Terpenoid biosynthesis in trichomes—current status and future opportunities
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Summary: Glandular trichomes are anatomical structures specialized for the synthesis of secreted natural products. In this review we focus on the description of glands that accumulate terpenoid essential oils and oleoresins. We also provide an in‐depth account of the current knowledge about the biosynthesis of terpenoids and secretion mechanisms in the highly specialized secretory cells of glandular trichomes, and highlight the implications for metabolic engineering efforts.
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This ability of trichomes to transfer compounds into extracellular cavities overcomes the problem of cellular toxicity.
“This ability of trichomes to transfer compounds into extracellular cavities (5, 6) overcomes the problem of cellular toxicity.”
From <i>Artemisia annua</i> mutant impaired in artemisinin synthesis demonstrates importance of nonenzymatic conversion in terpenoid metabolism (2016) · cites this paper as [6]
The section on peppermint peltate gland cells describes essential oil being secreted into an extracellular storage space. Our copy does not say that this transfer overcomes cellular toxicity; searches for toxicity and related terms found no such explanation. (LLM, conf=0.82)
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Research works printed but not linked: 8
- ª 2012 The Authors Plant Biotechnology Journal ª 2012 Society for Experimental Biology, Association of Applied Biologists and Blackwell Publishing Ltd, Plant Biotechnology Journal, 11, 2-22
- ª 2012 The Authors Plant Biotechnology Journal ª 2012 Society for Experimental Biology, Association of Applied Biologists and Blackwell Publishing Ltd, Plant Biotechnology Journal, 11, 2-22 Terpenoid biosynthesis in trichomes 19 14677652, 2013, 1, · DOI
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- Sallaud, C., Rontein, D., Onillon, S., Jabe `s, F., Duffe ´, P., Giacalone, C., Thoraval, S., Escoffier, C., Herbette, G., Leonhardt, N., Causse, M. and Tissier, A. ª 2012 The Authors Plant Biotechnology Journal ª 2012 Society for Experimental Biology, Association of Applied Biologists and Blackwell Publishing Ltd, Plant Biotechnology Journal, 11, 2-22 (2009)
- ª 2012 The Authors Plant Biotechnology Journal ª 2012 Society for Experimental Biology, Association of Applied Biologists and Blackwell Publishing Ltd, Plant Biotechnology Journal, 11, 2-22 Terpenoid biosynthesis in trichomes 21 14677652, 2013, 1, · DOI
- ª 2012 The Authors Plant Biotechnology Journal ª 2012 Society for Experimental Biology, Association of Applied Biologists and Blackwell Publishing Ltd, Plant Biotechnology Journal, 11, 2-22
Cited by
Sorted by citations
Biological Activities of Essential Oils: From Plant Chemoecology to Traditional Healing Systems
Sharifi-Rad, J., Sureda, A., Tenore, G., Daglia, M., Sharifi-Rad, M., Valussi, M., Tundis, R., Sharifi-Rad, M., Loizzo, M., Ademiluyi, A., et al. (2017) · Molecules · doi:10.3390/molecules22010070 · Cited by 889 · see citing works
Lange, B. M., & Ahkami, A. (2013) · Plant Biotechnology Journal · doi:10.1111/pbi.12022 · Cited by 206 · see citing works
Czechowski, T., Larson, T. R., Catania, T. M., Harvey, D., Brown, G. D., & Graham, I. A. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1611567113 · Cited by 94 · see citing works
Gurav, T. P., Dholakia, B. B., & Giri, A. P. (2022) · Phytochemistry Reviews · doi:10.1007/s11101-021-09767-z · Cited by 87 · see citing works
Progress in Catalytic Ring-Opening Polymerization of Biobased Lactones
Al-Shok, L., Haddleton, D. M., & Adams, F. (2022) · Advances in Polymer Science · doi:10.1007/12_2021_111 · Cited by 10 · see citing works
- Authors
- Markus Lange, B., & Turner, G. W.
- Affiliations
- Institute of Biological Chemistry M.J. Murdock Metabolomics Laboratory Washington State University Pullman WA USA
- Washington State University (US)
- ORCID
- Turner, Glenn W.
- Venue
- Plant Biotechnology Journal
- Publisher
- Wiley
- Published
- 2012-09-15
- Volume
- 11
- Issue
- 1
- Pages
- 2-22
- ISSN
- 1467-7644 (ISSN-L)
- 1467-7652
- OpenAlex
- W2068814403
- Cited by
- 195
- References
- 214
- Citations by year
- 2026: 12 · 2025: 16 · 2024: 10 · 2023: 14 · 2022: 14 · 2021: 17 · 2020: 18 · 2019: 16 · 2018: 13 · 2017: 16 · 2016: 14 · 2015: 20 · 2014: 9 · 2013: 3 · 2012: 2
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Plant Biotechnology Journal (publishedVersion, other-oa)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Energy (DE‐FG02‐, DE-FG02-09ER16054)
- Basic Energy Sciences (DE-FG02)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant tissue culture and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- terpenoid biosynthesis, glandular trichomes, essential oils, oleoresin, secretory cells, secretion mechanism, metabolic engineering, plant natural products
- MeSH terms
- Biotechnology, Oils, Volatile, Plant Extracts, Terpenes, Plant Epidermis, Plant Cells
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