The lipopolysaccharide Parkinson’s disease animal model: mechanistic studies and drug discovery

Dutta, Garima; Zhang, Ping; Liu, Bin

doi:10.1111/j.1472-8206.2008.00616.x

Cited by 235Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration MechanismsNuclear Receptors and Signaling

The lipopolysaccharide Parkinson’s disease animal model: mechanistic studies and drug discovery

Open access

Dutta, Garima, Zhang, Ping, Liu, Bin·2008·Fundamental & Clinical Pharmacology

DOI 10.1111/j.1472-8206.2008.00616.xPMC PMC2632601

Open this paper in CoChat — free account

Abstract

Research in the last two decades has unveiled an important role for neuroinflammation in the degeneration of the nigrostriatal dopaminergic (DA) pathway that constitutes the pathological basis of the prevailing movement disorder, Parkinson’s disease (PD). Neuroinflammation is characterized by the activation of brain glial cells, primarily microglia and astrocytes that release various soluble factors that include free radicals (reactive oxygen and nitrogen species), cytokines, and lipid metabolites. The majority of these glia‐derived factors are proinflammatory and neurotoxic and are particularly deleterious to oxidative damage‐vulnerable nigral DA neurons. As a proof of concept, various immunologic stimuli have been employed to directly induce glial activation to model DA neurodegeneration in PD. The bacterial endotoxin, lipopolysaccharide (LPS), has been the most extensively utilized glial activator for the induction of inflammatory DA neurodegeneration. In this review, we will summarize the various in vitro and in vivo LPS PD models. Furthermore, we will highlight the contribution of the LPS PD models to the mechanistic studies of PD pathogenesis and the search for neuroprotective agents for the treatment of PD.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/j.1472-8206.2008.00616.x

