Gastrointestinal-specific anxiety: an important factor for severity of GI symptoms and quality of life in IBS: GI-specific anxiety in IBS

Jerndal, P.; Ringström, G.; Agerforz, P.; Karpefors, M.; Akkermans, L. M.; Bayati, A.; Simrén, M.

doi:10.1111/j.1365-2982.2010.01493.x

Cited by 192Gastrointestinal motility and disordersPsychosomatic Disorders and Their TreatmentsAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Gastrointestinal-specific anxiety: an important factor for severity of GI symptoms and quality of life in IBS: GI-specific anxiety in IBS

Jerndal, P., Ringström, G., Agerforz, P., Karpefors, M., Akkermans, L. M., Bayati, A., Simrén, M.·2010·Neurogastroenterology & Motility

DOI 10.1111/j.1365-2982.2010.01493.x

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Abstract

BACKGROUND: Gastrointestinal (GI)-specific anxiety (GSA) has been proposed to influence symptom severity and quality of life (QOL) in patients with irritable bowel syndrome (IBS). The Visceral Sensitivity Index (VSI) is a recently developed, reliable and valid measure of GSA. Our aim was to evaluate the association between GSA, GI symptom severity, and QOL in IBS patients. METHODS: Sixty healthy subjects and 306 patients fulfilling the Rome II criteria for IBS were studied. Demographic and disease-related factors were assessed. Patients completed VSI and GI Symptom Rating Scale (GSRS) and questionnaires to determine psychological symptom severity (Hospital Anxiety and Depression Scale), QOL (Short form 36), and presence of functional GI disorders (Rome II Modular Questionnaire). KEY RESULTS: Compared with healthy subjects, patients with IBS had more severe GSA (34.7 +/- 16.9 vs. 2.2 +/- 4.4 [mean +/- standard deviation]; P < 0.0001). In the IBS group, more severe GSA was seen in patients with more severe GI symptoms (P < 0.0001), general anxiety (P < 0.0001) and depression (P < 0.0001), and with lower socioeconomic status (P < 0.05). In a regression analysis, GSA was the strongest predictor for GI symptom severity (GSRS total score), followed by number of Rome II diagnoses, presence of meal-related IBS symptoms, and gender (R(2) = 0.34). Gastrointestinal-specific anxiety was also, together with general anxiety, depression, socioeconomic status, and gender, found to be independently associated with mental QOL (R(2) = 0.62). CONCLUSIONS & INFERENCES: Gastrointestinal-specific anxiety seems to be an important factor for GI symptom severity and QOL in patients with IBS.

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GSA is a key feature in IBS symptom maintenance, and higher GSA is related to higher symptom severity and lower quality of life.
“GSA is a key feature in IBS symptom maintenance, by acting as an endogenous stressor, and higher levels of GSA have consistently been shown to be related to higher symptom severity and lower quality of life (Jerndal et al., 2010;Labus et al., 2004Labus et al., , 2007)).”
From Pilot study of acceptance and commitment therapy for irritable bowel syndrome: A preliminary analysis of treatment outcomes and processes of change. (2018) · cites this paper as Jerndal et al., 2010
Several studies have confirmed the impact of symptom-related fear and avoidance behaviors on symptom severity and quality of life in IBS.
“Several studies have confirmed the impact of symptom-related fear and avoidance behaviors on symptom severity and quality of life in IBS [24,27-30].”
