Gene–Environment Interactions in the Etiology of Human Violence
Abstract
This chapter reviews the current research on gene-environment interactions (G × E) with regard to human violence. Findings are summarized from both behavioral and molecular genetic studies that have investigated the interplay of genetic and environmental factors in terms of influencing violence-related behavior. Together, these studies reveal promising evidence that genetic factors combine with environmental influences to impact on the development of violent behavior and related phenotypes. G × E have been identified for a number of candidate genes implicated in violence. Moreover, the reviewed G × E were found to extend to a broad range of environmental characteristics, including both adverse and favorable conditions. As has been the case with other G × E research, findings have been mixed, with considerable heterogeneity between studies. Lack of replication together with serious methodological limitations remains a major challenge for drawing definitive conclusions about the nature of violence-related G × E. In order to fulfill its potential, it is recommended that future G × E research needs to shift its focus to dissecting the neural mechanisms and the underlying pathophysiological pathways by which genetic variation may influence differential susceptibility to environmental exposures.
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Human aggression has a complex genetic architecture that interacts with environmental factors.
“Its complex genetic architecture interacts with environmental factors [7–9].”
From An integrated analysis of genes and functional pathways for aggression in human and rodent models (2019) · cites this paper as [9]
Cites
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120 · see citing works
Role of genotype in the cycle of violence in maltreated children
Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., Taylor, A., & Poulton, R. (2002) · Science · doi:10.1126/science.1072290 · Cited by 4,842 · see citing works
Beyond diathesis stress: differential susceptibility to environmental influences
Belsky, J., & Pluess, M. (2009) · Psychological Bulletin · doi:10.1037/a0017376 · Cited by 3,039 · see citing works
Personal genomes: The case of the missing heritability
Maher, B. (2008) · Nature · doi:10.1038/456018a · Cited by 1,737 · see citing works
For Better <i>and</i> For Worse: Differential Susceptibility to Environmental Influences
Belsky, J., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2007) · Current Directions in Psychological Science · doi:10.1111/j.1467-8721.2007.00525.x · Cited by 1,515 · see citing works
Caspi, A., Moffitt, T. E., Cannon, M., McClay, J., Murray, R., Harrington, H., Taylor, A., Arseneault, L., Williams, B., Braithwaite, A., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.026 · Cited by 1,409 · see citing works
Caspi, A., Hariri, A. R., Holmes, A., Uher, R., & Moffitt, T. E. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09101452 · Cited by 1,346 · see citing works
Rhee, S. H., & Waldman, I. D. (2002) · Psychological Bulletin · doi:10.1037/0033-2909.128.3.490 · Cited by 1,266 · see citing works
Epigenetics and the biological definition of gene×environment interactions
Meaney, M. J. (2010) · Child Development · doi:10.1111/j.1467-8624.2009.01381.x · Cited by 1,239 · see citing works
Kim-Cohen, J., Caspi, A., Taylor, A., Williams, B., Newcombe, R., Craig, I. W., & Moffitt, T. E. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001851 · Cited by 1,158 · see citing works
Gene-environment interplay and psychopathology: multiple varieties but real effects
Rutter, M., Moffitt, T. E., & Caspi, A. (2006) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2005.01557.x · Cited by 1,058 · see citing works
Duncan, L. E., & Keller, M. C. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11020191 · Cited by 1,032 · see citing works
Vulnerability genes or plasticity genes?
