A cDNA clone for β-caryophyllene synthase from Artemisia annua

Qinghaosu (Artemisinin): an Antimalarial Drug from China

Klayman, D. L. (1985) · Science · doi:10.1126/science.3887571 · Cited by 2,186 · see citing works

Plant terpenoid synthases: Molecular biology and phylogenetic analysis

Bohlmann, J., Meyer-Gauen, G., & Croteau, R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4126 · Cited by 1,122 · see citing works

Floral scents—a checklist of volatile compounds isolated by head-space techniques

Knudsen, J. T., Tollsten, L., & Bergström, L. G. (1993) · Phytochemistry · doi:10.1016/0031-9422(93)85502-i · Cited by 984 · see citing works

Cyclization Enzymes in the Biosynthesis of Monoterpenes, Sesquiterpenes, and Diterpenes

Davis, E. M., & Croteau, R. (2000) · Topics in current chemistry · doi:10.1007/3-540-48146-x_2 · Cited by 507 · see citing works

Genomic Organization of Plant Terpene Synthases and Molecular Evolutionary Implications

Trapp, S., & Croteau, R. (2001) · Genetics · doi:10.1093/genetics/158.2.811 · Cited by 482 · see citing works

Isolation and identification

Khripach, V. A., Zhabinskii, V. N., & de Groot, A. E. (1999) · Elsevier eBooks · doi:10.1016/b978-012406360-0/50004-6 · Cited by 423 · see citing works

Sesquiterpene Synthases from Grand Fir (Abies grandis)

Steele, C. L., Crock, J. E., Bohlmann, J., & Croteau, R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.4.2078 · Cited by 415 · see citing works

Regulation of Monoterpene Accumulation in Leaves of Peppermint

Gershenzon, J., McConkey, M. E., & Croteau, R. (2000) · PLANT PHYSIOLOGY · doi:10.1104/pp.122.1.205 · Cited by 352 · see citing works

Sesquiterpenes from Clove (Eugenia caryophyllata) as Potential Anticarcinogenic Agents

Zheng, G.-Q., Kenney, P. M. J., & Lam, L. K. T. (1992) · Journal of Natural Products · doi:10.1021/np50085a029 · Cited by 346 · see citing works

Molecular Cloning, Expression, and Characterization of Amorpha-4,11-diene Synthase, a Key Enzyme of Artemisinin Biosynthesis in Artemisia annua L.

Mercke, P., Bengtsson, M., Bouwmeester, H. J., Posthumus, M. A., & Brodelius, P. E. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.1962 · Cited by 283 · see citing works

Amorpha-4,11-diene synthase catalyses the first probable step in artemisinin biosynthesis

Bouwmeester, H. J., Wallaart, T. E., Janssen, M. H. A., van Loo, B., Jansen, B. J. M., Posthumus, M. A., Schmidt, C. O., De Kraker, J.-W., König, W. A., & Franssen, M. C. R. (1999) · Phytochemistry · doi:10.1016/s0031-9422(99)00206-x · Cited by 266 · see citing works

Terpenoids from Salvia sclarea

Ulubelen, A., Topçu, G., Eriş, C., Sönmez, U., Kartal, M., Kurucu, S., & Bozok-Johansson, C. (1994) · Phytochemistry · doi:10.1016/s0031-9422(00)90474-6 · Cited by 255 · see citing works

Amorpha-4,11-diene synthase: cloning and functional expression of a key enzyme in the biosynthetic pathway of the novel antimalarial drug artemisinin

Wallaart, T. E., Bouwmeester, H. J., Hille, J., Poppinga, L., & Maijers, N. C. A. (2001) · Planta · doi:10.1007/s004250000428 · Cited by 242 · see citing works

Ubiquitin extension proteins of Arabidopsis thaliana. Structure, localization, and expression of their promoters in transgenic tobacco.

Callis, J., Raasch, J. A., & Vierstra, R. D. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38372-3 · Cited by 221 · see citing works

Cloning, Expression, and Characterization of (+)-δ-Cadinene Synthase: A Catalyst for Cotton Phytoalexin Biosynthesis

Chen, X., Chen, Y., Heinstein, P. F., & Davisson, V. J. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.0038 · Cited by 212 · see citing works

Isolation and bacterial expression of a sesquiterpene synthase cDNA clone from peppermint ( Mentha x piperita , L.) that produces the aphid alarm pheromone ( E )-β-farnesene

Crock, J. E., Wildung, M. R., & Croteau, R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.12833 · Cited by 176 · see citing works

Sesquiterpene Biosynthesis: Cyclization Mechanisms

Cane, D. E. (1999) · Elsevier eBooks · doi:10.1016/b978-0-08-091283-7.00039-4 · Cited by 164 · see citing works

Cytotoxic and Antioxidative Sesquiterpenoids from Heterotheca inuloides

Kubo, I., Chaudhuri, S. K., Kubo, Y., Sanchez, Y., Ogura, T., Saito, T., Ishikawa, H., & Haraguchi, H. (1996) · Planta Medica · doi:10.1055/s-2006-957932 · Cited by 154 · see citing works

Amorpha-4,11-diene synthase of Artemisia annua: cDNA isolation and bacterial expression of a terpene synthase involved in artemisinin biosynthesis

Chang, Y.-J., Song, S.-H., Park, S.-H., & Kim, S.-U. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.2061 · Cited by 154 · see citing works

Differential accumulation of isoprenoids in glanded and glandless Artemisia annua L

