Ventrolateral prefrontal cortex is required for performance of a strategy implementation task but not reinforcer devaluation effects in rhesus monkeys
Open accessAbstract
The ability to apply behavioral strategies to obtain rewards efficiently and make choices based on changes in the value of rewards is fundamental to the adaptive control of behavior. The extent to which different regions of the prefrontal cortex are required for specific kinds of decisions is not well understood. We tested rhesus monkeys with bilateral ablations of the ventrolateral prefrontal cortex on tasks that required the use of behavioral strategies to optimize the rate with which rewards were accumulated, or to modify choice behavior in response to changes in the value of particular rewards. Monkeys with ventrolateral prefrontal lesions were impaired in performing the strategy‐based task, but not on value‐based decision‐making. In contrast, orbital prefrontal ablations produced the opposite impairments in the same tasks. These findings support the conclusion that independent neural systems within the prefrontal cortex are necessary for control of choice behavior based on strategies or on stimulus value.
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Lesions elsewhere in prefrontal cortex, including bilateral ventral PF area 12/47 or dorsolateral PF area 46, have no effect on the devaluation task.
“Lesions elsewhere in the prefrontal cortex are without effect on the devaluation task, including bilateral lesions of ventral PF cortex (area 12/47) or the dorsolateral PF cortex (area 46) (79, 80).”
From Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala (2011) · cites this paper as [80]
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- Authors
- Baxter, M. G., Gaffan, D., Kyriazis, D. A., & Mitchell, A. S.
- Affiliations
- University of Oxford (GB)
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2009-05
- Volume
- 29
- Issue
- 10
- Pages
- 2049-2059
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- PMC
- PMC2688497
- OpenAlex
- W2049156730
- Cited by
- 65
- References
- 54
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 5 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 5 · 2015: 5 · 2014: 3 · 2013: 5
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- European Journal of Neuroscience (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (071291)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
- Keywords
- ventrolateral prefrontal cortex, orbitofrontal cortex, reinforcer devaluation, value-based decision making, choice behavior, prefrontal cortex lesions, rhesus monkeys
- MeSH terms
- Animals, Behavior, Animal, Choice Behavior, Discrimination Learning, Female, Macaca mulatta, Male, Reward, Prefrontal Cortex
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