Belsky, J., Jonassaint, C., Pluess, M., Stanton, M., Brummett, B., & Williams, R. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.44 · Cited by 1,017 · see citing works
Moffitt, T. E. (2005) · Psychological Bulletin · doi:10.1037/0033-2909.131.4.533 · Cited by 785 · see citing works
Strategy for Investigating Interactions Between Measured Genes and Measured Environments
Moffitt, T. E., Caspi, A., & Rutter, M. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.5.473 · Cited by 784 · see citing works
Gene–environment-wide association studies: emerging approaches
Thomas, D. C. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2764 · Cited by 694 · see citing works
Psychophysiology of aggression, psychopathy, and conduct problems: A meta-analysis
Lorber, M. F. (2004) · Psychological Bulletin · doi:10.1037/0033-2909.130.4.531 · Cited by 648 · see citing works
Childhood Adversity, Monoamine Oxidase A Genotype, and Risk for ConductDisorder
Foley, D. L., Eaves, L. J., Wormley, B., Silberg, J. L., Maes, H. H., Kuhn, J., & Riley, B. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.7.738 · Cited by 564 · see citing works
Bakermans‐Kranenburg, M. J., & van IJzendoorn, M. H. (2011) · Development and Psychopathology · doi:10.1017/s0954579410000635 · Cited by 533 · see citing works
Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2006) · Developmental Psychobiology · doi:10.1002/dev.20152 · Cited by 526 · see citing works
Gatt, J. M., Nemeroff, C. B., Dobson-Stone, C., Paul, R. H., Bryant, R. A., Schofield, P. R., Gordon, E., Kemp, A. H., & Williams, L. M. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.143 · Cited by 525 · see citing works
Genetic-Environmental Interaction in the Genesis of Aggressivity and Conduct Disorders
Cadoret, R. J. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950230030006 · Cited by 522 · see citing works
Uher, R., & McGuffin, P. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002067 · Cited by 507 · see citing works
Heart Rate Level and Antisocial Behavior in Children and Adolescents: A Meta-Analysis
ORTIZ, J., & Raine, A. (2004) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200402000-00010 · Cited by 479 · see citing works
Bakermans-Kranenburg, M. J., Van IJzendoorn, M. H., Pijlman, F. T. A., Mesman, J., & Juffer, F. (2008) · Developmental Psychology · doi:10.1037/0012-1649.44.1.293 · Cited by 479 · see citing works
The endophenotype concept in psychiatric genetics
FLINT, J., & MUNAFÒ, M. R. (2007) · Psychological Medicine · doi:10.1017/s0033291706008750 · Cited by 477 · see citing works
Neural substrates of pleiotropic action of genetic variation in COMT: a meta-analysis
Mier, D., Kirsch, P., & Meyer-Lindenberg, A. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.36 · Cited by 464 · see citing works
Moffitt, T. E., Caspi, A., & Rutter, M. (2006) · Perspectives on Psychological Science · doi:10.1111/j.1745-6916.2006.00002.x · Cited by 389 · see citing works
Monoamine oxidase A gene (MAOA) predicts behavioral aggression following provocation
McDermott, R., Tingley, D., Cowden, J., Frazzetto, G., & Johnson, D. D. P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808376106 · Cited by 384 · see citing works
MAOA and the neurogenetic architecture of human aggression
Buckholtz, J. W., & Meyer‐Lindenberg, A. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2007.12.006 · Cited by 358 · see citing works
Widom, C. S., & Brzustowicz, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.039 · Cited by 349 · see citing works
JAFFEE, S. R., CASPI, A., MOFFITT, T. E., DODGE, K. A., RUTTER, M., TAYLOR, A., & TULLY, L. A. (2005) · Development and Psychopathology · doi:10.1017/s0954579405050042 · Cited by 328 · see citing works
An Adoption Study of Antisocial Personality
Crowe, R. (1974) · Archives of General Psychiatry · doi:10.1001/archpsyc.1974.01760180027003 · Cited by 302 · see citing works
Kahn, R. S., Khoury, J. C., Nichols, W. C., & Lanphear, B. P. (2003) · The Journal of Pediatrics · doi:10.1016/s0022-3476(03)00208-7 · Cited by 284 · see citing works
Haberstick, B. C., Lessem, J. M., Hopfer, C. J., Smolen, A., Ehringer, M. A., Timberlake, D., & Hewitt, J. K. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30176 · Cited by 277 · see citing works