Tellez, M. R., Canel, C., Rimando, A. M., & Duke, S. O. (1999) · Phytochemistry · doi:10.1016/s0031-9422(99)00308-8 · Cited by 148 · see citing works

Gastric Cytoprotection of the Non-Steroidal Anti-Inflammatory Sesquiterpene, β-Caryophyllene

Tambe, Y., Tsujiuchi, H., Honda, G., Ikeshiro, Y., & Tanaka, S. (1996) · Planta Medica · doi:10.1055/s-2006-957942 · Cited by 145 · see citing works

Isolation and Identification of Dihydroartemisinic Acid from <i>Artemisia annua</i> and Its Possible Role in the Biosynthesis of Artemisinin

Wallaart, T. E., van Uden, W., Lubberink, H. G. M., Woerdenbag, H. J., Pras, N., & Quax, W. J. (1999) · Journal of Natural Products · doi:10.1021/np980370p · Cited by 129 · see citing works

Cloning, Expression, and Characterization of epi-Cedrol Synthase, a Sesquiterpene Cyclase from Artemisia annua L

Mercke, P., Crock, J., Croteau, R., & Brodelius, P. E. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1358 · Cited by 127 · see citing works

Anti-Inflammatory Activity of the Essential Oil ofBupleurum fruticescens

Martin, S., Padilla, E., Ocete, M. A., Gálvez, J., Jiménez, J., & Zarzuelo, A. (1993) · Planta Medica · doi:10.1055/s-2006-959755 · Cited by 114 · see citing works

Terpenoids from Artemisia annua and constituents of its essential oil

Ahmad, A., & Misra, L. N. (1994) · Phytochemistry · doi:10.1016/0031-9422(94)85021-6 · Cited by 87 · see citing works

(3R)-Linalool Synthase from Artemisia annua L.: cDNA Isolation, Characterization, and Wound Induction

Jia, J.-W., Crock, J., Lu, S., Croteau, R., & Chen, X.-Y. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1466 · Cited by 87 · see citing works

Independent elicitation of the oxidative burst and phytoalexin formation in cultured plant cells

Davis, D. A., Merida, J. R., Legendre, L., Low, P. S., & Heinstein, P. F. (1993) · Phytochemistry · doi:10.1016/s0031-9422(00)95144-6 · Cited by 71 · see citing works

Partial purification and characterization of two sesquiterpene cyclases from sage (Salvia officinalis) which catalyze the respective conversion of farnesyl pyrophosphate to humulene and caryophyllene

Dehal, S. S., & Croteau, R. (1988) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(88)90350-5 · Cited by 68 · see citing works

Wound-inducible pinene cyclase from grand fir: Purification, characterization, and renaturation after SDS-PAGE

Lewinsohn, E., Gijzen, M., & Croteau, R. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90380-f · Cited by 63 · see citing works

Expression Pattern of Genes Encoding Farnesyl Diphosphate Synthase and Sesquiterpene Cyclase in Cotton Suspension-Cultured Cells Treated with Fungal Elicitors

Liu, C.-J., Heinstein, P. F., & Chen, X. (1999) · Molecular Plant-Microbe Interactions · doi:10.1094/mpmi.1999.12.12.1095 · Cited by 54 · see citing works

The molecular cloning of 8-epicedrol synthase from Artemisia annua

Hua, L., & Matsuda, S. P. T. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1357 · Cited by 48 · see citing works

Purification and Characterization of an enzyme involved in biochemical transformation of arteannuin B to artemisinin from Artemisia annua

Dhingra, V., & Lakshmi Narasu, M. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.4197 · Cited by 27 · see citing works

Cloning and molecular analysis of two new sesquiterpene cyclases from Artemisia annua L.

Geldre, E. V., Pauw, I. D., Inzé, D., MONTAGU, M. V., & den Eeckhout, E. V. (2000) · Plant Science · doi:10.1016/s0168-9452(00)00322-8 · Cited by 21 · see citing works

Stimulation of Sesquiterpene Aldehyde Formation in Gossypium arboreum Cell Suspension Cultures by Conidia of Verticillium dahliae

Heinstein, P. F. (1985) · Journal of Natural Products · doi:10.1021/np50042a004 · Cited by 21 · see citing works

Aphids, Predators and Parasitoids

Wadhams, L. J., Birkett, M. A., Powell, W., & Woodcock, C. M. (2007) · Novartis Foundation symposium · doi:10.1002/9780470515679.ch5 · Cited by 16 · see citing works

Monoterpene and sesquiterpene synthases and the origin of terpene skeletal diversity in plants

Degenhardt, J., Köllner, T. G., & Gershenzon, J. (2009) · Phytochemistry · doi:10.1016/j.phytochem.2009.07.030 · Cited by 1,095 · see citing works

Arabidopsis MYC2 Interacts with DELLA Proteins in Regulating Sesquiterpene Synthase Gene Expression

Hong, G., Xue, X., Mao, Y., Wang, L.-J., & Chen, X. (2012) · The Plant Cell · doi:10.1105/tpc.112.098749 · Cited by 683 · see citing works

Plant Terpenoids: Biosynthesis and Ecological Functions

Cheng, A., Lou, Y., Mao, Y., Lu, S., Wang, L., & Chen, X. (2007) · Journal of Integrative Plant Biology · doi:10.1111/j.1744-7909.2007.00395.x · Cited by 493 · see citing works

The Jasmonate-Responsive AP2/ERF Transcription Factors AaERF1 and AaERF2 Positively Regulate Artemisinin Biosynthesis in Artemisia annua L.

