing works

Probiotic strain Bacillus subtilis CU1 stimulates immune system of elderly during common infectious disease period: a randomized, double-blind placebo-controlled study

Lefevre, M., Racedo, S. M., Ripert, G., Housez, B., Cazaubiel, M., Maudet, C., Jüsten, P., Marteau, P., & Urdaci, M. C. (2015) · Immunity & Ageing · doi:10.1186/s12979-015-0051-y · Cited by 147 · see citing works

Postoperative cognitive dysfunction in the aged: the collision of neuroinflammaging with perioperative neuroinflammation

Luo, A., Yan, J., Tang, X., Zhao, Y., Zhou, B., & Li, S. (2019) · Inflammopharmacology · doi:10.1007/s10787-018-00559-0 · Cited by 144 · see citing works

Dysbiosis, malnutrition and enhanced gut-lung axis contribute to age-related respiratory diseases

Saint‐Criq, V., Lugo‐Villarino, G., & Thomas, M. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101235 · Cited by 143 · see citing works

Characterization of age‐associated exhausted <scp>CD</scp>8⁺ T cells defined by increased expression of Tim‐3 and <scp>PD</scp>‐1

Lee, K., Shin, K., Kim, G., Song, Y. C., Bae, E., Kim, I., Koh, C., & Kang, C. (2016) · Aging Cell · doi:10.1111/acel.12435 · Cited by 125 · see citing works

The Impact of Immunosenescence on Pulmonary Disease

Murray, M., & Chotirmall, S. H. (2015) · Mediators of Inflammation · doi:10.1155/2015/692546 · Cited by 124 · see citing works

From lymphopoiesis to plasma cells differentiation, the age-related modifications of B cell compartment are influenced by “inflamm-ageing”

Bulati, M., Caruso, C., & Colonna‐Romano, G. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.04.001 · Cited by 113 · see citing works

Immunotherapy and radiotherapy in melanoma: a multidisciplinary comprehensive review

Tagliaferri, L., Lancellotta, V., Fionda, B., Mangoni, M., Casà, C., Stefani, A. D., Pagliara, M. M., D’Aviero, A., Schinzari, G., Chiesa, S., et al. (2021) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2021.1903827 · Cited by 111 · see citing works

Immunosenescence is both functional/adaptive and dysfunctional/maladaptive

Fülöp, T., Larbi, A., Hirokawa, K., Cohen, A. A., & Witkowski, J. M. (2020) · Seminars in Immunopathology · doi:10.1007/s00281-020-00818-9 · Cited by 106 · see citing works

Sex differences in ischaemic stroke: potential cellular mechanisms

Chauhan, A., Moser, H., & McCullough, L. D. (2017) · Clinical Science · doi:10.1042/cs20160841 · Cited by 105 · see citing works

Immunotherapy in Older Adults With Advanced Cancers: Implications for Clinical Decision-Making and Future Research

Kanesvaran, R., Córdoba, R., & Maggiore, R. J. (2018) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_201435 · Cited by 91 · see citing works

Host Resistance and Immune Aging

Bandaranayake, T., & Shaw, A. C. (2016) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2016.02.007 · Cited by 85 · see citing works

Possible correlation between gut microbiota and immunity among healthy middle-aged and elderly people in southwest China

Shen, X. P., Miao, J., Wan, Q., Wang, S., Li, M., Pu, F., Wang, G., Qian, W. P., Yu, Q., Marotta, F., et al. (2018) · Gut Pathogens · doi:10.1186/s13099-018-0231-3 · Cited by 79 · see citing works

Safe and Effective Antioxidant: The Biological Mechanism and Potential Pathways of Ergothioneine in the Skin

Liu, H., Tang, W., Wang, X., Jiang, J., Zhang, W., & Wang, W. (2023) · Molecules · doi:10.3390/molecules28041648 · Cited by 79 · see citing works

Splenectomy protects aged mice from injury after experimental stroke

Chauhan, A., Mamun, A. A., Spiegel, G., Harris, N., Zhu, L., & McCullough, L. D. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.09.022 · Cited by 79 · see citing works