From Acceptability, effectiveness, and cost-effectiveness of internet-based exposure treatment for irritable bowel syndrome in a clinical sample: A randomized controlled trial (2011) · cites this paper as [29]

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Öhman, L., Stridsberg, M., Isaksson, S., Jerlstad, P., & Simrén, M. (2012) · The American Journal of Gastroenterology · doi:10.1038/ajg.2011.458 · Cited by 74 · see citing works
Self-citation
Relations between symptom severity, illness perceptions, visceral sensitivity, coping strategies and well-being in irritable bowel syndrome guided by the common sense model of illness
Knowles, S. R., Austin, D., Sivanesan, S., Tye–Din, J. A., Leung, C., Wilson, J., Castle, D. J., Kamm, M. A., Macrae, F., & Hebbard, G. S. (2016) · Psychology Health & Medicine · doi:10.1080/13548506.2016.1168932 · Cited by 71 · see citing works
New insights into irritable bowel syndrome: from pathophysiology to treatment
Hadjivasilis, A. (2019) · Annals of Gastroenterology · doi:10.20524/aog.2019.0428 · Cited by 71 · see citing works
Markers for visceral hypersensitivity in patients with irritable bowel syndrome
Ludidi, S., Mujagic, Z., Jonkers, D. M. A. E., Keszthelyi, D., Hesselink, M., Kruimel, J. W., Conchillo, J. M., & Masclee, A. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12365 · Cited by 66 · see citing works
Impact of Psychological Comorbidity on the Prognosis of Irritable Bowel Syndrome
Goodoory, V. C., Mikocka‐Walus, A. A., Yiannakou, Y., Houghton, L. A., Black, C. J., & Ford, A. C. (2021) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000001247 · Cited by 66 · see citing works
Systematic review: instruments to assess abdominal pain in irritable bowel syndrome
Mujagic, Z., Keszthelyi, D., Aziz, Q., Reinisch, W., Quetglas, E. G., Leonardis, F. D., Segerdahl, M., & Masclee, A. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13378 · Cited by 64 · see citing works
A Theoretical Model of Financial Burden After Cancer Diagnosis
Jones, S. M. W., Henrikson, N. B., Panattoni, L. E., Syrjala, K. L., & Shankaran, V. (2020) · Future Oncology · doi:10.2217/fon-2020-0547 · Cited by 65 · see citing works
Quality of life in irritable bowel syndrome: Exploring mediating factors through structural equation modelling
Trindade, I. A., Melchior, C., Törnblom, H., & Simrén, M. (2022) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2022.110809 · Cited by 65 · see citing works
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Psychosocial Stress in Nurses With Shift Work Schedule Is Associated With Functional Gastrointestinal Disorders
Koh, S., Kim, M., Oh, D. Y., Kim, B. G., Lee, K. L., & Kim, J. W. (2014) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm14034 · Cited by 60 · see citing works
Further Validation of the Visual Analogue Scale for Irritable Bowel Syndrome After Use in Clinical Practice
Bengtsson, M., Persson, J., Sjölund, K., & Ohlsson, B. (2013) · Gastroenterology Nursing · doi:10.1097/sga.0b013e3182945881 · Cited by 59 · see citing works
A rapid, simple questionnaire to assess gastrointestinal symptoms after oral ferrous sulphate supplementation
Pereira, D. I. A., Irving, S. C., Lomer, M. C. E., & Powell, J. J. (2014) · BMC Gastroenterology · doi:10.1186/1471-230x-14-103 · Cited by 61 · see citing works
Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner
Chen, C., Lü, M., Pan, Q., Fichna, J., Zheng, L., Wang, K., Yu, Z., Li, Y., Li, K., Song, A., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145556 · Cited by 58 · see citing works
Cumulative Effect of Psychological Alterations on Gastrointestinal Symptom Severity in Irritable Bowel Syndrome
Midenfjord, I., Borg, A., Törnblom, H., & Simrén, M. (2020) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000001038 · Cited by 57 · see citing works
Self-citation
Age-related symptom and life quality changes in women with irritable bowel syndrome
Tang, Y. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i48.7175 · Cited by 56 · see citing works
AGA Clinical Practice Update on Management of Chronic Gastrointestinal Pain in Disorders of Gut–Brain Interaction: Expert Review
