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Cited by 509

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Role of vitamin D in the pathogenesis of type 2 diabetes mellitus

Palomer, X., González‐Clemente, J. M., Blanco‐Vaca, F., Mauricio, D.·2008·Diabetes, Obesity and Metabolism
DOI 10.1111/j.1463-1326.2007.00710.x
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Abstract

Vitamin D deficiency has been shown to alter insulin synthesis and secretion in both humans and animal models. It has been reported that vitamin D deficiency may predispose to glucose intolerance, altered insulin secretion and type 2 diabetes mellitus. Vitamin D replenishment improves glycaemia and insulin secretion in patients with type 2 diabetes with established hypovitaminosis D, thereby suggesting a role for vitamin D in the pathogenesis of type 2 diabetes mellitus. The presence of vitamin D receptors (VDR) and vitamin D–binding proteins (DBP) in pancreatic tissue and the relationship between certain allelic variations in the VDR and DBP genes with glucose tolerance and insulin secretion have further supported this hypothesis. The mechanism of action of vitamin D in type 2 diabetes is thought to be mediated not only through regulation of plasma calcium levels, which regulate insulin synthesis and secretion, but also through a direct action on pancreatic β‐cell function. Therefore, owing to its increasing relevance, this review focuses on the role of vitamin D in the pathogenesis of type 2 diabetes mellitus.

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Metadata

Authors
Palomer, X., González‐Clemente, J. M., Blanco‐Vaca, F., & Mauricio, D.
Venue
Diabetes, Obesity and Metabolism
Publisher
Wiley
Published
2007-02-12
Volume
10
Issue
3
Pages
185-197
ISSN
  • 1462-8902 (ISSN-L)
  • 1463-1326
DOI
10.1111/j.1463-1326.2007.00710.x
OpenAlex
W2019870128
Cited by
509
References
3
FWCI
12.43
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

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