Cited by 353Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and SenescenceRedox biology and oxidative stress

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

Open access

Pérez, Viviana I., Van Remmen, Holly, Bokov, Alex, Epstein, Charles J., Vijg, Jan, Richardson, Arlan·2009·Aging Cell

DOI 10.1111/j.1474-9726.2008.00449.xPMC PMC2667893

Open this paper in CoChat — free account

Abstract

We evaluated the effect of overexpressing antioxidant enzymes on the lifespans of transgenic mice that overexpress copper zinc superoxide dismutase (CuZnSOD), catalase, or combinations of either CuZnSOD and catalase or CuZnSOD and manganese superoxide dismutase (MnSOD). Our results show that the overexpression of these major antioxidant enzymes, which are known to scavenge superoxide and hydrogen peroxide in the cytosolic and mitochondrial compartments, is insufficient to extend lifespan in mice.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/j.1474-9726.2008.00449.x

Cites

19 of 19 references verified0 citation errors · 0 not checkable

Statistics

Fig. 1 Lifespans of male transgenic mice overexpressing various antioxidant enzymes. Survival studies were conducted as described by Ran et al. (2007), and all mice were on the C57BL/6J background. The mice were housed four animals per cage starting at 2 months of age and fed a commercial mouse chow (Teklad Diet LM485) ad libitum. The survival of the WT cohort is presented in each of the graphs. The number of animals and the survival data are given in Table 1.CC BY · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A Simple Sequentially Rejective Multiple Test Procedure
(1979) · Scandinavian Journal of Statistics · doi:10.2307/4615733 · Cited by 21,526
Statistical Models Based on Counting Processes
Andersen, P. K., Borgan, Ø., Gill, R. D., & Keiding, N. (1993) · Springer series in statistics · doi:10.1007/978-1-4612-4348-9 · Cited by 2,895
Statistical Models Based on Counting Processes
Bry, X., Andersen, P. K., Borgan, Ø., Gill, R. D., Keiding, N., & Borgan, Ø. (1997) · Population · doi:10.2307/1534625 · Cited by 2,884
Extension of murine life span by overexpression of catalase targeted to mitochondria
Schriner, S. E., Linford, N. J., Martin, G. M., Treuting, P., Ogburn, C. E., Emond, M., Coskun, P. E., Ladiges, W., Wolf, N., Van Remmen, H., et al. (2005) · Science · doi:10.1126/science.1106653 · Cited by 1,724
Extension of Life-Span by Overexpression of Superoxide Dismutase and Catalase in Drosophila melanogaster
Orr, W. C., & Sohal, R. S. (1994) · Science · doi:10.1126/science.8108730 · Cited by 1,461
Trends in oxidative aging theories
Muller, F. L., Lustgarten, M. S., Jang, Y., Richardson, A., & Van Remmen, H. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.034 · Cited by 1,053
Self-citation
FLP Recombinase-Mediated Induction of Cu/Zn-Superoxide Dismutase Transgene Expression Can Extend the Life Span of Adult Drosophila melanogaster Flies
Sun, J., & Tower, J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.216 · Cited by 467
Induced Overexpression of Mitochondrial Mn-Superoxide Dismutase Extends the Life Span of Adult Drosophila melanogaster
Sun, J., Folk, D. G., Bradley, T. J., & Tower, J. (2002) · Genetics · doi:10.1093/genetics/161.2.661 · Cited by 381
Understanding the structure and function of catalases: clues from molecular evolution and in vitro mutagenesis
Zámocký, M., & Koller, F. (1999) · Progress in Biophysics and Molecular Biology · doi:10.1016/s0079-6107(98)00058-3 · Cited by 376
Genetic mouse models of extended lifespan
Liang, H., Masoro, E. J., Nelson, J. F., Strong, R., McMahan, C. A., & Richardson, A. G. (2003) · Experimental Gerontology · doi:10.1016/j.exger.2003.10.019 · Cited by 239
Self-citation