Yu, Z.-X., Li, J., Yang, C., Hu, W., Wang, L.-J., & Chen, X. (2011) · Molecular Plant · doi:10.1093/mp/ssr087 · Cited by 474 · see citing works

A Maize ( E )-β-Caryophyllene Synthase Implicated in Indirect Defense Responses against Herbivores Is Not Expressed in Most American Maize Varieties

Köllner, T. G., Held, M., Lenk, C., Hiltpold, I., Turlings, T. C. J., Gershenzon, J., & Degenhardt, J. (2008) · The Plant Cell · doi:10.1105/tpc.107.051672 · Cited by 471 · see citing works

Biosynthesis and Emission of Terpenoid Volatiles from Arabidopsis Flowers

Chen, F., Tholl, D., D’Auria, J. C., Farooq, A., Pichersky, E., & Gershenzon, J. (2003) · The Plant Cell · doi:10.1105/tpc.007989 · Cited by 460 · see citing works

Two sesquiterpene synthases are responsible for the complex mixture of sesquiterpenes emitted from Arabidopsis flowers

Tholl, D., Chen, F., Petri, J., Gershenzon, J., & Pichersky, E. (2005) · The Plant Journal · doi:10.1111/j.1365-313x.2005.02417.x · Cited by 363 · see citing works

The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)

Brown, G. D. (2010) · Molecules · doi:10.3390/molecules15117603 · Cited by 363 · see citing works

Tomato linalool synthase is induced in trichomes by jasmonic acid

van Schie, C. C. N., Haring, M. A., & Schuurink, R. C. (2007) · Plant Molecular Biology · doi:10.1007/s11103-007-9149-8 · Cited by 245 · see citing works

Global characterization of Artemisia annua glandular trichome transcriptome using 454 pyrosequencing

Wang, W., Wang, Y., Zhang, Q., Qi, Y., & Guo, D. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-465 · Cited by 224 · see citing works

The rice (E)-β-caryophyllene synthase (OsTPS3) accounts for the major inducible volatile sesquiterpenes

Cheng, A., Xiang, C.-Y., Li, J., Yang, C., Hu, W., Wang, L.-J., Lou, Y., & Chen, X. (2007) · Phytochemistry · doi:10.1016/j.phytochem.2007.04.008 · Cited by 220 · see citing works

Biosynthesis of essential oils in aromatic plants: A review

Rehman, R., Hanif, M. A., Mushtaq, Z., & Al-Sadi, A. M. (2015) · Food Reviews International · doi:10.1080/87559129.2015.1057841 · Cited by 208 · see citing works

Terpenoid biosynthesis in trichomes—current status and future opportunities

Markus Lange, B., & Turner, G. W. (2013) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2012.00737.x · Cited by 195 · see citing works

Protective Effects of (E)-β-Caryophyllene (BCP) in Chronic Inflammation

Scandiffio, R., Geddo, F., Cottone, E., Querio, G., Antoniotti, S., Gallo, M. P., Maffei, M. E., & Bovolin, P. (2020) · Nutrients · doi:10.3390/nu12113273 · Cited by 187 · see citing works

Combined Transcript and Metabolite Analysis Reveals Genes Involved in Spider Mite Induced Volatile Formation in Cucumber Plants

Mercke, P., Kappers, I. F., Verstappen, F. W. A., Vorst, O., Dicke, M., & Bouwmeester, H. J. (2004) · PLANT PHYSIOLOGY · doi:10.1104/pp.104.048116 · Cited by 157 · see citing works

Relative expression of genes of terpene metabolism in different tissues of Artemisia annuaL

Olofsson, L., Engström, A., Lundgren, A., & Brodelius, P. E. (2011) · BMC Plant Biology · doi:10.1186/1471-2229-11-45 · Cited by 144 · see citing works

Isoprenoid biosynthesis in Artemisia annua: cloning and heterologous expression of a germacrene A synthase from a glandular trichome cDNA library

Bertea, C. M., Voster, A., Verstappen, F. W. A., Maffei, M., Beekwilder, J., & Bouwmeester, H. J. (2006) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2006.02.026 · Cited by 134 · see citing works

Expression, purification and characterization of recombinant (E)-β-farnesene synthase from Artemisia annua

Picaud, S., Brodelius, M., & Brodelius, P. E. (2005) · Phytochemistry · doi:10.1016/j.phytochem.2005.03.027 · Cited by 133 · see citing works

Cultivation and genetics of<i>Artemisia annua</i>L. for increased production of the antimalarial artemisinin

Ferreira, J. F. S., Laughlin, J. C., Delabays, N., & de Magalhães, P. M. (2005) · Plant Genetic Resources · doi:10.1079/pgr200585 · Cited by 130 · see citing works

Changing trends in biotechnology of secondary metabolism in medicinal and aromatic plants

Gandhi, S. G., Mahajan, V., & Bedi, Y. S. (2014) · Planta · doi:10.1007/s00425-014-2232-x · Cited by 124 · see citing works

Chemical constituents and biological research on plants in the genus Curcuma

Sun, W. C., Wang, S., Zhao, W., Wu, C., Guo, S., Gao, H., Tao, H., Lu, J., Wang, Y., & Chen, X. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2016.1176554 · Cited by 124 · see citing works

Expression, purification and characterization of recombinant amorpha-4,11-diene synthase from Artemisia annua L.

