Cited by 353Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and SenescenceRedox biology and oxidative stress

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The overexpression of major antioxidant enzymes does not extend the lifespan of mice

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Pérez, Viviana I., Van Remmen, Holly, Bokov, Alex, Epstein, Charles J., Vijg, Jan, Richardson, Arlan·2009·Aging Cell

DOI 10.1111/j.1474-9726.2008.00449.xPMC PMC2667893

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Abstract

We evaluated the effect of overexpressing antioxidant enzymes on the lifespans of transgenic mice that overexpress copper zinc superoxide dismutase (CuZnSOD), catalase, or combinations of either CuZnSOD and catalase or CuZnSOD and manganese superoxide dismutase (MnSOD). Our results show that the overexpression of these major antioxidant enzymes, which are known to scavenge superoxide and hydrogen peroxide in the cytosolic and mitochondrial compartments, is insufficient to extend lifespan in mice.

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Fig. 1 Lifespans of male transgenic mice overexpressing various antioxidant enzymes. Survival studies were conducted as described by Ran et al. (2007), and all mice were on the C57BL/6J background. The mice were housed four animals per cage starting at 2 months of age and fed a commercial mouse chow (Teklad Diet LM485) ad libitum. The survival of the WT cohort is presented in each of the graphs. The number of animals and the survival data are given in Table 1.CC BY · PubMed Central

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Authors: Pérez, V. I., Van Remmen, H., Bokov, A., Epstein, C. J., Vijg, J., & Richardson, A.
Affiliations: The University of Texas at San Antonio Health Science Center (US)
University of California, San Francisco (US)
Albert Einstein College of Medicine (US)
South Texas Veterans Health Care System (US)
Corresponding author: Richardson, Arlan
ORCID: Bokov, Alex
Epstein, Charles J.
Vijg, Jan
Richardson, Arlan
Venue: Aging Cell
Publisher: Wiley
Published: 2009-01-28
Volume: 8
Issue: 1
Pages: 73-75
ISSN: 1474-9718 (ISSN-L)
1474-9726
DOI: 10.1111/j.1474-9726.2008.00449.x
PMC: PMC2667893
OpenAlex: W2005586848
Cited by: 353
References: 19
Citations by year: 2026: 5 · 2025: 9 · 2024: 16 · 2023: 16 · 2022: 18 · 2021: 13 · 2020: 13 · 2019: 18 · 2018: 21 · 2017: 20 · 2016: 20 · 2015: 14 · 2014: 27 · 2013: 25 · 2012: 31
FWCI: 8.45
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Aging Cell (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (1P30- AG13319, P01 AG19316, R37AG026557, P01AG019316, P30AG013319)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: antioxidant enzymes, lifespan extension, superoxide dismutase, catalase, manganese superoxide dismutase, copper-zinc superoxide dismutase, transgenic mice, oxidative stress, aging, mitochondrial superoxide
MeSH terms: Animals, Catalase, Disease Models, Animal, Humans, Hydrogen Peroxide, Longevity, Mice, Inbred C57BL, Mice, Transgenic, Superoxide Dismutase, Oxidative Stress, Reverse Transcriptase Polymerase Chain Reaction, Mice

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The overexpression of major antioxidant enzymes does not extend the lifespan of mice

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