Developmental change in the ERP responses to familiar faces in toddlers with autism spectrum disorders versus typical development
Open accessAbstract
Individuals with autism spectrum disorder (ASD) show differences in face processing abilities from early in development. To examine whether these differences reflect an atypical versus delayed developmental trajectory, neural responses to familiar and unfamiliar faces in twenty-four 18- to 47-month-old children with ASD were compared with responses of thirty-two 12- to 30-month-old typically developing children. Results of 2 experiments revealed that neural responses to faces in children with ASD resembled those observed in younger typically developing children, suggesting delayed development. Electrophysiological responses to faces were also related to parent report of adaptive social behaviors for both children with ASD and typical development. Slower development of the face processing system in ASD may be related to reduced self-directed “expected” experience with faces in early development.
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Research has documented atypical EEG activity in young children with autism spectrum disorder in response to faces.
“Research has documented atypical patterns of EEG activity in young children with ASD in response to face stimuli.7–9”
From Early Behavioral Intervention Is Associated With Normalized Brain Activity in Young Children With Autism (2012) · cites this paper as [9]
The atypical EEG response in autism spectrum disorder involves delays in the development of the Nc attention-related event-related potential and the N290/N170 face-processing component.
“This atypical response is characterized by delays in the development of an attention-related event-related potential (ERP) component, the Nc, and a face-specific perceptual processing component, the N290 (and later in development, the N170).8,9”
From Early Behavioral Intervention Is Associated With Normalized Brain Activity in Young Children With Autism (2012) · cites this paper as [9]
The extent of the developmental delay in how facial familiarity modulates attention-related neural responses in toddlers with ASD relates to their general social level.
“Further, toddlers with ASD show developmental delays in how facial familiarity modulates attention-related neural responses, and the extent of the developmental delay relates to their general social level [27].”
Toddlers with ASD show developmental delays in how facial familiarity modulates attention-related neural responses.
“Further, toddlers with ASD show developmental delays in how facial familiarity modulates attention-related neural responses, and the extent of the developmental delay relates to their general social level [27].”
Previous work with toddlers with ASD has shown that the modulation of the Nc by facial familiarity is atypical.
“Previous work with toddlers with ASD has shown that the modulation of the Nc by facial familiarity is atypical [27].”
Toddlers and young children with ASD show developmentally delayed modulation of the Nc by facial familiarity, such that responses resemble those seen in younger typically developing toddlers.
“toddlers and young children with ASD show developmentally delayed modulation of the Nc by facial familiarity, such that responses resemble those seen in younger typically developing toddlers [27].”
The progressive decrease in interest in faces seen in infants with later ASD over the second year of life may fail to reinforce this initially advanced developmental trajectory of the face recognition system, leading to the gradual emergence of relatively slower learning and delayed neural correlates of face processing.
“Subsequently, the progressive decrease in interest in faces seen in infants with later ASD over the second year of life may fail to reinforce this initially advanced developmental trajectory of the face recognition system, leading to the gradual emergence of relatively slower learning [22] and delayed neural correlates of face processing [27].”
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“Further, toddlers with ASD show developmental delays in how facial familiarity modulates attention-related neural responses, and the extent of the developmental delay relates to their general social level [27].”
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Self-citationIncreased cortical reactivity to repeated tones at 8 months in infants with later ASD
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Self-citation
- Authors
- Webb, S. J., Jones, E. J. H., Merkle, K., Venema, K., Greenson, J., Murias, M., & Dawson, G.
- Affiliations
- University of Washington (US)
- Vanderbilt University (US)
- University of Washington
- University of Washington, Autism Speaks, and University of North Carolina
- Corresponding author
- Webb, Sara Jane
- Venue
- Child Development
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-11-01
- Volume
- 82
- Issue
- 6
- Pages
- 1868-1886
- ISSN
- 0009-3920 (ISSN-L)
- 1467-8624
- PMC
- PMC4141561
- OpenAlex
- W2161635825
- Cited by
- 76
- References
- 79
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 4 · 2023: 1 · 2022: 5 · 2021: 7 · 2020: 6 · 2019: 4 · 2018: 1 · 2017: 5 · 2016: 9 · 2015: 6 · 2014: 11 · 2013: 2 · 2012: 5
- FWCI
- 3.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Child Development (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- BIROn (Birkbeck, University of London) (submittedVersion)
- Funders
- Autism Speaks (AS2140)
- National Institute of Mental Health (U54MH066399)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD064820, P50HD055782)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Social Sciences › Psychology › Developmental and Educational Psychology › Child and Animal Learning Development
- Keywords
- autism spectrum disorder, face processing, event-related potentials, toddlers, developmental delay, familiar faces, social behavior
- MeSH terms
- Age Factors, Cerebral Cortex, Developmental Disabilities, Child Development Disorders, Pervasive, Child, Preschool, Dominance, Cerebral, Electroencephalography, Evoked Potentials, Face, Female, Humans, Infant, Male, Pattern Recognition, Visual, Reaction Time, Reference Values, Signal Processing, Computer-Assisted, Social Behavior, Recognition, Psychology
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