Cited by 18Neurotransmitter Receptor Influence on BehaviorPsychopathy, Forensic Psychiatry, Sexual OffendingBullying, Victimization, and Aggression

Gene–Environment Interactions in the Etiology of Human Violence

Laucht, Manfred, Brandeis, Daniel, Zohsel, Katrin·2013·Current Topics in Behavioral Neurosciences

Abstract

This chapter reviews the current research on gene-environment interactions (G × E) with regard to human violence. Findings are summarized from both behavioral and molecular genetic studies that have investigated the interplay of genetic and environmental factors in terms of influencing violence-related behavior. Together, these studies reveal promising evidence that genetic factors combine with environmental influences to impact on the development of violent behavior and related phenotypes. G × E have been identified for a number of candidate genes implicated in violence. Moreover, the reviewed G × E were found to extend to a broad range of environmental characteristics, including both adverse and favorable conditions. As has been the case with other G × E research, findings have been mixed, with considerable heterogeneity between studies. Lack of replication together with serious methodological limitations remains a major challenge for drawing definitive conclusions about the nature of violence-related G × E. In order to fulfill its potential, it is recommended that future G × E research needs to shift its focus to dissecting the neural mechanisms and the underlying pathophysiological pathways by which genetic variation may influence differential susceptibility to environmental exposures.

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Crossref · 10.1007/7854_2013_260

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Authors
Laucht, M., Brandeis, D., & Zohsel, K.
Affiliations
  • University of Potsdam (DE)
  • University of Zurich (CH)
  • Heidelberg University (DE)
Corresponding author
Laucht, Manfred
Venue
Current Topics in Behavioral Neurosciences
Published
2013
Volume
17
Pages
267-295
ISSN
  • 1866-3370 (ISSN-L)
  • 1866-3389
OpenAlex
W1493671493
Cited by
18
References
134
Citations by year
2026: 1 · 2025: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 2
FWCI
3.31
Type
book chapter
Language
en
Open access
closed
Locations
  • Current topics in behavioral neurosciences (publishedVersion)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
  • Social Sciences › Psychology › Social Psychology › Bullying, Victimization, and Aggression
Keywords
gene-environment interaction, violence, violent behavior, candidate genes, differential susceptibility, adverse environmental conditions, pathophysiological pathways
MeSH terms
Humans, Risk Factors, Social Environment, Violence, Genetic Predisposition to Disease, Gene-Environment Interaction

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