Cites

105 of 105 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Neuroinflammation is characterised by the activation of microglia and astrocytes.
“Neuroinflammation is characterised by the activation of microglia and astrocytes [29].”
From Neuroprotective Effect of Ceftriaxone on MPTP‐Induced Parkinson’s Disease Mouse Model by Regulating Inflammation and Intestinal Microbiota (2021) · cites this paper as [29]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., & Glass, C. K. (1998) · Nature · doi:10.1038/34178 · Cited by 3,525 · see citing works
LPS/TLR4 signal transduction pathway
Lu, Y.-C., Yeh, W.-C., & Ohashi, P. S. (2008) · Cytokine · doi:10.1016/j.cyto.2008.01.006 · Cited by 3,301 · see citing works
Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
McGeer, P. L., Itagaki, S., Boyes, B. E., & McGeer, E. G. (1988) · Neurology · doi:10.1212/wnl.38.8.1285 · Cited by 2,990 · see citing works
PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
Jiang, C., Ting, A. T., & Seed, B. (1998) · Nature · doi:10.1038/34184 · Cited by 2,899 · see citing works
Reactive astrocytes: cellular and molecular cues to biological function
Ridet, J., Privat, A., Malhotra, S. K., & Gage, F. H. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01139-9 · Cited by 1,766 · see citing works
ETIOLOGY AND PATHOGENESIS OF PARKINSON'S DISEASE
Olanow, C. W., & Tatton, W. G. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.123 · Cited by 1,394 · see citing works
Activated microglia mediate neuronal cell injury via a nitric oxide mechanism
Chao, C. C., Hu, S., Molitor, T. W., Shaskan, E. G., & Peterson, P. K. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.8.2736 · Cited by 1,137 · see citing works
Role of Microglia in Inflammation-Mediated Neurodegenerative Diseases: Mechanisms and Strategies for Therapeutic Intervention
Liu, B., & Hong, J.-S. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.035048 · Cited by 1,095 · see citing works
Self-citation
Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway
Lehnardt, S., Massillon, L., Follett, P., Jensen, F. E., Ratan, R., Rosenberg, P. A., Volpe, J. J., & Vartanian, T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432609100 · Cited by 1,052 · see citing works
Functional plasticity of microglia: A review
Streit, W. J., Graeber, M. B., & Kreutzberg, G. W. (1988) · Glia · doi:10.1002/glia.440010502 · Cited by 937 · see citing works
Regional Difference in Susceptibility to Lipopolysaccharide-Induced Neurotoxicity in the Rat Brain: Role of Microglia
Kim, W., Mohney, R. P., Wilson, B. C., Jeohn, G., Liu, B., & Hong, J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06309.2000 · Cited by 881 · see citing works
Self-citation
Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta.
Lee, S. C., Liu, W., Dickson, D. W., Brosnan, C., & Berman, J. (1993) · Journal of Immunology · doi:10.4049/jimmunol.150.7.2659 · Cited by 850 · see citing works
A meta‐analysis of coffee drinking, cigarette smoking, and the risk of Parkinson's disease
Hernán, M. A., Takkouche, B., Caamaño‐Isorna, F., & Gestal‐Otero, J. J. (2002) · Annals of Neurology · doi:10.1002/ana.10277 · Cited by 818 · see citing works
Peroxisome proliferator-activated receptors in inflammation control
Delerive, P., Fruchart, J., & Staels, B. (2001) · Journal of Endocrinology · doi:10.1677/joe.0.1690453 · Cited by 755 · see citing works
Parkinson's disease
Thomas, B., & Beal, M. F. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm159 · Cited by 748 · see citing works
Microglial activation‐mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease
Gao, H., Jiang, J., Wilson, B. C., Zhang, W., Hong, J., & Liu, B. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00928.x · Cited by 690 · see citing works
Self-citation
Production of tumor necrosis factor-alpha by microglia and astrocytes in culture
Sawada, M., Kondo, N., Suzumura, A., & Marunouchi, T. (1989) · Brain Research · doi:10.1016/0006-8993(89)90078-4 · Cited by 631 · see citing works
Animal models of Parkinson's disease
Betarbet, R. S., Sherer, T., & Greenamyre, J. T. (2002) · BioEssays · doi:10.1002/bies.10067 · Cited by 600 · see citing works
Endogenous nicotinic cholinergic activity regulates dopamine release in the striatum
Zhou, F.-M., Liang, Y., & Dani, J. A. (2001) · Nature Neuroscience · doi:10.1038/nn769 · Cited by 585 · see citing works
Toll-like receptors — taking an evolutionary approach
Leulier, F., & Lemaitre, B. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2303 · Cited by 581 · see citing works
NADPH Oxidase Mediates Lipopolysaccharide-induced Neurotoxicity and Proinflammatory Gene Expression in Activated Microglia
Qin, L., Liu, Y., Wang, T., Wei, S.-J., Block, M. L., Wilson, B., Liu, B., & Hong, J.-S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m307657200 · Cited by 574 · see citing works
Self-citation
The influence of systemic inflammation on inflammation in the brain: implications for chronic neurodegenerative disease
Perry, V. H. (2004) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2004.01.004 · Cited by 560 · see citing works
Cholinergic modulation of microglial activation by α7 nicotinic receptors
Shytle, R. D., Mori, T., Townsend, K. P., Vendrame, M., Sun, N., Zeng, J., Ehrhart, J. C., Silver, A. A., Sanberg, P. R., & Tan, J. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2004.02347.x · Cited by 537 · see citing works
Inhibition of Lipopolysaccharide-Induced Signal Transduction in Endotoxin-Tolerized Mouse Macrophages: Dysregulation of Cytokine, Chemokine, and Toll-Like Receptor 2 and 4 Gene Expression
Medvedev, A. E., Kopydlowski, K. M., & Vogel, S. N. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.11.5564 · Cited by 510 · see citing works
Gram‐negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction 1
Raetz, C. R. H., Ulevitch, R. I., Wright, S. D., Sibley, C. H., Ding, A. H., & Nathan, C. (1991) · The FASEB Journal · doi:10.1096/fasebj.5.12.1916089 · Cited by 507 · see citing works
Induction of Nitric Oxide Synthase in Glial Cells
Simmons, M. L., & Murphy, S. P. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb08328.x · Cited by 490 · see citing works
Infection and labor
Romero, R. J., Manogue, K. R., Mitchell, M. D., Wu, Y., Enrique Oyarzún, E., Hobbins, J. C., & Cerami, A. (1989) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(89)90515-2 · Cited by 426 · see citing works
Role of Nitric Oxide in Inflammation‐Mediated Neurodegeneration
Liu, B., Gao, H., Wang, J., Jeohn, G., Cooper, C. L., & Hong, J. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04077.x · Cited by 425 · see citing works
Self-citation
Lipopolysaccharide Induces Rac1-dependent Reactive Oxygen Species Formation and Coordinates Tumor Necrosis Factor-α Secretion through IKK Regulation of NF-κB
Sanlioglu, S., Williams, C. M., Samavati, L., Butler, N. S., Wang, G., McCray, P. B., Ritchie, T. C., Hunninghake, G. W., Zandi, E., & Engelhardt, J. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102061200 · Cited by 395 · see citing works
Lipopolysaccharide Intranigral Injection Induces Inflammatory Reaction and Damage in Nigrostriatal Dopaminergic System
Castaño, A., Herrera, A. J., Cano, J., & Machado, A. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70041584.x · Cited by 393 · see citing works
The Single Intranigral Injection of LPS as a New Model for Studying the Selective Effects of Inflammatory Reactions on Dopaminergic System
Herrera, A. J., Castaño, A., Venero, J. L., Cano, J., & Machado, A. (2000) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0289 · Cited by 392 · see citing works
Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes
Li, J., Baud, O., Vartanian, T. K., Volpe, J. J., & Rosenberg, P. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502552102 · Cited by 370 · see citing works
Axotomy of the rat facial nerve leads to increased CR3 complement receptor expression by activated microglial cells
Graeber, M. B., Streit, W. J., & Kreutzberg, G. W. (1988) · Journal of Neuroscience Research · doi:10.1002/jnr.490210104 · Cited by 367 · see citing works
Pooled analysis of tobacco use and risk of Parkinson disease.
Ritz, B., Ascherio, A., Checkoway, H., Marder, K., Nelson, L., Rocca, W., Ross, G., Strickland, D., den Eeden, S. K. V., & Gorell, J. (2007) · Archives of Neurology · doi:10.1001/archneur.64.7.990 · Cited by 366 · see citing works
Blocking Soluble Tumor Necrosis Factor Signaling with Dominant-Negative Tumor Necrosis Factor Inhibitor Attenuates Loss of Dopaminergic Neurons in Models of Parkinson's Disease
McCoy, M. K., Martinez, T. N., Ruhn, K. A., Szymkowski, D. E., Smith, C. G., Botterman, B. R., Tansey, K. E., & Tansey, M. G. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1504-06.2006 · Cited by 355 · see citing works
Naloxone Protects Rat Dopaminergic Neurons against Inflammatory Damage through Inhibition of Microglia Activation and Superoxide Generation
Liu, B., Du, L., & Hong, J.-S. (2000) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39275-4 · Cited by 347 · see citing works
Self-citation
Smoking, nicotine and Parkinson's disease
Quik, M. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.06.008 · Cited by 323 · see citing works
Inflammation induces mitochondrial dysfunction and dopaminergic neurodegeneration in the nigrostriatal system
Hunter, R. L., Dragicevic, N., Seifert, K., Choi, D. Y., Liu, M., Kim, H., Cass, W. A., Sullivan, P. G., & Bing, G. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04327.x · Cited by 322 · see citing works
Brain macrophages synthesize interleukin‐1 and interleukin‐1 mRNAs in vitro
Hetier, E., Ayala‐Sanmartín, J., Denèfle, P., Bousseau, A., Rouget, P., Mallat, M., & Prochiantz, A. (1988) · Journal of Neuroscience Research · doi:10.1002/jnr.490210230 · Cited by 287 · see citing works
An Essential Role of Interleukin-1β in Mediating NF-κB Activity and COX-2 Transcription in Cells of the Blood–Brain Barrier in Response to a Systemic and Localized Inflammation But Not During Endotoxemia
Laflamme, N., Lacroix, S., & Rivest, S. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-24-10923.1999 · Cited by 287 · see citing works
Parkinson's disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: role of neuroinflammation.
Liu, B., Gao, H., & Hong, J. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.6361 · Cited by 285 · see citing works
Self-citation
Free Radicals as Mediators of Neuronal Injury
Facchinetti, F., Dawson, V. L., & Dawson, T. M. (1998) · Cellular and Molecular Neurobiology · doi:10.1023/a:1020685903186 · Cited by 281 · see citing works
Activation of alpha7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E2 in rat microglial cultures.
Simone, R. D., Ajmone‐Cat, M. A., Carnevale, D., & Minghetti, L. (2005) · Journal of Neuroinflammation · doi:10.1186/1742-2094-2-4 · Cited by 248 · see citing works
Involvement of inducible nitric oxide synthase in inflammation-induced dopaminergic neurodegeneration.
Iravani, M. M., Kashefi, K., Mander, P., Rose, S., & Jenner, P. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00562-0 · Cited by 247 · see citing works
Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures
Dawson, V. L., Brahmbhatt, H., Mong, J. A., & Dawson, T. M. (1994) · Neuropharmacology · doi:10.1016/0028-3908(94)90045-0 · Cited by 243 · see citing works
Microglial α7 nicotinic acetylcholine receptors drive a phospholipase C/IP 3 pathway and modulate the cell activation toward a neuroprotective role
Suzuki, T., Hide, I., Matsubara, A., Hama, C., Harada, K., Miyano, K., Andrä, M., Matsubayashi, H., Sakai, N., Kohsaka, S., et al. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20850 · Cited by 241 · see citing works
In utero bacterial endotoxin exposure causes loss of tyrosine hydroxylase neurons in the postnatal rat midbrain
Ling, Z., Gayle, D. A., Ma, S. Y., Lipton, J. W., Tong, C. W., Hong, J., & Carvey, P. M. (2002) · Movement Disorders · doi:10.1002/mds.10078 · Cited by 241 · see citing works
The degenerative effect of a single intranigral injection of LPS on the dopaminergic system is prevented by dexamethasone, and not mimicked by rh‐TNF‐α, IL‐1β and IFN‐γ
Castaño, A., Herrera, A. J., Cano, J., & Machado, A. M. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00799.x · Cited by 239 · see citing works
In Vitro and In Vivo Effects of Genistein on Murine Alveolar Macrophage TNFα Production
Morris, P. E., Olmstead, L., Howard-Carroll, A. E., Dickens, G. R., Goltz, M. L., Courtney-Shapiro, C., & Fanti, P. (1999) · Inflammation · doi:10.1023/a:1020221919154 · Cited by 229 · see citing works
Smoking and Parkinson’s disease
Gorell, J. M., Rybicki, B. A., Johnson, C. C., & Peterson, E. L. (1999) · Neurology · doi:10.1212/wnl.52.1.115 · Cited by 224 · see citing works
Role of reactive oxygen species in LPS‐induced production of prostaglandin E2in microglia
Wang, T., Qin, L., Liu, B., Liu, Y., Wilson, B. C., Eling, T. E., Langenbach, R. I., Taniura, S., & Hong, J. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02242.x · Cited by 218 · see citing works
Self-citation
Parkinson disease, 10 years after its genetic revolution: Multiple clues to a complex disorder
Klein, C., & Schlossmacher, M. G. (2007) · Neurology · doi:10.1212/01.wnl.0000271880.27321.a7 · Cited by 209 · see citing works
Minocycline Reduces the Lipopolysaccharide-Induced Inflammatory Reaction, Peroxynitrite-Mediated Nitration of Proteins, Disruption of the Blood–Brain Barrier, and Damage in the Nigral Dopaminergic System
Tomás-Camardiel, M., Rite, I., Herrera, A. J., de Pablos, R. M., Cano, J., Machado, A., & Venero, J. L. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.01.010 · Cited by 203 · see citing works