Reif, A., Rösler, M., Freitag, C. M., Schneider, M., Eujen, A., Kissling, C., Wenzler, D., Jacob, C. P., Retz-Junginger, P., Thome, J., et al. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301359 · Cited by 277 · see citing works
Evidence for gene-environment interaction in the development of adolescent antisocial behavior
Cadoret, R. J., Cain, C. A., & Crowe, R. R. (1983) · Behavior Genetics · doi:10.1007/bf01071875 · Cited by 271 · see citing works
Huang, Y., Cate, S. P., Battistuzzi, C., Oquendo, M. A., Brent, D. A., & Mann, J. J. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300455 · Cited by 267 · see citing works
Bateman, C. (1995) · HarperCollins eBooks · Cited by 246 · see citing works
Morphometric Brain Abnormalities in Boys With Conduct Disorder
HUEBNER, T., VLOET, T. D., MARX, I., KONRAD, K., FINK, G. R., HERPERTZ, S. C., & HERPERTZ-DAHLMANN, B. (2008) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e3181676545 · Cited by 239 · see citing works
Ducci, F., Enoch, M.-A., Hodgkinson, C., Xu, K., Catena, M., Robin, R. W., & Goldman, D. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002034 · Cited by 229 · see citing works
Meta-analysis of gene–environment interactions in developmental psychopathology
Taylor, A., & Kim-Cohen, J. (2007) · Development and Psychopathology · doi:10.1017/s095457940700051x · Cited by 227 · see citing works
Cloninger, C. R. (1982) · Archives of General Psychiatry · doi:10.1001/archpsyc.1982.04290110010002 · Cited by 224 · see citing works
Role of Monoamine Oxidase A Genotype and Psychosocial Factors in Male Adolescent Criminal Activity
Nilsson, K. W., Sjöberg, R. L., Damberg, M., Leppert, J., Öhrvik, J., Alm, P. O., Lindström, L., & Oreland, L. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.06.024 · Cited by 223 · see citing works
Guo, G., Roettger, M. E., & Cai, T. (2008) · American Sociological Review · doi:10.1177/000312240807300402 · Cited by 214 · see citing works
Wang, D., Moshe Szyf, A., Benkelfat, C., Provençal, N., Turecki, G., Caramaschi, D., Côté, S. M., Vitaro, F., Tremblay, R. E., & Booij, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039501 · Cited by 209 · see citing works
Tuvblad, C., Grann, M., & Lichtenstein, P. (2006) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2005.01552.x · Cited by 207 · see citing works
Thapar, A., Langley, K., Fowler, T., Rice, F. J., Turic, D., Whittinger, N., Aggleton, J. P., van den Bree, M. B. M., Owen, M. J., & O’Donovan, M. C. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.11.1275 · Cited by 203 · see citing works
Epigenetic marking of the BDNF gene by early-life adverse experiences
Roth, T. L., & Sweatt, J. D. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.05.005 · Cited by 196 · see citing works
Genetic and neurocognitive contributions to the development of psychopathy
Viding, E., & McCrory, E. J. (2012) · Development and Psychopathology · doi:10.1017/s095457941200048x · Cited by 195 · see citing works
Frazzetto, G., Lorenzo, G. D., Carola, V., Proietti, L., Sokolowska, E., Siracusano, A., Gross, C. T., & Troisi, A. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000486 · Cited by 195 · see citing works
Weder, N., Yang, B. Z., Douglas-Palumberi, H., Massey, J., Krystal, J. H., Gelernter, J., & Kaufman, J. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.09.013 · Cited by 190 · see citing works
Childhood Maltreatment, Subsequent Antisocial Behavior, and the Role of Monoamine Oxidase A Genotype
Huizinga, D. H., Haberstick, B. C., Smolen, A., Menard, S., Young, S. E., Corley, R. P., Stallings, M. C., Grotpeter, J. K., & Hewitt, J. K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.12.022 · Cited by 186 · see citing works
Gregory, S., Ffytche, D., Simmons, A., Kumari, V., Howard, M., Hodgins, S., & Blackwood, N. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2012.222 · Cited by 185 · see citing works
Genetic determinants of aggression and impulsivity in humans
Pavlov, K. A., Chistiakov, D. A., & Chekhonin, V. P. (2012) · Journal of Applied Genetics · doi:10.1007/s13353-011-0069-6 · Cited by 184 · see citing works
Genotype × Environment Interaction in Psychopathology: Fact or Artifact?
Eaves, L. J. (2006) · Twin Research and Human Genetics · doi:10.1375/183242706776403073 · Cited by 183 · see citing works
Genotype × Environment Interaction in Psychopathology: Fact or Artifact?