Picaud, S., Olofsson, L., Brodelius, M., & Brodelius, P. E. (2005) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2005.02.012 · Cited by 117 · see citing works

Effect of arbuscular mycorrhizal (AM) colonization on terpene emission and content of Artemisia annua L.

Rapparini, F., Llusià, J., & Peñuelas, J. (2008) · Plant Biology · doi:10.1055/s-2007-964963 · Cited by 112 · see citing works

Rational engineering of plasticity residues of sesquiterpene synthases from Artemisia annua: product specificity and catalytic efficiency

Li, J., Fang, X., Zhao, Q., Ruan, J.-X., Yang, C., Wang, L.-J., Miller, D. J., Faraldos, J. A., Allemann, R. K., Chen, X., et al. (2013) · Biochemical Journal · doi:10.1042/bj20130041 · Cited by 99 · see citing works

The production of the sesquiterpene β-caryophyllene in a transgenic strain of the cyanobacterium Synechocystis

Reinsvold, R. E., Jinkerson, R. E., Radakovits, R., Posewitz, M. C., & Basu, C. (2010) · Journal of Plant Physiology · doi:10.1016/j.jplph.2010.11.006 · Cited by 97 · see citing works

Artemisinin: the biosynthetic pathway and its regulation in Artemisia annua, a terpenoid-rich species

Weathers, P. J., Elkholy, S., & Wobbe, K. K. (2006) · In Vitro Cellular &amp; Developmental Biology - Plant · doi:10.1079/ivp2006782 · Cited by 97 · see citing works

The co-evolutionary perspective of the food-medicine continuum and wild gathered and cultivated vegetables

Leonti, M. (2012) · Genetic Resources and Crop Evolution · doi:10.1007/s10722-012-9894-7 · Cited by 97 · see citing works

Identification, functional characterization and developmental regulation of sesquiterpene synthases from sunflower capitate glandular trichomes

Göpfert, J. C., MacNevin, G., Ro, D., & Spring, O. (2009) · BMC Plant Biology · doi:10.1186/1471-2229-9-86 · Cited by 96 · see citing works

Transgenic approach to increase artemisinin content in Artemisia annua L.

Tang, K., Shen, Q., Yan, T., & Fu, X. (2014) · Plant Cell Reports · doi:10.1007/s00299-014-1566-y · Cited by 96 · see citing works

Root volatiles in plant–plant interactions I: High root sesquiterpene release is associated with increased germination and growth of plant neighbours

Gfeller, V., Huber, M., Förster, C., Huang, W., Köllner, T. G., & Erb, M. (2019) · Plant Cell & Environment · doi:10.1111/pce.13532 · Cited by 87 · see citing works

Short term UV-B radiation-mediated transcriptional responses and altered secondary metabolism of in vitro propagated plantlets of Artemisia annua L.

Pandey, N., & Rai, S. P. (2013) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-013-0413-0 · Cited by 87 · see citing works

Molecular cloning and functional characterization of α-humulene synthase, a possible key enzyme of zerumbone biosynthesis in shampoo ginger (Zingiber zerumbet Smith)

Yu, F., Okamto, S., Nakasone, K., Adachi, K., Matsuda, S., Harada, H., Misawa, N., & Utsumi, R. (2008) · Planta · doi:10.1007/s00425-008-0700-x · Cited by 87 · see citing works

The organ-specific expression of terpene synthase genes contributes to the terpene hydrocarbon composition of chamomile essential oils

Irmisch, S., Krause, S. T., Kunert, G., Gershenzon, J., Degenhardt, J., & Köllner, T. G. (2012) · BMC Plant Biology · doi:10.1186/1471-2229-12-84 · Cited by 87 · see citing works

Making small molecules in plants: A chassis for synthetic biology‐based production of plant natural products

Liu, X., Zhang, P., Zhao, Q. L., & Huang, A. C. (2022) · Journal of Integrative Plant Biology · doi:10.1111/jipb.13330 · Cited by 85 · see citing works

High-density biosynthetic fuels: the intersection of heterogeneous catalysis and metabolic engineering

Harvey, B. G., Meylemans, H. A., Gough, R. V., Quintana, R. L., Garrison, M. D., & Bruno, T. J. (2014) · Physical Chemistry Chemical Physics · doi:10.1039/c3cp55349c · Cited by 83 · see citing works

AaPDR3, a PDR Transporter 3, Is Involved in Sesquiterpene β-Caryophyllene Transport in Artemisia annua

Fu, X., Shi, P., He, Q., Shen, Q., Tang, Y., Pan, Q., Ma, Y., Yan, T., Chen, M., Hao, X., et al. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.00723 · Cited by 79 · see citing works

Identification and Characterization of Terpene Synthases Potentially Involved in the Formation of Volatile Terpenes in Carrot (Daucus carota L.) Roots

Yahyaa, M., Tholl, D., Cormier, G., Jensen, R. V., Simon, P. W., & Ibdah, M. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b00546 · Cited by 80 · see citing works

Branch Pathway Blocking inArtemisia annuais a Useful Method for Obtaining High Yield Artemisinin

Lv, Z., Zhang, F., Pan, Q., Fu, X., Jiang, W., Shen, Q., Yan, T., Shi, P., Lu, X., Sun, X., et al. (2016) · Plant and Cell Physiology · doi:10.1093/pcp/pcw014 · Cited by 78 · see citing works

Enhancing artemisinin content in and delivery from Artemisia annua: a review of alternative, classical, and transgenic approaches

Wani, K. I., Choudhary, S., Zehra, A., Naeem, M., Weathers, P., & Aftab, T. (2021) · Planta · doi:10.1007/s00425-021-03676-3 · Cited by 74 · see citing works

Does egg deposition by herbivorous pine sawflies affect transcription of sesquiterpene synthases in pine?