Up-regulation of inducible nitric oxide synthase in the substantia nigra by lipopolysaccharide causes microglial activation and neurodegeneration.
Arimoto, T., & Bing, G. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(02)00017-7 · Cited by 202 · see citing works
Lipopolysaccharide (LPS)-induced dopamine cell loss in culture: roles of tumor necrosis factor-α, interleukin-1β, and nitric oxide
Gayle, D. A., Ling, Z., Tong, C. W., Landers, T. M., Lipton, J. W., & Carvey, P. M. (2002) · Developmental Brain Research · doi:10.1016/s0165-3806(01)00315-7 · Cited by 201 · see citing works
Production of nitrite by neonatal rat microglial cells/ brain macrophages
Zielasek, J., Tausch, M., Toyka, K. V., & Hartung, H. (1992) · Cellular Immunology · doi:10.1016/0008-8749(92)90131-8 · Cited by 195 · see citing works
Activation of murine microglial cell lines by lipopolysaccharide and interferon‐γ causes NO‐mediated decreases in mitochondrial and cellular function
Moss, D. W., & Bates, T. E. (2001) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2001.01418.x · Cited by 192 · see citing works
Systemic Infusion of Naloxone Reduces Degeneration of Rat Substantia Nigral Dopaminergic Neurons Induced by Intranigral Injection of Lipopolysaccharide
Liu, B., Jiang, J., Wilson, B. C., Du, L., Yang, S., Wang, J., Wu, G.-C., Cao, X.-D., & Hong, J. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38877-9 · Cited by 167 · see citing works
Self-citation
High dose steroid treatment in cerebral infarction.
Norris, J. W., & Hachinski, V. (1986) · BMJ · doi:10.1136/bmj.292.6512.21 · Cited by 163 · see citing works
Evaluation of animal models of Parkinson's disease for neuroprotective strategies
Emborg, M. E. (2004) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.08.004 · Cited by 156 · see citing works
Neuroprotective effect of nicotine on dopaminergic neurons by anti‐inflammatory action
Park, H.-J., Lee, P. H., Ahn, Y. W., Choi, Y. J., Lee, G., Lee, D., Chung, E. S., & Jin, B. K. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05636.x · Cited by 153 · see citing works
Interleukin-10 protects against inflammation-mediated degeneration of dopaminergic neurons in substantia nigra
Arimoto, T., Choi, D., Lü, X., Liu, M., Nguyen, X. V., Zheng, N., Stewart, C. A., Kim, H., & Bing, G. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.04.011 · Cited by 149 · see citing works
kappa opioid receptors in human microglia downregulate human immunodeficiency virus 1 expression.
Chao, C., Gekker, G., Hu, S., Sheng, W. S., Shark, K. B., Bu, D.-F., Archer, S., Bidlack, J. M., & Peterson, P. K. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.15.8051 · Cited by 144 · see citing works
Minocycline inhibits apoptotic cell death via attenuation of TNF‐α expression following iNOS/NO induction by lipopolysaccharide in neuron/glia co‐cultures
Lee, S. M., Yune, T. Y., Kim, S. J., Kim, Y. C., Oh, Y. J., Markelonis, G. J., & Oh, T. H. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02780.x · Cited by 139 · see citing works
Rotenone potentiates dopamine neuron loss in animals exposed to lipopolysaccharide prenatally
Ling, Z., Chang, Q. A., Tong, C. W., Leurgans, S. E., Lipton, J. W., & Carvey, P. M. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.08.006 · Cited by 131 · see citing works
Cyclooxygenase-2 Inhibitor NS-398 Protects Neuronal Cultures From Lipopolysaccharide-Induced Neurotoxicity
Araki, E., Forster, C. L., Dubinsky, J. M., Ross, M. E., & Iadecola, C. (2001) · Stroke · doi:10.1161/hs1001.096057 · Cited by 126 · see citing works
Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors
Wang, J., Gao, Q., Wang, Y., Lafyatis, R., Stamm, S., & Andreadis, A. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02232.x · Cited by 125 · see citing works
Immune processes in the pathogenesis of Parkinson's disease - a potential role for microglia and nitric oxide.
Członkowska, A., Kurkowska‐Jastrzębska, I., Członkowski, A., Peter, D., & Stefano, G. B. (2002) · PubMed · Cited by 123 · see citing works
The acute and the long‐term effects of nigral lipopolysaccharide administration on dopaminergic dysfunction and glial cell activation
Iravani, M. M., Leung, C. C. M., Sadeghian, M., Haddon, C. O., Rose, S., & Jenner, P. G. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04220.x · Cited by 123 · see citing works
Neurotoxic Effects of Lipopolysaccharide on Nigral Dopaminergic Neurons Are Mediated by Microglial Activation, Interleukin-1β, and Expression of Caspase-11 in Mice
Arai, H., Furuya, T., Yasuda, T., Miura, M., Mizuno, Y., & Mochizuki, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407328200 · Cited by 122 · see citing works
Stimulation of the NADPH oxidase in activated rat microglia removes nitric oxide but induces peroxynitrite production
Bal‐Price, A., Matthias, A., & Brown, G. C. (2001) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2001.00675.x · Cited by 122 · see citing works
Neuropathological imaging: in vivo detection of glial activation as a measure of disease and adaptive change in the brain
Banati, R. B. (2003) · British Medical Bulletin · doi:10.1093/bmb/65.1.121 · Cited by 122 · see citing works
Characterization of interleukin-1 production by microglia in culture
Yao, J., Keri, J. E., Taffs, R. E., & Colton, C. A. (1992) · Brain Research · doi:10.1016/0006-8993(92)90981-e · Cited by 118 · see citing works
Combined toxicity of prenatal bacterial endotoxin exposure and postnatal 6-hydroxydopamine in the adult rat midbrain
Ling, Z. D., Chang, Q., Lipton, J. W., Tong, C. W., Landers, T. M., & Carvey, P. M. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.12.017 · Cited by 114 · see citing works
Antagonistic effects of lipopolysaccharide binding protein and bactericidal/permeability-increasing protein on lipopolysaccharide-induced cytokine release by mononuclear phagocytes. Competition for binding to lipopolysaccharide.
Dentener, M. A., von Asmuth, E. J., Francot, G. J. M., MARRA, M. N., & Buurman, W. A. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.8.4258 · Cited by 112 · see citing works
Activation of Mu Opioid Receptors Inhibits Microglial Cell Chemotaxis
Chao, C. C., Hu, S., Shark, K. B., Sheng, W. S., Gekker, G., & Peterson, P. K. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36668-6 · Cited by 110 · see citing works
Parkinson’s Disease: Current and Future Challenges
Langston, J. W. (2002) · NeuroToxicology · doi:10.1016/s0161-813x(02)00098-0 · Cited by 109 · see citing works
A rat model of Parkinson's disease induced by Japanese encephalitis virus
Ogata, A., Tashiro, K., Nukuzuma, S., Nagashima, K., & Hall, W. W. (1997) · Journal of NeuroVirology · doi:10.3109/13550289709015803 · Cited by 105 · see citing works
The role of cyclo-oxygenase 1 and 2 activity in prostaglandin E2 secretion by cultured human adult microglia: Implications for Alzheimer’s disease
Hoozemans, J. J. M., Veerhuis, R., Janssen, I., van Elk, E.-J., Rozemüller, A. J. M., & Eikelenboom, P. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03164-5 · Cited by 104 · see citing works
L-dopa-responsive movement disorder caused by Nocardia asteroides localized in the brains of mice
Kohbata, S., & Beaman, B. L. (1991) · Infection and Immunity · doi:10.1128/iai.59.1.181-191.1991 · Cited by 104 · see citing works
Tumor Necrosis Factor-Alpha Production by Human Fetal Microglial Cells: Regulation by Other Cytokines
Chao, C. C., Hu, S., Sheng, W. S., & Peterson, P. K. (2007) · Developmental Neuroscience · doi:10.1159/000111278 · Cited by 103 · see citing works
Neuroprotection in Parkinson's disease: Clinical trials
Stocchi, F., & Olanow, C. W. (2003) · Annals of Neurology · doi:10.1002/ana.10488 · Cited by 102 · see citing works
Long-term development of mesencephalic dopaminergic neurons of mouse embryos in dissociated primary cultures: Morphological and histochemical characteristics
Berger, B., di Porzio, U., Daguet, M.-C., Gay, M., Vigny, A., Glowinski, J., & Prochiantz, A. (1982) · Neuroscience · doi:10.1016/0306-4522(82)90160-9 · Cited by 101 · see citing works
Modulation of microglial pro-inflammatory and neurotoxic activity for the treatment of Parkinson’s disease
Liu, B. (2006) · The AAPS Journal · doi:10.1208/aapsj080369 · Cited by 100 · see citing works
Self-citation
Naloxone prevents microglia-induced degeneration of dopaminergic substantia nigra neurons in adult rats
Lu, X., Bing, G., & Hagg, T. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00033-6 · Cited by 89 · see citing works
Neuroprotective strategies for Parkinson's disease: conceptual limits of animal models and clinical trials
Meissner, W. G., Hill, M. P., Tison, F., Gross, C. E., & Bézard, E. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.03.003 · Cited by 87 · see citing works
Extracellular accumulation of nitric oxide, hydrogen peroxide, and glutamate in astrocytic cultures following glutathione depletion, complex I inhibition, and/or lipopolysaccharide-induced activation
McNaught, K. S. P., & Jenner, P. G. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00415-9 · Cited by 86 · see citing works
Microglial NADPH oxidase is a novel target for femtomolar neuroprotection against oxidative stress
Qin, L., Block, M. L., Liu, Y., Bienstock, R. J., Pei, Z., Zhang, W., Wu, X., Wilson, B. C., Burka, T., & Hong, J. (2005) · The FASEB Journal · doi:10.1096/fj.04-2857com · Cited by 82 · see citing works
In Vivo Expression of Cyclooxygenase-2 in Rat Brain Following Intraparenchymal Injection of Bacterial Endotoxin and Inflammatory Cytokines
Minghetti, L., Walsh, D. T., Levi, G., & Perry, V. H. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199911000-00008 · Cited by 75 · see citing works
Reactive oxygen species mediate A??(25-35)-induced activation of BV-2 microglia
Kang, J., Park, E. J., Jou, I., Kim, J., & Joe, E.-H. (2001) · Neuroreport · doi:10.1097/00001756-200105250-00030 · Cited by 68 · see citing works
Intrapallidal lipopolysaccharide injection increases iron and ferritin levels in glia of the rat substantia nigra and induces locomotor deficits
Zhang, J., Stanton, D. M., Nguyen, X. V., Liu, M., Zhang, Z., Gash, D. M., & Bing, G. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.049 · Cited by 64 · see citing works
Children and Encephalitis Lethargica: A Historical Review
Vilensky, J. A., Foley, P. B., & Gilman, S. (2007) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2007.04.012 · Cited by 63 · see citing works
Corticosteroids in ischemic stroke.
Anderson, D. C., & Cranford, R. E. (1979) · Stroke · doi:10.1161/01.str.10.1.68 · Cited by 62 · see citing works
Role of microglia in inflammation-mediated degeneration of dopaminergic neurons: neuroprotective effect of Interleukin 10
Li, Q., Hong, J., & Flood, P. M. (2006) · Springer eBooks · doi:10.1007/978-3-211-45295-0_56 · Cited by 60 · see citing works
Primary Rat Mesencephalic Neuron-Glia, Neuron-Enriched, Microglia-Enriched, and Astroglia-Enriched Cultures
Liu, B., & Hong, J. (2003) · Humana Press eBooks · doi:10.1385/1-59259-358-5:387 · Cited by 50 · see citing works
Self-citation
Role of p38 and inducible nitric oxide synthase in the in vivo dopaminergic cells’ degeneration induced by inflammatory processes after lipopolysaccharide injection
Ruano, D., Revilla, E., Gavilán, M. P., Vizuete, M., Pintado, C., Vitórica, J., & Castaño, A. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.02.073 · Cited by 49 · see citing works
Lipopolysaccharide‐induced dopaminergic cell death in rat midbrain slice cultures: role of inducible nitric oxide synthase and protection by indomethacin
Shibata, H., Katsuki, H., Nishiwaki, M., Kume, T., Kaneko, S., & Akaike, A. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01929.x · Cited by 48 · see citing works
Does prepregnancy bacterial vaginosis increase a mother's risk of having a preterm infant with cerebral palsy?
Dammann, O., & Leviton, A. (1997) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1997.tb07554.x · Cited by 44 · see citing works
Lack of detection of influenza genes in archived formalin-fixed, paraffin wax-embedded brain samples of encephalitis lethargica patients from 1916 to 1920.
Lo, K. C., Geddes, J. F., Daniels, R. S., & OXFORD, J. S. (2003) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-003-0795-1 · Cited by 41 · see citing works
Brain Catecholamine Alterations and Pathological Features with Aging in Parkinson Disease Model Rat Induced by Japanese Encephalitis Virus
Hamaue, N., Ogata, A., Terado, M., Ohno, K., Kikuchi, S., Sasaki, H., Tashiro, K., Hirafuji, M., & Minami, M. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9197-5 · Cited by 29 · see citing works
Activated microglial supernatant induced motor neuron cytotoxicity is associated with upregulation of the TNFR1 receptor
Wen, W., Sanelli, T. R., Ge, W., Strong, W., & Strong, M. J. (2006) · Neuroscience Research · doi:10.1016/j.neures.2006.02.004 · Cited by 28 · see citing works
Art and artifice in the science of histology
RIO‐HORTEGA, P. D. (1993) · Histopathology · doi:10.1111/j.1365-2559.1993.tb00171.x · Cited by 27 · see citing works
Effects of the Combined Treatment of Naloxone and Indomethacin on Catecholamines and Behavior After Intranigral Lipopolysaccharide Injection
Wang, V., Chia, L., Ni, D.-R., Cheng, L., Ho, Y.-P., Cheng, F., & Hong, J. (2004) · Neurochemical Research · doi:10.1023/b:nere.0000013736.80749.4b · Cited by 13 · see citing works
Lack of evidence for Nocardia asteroides in brain specimens from Lewy body-containing disorders
Lü, L., Camp, D. M., Loeffler, D. A., & LeWitt, P. A. (2005) · Microbial Pathogenesis · doi:10.1016/j.micpath.2005.08.001 · Cited by 9 · see citing works
Workshop 11: Microglia, Cell of the Brain Decade
Graeber, M. B., & Kreutzberg, G. W. (1994) · Brain Pathology · doi:10.1111/j.1750-3639.1994.tb00920.x · Cited by 3 · see citing works