Ageing of the B-cell repertoire

Martin, V., Wu, Y.-C. B., Kipling, D., & Dunn‐Walters, D. K. (2015) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2014.0237 · Cited by 74 · see citing works

Biomarkers related to immunosenescence: relationships with therapy and survival in lung cancer patients

Saavedra, D., Verdecia, B. G., Lorenzo-Luaces, P., González, A., Popa, X., Fuentes, K. P., Mazorra, Z., Crombet, T., Neninger, E., & Lage, A. (2015) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-015-1773-6 · Cited by 71 · see citing works

Immunosenescence and COVID-19

Witkowski, J. M., Fülöp, T., & Bryl, E. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111672 · Cited by 71 · see citing works

The Neutrophil to Lymphocyte Ratio on Admission and Short-Term Outcomes in Orthogeriatric Patients

Fisher, A., Srikusalanukul, W., Fisher, L., & Smith, P. N. (2016) · International Journal of Medical Sciences · doi:10.7150/ijms.15445 · Cited by 68 · see citing works

Signal transduction changes in CD4 + and CD8 + T cell subpopulations with aging

Page, A. Y. L., Dupuis, G., Larbi, A., Witkowski, J. M., & Fülöp, T. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.01.005 · Cited by 65 · see citing works

Faster cytotoxicity with age: Increased perforin and granzyme levels in cytotoxic CD8 + T cells boost cancer cell elimination

Zöphel, D., Angenendt, A., Kaschek, L., Ravichandran, K., Hof, C., Janku, S., Hoth, M., & Lis, A. (2022) · Aging Cell · doi:10.1111/acel.13668 · Cited by 64 · see citing works

Inflammatory Endotypes and Microbial Associations in Chronic Rhinosinusitis

Hoggard, M., Waldvogel‐Thurlow, S., Zoing, M., Chang, K., Radcliff, F. J., Mackenzie, B. W., Biswas, K., Douglas, R. G., & Taylor, M. W. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02065 · Cited by 63 · see citing works

Aging and chronic kidney disease: epidemiology, therapy, management and the role of immunity

Tang, Y., Jiang, J., Zhao, Y., & Du, D. (2024) · Clinical Kidney Journal · doi:10.1093/ckj/sfae235 · Cited by 65 · see citing works

Natural Compounds and Aging: Between Autophagy and Inflammasome

Chuang, S.-Y., Lin, C.-H., & Fang, J. (2014) · BioMed Research International · doi:10.1155/2014/297293 · Cited by 57 · see citing works

Immunosenescence and Altered Vaccine Efficiency in Older Subjects: A Myth Difficult to Change

Fülöp, T., Larbi, A., Pawelec, G., Cohen, A. A., Provost, G., Khalil, A., Lacombe, G., Rodrigues, S., Desroches, M., Hirokawa, K., et al. (2022) · Vaccines · doi:10.3390/vaccines10040607 · Cited by 56 · see citing works

Circulating markers of ageing and allostatic load: A slow train coming

Shiels, P., Stenvinkel, P., Kooman, J., & McGuinness, D. (2016) · Practical Laboratory Medicine · doi:10.1016/j.plabm.2016.04.002 · Cited by 55 · see citing works

Intracellular signalling pathways: targets to reverse immunosenescence

Fülöp, T., Witkowski, J. M., Page, A. Y. L., Fortin, C. F., Pawelec, G., & Larbi, A. (2016) · Clinical & Experimental Immunology · doi:10.1111/cei.12836 · Cited by 53 · see citing works

Accelerated Vascular Aging as a Paradigm for Hypertensive Vascular Disease: Prevention and Therapy

Barton, M., Husmann, M. J. W., & Meyer, M. R. (2016) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2016.02.062 · Cited by 51 · see citing works

Aging-Associated Extracellular Vesicles Contain Immune Regulatory microRNAs Alleviating Hyperinflammatory State and Immune Dysfunction in the Elderly