Show all 19 references

Sorted by citations

The Hallmarks of Aging
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
ROS function in redox signaling and oxidative stress
Schieber, M., & Chandel, N. S. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.034 · Cited by 6,931
From discoveries in ageing research to therapeutics for healthy ageing
Campisi, J., Kapahi, P., Lithgow, G. J., Melov, S., Newman, J. C., & Verdin, E. (2019) · Nature · doi:10.1038/s41586-019-1365-2 · Cited by 1,389
The sites and topology of mitochondrial superoxide production
Brand, M. D. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.01.003 · Cited by 1,217
Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes
Hamanaka, R. B., & Chandel, N. S. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.04.002 · Cited by 1,011
Oxidative Stress Resistance in Deinococcus radiodurans
Slade, D., & Radman, M. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00015-10 · Cited by 761
Emerging roles of oxidative stress in brain aging and Alzheimer's disease
Ionescu-Tucker, A., & Cotman, C. W. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.07.014 · Cited by 737
Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix
Loeser, R. F. (2009) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2009.03.002 · Cited by 726
The metabolic roots of senescence: mechanisms and opportunities for intervention
Wiley, C. D., & Campisi, J. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00483-8 · Cited by 691
Taking a good look at free radicals in the aging process
Hekimi, S., Lapointe, J., & Wen, Y. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.06.008 · Cited by 606
Is the oxidative stress theory of aging dead?
Pérez, V. I., Bokov, A., Remmen, H. V., Mele, J., Ran, Q., Ikeno, Y., & Richardson, A. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.06.003 · Cited by 604
Self-citation
Ageing, age-related diseases and oxidative stress: What to do next?
Luo, J., Mills, K., le Cessie, S., Noordam, R., & van Heemst, D. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100982 · Cited by 581
“Once generated, it could be catalyzed spontaneously by SOD into H2O2.”
Influential
Genetics of longevity in model organisms: debates and paradigm shifts
Gems, D., & Partridge, L. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183712 · Cited by 499
Mitochondrial oxidative stress in aging and healthspan
Dai, D., Chiao, Y. A., Marcinek, D. J., Szeto, H. H., & Rabinovitch, P. S. (2014) · Longevity & Healthspan · doi:10.1186/2046-2395-3-6 · Cited by 496
Beneficial and Detrimental Effects of Reactive Oxygen Species on Lifespan: A Comprehensive Review of Comparative and Experimental Studies
Shields, H. J., Traa, A., & Van Raamsdonk, J. M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.628157 · Cited by 478
The redox stress hypothesis of aging
Sohal, R. S., & Orr, W. C. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.445 · Cited by 473
Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases
Giorgi, C., Marchi, S., Simões, I. C. M., Ren, Z., Morciano, G., Perrone, M., Patalas‐Krawczyk, P., Borchard, S., Jędrak, P., Pierzynowska, K., et al. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.05.006 · Cited by 484
Update on the oxidative stress theory of aging: Does oxidative stress play a role in aging or healthy aging?
Salmon, A. B., Richardson, A. G., & Pérez, V. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.12.015 · Cited by 451
Self-citation
Reactive Oxygen Species: the Dual Role in Physiological and Pathological Conditions of the Human Body
Bardaweel, S. K., Gül, M., Alzweiri, M., Ishaqat, A., ALSalamat, H., & Bashatwah, R. M. (2018) · Eurasian Journal of Medicine · doi:10.5152/eurasianjmed.2018.17397 · Cited by 402
Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples
Kell, D. B. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0577-x · Cited by 361
Manganese Superoxide Dismutase: Guardian of the Powerhouse
Holley, A. K., Bakthavatchalu, V., Velez-Roman, J. M., & St. Clair, D. K. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12107114 · Cited by 358