Köpke, D., Schröder, R., Fischer, H. M., Gershenzon, J., Hilker, M., & Schmidt, A. (2008) · Planta · doi:10.1007/s00425-008-0747-8 · Cited by 73 · see citing works

Hypericum sp.: essential oil composition and biological activities

Guedes, A. P., Franklin, G., & Fernandes‐Ferreira, M. (2012) · Phytochemistry Reviews · doi:10.1007/s11101-012-9223-y · Cited by 69 · see citing works

Isolation and characterization of terpene synthases in cotton (Gossypium hirsutum)

Yang, C., Wu, X., Ruan, J.-X., Hu, W., Mao, Y.-B., Chen, X., & Wang, L.-J. (2013) · Phytochemistry · doi:10.1016/j.phytochem.2013.09.009 · Cited by 67 · see citing works

Cloning, expression, purification and characterization of recombinant (+)-germacrene D synthase from Zingiber officinale

Picaud, S., Olsson, M. E., Brodelius, M., & Brodelius, P. E. (2006) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2006.06.007 · Cited by 66 · see citing works

From Plant to Yeast—Advances in Biosynthesis of Artemisinin

Zhao, L., Zhu, Y., Jia, H., Han, Y., Zheng, X., Wang, M., & Feng, W. (2022) · Molecules · doi:10.3390/molecules27206888 · Cited by 64 · see citing works

Terpenoid trans ‐caryophyllene inhibits weed germination and induces plant water status alteration and oxidative damage in adult Arabidopsis

Araniti, F., Sánchez‐Moreiras, A. M., Graña, E., Reigosa, M. J., & Abenavoli, M. R. (2016) · Plant Biology · doi:10.1111/plb.12471 · Cited by 63 · see citing works

The molecular basis of invasiveness: differences in gene expression of native and introduced common ragweed ( A mbrosia artemisiifolia) in stressful and benign environments

Hodgins, K. A., Lai, Z., Nurkowski, K. A., Huang, J., & Rieseberg, L. H. (2013) · Molecular Ecology · doi:10.1111/mec.12179 · Cited by 62 · see citing works

De novo formation of an aggregation pheromone precursor by an isoprenyl diphosphate synthase-related terpene synthase in the harlequin bug

Lancaster, J., Khrimian, A., Young, S., Lehner, B., Luck, K., Wallingford, A. K., Ghosh, S., Zerbe, P., Muchlinski, A., Marek, P. E., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1800008115 · Cited by 61 · see citing works

Evolution of a Strategy for the Enantioselective Total Synthesis of (+)-Psiguadial B

Chapman, L. M., Beck, J. C., Lacker, C. R., Wu, L., & Reisman, S. E. (2018) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.8b00728 · Cited by 60 · see citing works

Enhancing fluxes through the mevalonate pathway in Saccharomyces cerevisiae by engineering the HMGR and β‐alanine metabolism

Lu, S., Zhou, C., Guo, X., Du, Z., Cheng, Y., Wang, Z., & He, X. (2022) · Microbial Biotechnology · doi:10.1111/1751-7915.14072 · Cited by 58 · see citing works

The bZIP transcription factor HY5 interacts with the promoter of the monoterpene synthase gene QH6 in modulating its rhythmic expression

Zhou, F., Sun, T., Жао, Л., Pan, X., & Lu, S. (2015) · Frontiers in Plant Science · doi:10.3389/fpls.2015.00304 · Cited by 57 · see citing works

Engineering Escherichia coli to convert acetic acid to β-caryophyllene

Yang, J., & Nie, Q. (2016) · Microbial Cell Factories · doi:10.1186/s12934-016-0475-x · Cited by 57 · see citing works

Increased Accumulation of Artemisinin and Anthocyanins in Artemisia annua Expressing the Arabidopsis Blue Light Receptor CRY1

Hong, G., Hu, W., Li, J., Chen, X., & Wang, L.-J. (2009) · Plant Molecular Biology Reporter · doi:10.1007/s11105-008-0088-6 · Cited by 55 · see citing works

Plant specialized metabolism: Diversity of terpene synthases and their products

Bergman, M. E., & Dudareva, N. (2024) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2024.102607 · Cited by 48 · see citing works

Modulations of physiological responses and possible involvement of defense-related secondary metabolites in acclimation of Artemisia annua L. against short-term UV-B radiation

Pandey, N., & Rai, S. P. (2014) · Planta · doi:10.1007/s00425-014-2114-2 · Cited by 49 · see citing works

Expression of key genes affecting artemisinin content in five Artemisia species

Salehi, M., Karimzadeh, G., Naghavi, M. R., Naghdi Badi, H., & Rashidi Monfared, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-31079-0 · Cited by 44 · see citing works

An IDS-Type Sesquiterpene Synthase Produces the Pheromone Precursor (Z)-α-Bisabolene in Nezara viridula

Lancaster, J., Lehner, B., Khrimian, A., Muchlinski, A., Luck, K., Köllner, T. G., Weber, D. C., Gundersen‐Rindal, D. E., & Tholl, D. (2018) · Journal of Chemical Ecology · doi:10.1007/s10886-018-1019-0 · Cited by 41 · see citing works