Tsukamoto, H., Kouwaki, T., & Oshiumi, H. (2020) · iScience · doi:10.1016/j.isci.2020.101520 · Cited by 52 · see citing works

Aging hampers neutrophil extracellular traps (NETs) efficacy

Sabbatini, M., Bona, E., Novello, G., Migliario, M., & Renò, F. (2022) · Aging Clinical and Experimental Research · doi:10.1007/s40520-022-02201-0 · Cited by 51 · see citing works

Effects of exogenous vitamins A, C, and E and NADH supplementation on proliferation, cytokines release, and cell redox status of lymphocytes from healthy aged subjects

Bouamama, S., Merzouk, H., Medjdoub, A., Merzouk, A. S., & Merzouk, S. A. (2017) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0201 · Cited by 48 · see citing works

Immunomodulatory role of high-density lipoproteins: impact on immunosenescence

Larbi, A., Fortin, C. F., Dupuis, G., Berrougui, H., Khalil, A., & Fülöp, T. (2014) · AGE · doi:10.1007/s11357-014-9712-6 · Cited by 44 · see citing works

Polymorphonuclear Neutrophil Functions are Differentially Altered in Amnestic Mild Cognitive Impairment and Mild Alzheimer’s Disease Patients

Page, A. Y. L., Lamoureux, J., Bourgade, K., Frost, E. H., Pawelec, G., Witkowski, J. M., Larbi, A., Dupuis, G., & Fülöp, T. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170124 · Cited by 42 · see citing works

Functionally Diverse NK-Like T Cells Are Effectors and Predictors of Successful Aging

Michel, J. J., Griffin, P. C., & Vallejo, A. N. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00530 · Cited by 41 · see citing works

Altered neutrophil functions in elderly patients during a 6-month follow-up period after a hip fracture

Baëhl, S., Garneau, H., Page, A. Y. L., Lorrain, D., Viens, I., Svotelis, A., Lord, J. M., Phillips, A. C., Cabana, F., Larbi, A., et al. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.03.009 · Cited by 39 · see citing works

Systemic sclerosis-associated fibrosis

Luckhardt, T., & Thannickal, V. J. (2015) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000219 · Cited by 39 · see citing works

Targeting neutrophils: Mechanism and advances in cancer therapy

Yang, S., Jia, J., Wang, F., Wang, Y., Fang, Y., Yang, Y., Zhou, Q., Yuan, W., & Bian, Z. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1599 · Cited by 36 · see citing works

Cellular Senescence, Immunosenescence and HIV

Fülöp, T., Herbein, G., Cossarizza, A., Witkowski, J. M., Frost, E. H., Dupuis, G., Pawelec, G., & Larbi, A. (2016) · Interdisciplinary topics in gerontology and geriatrics · doi:10.1159/000448542 · Cited by 36 · see citing works

The equine immune responses to infectious and allergic disease: A model for humans?

Horohov, D. W. (2014) · Molecular Immunology · doi:10.1016/j.molimm.2014.09.020 · Cited by 37 · see citing works

The Aging of γδ T Cells

Xu, W., Lau, Z. W. X., Fülöp, T., & Larbi, A. (2020) · Cells · doi:10.3390/cells9051181 · Cited by 35 · see citing works

The Biology of Aging and Lymphoma: a Complex Interplay

Sarkozy, C., Salles, G. A., & Falandry, C. (2015) · Current Oncology Reports · doi:10.1007/s11912-015-0457-x · Cited by 36 · see citing works

Modelling T cell proliferation: Dynamics heterogeneity depending on cell differentiation, age, and genetic background

Vibert, J., & Thomas‐Vaslin, V. (2017) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005417 · Cited by 31 · see citing works

Aging and the microbiome: implications for asthma in the elderly?

