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Neural encoding of cocaine‐seeking behavior is coincident with phasic dopamine release in the accumbens core and shell
Open accessAbstract
Mesolimbic dopamine neurons projecting from the ventral tegmental area to the nucleus accumbens (NAc) are part of a complex circuit mediating cocaine‐directed behaviors. However, the precise role of rapid (subsecond) dopamine release within the primary subregions of the NAc (the core and shell) and its relationship to NAc cell firing during this behavior remain unknown. Here, using fast‐scan cyclic voltammetry in rats we report rapid dopamine signaling in both the core and shell; however, significant differences were observed in the timing of dopamine release events within seconds of the cocaine‐reinforced response during self‐administration sessions. Importantly, simultaneous voltammetric and electrophysiological recordings from the same electrode reveal that, at certain sites within both subregions, neurons exhibiting patterned activation were observed at locations where rapid dopamine release was present; the greater the strength of the neural signal the larger the dopamine release event. In addition, it was at those locations that electrically‐evoked stimulated release was greatest. No changes in dopamine were observed where nonphasic neurons were recorded. Thus, although differences are evident in dopamine release dynamics relative to cocaine‐reinforced responding within the core and shell, dopamine release is heterogeneous within each structure and varies as a function of precise neuronal targets during cocaine‐seeking behavior.
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“neutral stimuli that are linked to the reinforcer (whether a natural or a drug reinforcer) acquire the ability by themselves to increase DA in striatum (including NAc) in anticipation of the reward, thus engendering a strong motivation to perform and sustain the behaviours necessary to seek the drug or to seek the food (48).”
From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [48]
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“stimuli that cause fast and large increases in DA induce conditioned responses and elicit incentive motivation to procure them (48).”
From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [48]
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“This is important because, through the process of conditioning, neutral stimuli that are linked to the reinforcer (whether a natural reinforcer or a drug) acquire the ability by themselves to increase DA in striatum (including NAc) in anticipation of the reward, thus engendering a strong motivation to seek the drug (Owesson-White et al 2009).”
From Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction (2011) · cites this paper as Owesson-White et al 2009
In the citing paper
“DA's role in reinforcement is more complex than just coding for reward per se (hedonic pleasure) and stimuli that induce fast and large DA increases also trigger conditioned responses and elicit incentive motivation to procure them (Owesson-White et al 2009).”
From Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction (2011) · cites this paper as Owesson-White et al 2009
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Metadata
- Authors
- Owesson‐White, C. A., Ariansen, J., Stuber, G. D., Cleaveland, N. A., Cheer, J. F., Mark Wightman, R., & Carelli, R. M.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2009-09
- Volume
- 30
- Issue
- 6
- Pages
- 1117-1127
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- PMC
- PMC3107700
- OpenAlex
- W2130709479
- Cited by
- 126
- References
- 74
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 8 · 2019: 12 · 2018: 8 · 2017: 8 · 2016: 8 · 2015: 10 · 2014: 8 · 2013: 11 · 2012: 13
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Institutes of Health
- National Institute on Drug Abuse (DA10900, DA17318, R01DA017318, R01DA010900)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- cocaine self-administration, cocaine-seeking behavior, phasic dopamine release, nucleus accumbens core, nucleus accumbens shell, mesolimbic dopamine system, ventral tegmental area, neuronal firing patterns, fast-scan cyclic voltammetry
- MeSH terms
- Action Potentials, Animals, Behavior, Animal, Cocaine, Dopamine, Electrochemistry, Electrophysiology, Kinetics, Male, Neurons, Nucleus Accumbens, Self Administration, Signal Processing, Computer-Assisted, Behavior, Addictive, Rats, Sprague-Dawley, Cocaine-Related Disorders, Rats
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