Cited by 1,938Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

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Aβ Oligomers – a decade of discovery

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Walsh, Dominic M., Selkoe, Dennis J.·2007·Journal of Neurochemistry

DOI 10.1111/j.1471-4159.2006.04426.x

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Abstract

Converging lines of evidence suggest that progressive accumulation of the amyloid β‐protein (Aβ) plays a central role in the genesis of Alzheimer’s disease, but it was long assumed that Aβ had to be assembled into extracellular amyloid fibrils to exert its cytotoxic effects. Over the past decade, data have emerged from the use of synthetic Aβ peptides, cell culture models, β‐amyloid precursor protein transgenic mice and human brain to suggest that pre‐fibrillar, diffusible assemblies of Aβ are also deleterious. Although the precise molecular identity of these soluble toxins remains unsettled, accumulating evidence suggests that soluble forms of Aβ are indeed the proximate effectors of synapse loss and neuronal injury. Here we review recent progress in understanding the role of soluble oligomers in Alzheimer’s disease.

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1 retracted

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Loss of Neprilysin Function Promotes Amyloid Plaque Formation and Causes Cerebral Amyloid Angiopathy
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Untitled work
(1999) · doi:10.1002/1531-8249(199912)46:6

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Selkoe D. J., 2003, Annu. Rev. Pharmacol. Toxicol., 545
Shankar G. M., 2007, Natural oligomers of the Alzheimer amyloid beta‐protein induce hippocampal synapse loss but can be neutralized by antibodies and small molecules, J. Neurosci.

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Authors: Walsh, D. M., & Selkoe, D. J.
Affiliations: University College Dublin (IE)
Brigham and Women's Hospital (US)
Corresponding author: Walsh, Dominic M.
Selkoe, Dennis J.
ORCID: Walsh, Dominic M.
Selkoe, Dennis J.
Venue: Journal of Neurochemistry
Publisher: Wiley
Published: 2007-01-04
Volume: 101
Issue: 5
Pages: 1172-1184
ISSN: 0022-3042 (ISSN-L)
1471-4159
DOI: 10.1111/j.1471-4159.2006.04426.x
OpenAlex: W1981458288
Cited by: 1,938
References: 147
Citations by year: 2026: 48 · 2025: 36 · 2024: 46 · 2023: 47 · 2022: 50 · 2021: 63 · 2020: 76 · 2019: 81 · 2018: 81 · 2017: 109 · 2016: 120 · 2015: 136 · 2014: 134 · 2013: 159 · 2012: 167
FWCI: 14.23
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neurochemistry (publishedVersion)
PubMed (publishedVersion)
Funders: Foundation for Neurologic Diseases
Wellcome Trust (067660)
National Institutes of Health
National Institute on Aging (AG-06173)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: amyloid-beta oligomers, Alzheimer's disease, soluble amyloid-beta, synaptic loss, neuronal injury, amyloid fibrils, amyloid precursor protein, transgenic mouse model
MeSH terms: Alzheimer Disease, Humans, Male, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Protein Structure, Secondary

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Aβ Oligomers – a decade of discovery

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