Eaves, L. J. (2006) · Twin Research and Human Genetics · doi:10.1375/twin.9.1.1 · Cited by 183 · see citing works
White, M. G., Bogdan, R., Fisher, P. M., Muñoz, K. E., Williamson, D. E., & Hariri, A. R. (2012) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2012.00837.x · Cited by 180 · see citing works
Social Environment, Genes, and Aggression
Simons, R. L., Lei, M., Beach, S. R. H., Brody, G. H., Philibert, R. A., & Gibbons, F. X. (2011) · American Sociological Review · doi:10.1177/0003122411427580 · Cited by 179 · see citing works
Family dysfunction interacts with genes in the causation of antisocial symptoms
Button, T. M. M., Scourfield, J., Martin, N., Purcell, S., & McGuffin, P. (2005) · Behavior Genetics · doi:10.1007/s10519-004-0826-y · Cited by 171 · see citing works
Young, S. E., Smolen, A., Hewitt, J. K., Haberstick, B. C., Stallings, M. C., Corley, R. P., & Crowley, T. J. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.6.1019 · Cited by 170 · see citing works
Jaffee, S. R., Strait, L., & Odgers, C. L. (2011) · Psychological Bulletin · doi:10.1037/a0026020 · Cited by 169 · see citing works
Feinberg, M. E., Button, T. M. M., Neiderhiser, J. M., Reiss, D., & Hetherington, E. M. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.4.457 · Cited by 153 · see citing works
Influence of Functional Variant of Neuronal Nitric Oxide Synthase on Impulsive Behaviors in Humans
Reif, A., Jacob, C., Rujescu, D., Herterich, S., Lang, S., Gutknecht, L., Baehne, C. G., Strobel, A., Freitag, C. M., Giegling, I., et al. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2008.510 · Cited by 149 · see citing works
Challenges and opportunities in genome-wide environmental interaction (GWEI) studies
Aschard, H., Lutz, S. M., Maus, B., Duell, E. J., Fingerlin, T. E., Chatterjee, N., Kraft, P. L., & Steen, K. V. (2012) · Human Genetics · doi:10.1007/s00439-012-1192-0 · Cited by 144 · see citing works
P3 event-related potential impairments in antisocial and psychopathic individuals: A meta-analysis
Gao, Y., & Raine, A. (2009) · Biological Psychology · doi:10.1016/j.biopsycho.2009.06.006 · Cited by 144 · see citing works
Propper, C. B., Willoughby, M. T., Halpern, C. T., Carbone, M. A., & Cox, M. J. (2007) · Developmental Psychobiology · doi:10.1002/dev.20249 · Cited by 144 · see citing works
Adolescent girls and criminal activity: Role of MAOA-LPR genotype and psychosocial factors
Sjöberg, R. L., Nilsson, K. W., Wargelius, H., Leppert, J., Lindström, L., & Oreland, L. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30360 · Cited by 143 · see citing works
Interaction of dopamine transporter genotype with prenatal smoke exposure on ADHD symptoms
Becker, K., El-Faddagh, M., Schmidt, M. H., Esser, G., & Laucht, M. (2008) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2007.07.004 · Cited by 142 · see citing works
MAOA, abuse exposure and antisocial behaviour: 30-year longitudinal study
Fergusson, D. M., Boden, J. M., Horwood, L. J., Miller, A. L., & Kennedy, M. A. (2011) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.110.086991 · Cited by 141 · see citing works
Cicchetti, D., Rogosch, F. A., & Thibodeau, E. L. (2012) · Development and Psychopathology · doi:10.1017/s0954579412000442 · Cited by 141 · see citing works
Human Aggression Across the Lifespan
Tuvblad, C., & Baker, L. A. (2011) · Advances in Genetics · doi:10.1016/b978-0-12-380858-5.00007-1 · Cited by 139 · see citing works
Bevilacqua, L. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.152 · Cited by 137 · see citing works
Wakschlag, L. S., Kistner, E. O., Pine, D. S., Biesecker, G., Pickett, K. E., Skol, A. D., Dukić, V., Blair, J., LEVENTHAL, B. L., Cox, N. J., et al. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.22 · Cited by 135 · see citing works
Wermter, A., Laucht, M., SCHIMMELMANN, B. G., Banaschewski, T., Sonuga-Barke, E. J. S., Rietschel, M., & Becker, K. (2009) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-009-0082-z · Cited by 132 · see citing works