Keefer, L., Ko, C. W., & Ford, A. C. (2021) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2021.07.006 · Cited by 55 · see citing works
Alexithymia in Gastroenterology and Hepatology: A Systematic Review
Carrozzino, D., & Porcelli, P. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.00470 · Cited by 54 · see citing works
Anxiety is associated with impaired tolerance of colonoscopy preparation in inflammatory bowel disease and controls
Bessissow, T., Van Keerberghen, C.-A., Van Oudenhove, L., Ferrante, M., Vermeire, S., Rutgeerts, P., & Van Assche, G. (2013) · Journal of Crohn's and Colitis · doi:10.1016/j.crohns.2013.04.011 · Cited by 53 · see citing works
Genes, emotions and gut microbiota: The next frontier for the gastroenterologist
Panduro, A., Rivera‐Íñiguez, I., Sepúlveda-Villegas, M., & Román, S. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i17.3030 · Cited by 53 · see citing works
Internet-Delivered Exposure-Based Cognitive-Behavioral Therapy for Adolescents With Functional Abdominal Pain or Functional Dyspepsia: A Feasibility Study
Bonnert, M., Olén, O., Lalouni, M., Hedman‐Lagerlöf, E., Särnholm, J., Serlachius, E., & Ljótsson, B. (2018) · Behavior Therapy · doi:10.1016/j.beth.2018.05.002 · Cited by 53 · see citing works
Gastrointestinal specific anxiety in irritable bowel syndrome: validation of the Japanese version of the visceral sensitivity index for university students
Saigo, T., Tayama, J., Hamaguchi, T., Nakaya, N., Tomiie, T., Bernick, P. J., Kanazawa, M., Labus, J. S., Naliboff, B. D., Shirabe, S., et al. (2014) · BioPsychoSocial Medicine · doi:10.1186/1751-0759-8-10 · Cited by 50 · see citing works
Anxiety‐related factors associated with symptom severity in irritable bowel syndrome
Black, C. J., Yiannakou, Y., Houghton, L. A., Shuweihdi, F., West, R., Guthrie, E., & Ford, A. C. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.13872 · Cited by 48 · see citing works
Symptom pattern following a meal challenge test in patients with irritable bowel syndrome and healthy controls
Posserud, I., Strid, H., Störsrud, S., Törnblom, H., Svensson, U., Tack, J. F., Oudenhove, L. V., & Simrén, M. (2013) · United European Gastroenterology Journal · doi:10.1177/2050640613501817 · Cited by 48 · see citing works
Self-citation
Anxiety, depression and distress among irritable bowel syndrome and their subtypes: An epidemiological population based study
Roohafza, H., Bidaki, E. Z., Keshteli, A. H., Daghaghzade, H., Afshar, H., & Adibi, P. (2016) · Advanced Biomedical Research · doi:10.4103/2277-9175.190938 · Cited by 48 · see citing works
Fear of GI Symptoms has an Important Impact on Quality of Life in Patients With Moderate-to-Severe IBS
Lackner, J., Gudleski, G., Ma, C.-X., Dewanwala, A., & Naliboff, B. (2014) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.241 · Cited by 41 · see citing works
Predictors of Health-related Quality of Life in Irritable Bowel Syndrome Patients Compared With Healthy Individuals
Addante, R. A., Naliboff, B. D., Shih, W., Presson, A. P., Tillisch, K., Mayer, E. A., & Chang, L. (2018) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000978 · Cited by 47 · see citing works
Perception of lactose intolerance in irritable bowel syndrome patients
Dainese, R., Casellas, F., Mariné–Barjoan, E., Vivinus-Nébot, M., Schneider, S. M., Hébuterne, X., & Piche, T. (2014) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000000089 · Cited by 46 · see citing works
Psychological factors selectively upregulate rectal pain perception in hypersensitive patients with irritable bowel syndrome
Grinsvall, C., Törnblom, H., Tack, J. F., Oudenhove, L. V., & Simrén, M. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12689 · Cited by 46 · see citing works
Self-citation
A cross-sectional study of irritable bowel syndrome in nurses in China: prevalence and associated psychological and lifestyle factors
Liu, L., Xiao, Q., Zhang, Y., & Yao, S. (2014) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1300159 · Cited by 45 · see citing works
Pilot study of acceptance and commitment therapy for irritable bowel syndrome: A preliminary analysis of treatment outcomes and processes of change.