Synergistic re-channeling of mevalonate pathway for enhanced artemisinin production in transgenic Artemisia annua

Feng, L.-L., Yang, R.-Y., Yang, X.-Q., Zeng, X.-M., Lu, W.-J., & Zeng, Q.-P. (2009) · Plant Science · doi:10.1016/j.plantsci.2009.03.014 · Cited by 39 · see citing works

Important Secondary Metabolites and Essential Oils of Species Within the Anthemideae (Asteraceae)

da Silva, J. A. T., Yonekura, L., Kaganda, J., Mookdasanit, J., Nhựt, D. T., & Afach, G. (2005) · Journal of Herbs Spices & Medicinal Plants · doi:10.1300/j044v11n01_01 · Cited by 39 · see citing works

Cloning, expression and wounding induction of -caryophyllene synthase gene from Mikania micrantha H.B.K. and allelopathic potential of -caryophyllene

Wang, R., Peng, S., Zeng, R., Ding, L., & Xu, Z. (2009) · Cited by 37 · see citing works

Calamintha nepeta L. (Savi) as source of phytotoxic compounds: bio-guided fractionation in identifying biological active molecules

Araniti, F., Lupini, A., Mercati, F., Statti, G. A., & Abenavoli, M. R. (2013) · Acta Physiologiae Plantarum · doi:10.1007/s11738-013-1236-7 · Cited by 34 · see citing works

Biosynthesis of β-caryophyllene, a novel terpene-based high-density biofuel precursor, using engineered Escherichia coli

Yang, J., Li, Z., Guo, L., Du, J., & Bae, H. (2016) · Renewable Energy · doi:10.1016/j.renene.2016.06.061 · Cited by 34 · see citing works

An assessment of growth, floral morphology, and metabolites of a medicinal plant Sida cordifolia L. under the influence of elevated ozone

Ansari, N., Agrawal, M., & Agrawal, S. B. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-10340-y · Cited by 32 · see citing works

Responses of Mikania micrantha, an Invasive Weed to Elevated CO2: Induction of β-Caryophyllene Synthase, Changes in Emission Capability and Allelopathic Potential of β-Caryophyllene

Wang, R., Staehelin, C., Peng, S., Wang, W., Xie, X.-M., & Hui-ning, L. (2010) · Journal of Chemical Ecology · doi:10.1007/s10886-010-9843-x · Cited by 29 · see citing works

Characterization of α-humulene synthases responsible for the production of sesquiterpenes induced by methyl jasmonate in Aquilaria cell culture

Kumeta, Y., & Ito, M. (2016) · Journal of Natural Medicines · doi:10.1007/s11418-016-0999-8 · Cited by 28 · see citing works

Novel insights into the molecular mechanisms underlying the resistance of Camellia sinensis to Ectropis oblique provided by strategic transcriptomic comparisons

Wang, D., Li, C., Ma, C.-L., & Chen, L. (2015) · Scientia Horticulturae · doi:10.1016/j.scienta.2015.06.005 · Cited by 26 · see citing works

Studies on the Expression of Sesquiterpene Synthases Using Promoter-β-Glucuronidase Fusions in Transgenic Artemisia annua L

Wang, H., Han, J., Kanagarajan, S., Lundgren, A., & Brodelius, P. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080643 · Cited by 25 · see citing works

Identification and characterization of (+)-α-bisabolol and 7-epi-silphiperfol-5-ene synthases from Artemisia abrotanum

Muangphrom, P., Misaki, M., Suzuki, M., Shimomura, M., Suzuki, H., Seki, H., & Muranaka, T. (2019) · Phytochemistry · doi:10.1016/j.phytochem.2019.05.010 · Cited by 24 · see citing works

Evolution of isoprenyl diphosphate synthase-like terpene synthases in fungi

Wei, G., Eberl, F., Chen, X., Zhang, C., Unsicker, S. B., Köllner, T. G., Gershenzon, J., & Chen, F. (2020) · Scientific Reports · doi:10.1038/s41598-020-71219-z · Cited by 25 · see citing works

Amorpha-4,11-diene synthase: a key enzyme in artemisinin biosynthesis and engineering

Huang, J. Q., & Fang, X. (2021) · aBIOTECH · doi:10.1007/s42994-021-00058-x · Cited by 24 · see citing works

Enhancement of β-Caryophyllene Biosynthesis in Saccharomyces cerevisiae via Synergistic Evolution of β-Caryophyllene Synthase and Engineering the Chassis

Lu, S., Deng, H. X., Zhou, C., Du, Z., Guo, X., Cheng, Y., & He, X. (2023) · ACS Synthetic Biology · doi:10.1021/acssynbio.3c00024 · Cited by 23 · see citing works

Manual de Frascati

y Tecnología, F. E. C. (2010) · La Sociología en sus Escenarios · Cited by 23 · see citing works

An Update on Microbial Biosynthesis of β-Caryophyllene, a Sesquiterpene with Multi-Pharmacological Properties

Tsigoriyna, L., Sango, C., & Batovska, D. I. (2024) · Fermentation · doi:10.3390/fermentation10010060 · Cited by 23 · see citing works

Functional characterization and transient expression manipulation of a new sesquiterpene synthase involved in β-caryophyllene accumulation in Ocimum

Jayaramaiah, R. H., Anand, A., Beedkar, S. D., Dholakia, B. B., Punekar, S. A., Kalunke, R. M., Gade, W., Thulasiram, H. V., & Giri, A. P. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.03.090 · Cited by 20 · see citing works