Chotirmall, S. H., & Burke, C. M. (2015) · Expert Review of Respiratory Medicine · doi:10.1586/17476348.2015.1002473 · Cited by 31 · see citing works

Differential Action between Schisandrin A and Schisandrin B in Eliciting an Anti-Inflammatory Action: The Depletion of Reduced Glutathione and the Induction of an Antioxidant Response

Leong, P. K., Wong, H. S., Chen, J., Chan, W. M., Leung, H. Y., & Ko, K. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0155879 · Cited by 28 · see citing works

Targeting Impaired Antimicrobial Immunity in the Brain for the Treatment of Alzheimer’s Disease

Fülöp, T., Tripathi, S., Rodrigues, S., Desroches, M., Bunt, T., Eiser, A. R., Bernier, F., Beauregard, P. B., Barron, A. E., Khalil, A., et al. (2021) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s264910 · Cited by 27 · see citing works

The p38 mitogen‐activated protein kinase cascade modulates T helper type 17 differentiation and functionality in multiple sclerosis

Mitri, D. D., Sambucci, M., Loiarro, M., Bardi, M. D., Volpe, E., Cencioni, M. T., Gasperini, C., Centonze, D., Sette, C., Akbar, A. N., et al. (2015) · Immunology · doi:10.1111/imm.12497 · Cited by 27 · see citing works

Durvalumab for the management of urothelial carcinoma: a short review on the emerging data and therapeutic potential

Baldini, C., Champiat, S., Vuagnat, P., & Massard, C. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s141040 · Cited by 25 · see citing works

IL-10 deficiency aggravates cell senescence and accelerates BLM-induced pulmonary fibrosis in aged mice via PTEN/AKT/ERK pathway

Li, Y., Yin, H., Yuan, H., Wang, E., Wang, C., Li, H., Geng, X., Zhang, Y., & Bai, J. (2024) · BMC Pulmonary Medicine · doi:10.1186/s12890-024-03260-x · Cited by 24 · see citing works

The anti-inflammatory effects of resveratrol on human peripheral blood mononuclear cells are influenced by a superoxide dismutase 2 gene polymorphism

Capeleto, D., Barbisan, F., Azzolin, V. F., Dornelles, E. B., Rogalski, F., Teixeira, C. F., Machado, A. K., Cadoná, F. C., da Silva, T., Duarte, T., et al. (2015) · Biogerontology · doi:10.1007/s10522-015-9561-4 · Cited by 22 · see citing works

Proteodynamics in aging human T cells – The need for its comprehensive study to understand the fine regulation of T lymphocyte functions

Witkowski, J. M., Mikosik, A., Bryl, E., & Fülöp, T. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.10.009 · Cited by 22 · see citing works

The immune-nutrition interplay in aging – facts and controversies

Alam, I., Almajwal, A. M., Alam, W., Alam, I., Ullah, N., Abulmeaaty, M., Razak, S., Khan, S., Pawelec, G., & Paracha, P. I. (2019) · Nutrition and Healthy Aging · doi:10.3233/nha-170034 · Cited by 22 · see citing works

Effect of aging on the transcriptomic changes associated with the expression of the HERV-K (HML-2) provirus at 1q22

Autio, A., Nevalainen, T., Mishra, B. H., Jylhä, M. K., Flinck, H., & Hurme, M. (2020) · Immunity & Ageing · doi:10.1186/s12979-020-00182-0 · Cited by 22 · see citing works

From Senescent Cells to Systemic Inflammation: The Role of Inflammaging in Age-Related Diseases and Kidney Dysfunction

Luca, F. D., Camporeale, V., Leccese, G., Cuttano, R., Troise, D. E., Infante, B., Stallone, G., Netti, G. S., & Ranieri, E. (2025) · Cells · doi:10.3390/cells14221831 · Cited by 21 · see citing works

Aging-induced fragility of the immune system

Jones, E. W., Sheng, J., Carlson, J. M., & Wang, S. (2020) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2020.110473 · Cited by 21 · see citing works

Prolonged Fasting/Refeeding Promotes Hematopoietic Stem Cell Regeneration and Rejuvenation

Mendelsohn, A. R., & Larrick, J. W. (2014) · Rejuvenation Research · doi:10.1089/rej.2014.1595 · Cited by 19 · see citing works