Ferreira, N. B., Gillanders, D., Morris, P. G., & Eugenicos, M. (2018) · Clinical Psychologist · doi:10.1111/cp.12123 · Cited by 44 · see citing works
Evaluation of health related quality of life in irritable bowel syndrome patients
Jamali, R., Jamali, A., Poorrahnama, M., Omidi, A., Jamali, B., Moslemi, N., Ansari, R., Dolatshahi, S., & Daryani, N. E. (2012) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-10-12 · Cited by 44 · see citing works
Examining the mediational role of psychological flexibility, pain catastrophizing, and visceral sensitivity in the relationship between psychological distress, irritable bowel symptom frequency, and quality of life
Cassar, G. E., Knowles, S., Youssef, G. J., Moulding, R., Uiterwijk, D., Waters, L., & Austin, D. W. (2018) · Psychology, Health & Medicine · doi:10.1080/13548506.2018.1476722 · Cited by 40 · see citing works
“Consistent with past research, we found that increased symptom frequency was associated with increased visceral sensitivity, distress, and pain catastrophization, as well as poorer QoL (Jerndal et al., 2010; Knowles et al., 2016; Labus et al., 2007; Lackner et al., 2014; Saigo et al., 2014).”
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Alexithymia and gastrointestinal-specific anxiety in moderate to severe irritable bowel syndrome
Porcelli, P., Carne, M. D., & Leandro, G. (2014) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2014.05.022 · Cited by 42 · see citing works
The role of alexithymia and gastrointestinal-specific anxiety as predictors of treatment outcome in irritable bowel syndrome
Porcelli, P., Carne, M. D., & Leandro, G. (2016) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2016.11.010 · Cited by 41 · see citing works
Association of Financial Burden With Self-Rated and Mental Health in Older Adults With Cancer
Jones, S. M. W., Nguyễn, T. T., & Chennupati, S. R. (2019) · Journal of Aging and Health · doi:10.1177/0898264319826428 · Cited by 41 · see citing works
A Combined Nutrient and Lactulose Challenge Test Allows Symptom-Based Clustering of Patients With Irritable Bowel Syndrome
Nevé, B. L., Posserud, I., Böhn, L., Guyonnet, D., Rondeau, P., Tillisch, K., Naliboff, B. D., Mayer, E. A., & Simrén, M. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2013.75 · Cited by 39 · see citing works
Self-citation
The visceral sensitivity index: A novel tool for measuring GI‐symptom‐specific anxiety in inflammatory bowel disease
Trieschmann, K. D., Chang, L., Park, S. H., Naliboff, B. D., Joshi, S. M., Labus, J. S., Sauk, J. S., Limketkai, B. N., & Mayer, E. A. (2022) · Neurogastroenterology & Motility · doi:10.1111/nmo.14384 · Cited by 40 · see citing works
Coping Skills Are Associated With Gastrointestinal Symptom Severity and Somatization in Patients With Irritable Bowel Syndrome
Wilpart, K., Törnblom, H., Svedlund, J., Tack, J. F., Simrén, M., & Oudenhove, L. V. (2017) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2017.02.032 · Cited by 38 · see citing works
Self-citation
New psychological therapies for irritable bowel syndrome: Mindfulness, acceptance and commitment therapy (ACT)
Sebastián Sánchez, B., Gil Roales-Nieto, J., Ferreira, N. B., Gil Luciano, B., & Sebastián Domingo, J. J. (2017) · Revista Espanola de Enfermedades Digestivas · doi:10.17235/reed.2017.4660/2016 · Cited by 36 · see citing works
“The literature has shown that higher levels of GSA are related to higher symptom severity and lower quality of life in IBS (37,39,40).”
Background
Gastrointestinal Symptoms During Depressive Episodes in 3256 Patients with Major Depressive Disorders: Findings from the NSSD
Huang, J., Cai, Y., Su, Y., Zhang, M., Shi, Y., Zhu, N., Jin, F., Peng, D., & Fang, Y. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.02.039 · Cited by 35 · see citing works
Investigation of body image as a mediator of the effects of bowel and GI symptoms on psychological distress in female survivors of rectal and anal cancer
Benedict, C., Rodríguez, V. M., Carter, J., Temple, L. K. F., Nelson, C. J., & DuHamel, K. N. (2015) · Supportive Care in Cancer · doi:10.1007/s00520-015-2976-2 · Cited by 34 · see citing works
The link between negative affect, vagal tone, and visceral sensitivity in quiescent C rohn's disease
Rubio, A., Sonia Pellissier, A., Picot, A., Dantzer, C., & Bonaz, B. L. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12373 · Cited by 34 · see citing works
Development of Irritable Bowel Syndrome Features Over a 5-year Period
Clevers, E., Tack, J., Törnblom, H., Ringström, G., Luyckx, K., Simrén, M., & Van Oudenhove, L. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.02.043 · Cited by 34 · see citing works
Self-citation
Urinary Proteome Analysis of Irritable Bowel Syndrome (IBS) Symptom Subgroups
Goo, Y. A., Cain, K. C., Jarrett, M. E., Smith, L. T., Voss, J. G., Tolentino, E., Tsuji, J. M., Tsai, Y. S., Panchaud, A., Goodlett, D. R., et al. (2012) · Journal of Proteome Research · doi:10.1021/pr3004437 · Cited by 33 · see citing works
Fecal incontinence in irritable bowel syndrome: Prevalence and associated factors in Swedish and American patients
Simrén, M., Palsson, O. S., Heymen, S., Bajor, A., Törnblom, H., & Whitehead, W. E. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12919 · Cited by 33 · see citing works
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Anxiety-depressive disorders among irritable bowel syndrome patients in Guilan, Iran
Modabbernia, M.-J., Mansour‐Ghanaei, F., Imani, A., Mirsafa-Moghaddam, S.-A., Rahimabadi, M. S., Mashhour, M. Y., Joukar, F., Roshan, Z. A., & Bidel, S. (2012) · BMC Research Notes · doi:10.1186/1756-0500-5-112 · Cited by 32 · see citing works
Irritable bowel syndrome and functional dyspepsia in patients with eating disorders ‐ a systematic review
Hanel, V., Schalla, M. A., & Stengel, A. (2021) · European Eating Disorders Review · doi:10.1002/erv.2847 · Cited by 31 · see citing works
Internet-delivered cognitive behavior therapy for adolescents with functional gastrointestinal disorders — An open trial
Bonnert, M., Ljótsson, B., Hedman, E., Andersson, J., Arnell, H., Benninga, M., Simrén, M., Thulin, H., Thulin, U., Vigerland, S., et al. (2014) · Internet Interventions · doi:10.1016/j.invent.2014.07.002 · Cited by 33 · see citing works
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More similarities than differences between men and women with irritable bowel syndrome
Björkman, I., Ung, E. J., Ringström, G., Törnblom, H., & Simrén, M. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12551 · Cited by 30 · see citing works
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Irritable bowel syndrome: Factors of importance for disease‐specific quality of life
Melchior, C., Colomier, E., Trindade, I. A., Khadija, M., Hreinsson, J. P., Törnblom, H., & Simrén, M. (2022) · United European Gastroenterology Journal · doi:10.1002/ueg2.12277 · Cited by 29 · see citing works
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Learned Fear of Gastrointestinal Sensations in Healthy Adults
Ceunen, E., Zaman, J., Weltens, N., Sarafanova, E., Arijs, V., Vlaeyen, J. W. S., Oudenhove, L. V., & Diest, I. V. (2016) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2016.04.035 · Cited by 28 · see citing works
Fecal chromogranins and secretogranins are linked to the fecal and mucosal intestinal bacterial composition of IBS patients and healthy subjects
