Effect of Expected Reward Magnitude on the Response of Neurons in the Dorsolateral Prefrontal Cortex of the Macaque
Open accessAbstract
The dorsolateral prefrontal cortex plays a critical role in guiding actions that ensue seconds after an instruction. We recorded from neurons in area 46 and the frontal eye field (FEF) while monkeys performed a memory-guided eye movement task. A visual cue signaled whether a small or large liquid reward would accompany a correct response. Many neurons in area 46 responded more when the monkey expected a larger reward. Reward-related enhancement was evident throughout the memory period and was most pronounced when the remembered target appeared in the neuron's response field. Enhancement was not present in the FEF. The mixture of neural signals representing spatial working memory and reward expectation appears to be a distinct feature of area 46.
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- Authors
- Leon, M. I., & Shadlen, M. N.
- Affiliations
- University of Washington (US)
- Corresponding author
- Shadlen, Michael N.
- ORCID
- Shadlen, Michael N.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1999-10
- Volume
- 24
- Issue
- 2
- Pages
- 415-425
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2132346372
- Cited by
- 449
- References
- 62
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- FWCI
- 6.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5t32ns007395-05)
- National Eye Institute (EY11378, R01EY011378)
- National Institute of Neurological Disorders and Stroke (5T32NS07395)
- National Center for Research Resources (RR00166, P51RR000166)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- dorsolateral prefrontal cortex, area 46, frontal eye field, reward anticipation, reward magnitude, spatial working memory, macaque
- MeSH terms
- Animals, Behavior, Animal, Cues, Electrophysiology, Female, Macaca mulatta, Male, Memory, Neurons, Reward, Time Factors, Visual Pathways, Prefrontal Cortex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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