Flagged first, then by citations

1 of the 106 references couldn’t be matched to a known paper.

Sorted by citations

Microglial cell origin and phenotypes in health and disease
Saijo, K., & Glass, C. K. (2011) · Nature Reviews Immunology · doi:10.1038/nri3086 · Cited by 1,100 · see citing works
“Conversely, activation of microglia by LPS is sufficient to induce the death of dopaminergic neurons: injection of LPS into the intraperitoneal cavities of animals or the substantia nigra in the brain induces drastic microglial cell inflammatory responses followed by the death of dopaminergic neuron”
Background
Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention
Tansey, M. G., & Goldberg, M. S. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.11.004 · Cited by 1,045 · see citing works
“…Author M anuscript peripheral macrophage populations and study their role in degeneration of the nigrostriatal pathway (for a detailed review see (Dutta et al., 2008)) and depending on the route, dose, and frequency of administration may be modeling very different inflammatory responses in the…”
Background
A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders
Sorboni, S. G., Moghaddam, H. S., Jafarzadeh-Esfehani, R., & Soleimanpour, S. (2022) · Clinical Microbiology Reviews · doi:10.1128/cmr.00338-20 · Cited by 562 · see citing works
Intestinal dysbiosis and lowered serum lipopolysaccharide-binding protein in Parkinson's disease
Hasegawa, S., Goto, S., Tsuji, H., Okuno, T., Asahara, T., Nomoto, K., Shibata, A., Fujisawa, Y., Minato, T., Okamoto, A., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0142164 · Cited by 523 · see citing works
“Additional supporting evidence is that oral administration of LPS is able to induce intestinal PD pathology in rodents [31, 32].”
Background
Targeting Microglial Activation States as a Therapeutic Avenue in Parkinson’s Disease
Subramaniam, S., & Federoff, H. J. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00176 · Cited by 343 · see citing works
Gut microbiota in neurodegenerative disorders
Sarkar, S. R., & Banerjee, S. (2019) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2019.01.004 · Cited by 319 · see citing works
Microglial phenotypes in Parkinson’s disease and animal models of the disease
Joers, V., Tansey, M. G., Mulas, G., & Carta, A. R. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.04.006 · Cited by 285 · see citing works
“The bacterial endotoxin LPS administered either intranigrally or peripherally, induces a potent activation of microglia and secretion of pro-inflammatory factors which precede the degeneration of the nigrostriatal DA pathway, and is therefore used to investigate direct neuroinflammation-induced dopamine loss (Castano…”
Background
Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease
Collins, L. M., Toulouse, A., Connor, T. J., & Nolan, Y. M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.01.028 · Cited by 275 · see citing works
“…of the BBB resulting in granulocyte infiltration and activation of parenchymal microglia (Banks and Robinson, 2010; Laflamme et al., 1999; Laflamme and Rivest, 1999; Perry, 2004) which contribute to the degeneration of dopaminergic neurons in the SNpc (Brochard et al., 2009; Dutta et al., 2008).”
Background
Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson’s disease?
Matsumoto, J., Stewart, T., Sheng, L., Li, N., Bullock, K. M., Song, N., Shi, M. Y., Banks, W. A., & Zhang, J. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0470-4 · Cited by 294 · see citing works
“Moreover, injection of LPS has proven a useful PD model by which inflammation mediates the progression and selective degeneration of dopaminergic neuron in rodents [16].”
Background
Amyloid β-Induced Death in Neurons Involves Glial and Neuronal Hemichannels
Orellana, J. A., Shoji, K. F., Abudara, V., Ezan, P., Amigou, E., Sáez, P. J., Jiang, J. X., Naus, C. C. G., Sáez, J. C., & Giaume, C. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6417-10.2011 · Cited by 286 · see citing works
“Accordingly, minocycline, which blocks mainly microglial activation (Dutta et al., 2008), prevented the astroglial and neuronal A 25–35-induced Et uptake in hippocampal slices, indicating that this change could be an initial response to A 25–35 triggered in these cells.”
Background
Neurodegeneration by Activation of the Microglial Complement-Phagosome Pathway
Bodea, L.-G., Wang, Y., Linnartz-Gerlach, B., Kopatz, J., Sinkkonen, L., Musgrove, R., Kaoma, T., Muller, A., Vallar, L., Di Monte, D. A., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.5002-13.2014 · Cited by 234 · see citing works
“Systemic intraperitoneal application of bacterial lipopolysaccharides (LPS) in single or repeated challenges in experimental animal models can induce or even exacerbate neurodegeneration (Dutta et al., 2008; Cunningham, 2013).”
Background
Depressive-like behaviors alterations induced by intranigral MPTP, 6-OHDA, LPS and rotenone models of Parkinson's disease are predominantly associated with serotonin and dopamine
Santiago, R. M., Barbieiro, J., Lima, M. M. S., Dombrowski, P. A., Andreatini, R., & Vital, M. A. B. F. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.06.004 · Cited by 251 · see citing works
Gut as a target for cadmium toxicity
Tinkov, A. A., Гриценко, В. А., Геннадиевна, С. М., Sv, C., Aaseth, J., & Skalny, A. V. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2017.12.114 · Cited by 250 · see citing works
A primary neural cell culture model to study neuron, astrocyte, and microglia interactions in neuroinflammation
Goshi, N., Morgan, R. K., Lein, P. J., & Şeker, E. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01819-z · Cited by 248 · see citing works
Biological role of Toll-like receptor-4 in the brain
Trotta, T., Porro, C., Calvello, R., & Panaro, M. A. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.01.014 · Cited by 204 · see citing works
“PD is an age-related neurodegenerative disorder of the extrapyramidal motor neurons, characterized by loss of dopaminergic neurons from the substantia nigra pars compacta (SNpc) to the striatum (caudate and putamen) of the basal ganglia (Duttaa et al., 2008).”
Background
CNS Inflammation and Macrophage/Microglial Biology Associated with HIV-1 Infection
Yadav, A., & Collman, R. G. (2009) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-009-9174-2 · Cited by 199 · see citing works
“In addition, LPS has been extensively used as a microglial activator for the induction of inflammatory dopaminergic neurodegeneration in animal models of Parkinson’s disease (Castano et al. 1998; Liu et al. 2000a; Arai et al. 2004; Ling et al. 2004; Zhang et al. 2005; Dutta et al. 2008).”
Method
Curcumin affords neuroprotection and inhibits α-synuclein aggregation in lipopolysaccharide-induced Parkinson’s disease model
Sharma, N., & Nehru, B. (2017) · Inflammopharmacology · doi:10.1007/s10787-017-0402-8 · Cited by 177 · see citing works
Microglia plasticity during health and disease: An immunological perspective
Shemer, A., Erny, D., Jung, S., & Prinz, M. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.08.003 · Cited by 168 · see citing works
“lipopolysaccharide (LPS) treatment was shown to result in an inflammatory microglial response followed by the death of dopaminergic neurons, a major hallmark of PD [62].”
Background
Doxycycline Suppresses Microglial Activation by Inhibiting the P38 MAPK and NF-KB Signaling Pathways
Santa-Cecília, F. V., Socias, B., Ouidja, M. O., Sepulveda-Diaz, J. E., Acuña, L., Silva, R. L., Michel, P. P., Del-Bel, E., Cunha, T. M., & Raisman-Vozari, R. (2016) · Neurotoxicity Research · doi:10.1007/s12640-015-9592-2 · Cited by 165 · see citing works
“The results showed that doxycycline reduced the production of ROS and completely abolished the production of NO induced by LPS.”
BackgroundInfluential
The multiple faces of quercetin in neuroprotection
Ossola, B., Kääriäinen, T. M., & Männistö, P. T. (2009) · Expert Opinion on Drug Safety · doi:10.1517/14740330903026944 · Cited by 157 · see citing works
“It is well known that administration of LPS, by activating neuroinflammation, can induce cognitive impairment in rodents [91].”
Background
Role of Endogenous Lipopolysaccharides in Neurological Disorders
Kalyan, M., Hediyal, T. A., Sonali, S., Vichitra, C., Sunanda, T., Praveenraj, S. S., Ray, B., Gorantla, V. R., Rungratanawanich, W., Mahalakshmi, A. M., et al. (2022) · Cells · doi:10.3390/cells11244038 · Cited by 161 · see citing works
“Studies using rodent models have shown that orally administered LPS can induce intestinal PD pathology [78,79].”
Background
Diet in Parkinson’s Disease: Critical Role for the Microbiome
Jackson, A., Forsyth, C. B., Shaikh, M., Voigt, R. M., Engen, P. A., Ramirez, V., & Keshavarzian, A. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01245 · Cited by 145 · see citing works
P2X7 Receptors Amplify CNS Damage in Neurodegenerative Diseases
Illés, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21175996 · Cited by 141 · see citing works
Cholinergic Modulation of Glial Function During Aging and Chronic Neuroinflammation
Gamage, R. V., Wagnon, I. M., Rossetti, I., Childs, R., Niedermayer, G., Chesworth, R., & Gyengési, E. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.577912 · Cited by 133 · see citing works
“LPS administration is also used to model PD in animals, as it activates glial cells and induces inflammatory changes and dopaminergic neurodegeneration (Dutta et al., 2008).”
Treadmill exercise ameliorates dopaminergic neuronal loss through suppressing microglial activation in Parkinson's disease mice
Sung, Y.-H., Kim, S.-C., Hong, H.-P., Park, C.-Y., Shin, M.-S., Kim, C., Seo, J.-H., Kim, D., Kim, D.-J., & Cho, H. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.10.003 · Cited by 129 · see citing works
Repairing the parkinsonian brain with neurotrophic factors
Aron, L., & Klein, R. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.11.001 · Cited by 126 · see citing works
Anti-Inflammatory Effects of Angiotensin Receptor Blockers in the Brain and the Periphery
Benický, J., Sánchez-Lemus, E., Pavel, J., & Saavedra, J. M. (2009) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-009-9368-4 · Cited by 126 · see citing works
“Chronic brain inflammation has been linked to the development of a number of neuro- psychiatric diseases including depression, Parkinson’s and Alzheimer’s diseases (Dutta et al. 2008; Fassbender et al. 2004; Rogers et al. 2007).”
Background
α7 nicotinic acetylcholine receptor-mediated neuroprotection against dopaminergic neuron loss in an MPTP mouse model via inhibition of astrocyte activation
Liu, Y., Hu, J., Wu, J., Zhu, C., Hui, Y., Han, Y., Huang, Z., Ellsworth, K. R., & Fan, W. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-98 · Cited by 124 · see citing works
“The potential anti-inflammatory mechanism(s) and regulation of astrocyte activation by nicotine were further investigated using lipopolysaccharide (LPS), which is the most extensively used glial cell activator because of its induction of inflammatory changes and consequent dopaminergic neurodegeneration [9].”
BackgroundMethod
Anti-inflammatory Activity of a Honey Flavonoid Extract on Lipopolysaccharide-Activated N13 Microglial Cells
Candiracci, M., Piatti, E., Dominguez-Barragán, M., García-Antrás, D., Rodríguez-Morgado, B., Ruano, D., Gutiérrez, J. F., Parrado, J., & Castaño, A. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf302468h · Cited by 122 · see citing works
Characterization of the lipopolysaccharide induced model of Parkinson's disease: Role of oxidative stress and neuroinflammation
Sharma, N., & Nehru, B. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.06.004 · Cited by 115 · see citing works
“…2010); therefore, it is when injected unilaterally into the rat substantia nigra, produced microglia activation and stable loss of nigral dopamine neurons along with a stable reduction of around 60% in the striatal dopamine level (Dutta et al., 2008; Herrera et al., 2000; Iravani et al., 2002).”
Toll-Like Receptors Expression and Signaling in Glia Cells in Neuro-Amyloidogenic Diseases: Towards Future Therapeutic Application
Trudler, D., Farfara, D., & Frenkel, D. (2010) · Mediators of Inflammation · doi:10.1155/2010/497987 · Cited by 117 · see citing works
“One of the Parkinson’s disease animal models is composed of an intranigral LPS injection, which stimulates dopaminergic cell death [123].”
Background
Further characterisation of the LPS model of Parkinson’s disease: A comparison of intra-nigral and intra-striatal lipopolysaccharide administration on motor function, microgliosis and nigrostriatal neurodegeneration in the rat
Hoban, D. B., Connaughton, E., Connaughton, C., Hogan, G., Thornton, C., Mulcahy, P. J., Moloney, T. C., & Dowd, E. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.10.001 · Cited by 113 · see citing works
BDNF receptor blockade hinders the beneficial effects of exercise in a rat model of Parkinson s disease
Real, C. C., Ferreira, A. F. B., Chaves-Kirsten, G. P., Torrão, A. S., Pires, R. S., & Britto, L. R. G. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.01.060 · Cited by 109 · see citing works
“For example, intraperitoneal injections of LPS promote a quick systemic and intense inflammation that activates microglial response in the SNc and other brain regions (Dutta et al., 2008; Wu et al., 2011), resulting in a severe loss of 76% of the TH-positive cells (Wu et al.”
Impaired CD200-CD200R-mediated microglia silencing enhances midbrain dopaminergic neurodegeneration: roles of aging, superoxide, NADPH oxidase, and p38 MAPK
