CoChat
Sign Up
Cited by 157Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeurogenesis and neuroplasticity mechanisms

Peripubertal refinement of the intrinsic and associational circuitry in monkey prefrontal cortex

Woo, T.-U., Pucak, M.L., Kye, C.H., Matus, C.V., Lewis, D.A.·1997·Neuroscience
DOI 10.1016/s0306-4522(97)00059-6
Open this paper in CoChat — free account

Abstract

The peripubertal elimination of axospinous synapses and dendritic spines in monkey prefrontal cortex suggests that this region undergoes substantial reorganization during late postnatal development. Understanding the functional impact of these maturational refinements requires knowledge of the specific presynaptic elements involved in these changes. Two potential sources of these presynaptic terminals are the intrinsic axon collaterals furnished by pyramidal cells within a region and the associational axons that arise from pyramidal neurons in other cortical regions in the same hemisphere. In the adult, both of these types of axon terminals form synapses predominantly with dendritic spines on other pyramidal neurons, and thus they may be preferentially involved in the peripubertal pruning of axospinous synapses and dendritic spines. In order to test this hypothesis, iontophoretic injections of the anterograde tracer biotinylated dextran amine were made into the superficial layers of areas 9 or 46 of the prefrontal cortex of four prepubertal juvenile (14.9-21.5 months old) and three young adult macaque monkeys. Tangential reconstructions revealed a stripe-like pattern of labeled terminals for intrinsic and associational projections in both juvenile and adult animals. During puberty, the intrinsic circuitry underwent extensive topographic refinement, as demonstrated by a 42.7% decrease in stripe area and a 28.0% increase in gap distance between stripes. Furthermore, the mediolateral tangential spread of labeled stripes around the injection site decreased by 27.0%. In contrast, topographic refinement was not evident in the associational circuitry. In both layers 1 and 3, the densities of varicosities and branch points on labeled axons decreased by about 50% in intrinsic stripes during puberty, but only by approximately 30% in associational stripes. These findings suggest that the spatial form and magnitude of peripubertal refinements in prefrontal cortical connectivity may be specific for certain neural elements.

Integrity signals

Registry

Crossref · 10.1016/s0306-4522(97)00059-6

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Woo, T.-U., Pucak, M. L., Kye, C. H., Matus, C. V., & Lewis, D. A.
Affiliations
University of Pittsburgh (US)
Corresponding author
Lewis, D.A.
ORCID
Venue
Neuroscience
Publisher
Elsevier BV
Published
1997-08
Volume
80
Issue
4
Pages
1149-1158
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/s0306-4522(97)00059-6
OpenAlex
W1964259370
Cited by
157
References
40
Citations by year
2026: 1 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 6 · 2018: 5 · 2017: 2 · 2016: 5 · 2015: 7 · 2014: 3 · 2013: 9 · 2012: 11
FWCI
1.58
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Mental Health (MH-51234, MH 45156, R01MH051234, P50MH045156)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 08610)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
prefrontal cortex, dendritic spines, axospinous synapses, pyramidal neurons, axon collaterals, postnatal development, macaque, varicosities, cortical connectivity
MeSH terms
Aging, Animals, Axons, Axonal Transport, Dendrites, Macaca fascicularis, Macaca mulatta, Male, Sexual Maturation, Synapses, Prefrontal Cortex, Pyramidal Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review