Plasma 25(OH)D concentration in children with Autism Spectrum Disorder
Open accessAbstract
Children with autism spectrum disorder (ASD) are reported to have decreased bone cortical thickness (BCT). Vitamin D plays an important physiological role in bone growth and development, so deficiency of vitamin D could contribute to decreased BCT. The goal of this study was to compare plasma 25(OH)D concentration in three groups of Caucasian males age 4 to 8 years old: (1) ASD and an unrestricted diet (n=40), (2) ASD and a casein-free diet (n=9), and (3) unaffected controls (n=40). No significant group differences were observed (p=0.4). However, a total of 54 (61%) of the children in the entire cohort had a plasma 25(OH)D concentration of less than 20ng/mL, similar to findings of low 25(OH)D concentrations in population-based studies. Children with ASD should be monitored for vitamin D deficiency.
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Molloy et al. (2010) included boys with catheters placed for tonsillectomies as controls.
“Molloy et al. (2010) [113] included boys with catheters placed for tonsillectomies as controls.”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [113]
Three other studies that failed to show any relationship had somewhat larger sample sizes (ranging from 54 to 71 per group) and controlled for several covariates and matched controls to cases on several attributes.
“Three other studies that also failed to show any relationship had somewhat larger sample sizes (ranging from 54 to 71 per group) and controlled for several covariates [113] and matched controls to cases on several attributes [79,116].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [113]
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- Authors
- Molloy, C. A., Kalkwarf, H. J., Manning‐Courtney, P., Mills, J. L., & Hediger, M. L.
- Affiliations
- Cincinnati Children's Hospital Medical Center (US)
- National Institutes of Health (US)
- Corresponding author
- Molloy, Cynthia A
- Venue
- Developmental Medicine & Child Neurology
- Publisher
- Wiley
- Published
- 2010-09-06
- Volume
- 52
- Issue
- 10
- Pages
- 969-971
- ISSN
- 0012-1622 (ISSN-L)
- 1469-8749
- PMC
- PMC2939162
- OpenAlex
- W1604687055
- Cited by
- 54
- References
- 13
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 5 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 4 · 2013: 6 · 2012: 4
- FWCI
- 2.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Developmental Medicine & Child Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000077)
- National Center for Research Resources (M01RR008084)
- National Center for Advancing Translational Sciences
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (ZIAHD008742, Z01HD008742)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- autism spectrum disorder, vitamin D deficiency, 25-hydroxyvitamin D, casein-free diet, children, skeletal development
- MeSH terms
- Child, Child Development Disorders, Pervasive, Child, Preschool, Humans, Male, Radioimmunoassay, Vitamin D, White People
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