Wang, X.-J., Zhang, S., Yan, Z.-Q., Zhao, Y.-X., Zhou, H.-Y., Wang, Y., Lu, G.-Q., & Zhang, J.-D. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.01.032 · Cited by 108 · see citing works
DJ ‐1 deficiency triggers microglia sensitivity to dopamine toward a pro‐inflammatory phenotype that is attenuated by rasagiline
Trudler, D., Weinreb, O., Mandel, S. A., Youdim, M. B. H., & Frenkel, D. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12633 · Cited by 108 · see citing works
“are significantly lower than that observed in another LPS model (Dutta et al. 2008).”
BackgroundMethodResultInfluential
The Endotoxin-Induced Neuroinflammation Model of Parkinson's Disease
Tüfekçi, K. U., Genç, Ş., & Genç, K. (2011) · Parkinson s Disease · doi:10.4061/2011/487450 · Cited by 108 · see citing works
“Compared with the in vitro LPS model, a single injection of low microgram quantities of LPS to the SN enables the comparison of the relative vulnerability to inflammatory damage of dopaminergic neurons in the SN versus those in the VTA, dopaminergic versus nondopaminergic neurons in the SN, and dopaminergic versus non…”
BackgroundMethodInfluential
The gut microbiome in Parkinson's disease: A culprit or a bystander?
Keshavarzian, A., Engen, P. A., Bonvegna, S., & Cilia, R. (2020) · Progress in brain research · doi:10.1016/bs.pbr.2020.01.004 · Cited by 104 · see citing works
Phosphodiesterase 7 Inhibition Preserves Dopaminergic Neurons in Cellular and Rodent Models of Parkinson Disease
Morales-Garcia, J. A., Redondo, M., Alonso‐Gil, S., Gil, C., Pérez, C., Martı́nez, A., Santos, Á., & Pérez‐Castillo, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017240 · Cited by 101 · see citing works
“Administration of the bacterial endotoxin LPS in rats induces a consistent glial activation and a subsequent dopaminergic cell loss that parallels many aspects of PD [29,44,45].”
Background
Natural Molecules and Neuroprotection: Kynurenic Acid, Pantethine and α-Lipoic Acid
Tóth, F., Cseh, E., & Vécsei, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22010403 · Cited by 92 · see citing works
Neuroprotective Effect of Ceftriaxone on MPTP‐Induced Parkinson’s Disease Mouse Model by Regulating Inflammation and Intestinal Microbiota
Zhou, X., Lu, J., Wei, K., Wei, J., Tian, P., Yue, M., Wang, Y., Hong, D., Li, F., Wang, B., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/9424582 · Cited by 85 · see citing works
“Neuroinflammation is characterised by the activation of microglia and astrocytes [29].”
Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway
Ye, J.-M., Liu, Z., Wei, J.-P., Lu, L., Huang, Y., Luo, L., & Xie, H. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.08.020 · Cited by 93 · see citing works
Epigallocatechin-3-Gallate-Loaded Liposomes Favor Anti-Inflammation of Microglia Cells and Promote Neuroprotection
Cheng, C., Barro, L., Tsai, S., Feng, T.-W., Wu, X., Chao, C.-W., Yu, R.-S., Chin, T., & Hsieh, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063037 · Cited by 93 · see citing works
“The neuroinflammation process that causes PD is preceded by primary damage of neurons caused by environmental toxins, including rotenone [9], lipopolysaccharide (LPS) [5,7], and the effects of abnormal protein accumulation [10].”
Background
Role and Mechanism of Microglial Activation in Iron-Induced Selective and Progressive Dopaminergic Neurodegeneration
Zhang, W., Yan, Z., Gao, J., Sun, L., Huang, X., Liu, Z., Yu, S., Cao, C.-J., Zuo, L.-J., Chen, Z., et al. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8586-4 · Cited by 90 · see citing works
“[39, 40], which causes subsequent neurotoxicity.”
Neonatal lipopolysaccharide exposure induces long-lasting learning impairment, less anxiety-like response and hippocampal injury in adult rats
Wang, K.-C., Fan, L.-W., Kaizaki, A., Pang, Y., Cai, Z., & Tien, L.-T. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2012.12.049 · Cited by 92 · see citing works
“…responses establish feedforward loops and uncontrolled sustained inflammation may result in production of neurotoxic factors that amplify underlying neurodegenerative disease states, including Parkinson’s disease and Alzheimer’s disease (Dutta et al., 2008, Glass et al., 2010, Qian et al., 2010).”
Background
Motor and Non-Motor Features of Parkinson’s Disease – A Review of Clinical and Experimental Studies
Lima, M. M. S., Fachin‐Martins, E., Delattre, A. M., Proença, M. B., Mori, M. A., Carabelli, B., & Ferraz, A. C. (2012) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152712800792893 · Cited by 87 · see citing works
“Furthermore, other studies described the occurrence of depressive-like behaviors promoted by different neurotoxins, such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), lipopolysaccharide (LPS) and rotenone [43-45].”
Background
Potential role of gut microbiota and tissue barriers in Parkinson's disease and amyotrophic lateral sclerosis
Fang, X. (2015) · International Journal of Neuroscience · doi:10.3109/00207454.2015.1096271 · Cited by 84 · see citing works
“It is well known that LPS can be used to model PD [35,36].”
Background
Toll-Like Receptor 4: A Promising Therapeutic Target for Alzheimer’s Disease
Wu, L., Xian, X., Xu, G., Tan, Z., Dong, F., Zhang, M., & Zhang, F. (2022) · Mediators of Inflammation · doi:10.1155/2022/7924199 · Cited by 85 · see citing works
“AD was associated with damage to the intestinal barrier, through which LPS and proinflammatory factors produced by pathogens entered the body, disrupted the integrity of the blood-brain barrier (BBB), enhanced the uptake of Aβ and α-syn in the brain, and activated microglia-induced immune reactions through the LPS/ TL…”
Background
Inhibiting purinergic P2X7 receptors with the antagonist brilliant blue G is neuroprotective in an intranigral lipopolysaccharide animal model of Parkinson's disease
Wang, X., Xie, X., Luo, X., Shang, H., & He, Z. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.6070 · Cited by 83 · see citing works
“LPS (5.0 µl; 2 µg/µl) was purchased from Sigma‑Aldrich; Merck Millipore (Darmstadt, Germany) and injected into the right substantia nigra (30,32,33).”
Influential
Glycogen Synthase Kinase-3 Inhibitors as Potent Therapeutic Agents for the Treatment of Parkinson Disease.
Morales-Garcia, J. A., Susín, C., Alonso‐Gil, S., Pérez, D. I., Palomo, V., Pérez, C., Conde, S., Santos, Á., Gil, C., Martı́nez, A., et al. (2012) · ACS Chemical Neuroscience · doi:10.1021/cn300182g · Cited by 83 · see citing works
Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders
Anderson, K. M., Olson, K. E., Estes, K. A., Flanagan, K., Gendelman, H. E., & Mosley, R. L. (2014) · Translational Neurodegeneration · doi:10.1186/2047-9158-3-25 · Cited by 81 · see citing works
“These data, combined with the sensing of LPS as MAMPs, show that induction of microglial activation, neurotoxic factor production, and significant dopaminergic neurodegeneration provided evidence for LPS as an animal model of nigral dopaminergic neurodegeneration [113,120-122].”
Background
Causes and consequences of low grade endotoxemia and inflammatory diseases
Glaros, T. (2012) · Frontiers in Bioscience-Scholar · doi:10.2741/s405 · Cited by 78 · see citing works
Astrocytes and Microglia: Responses to Neuropathological Conditions
Singh, S., Swarnkar, S., Goswami, P., & Nath, C. (2011) · International Journal of Neuroscience · doi:10.3109/00207454.2011.598981 · Cited by 77 · see citing works
Alternative microglial activation is associated with cessation of progressive dopamine neuron loss in mice systemically administered lipopolysaccharide
Beier, E. E., Neal, M. P., Alam, G., Edler, M. K., Wu, L., & Richardson, J. R. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.08.009 · Cited by 76 · see citing works
“Experimental studies demonstrate that bacterial lipopolysaccharide (LPS) can induce and/or accelerate dopaminergic neurodegeneration in mice and rats (Dutta et al., 2008).”
Background
Lipolysaccharide-Induced Neuroinflammation Is Associated with Alzheimer-Like Amyloidogenic Axonal Pathology and Dendritic Degeneration in Rats
Deng, X., Li, M., Ai, W., He, L., Lu, D., Patrylo, P. R., Cai, H., Luo, X., Li, Z., & Yan, X. (2014) · Advances in Alzheimer s Disease · doi:10.4236/aad.2014.32009 · Cited by 75 · see citing works
“88 eases such as AD and PD [15] [16] [38] [44]-[50].”
Background
"Lipopolysaccharide-induced animal models for neuroinflammation – An overview."
Silva, A., Fiadeiro, M. B., Bernardino, L. I., Fonseca, C. P., Baltazar, G., & Cristóvão, A. C. (2023) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2023.578273 · Cited by 76 · see citing works
“Upon activation, through stimulation by mediators, a series of intracellular signaling pathways are activated (Dutta et al., 2008; Calcia et al., 2016; Batista et al., 2019; Lee et al., 2019), and consequently, microglia change to an amoeboid morphology generating an inflammatory response via two…”
BackgroundInfluential
Synergistic dopaminergic neurotoxicity of manganese and lipopolysaccharide: differential involvement of microglia and astroglia
Zhang, P., Lokuta, K. M., Turner, D. E., & Liu, B. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06477.x · Cited by 73 · see citing works
Self-citation
Intranasal LPS-Mediated Parkinson’s Model Challenges the Pathogenesis of Nasal Cavity and Environmental Toxins
He, Q. W., Yu, W., Wu, J., Chen, C., Lou, Z., Zhang, Q., Zhao, J., Wang, J., & Xiao, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078418 · Cited by 72 · see citing works
“Lipopolysaccharide (LPS), as a potent glial activator, has been used for the induction of dopamine (DA) neurodegeneration through intracranial and intraperitoneal injection [7].”
BackgroundInfluential
Genetically engineered mouse models of Parkinson's disease
Crabtree, D., & Zhang, J. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.07.019 · Cited by 71 · see citing works
“The bacterial endotoxin LPS models the inflammatory aspect of PD, causing glial activation (via binding of TLR-4 receptors) which in turn causes release of proinflammatory cytokines and free radicals with subsequent dopaminergic neurodegeneration [9].”
Background
Modulating Microglia Activity with PPAR-γ Agonists: A Promising Therapy for Parkinson’s Disease?
Carta, A. R., & Pisanu, A. (2012) · Neurotoxicity Research · doi:10.1007/s12640-012-9342-7 · Cited by 70 · see citing works
Dopaminergic neuronal injury in the adult rat brain following neonatal exposure to lipopolysaccharide and the silent neurotoxicity
Fan, L., Tien, L., Zheng, B., Pang, Y., Lin, R. C. S., Simpson, K. L., Ma, T., Rhodes, P. G., & Cai, Z. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.09.020 · Cited by 71 · see citing works
“Perinatal exposure to an endotoxin, lipopolysaccharide (LPS), has been shown to increase the risk for dopaminergic disorders in animal models of Parkinson’s disease, schizophrenia, autism and cerebral palsy (Boksa, 2010; Dutta et al., 2008; Feleder et al., 2010; Ling et al., 2002, 2004, 2006).”
Background
Therapeutic effect of GLP-1 engineered strain on mice model of Alzheimer’s disease and Parkinson’s disease
Fang, X., Zhou, X., Miao, Y., Han, Y., Wei, J., & Chen, T. (2020) · AMB Express · doi:10.1186/s13568-020-01014-6 · Cited by 70 · see citing works
Peripheral-Central Neuroimmune Crosstalk in Parkinson's Disease: What Do Patients and Animal Models Tell Us?
Armentero, M., Cerri, S., & Blandini, F. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00232 · Cited by 70 · see citing works
New avenues for Parkinson's disease therapeutics: disease-modifying strategies based on the gut microbiota
Lorente-Picón, M., & Laguna, A. (2021) · Biomolecules · doi:10.3390/biom11030433 · Cited by 69 · see citing works
Microglia enhance manganese chloride-induced dopaminergic neurodegeneration: Role of free radical generation
Zhang, P., Wong, T. A., Lokuta, K. M., Turner, D. E., Vujisic, K., & Liu, B. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.02.013 · Cited by 68 · see citing works
“Treatment of cells for 72 h with lipopolysaccharide (LPS), an inducer of glial activation-mediated DA neurodegeneration (Dutta et al., 2008; Gao et al., 2002a), however, did not have any effect on the viability of N27 neuronal cells (Fig.”
BackgroundSelf-citation
Divergent Effects of Metformin on an Inflammatory Model of Parkinson’s Disease
Tayara, K., Espinosa‐Oliva, A. M., García-Domínguez, I., Ismaiel, A. A., Boza‐Serrano, A., Deierborg, T., Machado, A., Herrera, A. J., Venero, J. L., & de Pablos, R. M. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00440 · Cited by 66 · see citing works
Systemic lipopolysaccharide (LPS)-induced microglial activation results in different temporal reduction of CD200 and CD200 receptor gene expression in the brain
Masocha, W. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.06.022 · Cited by 65 · see citing works
“Lipopolysaccharide (LPS), a bacterial endotoxin, activates microglia and can cause neurodegeneration (reviewed in Dutta et al., 2008; Perry and Andersson, 1992; Zielasek and Hartung, 1996).”
Neuroinflammation in Parkinson’s Disease Animal Models: A Cell Stress Response or a Step in Neurodegeneration?
Cebrián, C., Loike, J. D., & Sulzer, D. (2014) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2014_356 · Cited by 65 · see citing works
“2002) or neutralizing antibodies against TNF-α or IL-1 that block microglial activation (Dutta et al. 2008; McCoy and Tansey 2008).”
Background
Aldose reductase inhibitors attenuate β-amyloid-induced TNF-α production in microlgia via ROS-PKC-mediated NF-κB and MAPK pathways
Song, X.-M., Yu, Q., Dong, X., Yang, H. O., Zeng, K.-W., Li, J., & Tu, P.-F. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.06.005 · Cited by 60 · see citing works