Exploring the Interplay between Cellular Senescence, Immunity, and Fibrosing Interstitial Lung Diseases: Challenges and Opportunities

Hernández‐González, F., Pietrocola, F., Cameli, P., Bargagli, E., Prieto‐González, S., Cruz, T., Mendoza, N., Rojas, M. M., Serrano, M., Agustí, A. G. N., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147554 · Cited by 18 · see citing works

Late Passage Cultivation Induces Aged Astrocyte Phenotypes in Rat Primary Cultured Cells

Bang, M., Gonzales, E. L., Shin, C. Y., & Kwon, K. J. (2021) · Biomolecules &amp; Therapeutics · doi:10.4062/biomolther.2020.175 · Cited by 19 · see citing works

The dual role of the immune system in the course of COVID-19. The fatal impact of the aging immune system

Marcinkiewicz, J., Witkowski, J. M., & Olszanecki, R. (2021) · Central European Journal of Immunology · doi:10.5114/ceji.2021.105240 · Cited by 18 · see citing works

Rhodomeroterpene alleviates macrophage infiltration and the inflammatory response in renal tissue to improve acute kidney injury

Wu, Y., Shi, Q., Zhu, P., Ma, H., Cui, S., Li, J., Hou, A., & Li, J. (2021) · The FASEB Journal · doi:10.1096/fj.202100981rr · Cited by 18 · see citing works

Immune system aging and the aging-related diseases in the COVID-19 era

Witkowski, J. M. (2022) · Immunology Letters · doi:10.1016/j.imlet.2022.01.005 · Cited by 19 · see citing works

Alterations in Monocyte Phenotypes and Functions after a Hip Fracture in Elderly Individuals: A 6-Month Longitudinal Study

Baëhl, S., Garneau, H., Lorrain, D., Viens, I., Svotelis, A., Lord, J. M., Cabana, F., Larbi, A., Dupuis, G., & Fülöp, T. (2016) · Gerontology · doi:10.1159/000443142 · Cited by 17 · see citing works

Age has a role in driving host immunopathological response to alphavirus infection

Chan, Y., & Ng, L. F. P. (2017) · Immunology · doi:10.1111/imm.12799 · Cited by 17 · see citing works

Mechanisms of Disease and Immunity

Mealey, R. H., & Long, M. T. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-44329-6.00001-2 · Cited by 16 · see citing works

Alterations in metabolic pathways: a bridge between aging and weaker innate immune response

Saleh, Z., Mirzazadeh, S., Mirzaei, F., Heidarnejad, K., Meri, S., & Kalantar, K. (2024) · Frontiers in Aging · doi:10.3389/fragi.2024.1358330 · Cited by 16 · see citing works

The immune response and aging in chronic inflammatory demyelinating polyradiculoneuropathy

Hagen, K. M., & Ousman, S. S. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02113-2 · Cited by 16 · see citing works

Neoadjuvant chemotherapy modulates exhaustion of T cells in breast cancer patients

Rodríguez, I. J., Bernal-Estévez, D. A., Llano-León, M., Bonilla, C., & Parra-López, C. (2023) · PLoS ONE · doi:10.1371/journal.pone.0280851 · Cited by 16 · see citing works

Immune Checkpoint Inhibitors: The Unexplored Landscape of Geriatric Oncology

Choucair, K., Naqash, A. R., Nebhan, C. A., Nipp, R. D., Johnson, D. B., & Saeed, A. (2022) · The Oncologist · doi:10.1093/oncolo/oyac119 · Cited by 15 · see citing works

Immunosenescence and hurdles in the clinical management of older HIV-patients

Ripa, M., Chiappetta, S., & Tambussi, G. (2017) · Virulence · doi:10.1080/21505594.2017.1292197 · Cited by 16 · see citing works

‘Molecular habituation’ as a potential mechanism of gradual homeostatic loss with age

Guimera, A. M., Welsh, C., Proctor, C. J., McArdle, A., & Shanley, D. P. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.11.010 · Cited by 15 · see citing works

From Clinical Trials to Clinical Use of Checkpoint Inhibitors for Patients With Metastatic Urothelial Cancer

