Dorsolateral prefrontal lesions do not impair tests of scene learning and decision-making that require frontal-temporal interaction
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Theories of dorsolateral prefrontal cortex (DLPFC) involvement in cognitive function variously emphasize its involvement in rule implementation, cognitive control, or working and/or spatial memory. These theories predict broad effects of DLPFC lesions on tests of visual learning and memory. We evaluated the effects of DLPFC lesions (including both banks of the principal sulcus) in rhesus monkeys on tests of scene learning and strategy implementation that are severely impaired following crossed unilateral lesions of frontal cortex and inferotemporal cortex. Dorsolateral lesions had no effect on learning of new scene problems postoperatively, or on the implementation of preoperatively acquired strategies. They were also without effect on the ability to adjust choice behaviour in response to a change in reinforcer value, a capacity that requires interaction between the amygdala and frontal lobe. These intact abilities following DLPFC damage support specialization of function within the prefrontal cortex, and suggest that many aspects of memory and strategic and goal‐directed behaviour can survive ablation of this structure.
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Lesions elsewhere in prefrontal cortex, including bilateral ventral PF area 12/47 or dorsolateral PF area 46, have no effect on the devaluation task.
“Lesions elsewhere in the prefrontal cortex are without effect on the devaluation task, including bilateral lesions of ventral PF cortex (area 12/47) or the dorsolateral PF cortex (area 46) (79, 80).”
From Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala (2011) · cites this paper as [79]
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- Authors
- Baxter, M. G., Gaffan, D., Kyriazis, D. A., & Mitchell, A. S.
- Affiliations
- University of Oxford (GB)
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2008-07-23
- Volume
- 28
- Issue
- 3
- Pages
- 491-499
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- PMC
- PMC2522287
- OpenAlex
- W2056605934
- Cited by
- 37
- References
- 47
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (071291/Z/03/Z)
- Medical Research Council (MC_qA137504)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- dorsolateral prefrontal cortex, prefrontal lesions, decision-making, strategy implementation, inferotemporal cortex, reinforcer value, amygdala, rhesus monkeys, cognitive control, spatial memory, goal-directed behavior
- MeSH terms
- Animals, Behavior, Animal, Decision Making, Discrimination Learning, Female, Macaca mulatta, Male, Memory, Neuropsychological Tests, Prefrontal Cortex
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