“In neurodegenerative diseases, the inflammatory response is mediated by activated microglia which release pro-inflammatory mediators such as TNF-α, IL-1β to exacerbate these diseases [17,18].”
Background
Animal models of neurodegenerative diseases.
Ribeiro, F. M., Camargos, E. R. D. S., de Souza, L. D., & Teixeira, A. (2013) · Revista Brasileira de Psiquiatria · doi:10.1590/1516-4446-2013-1157 · Cited by 203 · see citing works
Cognitive dysfunction and depression in Parkinson’s disease: what can be learned from rodent models?
Lindgren, H. S., & Dunnett, S. B. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08162.x · Cited by 56 · see citing works
“This results in an inflammatory DA neurodegeneration to a variable extent depending on the dosing regimen (Dutta et al., 2008), but the accompanying motor impairment has not been reproducible between studies (Liu et al., 2008; Choi et al., 2009; Ariza et al., 2010).”
Background
Diet, Microbiota and Brain Health: Unraveling the Network Intersecting Metabolism and Neurodegeneration
Gentile, F., Doneddu, P. E., Riva, N., Nobile‐Orazio, E., & Quattrini, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207471 · Cited by 57 · see citing works
“Intrastriatal injection of LPS has been shown to replicate PD‐like phenotype and progressive neurodegeneration in mice [258].”
Background
RNA-Seq transcriptomic profiling of primary murine microglia treated with LPS or LPS + IFNγ
Pulido-Salgado, M., Vidal-Taboada, J. M., Barriga, G. G.-D., Solà, C., & Saura, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-34412-9 · Cited by 53 · see citing works
Interleukin-10 Protection against Lipopolysaccharide-Induced Neuro-Inflammation and Neurotoxicity in Ventral Mesencephalic Cultures
Zhu, Y., Chen, X., Liu, Z., Peng, Y.-P., & Qiu, Y. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms17010025 · Cited by 55 · see citing works
“LPS has been the most extensively utilized glial activator for the induction of inflammatory dopaminergic neurodegeneration [2].”
BackgroundInfluential
Exploiting the therapeutic potential of ready-to-use drugs: Repurposing antibiotics against amyloid aggregation in neurodegenerative diseases
Socías, S. B., González‐Lizárraga, F., Ávila, C. L., Vera, C., Acuña, L., Sepulveda-Diaz, J. E., Bel, E. A. D., Raisman‐Vozari, R., & Chehín, R. N. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.12.002 · Cited by 54 · see citing works
“On the other hand, since it was demonstrated that the oxidation of Ab by free radicals induces peptide fibrillization (Dyrks et al., 1992), antioxidant agents may exert anti-aggregating effects on the Ab peptide.”
Background
Human neuromelanin an endogenous microglial activator for dopaminergic neuron death
Zhang, W. (2012) · Frontiers in Bioscience-Elite · doi:10.2741/e591 · Cited by 53 · see citing works
“9 Strong evidence indicates that in the disease states, over-activated microglia produce and secret a myriad of factors, including reactive oxygen species (ROS), nitrogen species, cytokines, prostaglandins and chemokines (18-19), which may cause neuronal damage.”
Background
Peptidoglycan recognition protein genes and risk of Parkinson's disease
Goldman, S. M., Kamel, F., Ross, G. W., Jewell, S. A., Marras, C., Hoppin, J. A., Umbach, D. M., Bhudhikanok, G. S., Meng, C., Korell, M., et al. (2014) · Movement Disorders · doi:10.1002/mds.25895 · Cited by 52 · see citing works
“Systemic administration of gram-negative bacterial endotoxin (lipopolysaccharide [LPS]) activates microglia in the substantia nigra and induces progressive dopaminergic degeneration in a rodent model of parkinsonism.(18) However, little is known about possible effects of other bacterial components.”
Background
High glucocorticoid levels during gestation activate the inflammasome in hippocampal oligodendrocytes of the offspring
Maturana, C. J., Aguirre, A., & Sáez, J. C. (2016) · Developmental Neurobiology · doi:10.1002/dneu.22409 · Cited by 51 · see citing works
“The role of reactive astrocytes in this cell-cell conversation was specifically demonstrated by the effect of minocycline, which is an astrocyte activation inhibitor (Dutta et al., 2008), which also blocked oligodendrocyte hemichannel activity in brain slices of offspring from DEX-treated mice.”
BackgroundMethod
Acute Neuroinflammatory Response in the Substantia Nigra Pars Compacta of Rats after a Local Injection of Lipopolysaccharide
Flores-Martinez, Y. M., Fernandez-Parrilla, M. A., Ayala-Dávila, J., Reyes-Corona, D., Blanco-Álvarez, V. M., Soto-Rojas, L. O., Luna-Herrera, C., González-Barrios, J. A., León‐Chávez, B. A., Gutiérrez-Castillo, M. E., et al. (2018) · Journal of Immunology Research · doi:10.1155/2018/1838921 · Cited by 53 · see citing works
“Lipopolysaccharide (LPS) appears to be a neuroinflammatory stimulus more suitable to mimic the acute response of microglia that might also occur in the early stage of Parkinson’s disease [20].”
Background
NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson’s disease
Cheng, L. T., Chen, L., Wei, X., Wang, Y., Ren, Z.-P., Zeng, S., Zhang, X., Wen, H., Gao, C., & Liu, H. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1289-z · Cited by 52 · see citing works
RIFAMPICIN: An antibiotic with brain protective function
Yuluğ, B., Hanoğlu, L., Kılıç, E., & Schabitz, W. R. (2014) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2014.05.007 · Cited by 51 · see citing works
Considerations on the role of environmental toxins in idiopathic Parkinson’s disease pathophysiology
Pan-Montojo, F. J., & Reichmann, H. (2014) · Translational Neurodegeneration · doi:10.1186/2047-9158-3-10 · Cited by 51 · see citing works
“In animal experiments, exposure to the bacterial endotoxin lipopolysaccharide induced dopaminergic neurodegeneration [136,138,139].”
Background
miR-142 downregulation alleviates rat PTSD-like behaviors, reduces the level of inflammatory cytokine expression and apoptosis in hippocampus, and upregulates the expression of fragile X mental retardation protein
Nie, P.-Y., Tong, L., Li, M.-D., Fu, C.-H., Peng, J., & Ji, L.-L. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-020-02064-0 · Cited by 48 · see citing works
“Most of these glia-derived factors are proinflammatory and neurotoxic and are particularly deleterious to neurons [9, 10].”
Background
RETRACTED: Inhibition of Rho‐kinase by Fasudil protects dopamine neurons and attenuates inflammatory response in an intranasal lipopolysaccharide‐mediated Parkinson's model
He, Q., Li, Y., Guo, S., Wang, Y., Lin, W., Zhang, Q., Wang, J., Ma, C., & Xiao, B. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13132 · Cited by 48 · see citing works
“, 1993), and has been used for the induction of dopamine neurodegeneration through intracranial and intraperitoneal injection (Dutta et al., 2008).”
Background
Retracted
The effects of age and lipopolysaccharide (LPS)-mediated peripheral inflammation on numbers of central catecholaminergic neurons
Mouton, P. R., Kelley-Bell, B., Tweedie, D., Spangler, E. L., Perez, E., Carlson, O. D., Short, R. G., de Cabo, R., Chang, J. P., Ingram, D. K., et al. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.09.025 · Cited by 47 · see citing works
“Studies carried out in vitro indicate that LPSactivated macrophages and microglial cells stimulate multiple signaling pathways of the innate immune system, including the up-regulation and release of proinflammatory cytokines, including TNF-α, IL-1β, and IL-6, anti-inflammatory cytokine IL-10, and reactive oxygen speci…”
Background
Involvement of dopaminergic neuronal cystatin C in neuronal injury‐induced microglial activation and neurotoxicity
Dutta, G., Barber, D. S., Zhang, P., Doperalski, N. J., & Liu, B. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07826.x · Cited by 45 · see citing works
“up-regulation was observed with LPS, a potent stimulator of immune cells (Liu 2006; Dutta et al. 2008).”
MethodSelf-citation
Neonatal exposure to lipopolysaccharide enhances vulnerability of nigrostriatal dopaminergic neurons to rotenone neurotoxicity in later life
Fan, L., Tien, L., Lin, R. C. S., Simpson, K. L., Rhodes, P. G., & Cai, Z. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.07.011 · Cited by 46 · see citing works
Ketamine inhibits LPS‐mediated BV2 microglial inflammation via NMDA receptor blockage
Lu, Y., Ding, X., Wu, X., & Huang, S. (2019) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12508 · Cited by 46 · see citing works
Rifampicin and Parkinson’s disease
Bi, W., Zhu, L., Jing, X., Liang, Y., & Tao, E. (2012) · Neurological Sciences · doi:10.1007/s10072-012-1156-0 · Cited by 46 · see citing works
“Further investigations using LPS-stimulated BV2 microglial cells [49] demonstrate that rifampicin signifi-”
Method
Lipoic acid protects dopaminergic neurons in LPS-induced Parkinson’s disease model
Li, Y., He, Q. W., Yu, J., Liu, C., Feng, L., Chai, Z., Wang, Q., Zhang, H., Zhang, G., Xiao, B., et al. (2015) · Metabolic Brain Disease · doi:10.1007/s11011-015-9698-5 · Cited by 45 · see citing works
“Microglia have both neurotoxic and neurotrophic effects and serve as key components of brain inflammatory response , exerting a deleterious role on dopaminergic neurons in PD. (Trudler et al. 2014) Type 1 macrophages/microglia (M1) produce inflammatory cytokines and oxidative metabolites to exacerbate tissue injury, t…”
BackgroundInfluential
Brain region-specific microglial and astrocytic activation in response to systemic lipopolysaccharides exposure
Brandi, E., Torres-Garcia, L., Svanbergsson, A., Haikal, C., Liu, D., Li, W., & Li, J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.910988 · Cited by 44 · see citing works
“This neuronal population is more sensitive to reactive oxygen species (ROS), which exacerbate the detrimental effect of pathological agents such as α-synuclein or toxins (Drechsel and Patel, 2008; Dutta et al., 2008; Gao et al., 2008; Ramsey and Tansey, 2013; Rai and Singh, 2020; Rai et al., 2020).”
Background
Protective effects of agmatine on lipopolysaccharide-injured microglia and inducible nitric oxide synthase activity
Ahn, S. K., Hong, S., Park, Y. M., Choi, J. Y., Lee, W. T., Park, K. A., & Lee, J. E. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.10.010 · Cited by 44 · see citing works
“And LPS, a bacterial endotoxin, has been widely utilized as a potent inflammation inducer in various experimental systems (Dutta et al., 2008).”
Neonatal Systemic Exposure to Lipopolysaccharide Enhances Susceptibility of Nigrostriatal Dopaminergic Neurons to Rotenone Neurotoxicity in Later Life
Cai, Z., Fan, L., Kaizaki, A., Tien, L., Ma, T., Pang, Y., Lin, S., Lin, R. C. S., & Simpson, K. L. (2013) · Developmental Neuroscience · doi:10.1159/000346156 · Cited by 43 · see citing works
Crosstalk between peripheral inflammation and brain: Focus on the responses of microglia and astrocytes to peripheral challenge
Geloso, M. C., Zupo, L., & Corvino, V. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105872 · Cited by 42 · see citing works
Quantitative Proteomic Characterization of Ethanol-Responsive Pathways in Rat Microglial Cells
Bell‐Temin, H., Zhang, P., Chaput, D., King, M. A., You, M., Liu, B., & Stevens, S. M. (2013) · Journal of Proteome Research · doi:10.1021/pr301038f · Cited by 41 · see citing works
Self-citation
Silencing phosphodiesterase 7B gene by lentiviral-shRNA interference attenuates neurodegeneration and motor deficits in hemiparkinsonian mice
Morales-Garcia, J. A., Morante, D. A., Hernández-Encinas, E., Alonso‐Gil, S., Gil, C., Martı́nez, A., Santos, Á., & Pérez‐Castillo, A. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.10.008 · Cited by 41 · see citing works
Targeting the Nicotinic Acetylcholine Receptors (nAChRs) in Astrocytes as a Potential Therapeutic Target in Parkinson's Disease
Jurado-Coronel, J. C., Ávila-Rodriguez, M., Capani, F., González, J., Echeverrı́a, V., & Barreto, G. E. (2016) · Current Pharmaceutical Design · doi:10.2174/138161282210160304112133 · Cited by 39 · see citing works
Lipopolysaccharide administration for a mouse model of cerebellar ataxia with neuroinflammation
Hong, J., Yoon, D., Nam, Y., Seo, D., Kim, J., Kim, M. S., Lee, T. Y., Kim, K. S., Ko, P., Lee, H., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-70390-7 · Cited by 39 · see citing works
Helicobacter pylori infection and Parkinson’s Disease: etiology, pathogenesis and levodopa bioavailability
Wei, B.-R., Zhao, Y., Cheng, Y., Huang, C., & Zhang, F. (2024) · Immunity & Ageing · doi:10.1186/s12979-023-00404-1 · Cited by 38 · see citing works
“Mean-while, LPS up-regulates the expression of inducible nitric oxide synthase (iNOS) to promote NO release from microglia and astrocytes [64].”
BackgroundInfluential
Switching the Microglial Harmful Phenotype Promotes Lifelong Restoration of Subtantia Nigra Dopaminergic Neurons from Inflammatory Neurodegeneration in Aged Mice
L’Episcopo, F., Tirolo, C., Testa, N., Caniglia, S., Morale, M. C., Impagnatiello, F., & Marchetti, B. (2011) · Rejuvenation Research · doi:10.1089/rej.2010.1134 · Cited by 38 · see citing works
“In addition, LPS-induced microglial ROS production herein observed, further combined with iNOS-derived NO, forms the more damaging peroxynitrite.(25,31,51,61) In addition, a rise in intracellular ROS can further enhance the gene expression of TNF-a and IL-1b.”
Influential
Plant-Derived Natural Products for Parkinson’s Disease Therapy
Sengupta, T. K., Vinayagam, J., Singh, R. P., Jaisankar, P., & Mohanakumar, K. P. (2016) · Advances in neurobiology · doi:10.1007/978-3-319-28383-8_23 · Cited by 39 · see citing works

