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Cited by 690

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Probabilistic epigenesis

Gottlieb, Gilbert·2007·Developmental Science

Abstract

The notion that phenotypic traits, including behavior, can be predetermined has slowly given way in biology and psychology over the last two decades. This shift in thinking is due in large part to the growing evidence for the fundamental role of developmental processes in the generation of the stability and variations in phenotype that researchers in developmental and evolutionary sciences seek to understand. Here I review the tenets of a metatheoretical model of development called probabilistic epigenesis (PE) and explore its implications for furthering our understanding of developmental and evolutionary processes. The PE framework emphasizes the reciprocity of influences within and between levels of an organism's developmental manifold (genetic activity, neural activity, behavior, and the physical, social, and cultural influences of the external environment) and the ubiquity of gene–environment interaction in the realization of all phenotypes.

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Cites

  • Childhood Adversity, Monoamine Oxidase A Genotype, and Risk for ConductDisorder

    Foley, D. L., Eaves, L. J., Wormley, B., Silberg, J. L., Maes, H. H., Kuhn, J., & Riley, B. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.7.738 · Cited by 564 · cited 1×

    “If the reaction-range idea were correct and the genes coded for a range of learning ability (brackets on the right side of Gottesman’s Figure 4), when these rat strains were reared under enriched or restricted conditions, the relative difference between them would be preserved. Instead, the experiment shows the genes…”
  • Child Development and Neuroscience.

    Nelson, C. A., & Bloom, F. E. (1997) · Child Development · doi:10.1111/j.1467-8624.1997.tb01974.x · Cited by 236

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Metadata

Authors
Gottlieb, G.
Venue
Developmental Science
Publisher
Wiley
Published
2006-12-20
Volume
10
Issue
1
Pages
1-11
ISSN
  • 1363-755X (ISSN-L)
  • 1467-7687
OpenAlex
W4248744448
Cited by
690
References
2
FWCI
61.53
Type
journal article
Language
en
Open access
closed

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Gottlieb, G. (2007). Probabilistic epigenesis. Developmental Science. https://doi.org/10.1111/j.1467-7687.2007.00556.x

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