Sundin, J., Stridsberg, M., Tap, J., Derrien, M., Nevé, B. L., Dore, J. M., Törnblom, H., Simrén, M., & Öhman, L. (2018) · Scientific Reports · doi:10.1038/s41598-018-35241-6 · Cited by 29 · see citing works
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A primer for the gastroenterology provider on psychosocial assessment of patients with disorders of gut‐brain interaction
Ballou, S., Vasant, D. H., Guadagnoli, L. A., Reed, B., Chiarioni, G., ten Cate, L., Keefer, L., & Kinsinger, S. W. (2024) · Neurogastroenterology & Motility · doi:10.1111/nmo.14894 · Cited by 27 · see citing works
Review article: exclude or expose? The paradox of conceptually opposite treatments for irritable bowel syndrome
Biesiekierski, J. R., Manning, L. P., Murray, H. B., Vlaeyen, J. W. S., Ljótsson, B., & Oudenhove, L. V. (2022) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.17111 · Cited by 27 · see citing works
Nasogastric Tube Feeding for Individuals With Anorexia Nervosa
Kells, M. R., & Kelly‐Weeder, S. (2016) · Journal of the American Psychiatric Nurses Association · doi:10.1177/1078390316657872 · Cited by 27 · see citing works
A randomized clinical trial of the Unified Protocol for Transdiagnostic treatment of emotional and gastrointestinal symptoms in patients with irritable bowel syndrome: evaluating efficacy and mechanism of change
Mohsenabadi, H., Zanjani, Z., Shabani, M. J., & Arj, A. (2018) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2018.07.003 · Cited by 26 · see citing works
Patient satisfaction after gut‐directed hypnotherapy in irritable bowel syndrome
Lindfors, P., Ljótsson, B., Bjornsson, E., Abrahamsson, H., & Simrén, M. (2012) · Neurogastroenterology & Motility · doi:10.1111/nmo.12022 · Cited by 26 · see citing works
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Bromelain supplementation and inflammatory markers: A systematic review of clinical trials
Pereira, I. C., Vieira, E. E. S., Torres, L. R. D. O., da Silva, F. C. C., Sousa, J. M. D. C. E., & Torres‐Leal, F. L. (2023) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2023.02.028 · Cited by 26 · see citing works
Quality of life in coeliac disease: relationship between psychosocial processes and quality of life in a sample of 1697 adults living with coeliac disease
Möller, S. P., Apputhurai, P., Tye–Din, J. A., & Knowles, S. R. (2021) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2021.110652 · Cited by 26 · see citing works
Prediction of symptomatic improvement after exposure-based treatment for irritable bowel syndrome
Ljótsson, B., Andersson, E., Lindfors, P., Lackner, J. M., Grönberg, K., Molin, K., Norén, J., Romberg, K., Andersson, E., Hursti, T. J., et al. (2013) · BMC Gastroenterology · doi:10.1186/1471-230x-13-160 · Cited by 25 · see citing works
Irritable bowel syndrome: A comparison of subtypes
de Castro, N. R., Miller, V., Carruthers, H. R., & Whorwell, P. J. (2014) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12704 · Cited by 24 · see citing works
Associations among neurophysiology measures in irritable bowel syndrome (IBS) and their relevance for IBS symptoms
Midenfjord, I., Polster, A. V., Sjövall, H., Friberg, P., Törnblom, H., & Simrén, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-66558-w · Cited by 24 · see citing works
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Efficacy of tandospirone in patients with irritable bowel syndrome-diarrhea and anxiety
Lan, L. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i32.11422 · Cited by 24 · see citing works
Greater intolerance to uncertainty predicts poorer quality of life in adults with cyclic vomiting syndrome
Levinthal, D. J., Romutis, S., Rajalaban, A., Kumar, V. C. S., Feldman, R., Althouse, A. D., & Venkatesan, T. (2021) · Neurogastroenterology & Motility · doi:10.1111/nmo.14159 · Cited by 23 · see citing works
The psychobiological model of disorders of gut-brain interaction: introduction of a novel, integrated, and testable model.