Targeting the noradrenergic system for anti-inflammatory and neuroprotective actions in an animal model of Parkinson's disease
Yssel, J. D. (2015) · Arrow@dit (Dublin Institute of Technology)
Lipopolysaccharide Animal Models for Parkinson's Disease
Liu, M., & Bing, G. (2011) · Parkinson s Disease · doi:10.4061/2011/327089 · Cited by 191 · see citing works
Inflammatory Animal Model for Parkinson's Disease: The Intranigral Injection of LPS Induced the Inflammatory Process along with the Selective Degeneration of Nigrostriatal Dopaminergic Neurons
Machado, A., Herrera, A. J., Venero, J. L., Santiago, M., de Pablos, R. M., Villarán, R. F., Espinosa‐Oliva, A. M., Argüelles, S., Sarmiento, M., Delgado‐Cortés, M. J., et al. (2011) · ISRN Neurology · doi:10.5402/2011/476158 · Cited by 47 · see citing works
Characterization of the lipopolysaccharide induced model of Parkinson's disease: Role of oxidative stress and neuroinflammation
Sharma, N., & Nehru, B. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.06.004 · Cited by 115 · see citing works
Lipopolysaccharide animal models of Parkinson’s disease: Recent progress and relevance to clinical disease
Deng, I. B., Corrigan, F., Zhai, G., Zhou, X., & Bobrovskaya, L. (2020) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2020.100060 · Cited by 120 · see citing works

