Cited by 278Stress Responses and CortisolMaternal Mental Health During Pregnancy and PostpartumNeuroscience and Neuropharmacology Research

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Changes of spine density and dendritic complexity in the prefrontal cortex in offspring of mothers exposed to stress during pregnancy

Murmu, Meena Sriti, Salomon, Shiri, Biala, Yaarit, Weinstock, Marta, Braun, Katharina, Bock, Jörg·2006·European Journal of Neuroscience

DOI 10.1111/j.1460-9568.2006.05024.x

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Abstract

Both chronic stress in adulthood and episodes of stress in the early postnatal period have been shown to interfere with neuronal development in limbic prefrontal cortical regions. The present study in rats showed for the first time that the development of layer II/III pyramidal neurons in the dorsal anterior cingulate (ACd) and orbitofrontal cortex (OFC) is significantly affected in offspring of mothers exposed to stress during pregnancy. In prenatally stressed (PS) male rat pups the ACd and OFC showed significantly lower spine densities on the apical dendrite (ACd, −20%; OFC, −25%), on basal dendrites reduced spine densities where found only in the OFC (−20% in PS males). Moreover, in both cortical areas a significant reduction of dendritic length was observed in PS males compared to control offspring, which was confined to the apical dendrites (ACd, −30%, OFC, −26%). Sholl analysis revealed that these alterations were accompanied by a significantly reduced complexity of the dendritic trees in both cortical regions. PS females displayed reductions of dendritic spine densities in the ACd and OFC on both the basal (ACd, −21%; OFC, −20%) and apical dendrites (ACd, −21%; OFC, −21%), however, in contrast to the findings in PS males, no dendritic atrophy was detected in the PS females. These findings demonstrate that gestational stress leads to significant alterations of prefrontal neuronal structure in the offspring of the stressed mothers in a sex‐specific manner.

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Authors: Murmu, M. S., Salomon, S., Biala, Y., Weinstock, M., Braun, K., & Bock, J.
Affiliations: Otto-von-Guericke-Universität Magdeburg (DE)
Hebrew University of Jerusalem (IL)
Weizmann Institute of Science (IL)
Corresponding author: Bock, Jörg
ORCID: Weinstock, Marta
Braun, Katharina
Venue: European Journal of Neuroscience
Publisher: Wiley
Published: 2006-09
Volume: 24
Issue: 5
Pages: 1477-1487
ISSN: 0953-816X (ISSN-L)
1460-9568
DOI: 10.1111/j.1460-9568.2006.05024.x
OpenAlex: W2076507942
Cited by: 278
References: 78
Citations by year: 2026: 3 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 8 · 2021: 18 · 2020: 13 · 2019: 7 · 2018: 11 · 2017: 17 · 2016: 21 · 2015: 23 · 2014: 23 · 2013: 25 · 2012: 17
FWCI: 5.18
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 7 d)
Locations: European Journal of Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Israel Science Foundation
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: prenatal stress, dendritic spine density, dendritic complexity, prefrontal cortex, dorsal anterior cingulate cortex, orbitofrontal cortex, layer II/III pyramidal neurons, sex differences, neuronal development, Sholl analysis, dendritic atrophy
MeSH terms: Animals, Animals, Newborn, Corticosterone, Dendrites, Female, Functional Laterality, Male, Pregnancy, Prenatal Exposure Delayed Effects, Radioimmunoassay, Sex Factors, Stress, Psychological, Rats, Sprague-Dawley, Prefrontal Cortex, Dendritic Spines, Rats

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Changes of spine density and dendritic complexity in the prefrontal cortex in offspring of mothers exposed to stress during pregnancy

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