Tambaro, R., Napoli, M. D., Pisano, C., Cecere, S. C., Attademo, L., Rossetti, S., Feroce, F., Setola, S. V., Califano, D., Russo, D., et al. (2020) · Immunotherapy · doi:10.2217/imt-2020-0128 · Cited by 14 · see citing works

Proteodynamics and aging of eukaryotic cells

Witkowski, J. M., Bryl, E., & Fülöp, T. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111430 · Cited by 14 · see citing works

Association between Neutrophil Levels on Admission and All‐Cause Mortality in Geriatric Patients with Hip Fractures: A Prospective Cohort Study of 2,589 Patients

Liu, R., Zhang, Y.-N., Fei, X.-J., Wang, J.-Y., Hua, R.-L., Tong, Y.-N., Li, K., Cao, W.-W., Chen, S., Zhang, B.-F., et al. (2022) · International Journal of Clinical Practice · doi:10.1155/2022/1174521 · Cited by 14 · see citing works

Noni ( Morinda citrifolia L.) fruit juice reverses age-related decline in neural-immune interactions in the spleens of old F344 rats

Pratap, U. P., Hima, L., Priyanka, H. P., & ThyagaRajan, S. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.01.034 · Cited by 12 · see citing works

Characterization of Age-Associated, Neutrophil-to-Lymphocyte Ratio (NLR) and Systemic Immune-Inflammatory Index (SII) as Biomarkers of Inflammation in Geriatric Patients with Cancer Treated with Immune Checkpoint Inhibitors: Impact on Efficacy and Survival

Choucair, K., Nebhan, C. A., Cortellini, A., Hentzen, S., Wang, Y., Liu, C., Giusti, R., Filetti, M., Ascierto, P. A., Vanella, V., et al. (2023) · Cancers · doi:10.3390/cancers15205052 · Cited by 11 · see citing works

Colonic Aging and Colorectal Cancer: An Unignorable Interplay and Its Translational Implications

Yin, Q., Qin, F.-C., Gan, F., Zhao, G., Chen, R., Wen, Y., Hua, X., Zeng, F.-G., Zhang, Y.-Z., Xiao, Y.-L., et al. (2025) · Biology · doi:10.3390/biology14070805 · Cited by 16 · see citing works

Innovative approach to older patients with malignant hemopathies

Bron, D., Soubeyran, P., Fülöp, T., & EHA, O. B. O. T. S. ". A. H. O. T. (2016) · Haematologica · doi:10.3324/haematol.2016.142810 · Cited by 10 · see citing works

Immune checkpoint inhibitor toxicity and associated outcomes in older patients with cancer

Hayashi‐Tanner, Y., Polewski, P. J., Gaddam, M., Fisher, N. R., Kovacs, A. J., & Marinier, D. E. (2022) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2022.05.007 · Cited by 9 · see citing works

Regenerative Medicine

Marongiu, F., Serra, M. P., Fanti, M., Cadoni, E., Serra, M., & Laconi, E. (2017) · Cell Transplantation · doi:10.1177/0963689717721224 · Cited by 7 · see citing works

Emerging ST121/ agr 4 community-associated methicillin-resistant Staphylococcus aureus (MRSA) with strong adhesin and cytolytic activities: trigger for MRSA pneumonia and fatal aspiration pneumonia in an influenza-infected elderly

Wan, T., Tomita, Y., Saita, N., Konno, K., Iwao, Y., Hung, W., Teng, L., & Yamamoto, T. (2016) · New Microbes and New Infections · doi:10.1016/j.nmni.2016.05.011 · Cited by 7 · see citing works

An Investigation Into the Prognostic Significance of High Proteasome PSB7 Protein Expression in Colorectal Cancer

Yoon, J., Wang, J. Y., & Roehrl, M. H. A. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00401 · Cited by 7 · see citing works

Immunostimulatory effects of RACK1 pseudosubstrate in human leukocytes obtained from young and old donors

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Investigating population-level immunosenescence: From bench to bedside

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