Cardiac Aging: From Molecular Mechanisms to Significance in Human Health and Disease
Dai, D.-F., Chen, T., Johnson, S. C., Szeto, H., & Rabinovitch, P. S. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4179 · Cited by 334
Insulin in Central Nervous System: More than Just a Peripheral Hormone
Duarte, A. I., Moreira, P. I., & Oliveira, C. R. (2012) · Journal of Aging Research · doi:10.1155/2012/384017 · Cited by 337
Vitamin E: Regulatory Redox Interactions
Miyazawa, T., Burdeos, G. C., Itaya, M., Nakagawa, K., & Miyazawa, T. (2019) · IUBMB Life · doi:10.1002/iub.2008 · Cited by 344
The Thioredoxin System as a Therapeutic Target in Human Health and Disease
Mahmood, D. F. D., Abderrazak, A., Hadri, K. E., Simmet, T., & Rouis, M. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4757 · Cited by 311
The Mechanobiology of Aging
Phillip, J. M., Aifuwa, I., Walston, J. D., & Wirtz, D. (2015) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071114-040829 · Cited by 304
Calorie restriction and prevention of age‐associated chronic disease
Omodei, D., & Fontana, L. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.015 · Cited by 293
Strategies for Reducing or Preventing the Generation of Oxidative Stress
Poljšak, B. (2011) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2011/194586 · Cited by 299
The Free Radical Theory of Aging Is Dead. Long Live the Damage Theory!
Gladyshev, V. N. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5228 · Cited by 298
The path from mitochondrial ROS to aging runs through the mitochondrial permeability transition pore
Rottenberg, H., & Hoek, J. B. (2017) · Aging Cell · doi:10.1111/acel.12650 · Cited by 275
The sirtuins, oxidative stress and aging: an emerging link
Merksamer, P. I., Liu, Y., He, W., Hirschey, M. D., Chen, D., & Verdin, E. (2013) · Aging · doi:10.18632/aging.100544 · Cited by 275
The role of mitochondrial DNA mutations and free radicals in disease and ageing
Lagouge, M., & Larsson, N. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12055 · Cited by 284
When a theory of aging ages badly
Lapointe, J., & Hekimi, S. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0138-8 · Cited by 274
The free‐radical damage theory: Accumulating evidence against a simple link of oxidative stress to ageing and lifespan
Speakman, J. R., & Selman, C. (2011) · BioEssays · doi:10.1002/bies.201000132 · Cited by 266
Physiological and pathological consequences of cellular senescence
Burton, D. G. A., & Krizhanovsky, V. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1691-3 · Cited by 253
The SirT3 Divining Rod Points to Oxidative Stress
Bell, E. L., & Guarente, L. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.05.008 · Cited by 235
Adaptive homeostasis and the free radical theory of ageing
Pomatto, L. C. D., & Davies, K. J. A. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.06.016 · Cited by 233
The Emergence of Geroscience as an Interdisciplinary Approach to the Enhancement of Health Span and Life SpanPreprint
Sierra, F. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025163 · Cited by 226
Oxidative stress and life histories: unresolved issues and current needs
Speakman, J. R., Blount, J. D., Bronikowski, A. M., Buffenstein, R., Isaksson, C., Kirkwood, T. B. L., Monaghan, P., Ozanne, S. E., Beaulieu, M., Briga, M., et al. (2015) · Ecology and Evolution · doi:10.1002/ece3.1790 · Cited by 208
Oxidative stress and aging: Is methylglyoxal the hidden enemy?This review is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease.
Desai, K. M., Chang, T., Wang, H., Banigesh, A., Dhar, A., Liu, J., Untereiner, A. A., & Wu, L. (2010) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y10-001 · Cited by 217
Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity
Zhang, Y., Ikeno, Y., Qi, W., Chaudhuri, A., Li, Y., Bokov, A., Thorpe, S. R., Baynes, J. W., Epstein, C., Richardson, A., et al. (2009) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glp132 · Cited by 172
Self-citation
The Microbiome and Aging
Bana, B., & Cabreiro, F. (2019) · Annual Review of Genetics · doi:10.1146/annurev-genet-112618-043650 · Cited by 212
Answering the ultimate question “What is the Proximal Cause of Aging?”