Transcriptome Sequencing of Two Phenotypic Mosaic Eucalyptus Trees Reveals Large Scale Transcriptome Re-Modelling

Padovan, A., Patel, H. R., Chuah, A., Huttley, G. A., Krause, S. T., Degenhardt, J., Foley, W. J., & Külheim, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123226 · Cited by 20 · see citing works

Cloning of a sesquiterpene synthase from Lavandula x intermedia glandular trichomes

Sarker, L. S., Demissie, Z. A., & Mahmoud, S. S. (2013) · Planta · doi:10.1007/s00425-013-1937-6 · Cited by 20 · see citing works

Silencing amorpha-4,11-diene synthase Genes in Artemisia annua Leads to FPP Accumulation

Catania, T. M., Branigan, C. A., Stawniak, N., Hodson, J., Harvey, D., Larson, T. R., Czechowski, T., & Graham, I. A. (2018) · Frontiers in Plant Science · doi:10.3389/fpls.2018.00547 · Cited by 20 · see citing works

Molecular cloning and functional characterization of three terpene synthases from unripe fruit of black pepper (Piper nigrum)

Jin, Z., Kwon, M., Lee, A., Ro, D., Wungsintaweekul, J., & Kim, S.-U. (2017) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2017.12.011 · Cited by 19 · see citing works

Zucchini Plants Alter Gene Expression and Emission of (E)-β-Caryophyllene Following Aphis gossypii Infestation

Vitiello, A., Molisso, D., Digilio, M. C., Giorgini, M., Corrado, G., Bruce, T. J. A., D’Agostino, N., & Rao, R. (2021) · Frontiers in Plant Science · doi:10.3389/fpls.2020.592603 · Cited by 18 · see citing works

Transient expression and purification of β-caryophyllene synthase in Nicotiana benthamiana to produce β-caryophyllene in vitro

Muthusamy, S., Vetukuri, R. R., Lundgren, A., Ganji, S., Zhu, L., Brodelius, P. E., & Kanagarajan, S. (2020) · PeerJ · doi:10.7717/peerj.8904 · Cited by 19 · see citing works

Purification and biochemical characterization of recombinant Persicaria minor β -sesquiphellandrene synthase

Ker, D., Pang, S. L., Othman, N. F., Kumaran, S., Tan, E.-F., Krishnan, T., Chan, K., Othman, R., Hassan, M., & Ng, C. L. (2017) · PeerJ · doi:10.7717/peerj.2961 · Cited by 17 · see citing works

Homologous and heterologous expression of grapevine E-(β)-caryophyllene synthase (VvGwECar2)

Salvagnin, U., Carlin, S., Angeli, S., Vrhovšek, U., Anfora, G., Malnoy, M., & Martens, S. (2016) · Phytochemistry · doi:10.1016/j.phytochem.2016.08.002 · Cited by 15 · see citing works

Iron oxide nanoparticles and light intensity modulate biomass, antioxidant capacity and anti-leishmanial activity in callus cultures of Artemisia scoparia

Yousaf, R., Khan, M. A., Raza, A., Ambreen, A., Ali, H., Darwish, H., Alharbi, K., Kashgry, N. A. T. A., & Noureldeen, A. (2025) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-025-02972-0 · Cited by 14 · see citing works

Identification and characterization of terpene synthase OjTPS1 involved in β-caryophyllene biosynthesis in Oenanthe javanica (Blume) DC.

Feng, K., Kan, X.-Y., Yan, Y.-J., Wang, Y., Sun, N., Yang, Z.-Y., Zhao, S., Wu, P., & Li, L. (2022) · Industrial Crops and Products · doi:10.1016/j.indcrop.2022.115998 · Cited by 14 · see citing works

Systematic engineering of the sterol synthesis pathway for Saccharomyces cerevisiae promotes the efficient production of β-caryophyllene

Zhang, Y., Liu, C., Li, W., Ma, Z., Lv, B., Qin, L., & Li, C. (2025) · Metabolic Engineering · doi:10.1016/j.ymben.2025.06.004 · Cited by 14 · see citing works

Bacterial transformation of terpenoids

Grishko, V. V., Nogovitsina, Y. M., & Ившина, И. Б. (2014) · Russian Chemical Reviews · doi:10.1070/rc2014v083n04abeh004396 · Cited by 12 · see citing works

Enhanced Production of β-Caryophyllene by Farnesyl Diphosphate Precursor-Treated Callus and Hairy Root Cultures of Artemisia vulgaris L.

Balasubramani, S., Kumari, B. D. R., Moola, A. K., Sathish, D., Kumar, G. P., Srimurali, S., & Rajendran, R. B. (2021) · Frontiers in Plant Science · doi:10.3389/fpls.2021.634178 · Cited by 12 · see citing works

Studies on the expression of linalool synthase using a promoter-β-glucuronidase fusion in transgenic Artemisia annua

Wang, H., Kanagarajan, S., Han, J., Hao, M.-S., Yang, Y., Lundgren, A., & Brodelius, P. E. (2013) · Journal of Plant Physiology · doi:10.1016/j.jplph.2013.09.019 · Cited by 11 · see citing works

Highly Oxygenated Caryophyllene-Type Sesquiterpenes from a Plant-Associated Fungus, Pestalotiopsis hainanensis, and Their Biosynthetic Gene Cluster

Zhang, Y., Bai, J., Yan, D., Liu, B., Zhang, L., Zhang, C., Chen, M., Mou, Y., & Hu, Y. (2020) · Journal of Natural Products · doi:10.1021/acs.jnatprod.0c00501 · Cited by 11 · see citing works