Self-citationSadeh, N., Javdani, S., Jackson, J. J., Reynolds, E. K., Potenza, M. N., Gelernter, J. E., Lejuez, C. W., & Verona, E. (2010) · Journal of Abnormal Psychology · doi:10.1037/a0019709 · Cited by 132 · see citing works
Sonuga‐Barke, E. J. S., Oades, R. D., Psychogiou, L., Chen, W., Franke, B., Buitelaar, J., Banaschewski, T., Ebstein, R. P., Gil, M., Anney, R., et al. (2009) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2009.02095.x · Cited by 131 · see citing works
Åslund, C., Nordquist, N., Comasco, E., Leppert, J., Oreland, L., & Nilsson, K. W. (2010) · Behavior Genetics · doi:10.1007/s10519-010-9356-y · Cited by 126 · see citing works
Life stress, 5-HTTLPR and mental disorder: findings from a 30-year longitudinal study
Fergusson, D. M., Horwood, L. J., Miller, A. L., & Kennedy, M. A. (2011) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.110.085993 · Cited by 124 · see citing works
Gerritsen, L., Tendolkar, I., Franke, B., Vásquez, A. A., Kooijman, S., Buitelaar, J. K., Fernández, G., & Rijpkema, M. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.51 · Cited by 115 · see citing works
Pinsonneault, J. K., Papp, A. C., & Sadée, W. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl192 · Cited by 114 · see citing works
Desistance from delinquency: the marriage effect revisited and extended.
Beaver, K., Wright, J. P., Delisi, M., & Vaughn, M. (2008) · Social Science Research · doi:10.1016/j.ssresearch.2007.11.003 · Cited by 107 · see citing works
Enoch, M., Steer, C. D., Newman, T. K., Gibson, N. P. S. J., & Goldman, D. A. (2009) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2009.00535.x · Cited by 104 · see citing works
Understanding risk for psychopathology through imaging gene–environment interactions
Hyde, L. W., Bogdan, R., & Hariri, A. R. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.07.001 · Cited by 102 · see citing works
Beach, S. R. H., Brody, G. H., Gunter, T. D., Packer, H., Wernett, P., & Philibert, R. A. (2010) · Journal of Family Psychology · doi:10.1037/a0018074 · Cited by 100 · see citing works
Moderating role of the MAOA genotype in antisocial behaviour
Fergusson, D. M., Boden, J. M., Horwood, L. J., Miller, A. L., & Kennedy, M. A. (2012) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.111.093328 · Cited by 96 · see citing works
Vaughn, M. G., DeLisi, M., Beaver, K. M., & WRIGHT, J. P. (2009) · Criminal Justice and Behavior · doi:10.1177/0093854809342839 · Cited by 90 · see citing works
Gatt, J. M., Nemeroff, C. B., Schofield, P. R., Paul, R. H., Clark, C. R., Gordon, E., & Williams, L. M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.025 · Cited by 88 · see citing works
Baehne, C. G., Ehlis, A., Plichta, M. M., Conzelmann, A., Pauli, P., Jacob, C., Gutknecht, L., Lesch, K., & Fallgatter, A. J. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.39 · Cited by 88 · see citing works
The Dopamine Receptor D4 Gene (DRD4) Moderates Family Environmental Effects on ADHD
Martel, M. M., Nikolas, M. A., Jernigan, K. A., Friderici, K. H., Waldman, I. D., & Nigg, J. T. (2010) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-010-9439-5 · Cited by 86 · see citing works
Evidence of a Gene X Environment Interaction in the Creation of Victimization
Beaver, K. M., WRIGHT, J. P., DeLisi, M., Daigle, L. E., Swatt, M. L., & Gibson, C. L. (2007) · International Journal of Offender Therapy and Comparative Criminology · doi:10.1177/0306624x07304157 · Cited by 86 · see citing works
Monoamine oxidase A and childhood adversity as risk factors for conduct disorder in females
Prom‐Wormley, E. C., Eaves, L. J., Foley, D. L., Gardner, C. O., Archer, K. J., Wormley, B., MAES, H. H. M., Riley, B. P., & Silberg, J. L. (2008) · Psychological Medicine · doi:10.1017/s0033291708004170 · Cited by 83 · see citing works
Brendgen, M., Boivin, M., Vitaro, F., Bukowski, W. M., Dionne, G., Tremblay, R., & Perusse, D. (2008) · Child Development · doi:10.1111/j.1467-8624.2007.01108.x · Cited by 82 · see citing works
Delinquent peer affiliation and conduct problems: A twin study.
Button, T. M. M., Corley, R. P., Rhee, S. H., Hewitt, J. K., Young, S. E., & Stallings, M. C. (2007) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.116.3.554 · Cited by 82 · see citing works
The contribution of gene–environment interaction to psychopathology
Thapar, A., Harold, G. T., Rice, F. J., Langley, K., & O’Donovan, M. C. (2007) · Development and Psychopathology · doi:10.1017/s0954579407000491 · Cited by 82 · see citing works
Infant Pathways to Externalizing Behavior: Evidence of Genotype × Environment Interaction
Leve, L. D., Kerr, D., Shaw, D. S., Ge, X., Neiderhiser, J. M., Scaramella, L. V., Reid, J. B., Conger, R. D., & Reiss, D. (2010) · Child Development · doi:10.1111/j.1467-8624.2009.01398.x · Cited by 74 · see citing works
School context and genetic influences on aggression in adolescence
Rowe, D. C., Almeida, D. M., & Jacobson, K. C. (1999) · Psychological Science · doi:10.1111/1467-9280.00150 · Cited by 74 · see citing works
Nobile, M., Giorda, R., Marino, C., Carlet, O., Pastore, V., Vanzin, L., Bellina, M., Molteni, M., & Battaglia, M. (2007) · Development and Psychopathology · doi:10.1017/s0954579407000594 · Cited by 72 · see citing works
A Meta-Analysis of the Val158Met COMT Polymorphism and Violent Behavior in Schizophrenia
Singh, J. P., Volavka, J., Czobor, P., & Dorn, R. A. V. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043423 · Cited by 70 · see citing works
Brendgen, M. R., Boivin, M., Dionne, G., Barker, E. D., Vitaro, F., Girard, A., Tremblay, R. E., & Pérusse, D. (2011) · Child Development · doi:10.1111/j.1467-8624.2011.01644.x · Cited by 69 · see citing works
Beaver, K. M., Gibson, C. L., Jennings, W. G., & Ward, J. T. (2009) · Biodemography and Social Biology · doi:10.1080/19485560903054689 · Cited by 69 · see citing works
Kinnally, E. L., Huang, Y., Haverly, R., Burke, A. K., Galfalvy, H., Brent, D. A., Oquendo, M. A., & Mann, J. J. (2009) · Psychiatric Genetics · doi:10.1097/ypg.0b013e32832a50a7 · Cited by 69 · see citing works
Langley, K., Turic, D., Rice, F., Holmans, P., van den Bree, M. V. D., Craddock, N., Kent, L., Owen, M. J., O'Donovan, M., & Thapar, A. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30571 · Cited by 68 · see citing works
MAOA‐uVNTR and early physical discipline interact to influence delinquent behavior
Edwards, A. C., Dodge, K. A., Latendresse, S. J., Lansford, J. E., Bates, J. E., Pettit, G. S., Budde, J. P., Goate, A. M., & Dick, D. M. (2010) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2009.02196.x · Cited by 67 · see citing works
Gene–environment interaction between peer victimization and child aggression
Brendgen, M. R., Boivin, M., Vitaro, F., Girard, A., Dionne, G., & Pérusse, D. (2008) · Development and Psychopathology · doi:10.1017/s0954579408000229 · Cited by 67 · see citing works
Douglas, K., Chan, G., Gelernter, J. E., Arias, A. J., Anton, R. F., Poling, J. C., Farrer, L. A., & Kranzler, H. R. (2011) · Psychiatric Genetics · doi:10.1097/ypg.0b013e3283457c15 · Cited by 66 · see citing works
Replication and heterogeneity in gene×environment interaction studies
Munafo, M. R., & Flint, J. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709000479 · Cited by 65 · see citing works
Baker, L. A., Tuvblad, C., Reynolds, C. A., Zheng, M., Lozano, D. I., & Raine, A. (2009) · Development and Psychopathology · doi:10.1017/s0954579409000509 · Cited by 64 · see citing works
The etiology of criminal onset: The enduring salience of nature and nurture
DeLisi, M., Beaver, K. M., Wright, J. P., & Vaughn, M. G. (2008) · Journal of Criminal Justice · doi:10.1016/j.jcrimjus.2008.04.001 · Cited by 64 · see citing works