Blagosklonny, M. V. (2012) · Aging · doi:10.18632/aging.100525 · Cited by 193
Reactive oxygen species: A radical role in development?
Hernández-García, D., Wood, C. D., Castro‐Obregón, S., & Covarrubias, L. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.03.020 · Cited by 199
Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells
Ogrodnik, M., Salmonowicz, H., & Gladyshev, V. N. (2019) · Aging Cell · doi:10.1111/acel.12841 · Cited by 184
The mitochondrial theory of aging: Insight from transgenic and knockout mouse models
Jang, Y. C., & Remmen, H. V. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2008.12.006 · Cited by 185
Molecular and cellular pathways contributing to brain aging
Zia, A., Pourbagher‐Shahri, A. M., Farkhondeh, T., & Samarghandian, S. (2021) · Behavioral and Brain Functions · doi:10.1186/s12993-021-00179-9 · Cited by 195
Cytoplasmic and Mitochondrial NADPH-Coupled Redox Systems in the Regulation of Aging
Bradshaw, P. C. (2019) · Nutrients · doi:10.3390/nu11030504 · Cited by 178
Ketone bodies mimic the life span extending properties of caloric restriction
Veech, R. L., Bradshaw, P. C., Clarke, K., Curtis, W., Pawlosky, R. J., & King, M. T. (2017) · IUBMB Life · doi:10.1002/iub.1627 · Cited by 171
The Good, the Bad, and the Ugly of ROS: New Insights on Aging and Aging‐Related Diseases from Eukaryotic and Prokaryotic Model Organisms
Santos, A. L., Sinha, S., & Lindner, A. B. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/1941285 · Cited by 168
DNA repair in organelles: Pathways, organization, regulation, relevance in disease and aging
Boesch, P., Weber‐Lotfi, F., Ibrahim, N., Тарасенко, В. И., Cosset, A., Paulus, F., Lightowlers, R. N., & Dietrich, A. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.10.002 · Cited by 171
Mitochondrial Dysfunction and Ovarian Aging
Kasapoğlu, I., & Seli, E. U. (2020) · Endocrinology · doi:10.1210/endocr/bqaa001 · Cited by 158
Role of Reactive Oxygen Species in Aging and Age-Related Diseases: A Review
Anik, M. I., Mahmud, N., Masud, A. A., Khan, M. I., Islam, M. N., Uddin, S., & Hossain, M. K. (2022) · ACS Applied Bio Materials · doi:10.1021/acsabm.2c00411 · Cited by 163
Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging
Robinson, A. R., Yousefzadeh, M. J., Rozgaja, T. A., Wang, J., Li, X., Tilstra, J. S., Feldman, C. H., Gregg, S. Q., Johnson, C. H., Skoda, E. M., et al. (2018) · Redox Biology · doi:10.1016/j.redox.2018.04.007 · Cited by 155
Tipping the metabolic scales towards increased longevity in mammals
Riera, C. E., & Dillin, A. (2015) · Nature Cell Biology · doi:10.1038/ncb3107 · Cited by 153
Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging
Gambino, V., de Michele, G., Venezia, O., Migliaccio, P., Dall’Olio, V., Bernard, L., Minardi, S. P., Fazia, M. A. D., Bartoli, D., Servillo, G., et al. (2013) · Aging Cell · doi:10.1111/acel.12060 · Cited by 153
NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?
Sahoo, S., Meijles, D. N., & Pagano, P. J. (2016) · Clinical Science · doi:10.1042/cs20150087 · Cited by 147
Behavioral changes in aging female C57BL/6 mice.
Fahlström, A., Yu, Q., & Ulfhake, B. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.11.003 · Cited by 132
Nrf2 Signaling, a Mechanism for Cellular Stress Resistance in Long-Lived Mice
Leiser, S. F., & Miller, R. A. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01145-09 · Cited by 138
Mitochondrial ROS regulate oxidative damage and mitophagy but not age-related muscle fiber atrophy
Sakellariou, G. K., Pearson, T., Lightfoot, A. P., Nye, G. A., Wells, N., Giakoumaki, I. I., Vasilaki, A., Griffiths, R. D., Jackson, M. J., & McArdle, A. (2016) · Scientific Reports · doi:10.1038/srep33944 · Cited by 133
Forkhead Box O as a Sensor, Mediator, and Regulator of Redox Signaling
de Keizer, P. L. J., Burgering, B. M. T., & Dansen, T. B. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3403 · Cited by 131
Lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish life span
Salmon, A. B., Pérez, V., Bokov, A. F., Jernigan, A., Kim, G., Zhao, H., Levine, R. L., & Richardson, A. (2009) · The FASEB Journal · doi:10.1096/fj.08-127415 · Cited by 131