Guadagnoli, L., Heathcote, L., Oudenhove, L. V., Elsenbruch, S., & Keefer, L. (2025) · The Lancet Gastroenterology and Hepatology · doi:10.1016/s2468-1253(25)00205-5 · Cited by 18 · see citing works
Irritable Bowel Syndrome prevalence and work ability in a sample of healthcare workers exposed to occupational stress
Buselli, R., Veltri, A., Corsi, M., Marino, R., Necciari, G., Baldanzi, S., Chiumiento, M., Lupo, E. D., Foddis, R., Caldi, F., et al. (2021) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2021.110566 · Cited by 23 · see citing works
Relationship of Cannabis Use Disorder and Irritable Bowel Syndrome (IBS): An Analysis of 6.8 Million Hospitalizations in the United States
Patel, R. S., Goyal, H., Satodiya, R. M., & Tankersley, W. E. (2019) · Substance Use & Misuse · doi:10.1080/10826084.2019.1664591 · Cited by 19 · see citing works
Quality of Life and Bidirectional Gut-Brain Interactions in Irritable Bowel Syndrome From Adolescence to Adulthood
Sjölund, J., Kull, I., Bergström, A., Ljótsson, B., Törnblom, H., Olén, O., & Simrén, M. (2023) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2023.09.022 · Cited by 20 · see citing works
Self-citation
Small Intestinal Bacterial Overgrowth in Patients with Irritable Bowel Syndrome: Clinical Characteristics, Psychological Factors, and Peripheral Cytokines
Chu, H., Fox, M. R., Zheng, X., Deng, Y., Long, Y., Huang, Z., Du, L., Xu, F., & Dai, N. (2016) · Gastroenterology Research and Practice · doi:10.1155/2016/3230859 · Cited by 19 · see citing works
Psychological Predictors of Response to Open-Label Versus Double-Blind Placebo in a Randomized Controlled Trial in Irritable Bowel Syndrome
Ballou, S., Haas, J. W., Iturrino, J., Nee, J. W., Kirsch, I., Rangan, V., Cheng, V., Lembo, A. J., Kaptchuk, T. J., & Kelley, J. M. (2022) · Psychosomatic Medicine · doi:10.1097/psy.0000000000001078 · Cited by 19 · see citing works
Food Insecurity in Digestive Diseases
Leiman, D. A., Madigan, K. E., Carlin, M., Cantrell, S. E., & Palakshappa, D. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.05.040 · Cited by 18 · see citing works
Categorical interoception and the role of threat
Zacharioudakis, N., Vlemincx, E., & den Bergh, O. V. (2019) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2019.12.009 · Cited by 17 · see citing works
Quality of life of patients with irritable bowel syndrome before and after education
Joć, E., Mądro, A., Celiński, K., Słomka, M., Kasztelan‐Szczerbińska, B., Pacian, A. B., & Kulik, T. B. (2015) · Psychiatria Polska · doi:10.12740/pp/26078 · Cited by 16 · see citing works
Using acceptance and commitment therapy in irritable bowel syndrome
Bravo Ferreira, N., Eugenicos, M., Graham Morris, P., & Gillanders, D. (2011) · Gastrointestinal Nursing · doi:10.12968/gasn.2011.9.9.28 · Cited by 15 · see citing works
Assessing Worry About Affording Healthcare in a General Population Sample
Jones, S. M. W., Du, Y., Panattoni, L. E., & Henrikson, N. B. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.02622 · Cited by 15 · see citing works

Increased risk of irritable bowel syndrome in university students due to gastrointestinal symptom-specific anxiety