Lahey, B. B., Rathouz, P. J., Lee, S. S., Chronis-Tuscano, A., Pelham, W. E., Waldman, I. D., & Cook, E. H. (2011) · Journal of Abnormal Psychology · doi:10.1037/a0021133 · Cited by 63 · see citing works
Li, J. J., & Lee, S. S. (2010) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-010-9409-y · Cited by 58 · see citing works
Derringer, J., Krueger, R., Irons, D., & Iacono, W. (2010) · Behavior Genetics · doi:10.1007/s10519-010-9358-9 · Cited by 57 · see citing works
Tikkanen, R., Ducci, F., Goldman, D. A., Holi, M. M., Lindberg, N., Tiihonen, J., & Virkkunen, M. E. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01157.x · Cited by 56 · see citing works
Wagner, S., Başkaya, Ö., Anicker, N. J., Dahmen, N., Lieb, K., & Tadić, A. (2009) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2009.01501.x · Cited by 56 · see citing works
CHRM2 , Parental Monitoring, and Adolescent Externalizing Behavior
Dick, D. M., Meyers, J. L., Latendresse, S. J., Creemers, H. E., Lansford, J. E., Pettit, G. S., Bates, J. E., Dodge, K. A., Budde, J., Goate, A., et al. (2011) · Psychological Science · doi:10.1177/0956797611403318 · Cited by 56 · see citing works
No evidence for interaction between MAOA and childhood adversity for antisocial behavior
Prichard, Z. M., Mackinnon, A. J., Jorm, A. F., & Easteal, S. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30581 · Cited by 55 · see citing works
Developmental Origins of Chronic Physical Aggression and Epigenetics
Tremblay, R. E., & Moshe Szyf, A. (2010) · Epigenomics · doi:10.2217/epi.10.40 · Cited by 54 · see citing works
van Lier, P. A. C., Boivin, M., Dionne, G., Vitaro, F., Brendgen, M. R., Koot, H. M., Tremblay, R. E., & Pérusse, D. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e318067733e · Cited by 53 · see citing works
Latendresse, S. J., Bates, J. E., Goodnight, J. A., Lansford, J. E., Budde, J., Goate, A., Dodge, K. A., Pettit, G. S., & Dick, D. M. (2011) · Child Development · doi:10.1111/j.1467-8624.2011.01640.x · Cited by 53 · see citing works
Physical punishment and childhood aggression: the role of gender and gene–environment interplay
Boutwell, B. B., Franklin, C. A., Barnes, J. C., & Beaver, K. M. (2011) · Aggressive Behavior · doi:10.1002/ab.20409 · Cited by 52 · see citing works
Prefrontal brain asymmetry and aggression in imprisoned violent offenders
Keune, P. M., van der Heiden, L., Várkuti, B., Konicar, L., Veit, R., & Birbaumer, N. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.03.058 · Cited by 51 · see citing works
Lee, S. S. (2010) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-010-9474-2 · Cited by 51 · see citing works
Philibert, R. A., Wernett, P., Plume, J., Packer, H., Brody, G. H., & Beach, S. R. H. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2011.04.007 · Cited by 46 · see citing works
Brennan, P. A., Hammen, C. L., Sylvers, P. D., Bor, W., Najman, J. M., Lind, P. A., Montgomery, G. W., & Smith, A. K. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2011.02.013 · Cited by 44 · see citing works
Nobile, M., Rusconi, M., Bellina, M., Marino, C., Giorda, R., Carlet, O., Vanzin, L., Molteni, M., & Battaglia, M. (2009) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-009-0080-1 · Cited by 44 · see citing works
Åslund, C., Comasco, E., Nordquist, N., Leppert, J., Oreland, L., & Nilsson, K. W. (2012) · Aggressive Behavior · doi:10.1002/ab.21451 · Cited by 43 · see citing works
COMT x DRD4 epistasis impacts prefrontal cortex function underlying response control.