Authors: Dutta, G., Zhang, P., & Liu, B.
Affiliations: University of Florida (US)
Corresponding author: Liu, Bin
ORCID: Liu, Bin
Venue: Fundamental & Clinical Pharmacology
Publisher: Wiley
Published: 2008-09-21
Volume: 22
Issue: 5
Pages: 453-464
ISSN: 0767-3981 (ISSN-L)
1472-8206
DOI: 10.1111/j.1472-8206.2008.00616.x
PMC: PMC2632601
OpenAlex: W2057913943
Cited by: 235
References: 106
Citations by year: 2026: 2 · 2025: 11 · 2024: 14 · 2023: 10 · 2022: 15 · 2021: 19 · 2020: 15 · 2019: 10 · 2018: 13 · 2017: 14 · 2016: 14 · 2015: 13 · 2014: 14 · 2013: 16 · 2012: 22
FWCI: 1.63
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Fundamental and Clinical Pharmacology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Environmental Health Sciences (ES013265, R01ES013265)
Topics: Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
Keywords: Parkinson's disease, lipopolysaccharide, neuroinflammation, nigrostriatal pathway, dopaminergic neuron loss, microglial activation, astrocytes, glial activation, neuroprotection, drug discovery, oxidative stress, cytokines, Parkinson's disease model
MeSH terms: Animals, Antiparkinson Agents, Disease Models, Animal, Humans, Lipopolysaccharides, Parkinson Disease, Drug Discovery

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The lipopolysaccharide Parkinson’s disease animal model: mechanistic studies and drug discovery

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks