Cited by 151Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and ManagementDiet, Metabolism, and Disease

Effectiveness of interventions for reducing diabetes and cardiovascular disease risk in people with metabolic syndrome: Systematic review and mixed treatment comparison meta-analysis

Dunkley, A. J., Charles, K., Gray, L. J., Camosso‐Stefinovic, J., Davies, M. J., Khunti, K.·2012·Diabetes Obesity and Metabolism

Abstract

AIMS: To review the evidence on interventions for reversing metabolic syndrome or preventing development of type 2 diabetes and cardiovascular disease in people with metabolic syndrome. METHODS: A systematic review and Bayesian mixed treatment comparison meta-analysis was conducted. Relevant electronic bibliographic databases were searched up to January 2010. Included studies were randomized controlled trials with a follow-up of ≥24 weeks and outcomes comparing incidence of diabetes and/or cardiovascular disease, or reversal of metabolic syndrome. RESULTS: A total of 16 studies met the inclusion criteria. Thirteen studies with outcome data for reversal of metabolic syndrome, involving 3907 participants, were included in the meta-analysis. Insufficient trials reported cardiovascular events/mortality, or incidence of type 2 diabetes, to conduct a meta-analysis for these outcomes. Interventions, alone or in combination, included lifestyle (diet and/or exercise) and pharmacological therapy. Using random-effect models, both lifestyle (odds ratio, OR 3.81; 95% confidence interval, CI 2.47-5.88) and pharmacological interventions (OR 1.59; 95% CI 1.04-2.45) were statistically superior compared with control for reversing metabolic syndrome. Using mixed treatment comparison methods, the probability that lifestyle interventions were the most clinically effective was 87%. CONCLUSIONS: Evidence suggests that both lifestyle and pharmacological interventions can reverse metabolic syndrome. However, there is a lack of data on whether these benefits are sustained and translate into longer term prevention of diabetes and/or cardiovascular disease.

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Crossref · 10.1111/j.1463-1326.2012.01571.x

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Authors
Dunkley, A. J., Charles, K., Gray, L. J., Camosso‐Stefinovic, J., Davies, M. J., & Khunti, K.
Affiliations
University of Leicester (GB)
Corresponding author
Dunkley, A. J.
Venue
Diabetes Obesity and Metabolism
Publisher
Wiley
Published
2012-02-21
Volume
14
Issue
7
Pages
616-625
ISSN
  • 1462-8902 (ISSN-L)
  • 1463-1326
OpenAlex
W2091832011
Cited by
151
References
46
Citations by year
2026: 7 · 2025: 8 · 2024: 6 · 2023: 3 · 2022: 8 · 2021: 11 · 2020: 15 · 2019: 13 · 2018: 9 · 2017: 14 · 2016: 9 · 2015: 16 · 2014: 17 · 2013: 13 · 2012: 2
FWCI
2.11
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes Obesity and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Leicester Research Archive (University of Leicester) (submittedVersion)
Funders
  • National Institute for Health and Care Research (RP-DG-1210-10183, RP-PG-0606-1272)
  • University of Leicester
  • National Institutes of Health
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords
metabolic syndrome, type 2 diabetes prevention, cardiovascular disease prevention, lifestyle intervention, pharmacotherapy, diet, physical activity, diabetes risk
MeSH terms
Bayes Theorem, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Female, Humans, Hypoglycemic Agents, Male, Prognosis, Exercise, Odds Ratio, Outcome Assessment, Health Care, Metabolic Syndrome, Risk Reduction Behavior

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