Saigo, T., Tayama, J., Ogawa, S., Bernick, P. J., Takeoka, A., Hayashida, M., & Shirabe, S. (2018) · Institutional Repositories DataBase (IRDB) · doi:10.11343/amn.61.137 · Cited by 3 · see citing works
Anxiety‐related factors associated with symptom severity in irritable bowel syndrome
Black, C. J., Yiannakou, Y., Houghton, L. A., Shuweihdi, F., West, R., Guthrie, E., & Ford, A. C. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.13872 · Cited by 48 · see citing works
O63 Gastrointestinal symptom-specific anxiety and symptom severity in irritable bowel syndrome: new insights from factor analysis
Black, C. J., Yiannakou, Y., Houghton, L. A., Shuweihdi, F., West, R. M., Guthrie, E., & Ford, A. C. (2021) · doi:10.1136/gutjnl-2020-bsgcampus.63
The visceral sensitivity index: A novel tool for measuring GI‐symptom‐specific anxiety in inflammatory bowel disease
Trieschmann, K. D., Chang, L., Park, S. H., Naliboff, B. D., Joshi, S. M., Labus, J. S., Sauk, J. S., Limketkai, B. N., & Mayer, E. A. (2022) · Neurogastroenterology & Motility · doi:10.1111/nmo.14384 · Cited by 40 · see citing works
Validating a Brief Screening Questionnaire for IBS Patients With Symptoms Aggravated by GI-Specific Anxiety
Lackner, J. M., Quigley, B. M., Gudleski, G. D., Labus, J. S., Mayer, E. A., Tillisch, K., Keefer, L., Brenner, D. M., Firth, R. S., Pettle, T., et al. (2014) · The American Journal of Gastroenterology · doi:10.14309/00000434-201410002-01808

Authors: Jerndal, P., Ringström, G., Agerforz, P., Karpefors, M., Akkermans, L. M., Bayati, A., & Simrén, M.
Affiliations: University of Gothenburg (SE)
AstraZeneca (Sweden) (SE)
University Medical Center Utrecht (NL)
Corresponding author: Simrén, M.
ORCID: Ringström, G.
Karpefors, M.
Simrén, M.
Venue: Neurogastroenterology & Motility
Publisher: Wiley
Published: 2010-02-16
Volume: 22
Issue: 6
Pages: 646-e179
ISSN: 1350-1925 (ISSN-L)
1365-2982
DOI: 10.1111/j.1365-2982.2010.01493.x
OpenAlex: W2147789313
Cited by: 192
References: 51
Citations by year: 2026: 5 · 2025: 15 · 2024: 10 · 2023: 15 · 2022: 17 · 2021: 14 · 2020: 7 · 2019: 13 · 2018: 15 · 2017: 9 · 2016: 17 · 2015: 8 · 2014: 18 · 2013: 13 · 2012: 11
FWCI: 9.54
Type: journal article
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 2023 d)
Locations: Neurogastroenterology & Motility (publishedVersion)
PubMed (publishedVersion)
Funders: AstraZeneca
Sahlgrenska Universitetssjukhuset
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: irritable bowel syndrome, quality of life, anxiety, depression, socioeconomic status
MeSH terms: Adult, Aged, Analysis of Variance, Anxiety, Data Interpretation, Statistical, Depression, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Quality of Life, Surveys and Questionnaires, Regression Analysis, Gastrointestinal Tract, Irritable Bowel Syndrome, Young Adult

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Gastrointestinal-specific anxiety: an important factor for severity of GI symptoms and quality of life in IBS: GI-specific anxiety in IBS

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