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Cited by 122Motor Control and AdaptationMemory and Neural MechanismsNeurotransmitter Receptor Influence on Behavior

Changes in activity of the striatum during formation of a motor habit

Tang, Chengke, Pawlak, Anthony P., Prokopenko, Volodymyr, West, Mark O.·2007·European Journal of Neuroscience
DOI 10.1111/j.1460-9568.2007.05353.x
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Abstract

To examine experience‐dependent plasticity of striatal neurons during habit learning in awake, freely moving animals, single neurons in the dorsolateral striatum (54 neurons related specifically to vertical head movement and 14 unresponsive neurons, i.e. not related to any body movement) were recorded and tracked off‐line to assess changes in firing rate over sessions as performance of instrumental head movement became automatic and habitual. Rats were trained to emit operant vertical head movements that triggered water delivery for 14 sessions (2 h per session, one session per day). Rats significantly increased the number and efficiency of head movements over sessions until reaching asymptotic behaviour. Habit formation was indicated by significantly higher levels of instrumental responding exhibited by rats during a late, relative to an early, session in which the reward was devalued. As head movements became habitual across sessions, most head movement‐related neurons (89%) exhibited decreased firing rate, while a small population (11%) exhibited increased or maintained firing rate. The rate of decrease in firing by the majority correlated with the rate of improvement in movement efficiency over sessions. All unresponsive neurons, though not apparently related to movement, exhibited decreased firing rate over sessions. Our findings suggest that, during habit learning, the striatum may shift from facilitating acquisition of efficient movement with a large population of neurons to modulating or maintaining habitual movement with stronger firing of fewer movement‐related neurons.

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Crossref · 10.1111/j.1460-9568.2007.05353.x

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71 of 71 references verified0 citation errors · 0 not checkable

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  • The response of the sensorimotor striatum to extended training depends on the type of task used.

    “On the other hand, there is evidence that the response of the sensorimotor striatum to extended training may depend on the type of task that is used.”

    From Cortical and basal ganglia contributions to habit learning and automaticity (2010) · cites this paper as [24]

  • In tasks with a single motor response, extended training leads to a decrease in the number of neurons within the sensorimotor striatum showing task-related activation.

    “These studies have reported that extended training leads to a decrease in the number of neurons within the sensorimotor striatum showing task-related activation.”

    From Cortical and basal ganglia contributions to habit learning and automaticity (2010) · cites this paper as [24]

  • Other studies reported a decrease in the number of sensorimotor striatal neurons showing task-relevant phasic activations over the course of training.

    “Other studies also reported a decrease in the number of sensorimotor striatal neurons showing task-relevant phasic activations over the course of training, but in addition, reported that a small group of neurons within the sensorimotor striatum continued to show task-related activations and that the magnitude of the phasic neuronal responses in this restricted population of neurons increased over”

    From Cortical and basal ganglia contributions to habit learning and automaticity (2010) · cites this paper as [24]

  • A small group of neurons within the sensorimotor striatum continued to show task-related activations over extended training.

    “Other studies also reported a decrease in the number of sensorimotor striatal neurons showing task-relevant phasic activations over the course of training, but in addition, reported that a small group of neurons within the sensorimotor striatum continued to show task-related activations and that the magnitude of the phasic neuronal responses in this restricted population of neurons increased over”

    From Cortical and basal ganglia contributions to habit learning and automaticity (2010) · cites this paper as [24]

  • The magnitude of phasic neuronal responses in this restricted population of sensorimotor striatal neurons increased over the course of extended training.

    “Other studies also reported a decrease in the number of sensorimotor striatal neurons showing task-relevant phasic activations over the course of training, but in addition, reported that a small group of neurons within the sensorimotor striatum continued to show task-related activations and that the magnitude of the phasic neuronal responses in this restricted population of neurons increased over”

    From Cortical and basal ganglia contributions to habit learning and automaticity (2010) · cites this paper as [24]

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Authors
Tang, C., Pawlak, A. P., Prokopenko, V., & West, M. O.
Affiliations
Rutgers, The State University of New Jersey (US)
Corresponding author
West, Mark O.
ORCID
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
2007-02
Volume
25
Issue
4
Pages
1212-1227
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
DOI
10.1111/j.1460-9568.2007.05353.x
OpenAlex
W1555402028
Semantic Scholar
b321a89048c173e98f170e506ada426d49ab0947
Cited by
122
References
71
Citations by year
2026: 2 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 5 · 2016: 7 · 2015: 7 · 2014: 7 · 2013: 10 · 2012: 12
FWCI
5.83
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 25 d)
Locations
  • European Journal of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Drug Abuse (R01DA006886, DA-06886, DA04551)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
striatum, dorsolateral striatum, motor habits, habit learning, experience-dependent plasticity, single-unit recording, reward devaluation, movement efficiency, striatal neurons
MeSH terms
Action Potentials, Animals, Behavior, Animal, Conditioning, Operant, Corpus Striatum, Habits, Male, Neuronal Plasticity, Wakefulness, Statistics, Nonparametric, Head Movements, Rats, Long-Evans, Rats

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