Self-citation
Gender and longevity: Why do men die earlier than women? Comparative and experimental evidence
Regan, J. C., & Partridge, L. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.05.016 · Cited by 134
Relative importance of redox buffers GSH and NAD (P)H in age‐related neurodegeneration and Alzheimer disease‐like mouse neurons
Ghosh, D., LeVault, K. R., & Brewer, G. J. (2014) · Aging Cell · doi:10.1111/acel.12216 · Cited by 126
Riding the tiger – physiological and pathological effects of superoxide and hydrogen peroxide generated in the mitochondrial matrix
Brand, M. D. (2020) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2020.1828258 · Cited by 123
New Insights into the Role of Mitochondrial Dynamics and Autophagy during Oxidative Stress and Aging in the Heart
Ikeda, Y., Sciarretta, S., Nagarajan, N., Rubattu, S., Volpe, M., Frati, G., & Sadoshima, J. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/210934 · Cited by 126
The role of melatonin, a multitasking molecule, in retarding the processes of ageing
Majidinia, M., Reiter, R. J., Shakouri, S. K., & Yousefi, B. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.07.010 · Cited by 126
Targeting the “hallmarks of aging” to slow aging and treat age-related disease: fact or fiction?
Keshavarz, M., Xie, K., Schaaf, K., Bano, D., & Ehninger, D. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01680-x · Cited by 130
Atherothrombosis and Oxidative Stress: Mechanisms and Management in Elderly
Violi, F., Loffredo, L., Carnevale, R., Pignatelli, P., & Pastori, D. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6963 · Cited by 125
Restoring mitochondrial DNA copy number preserves mitochondrial function and delays vascular aging in mice
Foote, K., Reinhold, J., Yu, E., Figg, N. L., Finigan, A. J., Murphy, M. P., & Bennett, M. R. (2018) · Aging Cell · doi:10.1111/acel.12773 · Cited by 120
The Effect of Physiological Stimuli on Sarcopenia; Impact of Notch and Wnt Signaling on Impaired Aged Skeletal Muscle Repair
Arthur, S. T., & Cooley, I. D. (2012) · International Journal of Biological Sciences · doi:10.7150/ijbs.4262 · Cited by 131
Aging: Molecular Pathways and Implications on the Cardiovascular System
de Almeida, A. J. P. O., Ribeiro, T. P., & de Medeiros, I. A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7941563 · Cited by 120
ROS in AgingCaenorhabditis elegans: Damage or Signaling?
Back, P., Braeckman, B. P., & Matthijssens, F. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/608478 · Cited by 122
Biochemical Genetic Pathways that Modulate Aging in Multiple Species: Figure 1.Preprint
Bitto, A., Wang, A. M., Bennett, C. F., & Kaeberlein, M. R. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025114 · Cited by 122
Oxidative Stress, Mitochondrial Dysfunction and the Mitochondria Theory of Aging
Kong, Y., Trabucco, S. E., & Zhang, H. (2014) · Interdisciplinary topics in gerontology and geriatrics · doi:10.1159/000358901 · Cited by 117
The decay of Redox-stress Response Capacity is a substantive characteristic of aging: Revising the redox theory of aging
Meng, J., Lv, Z., Qiao, X., Li, X., Li, Y., Zhang, Y., & Chen, C. (2016) · Redox Biology · doi:10.1016/j.redox.2016.12.026 · Cited by 115
Redox proteomics in aging rat brain: Involvement of mitochondrial reduced glutathione status and mitochondrial protein oxidation in the aging process
Marzia Perluigi, A., Domenico, F. D., Giorgi, A., Schininà, M. E., Coccia, R., Cini, C., Bellia, F., Cambria, M. T., Cornelius, C., Butterfield, D. A., et al. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22500 · Cited by 110
Aging and Injury: Alterations in Cellular Energetics and Organ Function
Poulose, N. (2014) · Aging and Disease · doi:10.14336/ad.2014.0500101 · Cited by 109
Epigenetic oxidative redox shift (EORS) theory of aging unifies the free radical and insulin signaling theories
Brewer, G. J. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.11.007 · Cited by 104
Extreme Longevity Is Associated With Increased Resistance to Oxidative Stress in Arctica islandica, the Longest-Living Non-Colonial Animal
Ungvari, