The 5‐HT2A receptor antagonist M100,907 prevents extracellular glutamate rising in response to NMDA receptor blockade in the mPFC

Ceglia, Ilaria; Carli, Mirjana; Baviera, Marta; Renoldi, Giuliano; Calcagno, Eleonora; Invernizzi, Roberto W.

doi:10.1111/j.1471-4159.2004.02704.x

Cited by 79Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchSchizophrenia research and treatment

The 5‐HT2A receptor antagonist M100,907 prevents extracellular glutamate rising in response to NMDA receptor blockade in the mPFC

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Ceglia, Ilaria, Carli, Mirjana, Baviera, Marta, Renoldi, Giuliano, Calcagno, Eleonora, Invernizzi, Roberto W.·2004·Journal of Neurochemistry

DOI 10.1111/j.1471-4159.2004.02704.x

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Abstract

We recently found that intracortical injection of the selective and competitive N‐methyl‐d‐aspartate (NMDA) receptor antagonist 3‐(R)‐2‐carboxypiperazin‐4‐propyl‐1‐phosphonic acid (CPP) impaired attentional performance in rats and blockade of 5‐hydroxytryptamine (5‐HT)2A receptors antagonized this effect. Here, we used the microdialysis technique in conscious rats to study the effect of CPP on extracellular glutamate (GLU) in the medial prefrontal cortex (mPFC) and the regulation of this effect by 5‐HT 2A receptors. Intraperitoneal injection of 20 mg/kg CPP increased extracellular GLU in the mPFC (201% of basal levels) but had no effect on 5‐HT. Intracortical infusion of 100 µ m CPP increased extracellular GLU (230% of basal values) and 5‐HT (150% of basal values) in the mPFC, whereas 30 µ m had no significant effect. The effect of 100 µ m CPP on extracellular GLU was abolished by tetrodotoxin, suggesting that neuronal activity is required. Subcutaneous injection of 40 µg/kg M100,907 completely antagonized the effect of 100 µ m cpp on extracellular GLU, whereas 10 µg/kg caused only partial attenuation. Likewise, intracortical infusion of 0.1 µ m M100,907 completely reversed the increase of extracellular GLU induced by CPP. These findings show that blockade of NMDA receptors in the mPFC is sufficient to increase extracellular GLU locally. The increase of cortical extracellular GLU may contribute to CPP‐induced cognitive deficits and blockade of 5‐HT 2A receptors may provide a molecular mechanism for reversing these deficits caused by dysfunctional glutamatergic transmission in the mPFC.

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M100907 prevents (R)-CPP-induced increases in premature responding.
“administration of the serotonin 5-HT2A receptor antagonist M100907 prevents increases in premature responding induced by MK-801 (Higgins et al 2003) and (R)-CPP (Ceglia et al 2004).”
From Prefrontal cortex executive processes affected by stress in health and disease (2018) · cites this paper as Ceglia et al 2004

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Invernizzi R. W., Carli M., Baviera M. and Ceglia I. (2003) The 5-HT 2A receptor antagonist M100907 prevents the increase of cortical extracellular glutamate induced by the local infusion of the NMDA receptor antagonist CPP. In: Monitoring Molecules in Neuro- science. 10th International Conference on in vivo Methods (Kehr J., Fuxe K., Ungerstedt U. and Svensson T. H., eds), pp. 79-81. Karolinska University Press, Stockholm, Sweden.
5-HT 2A receptors and extracellular GLU 199 Ó 2004 International Society for Neurochemistry, J. Neurochem. (2004) 91, 189-199 14714159, 2004, 1, · DOI

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Authors: Ceglia, I., Carli, M., Baviera, M., Renoldi, G., Calcagno, E., & Invernizzi, R. W.
Affiliations: Mario Negri Institute for Pharmacological Research (IT)
Corresponding author: Invernizzi, Roberto W.
ORCID: Ceglia, Ilaria
Carli, Mirjana
Baviera, Marta
Invernizzi, Roberto W.
Venue: Journal of Neurochemistry
Publisher: Wiley
Published: 2004-09-06
Volume: 91
Issue: 1
Pages: 189-199
ISSN: 0022-3042 (ISSN-L)
1471-4159
DOI: 10.1111/j.1471-4159.2004.02704.x
OpenAlex: W1983842067
Cited by: 79
References: 101
Citations by year: 2024: 3 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 5 · 2014: 2 · 2013: 2 · 2012: 7
FWCI: 1.88
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neurochemistry (publishedVersion)
PubMed (publishedVersion)
Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords: 5-HT2A receptor, NMDA receptor antagonists, CPP, extracellular glutamate, medial prefrontal cortex, glutamatergic neurotransmission, attention deficits, tetrodotoxin, cognitive impairment
MeSH terms: Analysis of Variance, Animals, Dose-Response Relationship, Drug, Drug Interactions, Extracellular Space, Fluorobenzenes, Male, Nicotine, Piperazines, Piperidines, Potassium Chloride, Serotonin, Serotonin Antagonists, Tetrodotoxin, 2-Amino-5-phosphonovalerate, Receptors, N-Methyl-D-Aspartate, Prefrontal Cortex, Microdialysis, Excitatory Amino Acid Antagonists, Glutamic Acid, Receptor, Serotonin, 5-HT2A, Rats, Serotonin 5-HT2 Receptor Antagonists

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The 5‐HT2A receptor antagonist M100,907 prevents extracellular glutamate rising in response to NMDA receptor blockade in the mPFC

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