Promoter variations in DBR2-like affect artemisinin production in different chemotypes of Artemisia annua

Wang, X., Wu, L., Li, X., Gao, R., Yin, Q., Wang, M., Liu, Z., Leng, L., Su, Y., Wan, H., et al. (2023) · Horticulture Research · doi:10.1093/hr/uhad164 · Cited by 10 · see citing works

Functional characterization of (E)-β-caryophyllene synthase from lima bean and its up-regulation by spider mites and alamethicin

Li, F., Fu, N., Zhou, J., & Wang, G. (2017) · Journal of Integrative Agriculture · doi:10.1016/s2095-3119(16)61593-9 · Cited by 11 · see citing works

Molecular Biology of Glandular Trichomes and Their Functions in Environmental Stresses

Kundan, M., Gani, U., Nautiyal, A. K., & Misra, P. (2019) · Energy, environment, and sustainability · doi:10.1007/978-981-15-0690-1_17 · Cited by 12 · see citing works

Citrus somatic allotetraploid hybrids exhibit a differential reduction of leaf sesquiterpenoid biosynthesis compared with their parents

Gancel, A., Ollitrault, P., Froelicher, Y., Tomi, F., Jacquemond, C., Luro, F. L., & Brillouet, J. (2005) · Flavour and Fragrance Journal · doi:10.1002/ffj.1512 · Cited by 11 · see citing works

Functional analysis of orthologous artemisinic aldehyde Δ11(13)-reductase reveals potential artemisinin-producing activity in non-artemisinin-producing Artemisia absinthium

Muangphrom, P., Suzuki, M., Seki, H., Fukushima, E. O., & Muranaka, T. (2014) · Plant Biotechnology · doi:10.5511/plantbiotechnology.14.0807a · Cited by 10 · see citing works

Chemical composition of the essential oil of Eremostachys Laevigata bung

Amiri, H., Alsadat, M. H. M., & Yazdi, H. L. (2007) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 10 · see citing works

Essential Oil Composition ofCentaurea atropurpureaandCentaurea orientalisInflorescences from the Central Balkans – Ecological Significance and Taxonomic Implications

Novaković, J., Rajčević, N. F., Milanovici, S. J., Marin, P. D., & Janaćković, P. (2016) · Chemistry & Biodiversity · doi:10.1002/cbdv.201600029 · Cited by 10 · see citing works

Identification and Functional Characterization of Tissue-Specific Terpene Synthases in Stevia rebaudiana

Dhandapani, S., Kim, M. J., Chin, H. J., Leong, S. H., & Jang, I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228566 · Cited by 10 · see citing works

Efficient biosynthesis of β-caryophyllene in Saccharomyces cerevisiae by β-caryophyllene synthase from Artemisia argyi

Li, Z., Gan, Y., Gou, C., Ye, Q., Wu, Y., Wu, Y., Yang, T., Fan, B., Ji, A., Shen, Q., et al. (2024) · Synthetic and Systems Biotechnology · doi:10.1016/j.synbio.2024.09.005 · Cited by 9 · see citing works

Red and blue light-mediated physiological and metabolic insights in Artemisia annua L.

Rai, N., Ansari, N., Apoorva, Kumari, S., Singh, S., Saha, P., Bisen, M. S., & Rai, S. P. (2024) · Industrial Crops and Products · doi:10.1016/j.indcrop.2024.119879 · Cited by 9 · see citing works

High-Level Patchoulol Biosynthesis in Artemisia annua L.

Fu, X., Zhang, F., Ma, Y., Hassani, D., Peng, B., Pan, Q., Zhang, Y., Deng, Z., Liu, W., Zhang, J., et al. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.621127 · Cited by 9 · see citing works

Metabolie Engineering of Floral Scent of Ornamentals

Dudareva, N., & Pichersky, E. (2006) · Journal of Crop Improvement · doi:10.1300/j411v18n01_02 · Cited by 9 · see citing works

Cloning, Expression, and Characterization of epi-Cedrol Synthase, a Sesquiterpene Cyclase from Artemisia annua L

Mercke, P., Crock, J., Croteau, R., & Brodelius, P. E. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1358 · Cited by 127 · see citing works

Functional characterization of (E)-β-caryophyllene synthase from lima bean and its up-regulation by spider mites and alamethicin

Li, F., Fu, N., Zhou, J., & Wang, G. (2017) · Journal of Integrative Agriculture · doi:10.1016/s2095-3119(16)61593-9 · Cited by 11 · see citing works

Cloning, E. coli Expression and Molecular Analysis of a Novel Sesquiterpene Synthase Gene from Artemisia annua

Liu, Y., Ye, H., & Li, G. (2002) · Europe PMC (PubMed Central) · Cited by 8 · see citing works

Expression, purification and characterization of recombinant (E)-β-farnesene synthase from Artemisia annua

Picaud, S., Brodelius, M., & Brodelius, P. E. (2005) · Phytochemistry · doi:10.1016/j.phytochem.2005.03.027 · Cited by 133 · see citing works

Molecular Cloning, Expression, and Characterization of Amorpha-4,11-diene Synthase, a Key Enzyme of Artemisinin Biosynthesis in Artemisia annua L.

Mercke, P., Bengtsson, M., Bouwmeester, H. J., Posthumus, M. A., & Brodelius, P. E. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.1962 · Cited by 283 · see citing works