Heinzel, S., Dresler, T., Baehne, C., Heine, M., Boreatti-Hümmer, A., Jacob, C., Renner, T., Reif, A., Lesch, K., Fallgatter, A., et al. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhs132 · Cited by 42 · see citing works
Dresler, T., Ehlis, A., Heinzel, S., Renner, T., Reif, A., Baehne, C. G., Heine, M., Boreatti‐Hümmer, A., Jacob, C., Lesch, K., et al. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.91 · Cited by 42 · see citing works
Conway, C., Keenan‐Miller, D., Hammen, C. L., Lind, P. A., Najman, J. M., & Brennan, P. A. (2012) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2012.632351 · Cited by 41 · see citing works
Lamb, D. J., Middeldorp, C., van Beijsterveldt, C. E. M., & Boomsma, D. (2012) · Journal of Child Psychology and Psychiatry and Allied Disciplines · doi:10.1111/j.1469-7610.2011.02497.x · Cited by 33 · see citing works
COMT Val108/158Met Gene Variant, Birth Weight, and Conduct Disorder in Children With ADHD
Sengupta, S. M., Grizenko, N., Schmitz, N., Schwartz, G. J., Amor, L. B., Bellingham, J., de Guzman, R., Polotskaia, A., Ter-Stepanian, M., THAKUR, G., et al. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000251212.44491.46 · Cited by 33 · see citing works
Beaver, K. M., Sak, A., Vaske, J. C., & Nilsson, J. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2009.01.024 · Cited by 29 · see citing works
5-HTTLPR–environment interplay and its effects on neural reactivity in adolescents
Walsh, N., Dalgleish, T., Dunn, V. J., Abbott, R., Clair, M. S., Owens, M., Fairchild, G. F., Kerslake, W. S., Hiscox, L. V., Passamonti, L., et al. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.07.067 · Cited by 29 · see citing works
van der Vegt, E. J. M., Oostra, B. A., Vásquez, A. A., van der Ende, J., Verhulst, F. C., & Tiemeier, H. W. (2009) · Psychiatric Genetics · doi:10.1097/ypg.0b013e32832a5084 · Cited by 29 · see citing works
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An integrated analysis of genes and functional pathways for aggression in human and rodent models
Zhang-James, Y., Fernàndez-Castillo, N., Hess, J. L., Malki, K., Glatt, S. J., Cormand, B., & Faraone, S. V. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0068-7 · Cited by 98 · see citing works
- Authors
- Laucht, M., Brandeis, D., & Zohsel, K.
- Affiliations
- University of Potsdam (DE)
- University of Zurich (CH)
- Heidelberg University (DE)
- Corresponding author
- Laucht, Manfred
- ORCID
- Laucht, Manfred
- Venue
- Current Topics in Behavioral Neurosciences
- Publisher
- Springer Berlin Heidelberg
- Published
- 2013
- Volume
- 17
- Pages
- 267-295
- ISSN
- 1866-3370 (ISSN-L)
- 1866-3389
- OpenAlex
- W1493671493
- Semantic Scholar
- 9b99a1fc51d5e93a592ff7954eb6542d86f7d700
- Cited by
- 18
- References
- 134
- Citations by year
- 2026: 1 · 2025: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 2
- FWCI
- 3.31
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Current topics in behavioral neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Social Sciences › Psychology › Social Psychology › Bullying, Victimization, and Aggression
- Keywords
- gene-environment interaction, violence, violent behavior, candidate genes, differential susceptibility, adverse environmental conditions, pathophysiological pathways
- MeSH terms
- Humans, Risk Factors, Social Environment, Violence, Genetic Predisposition to Disease, Gene-Environment Interaction
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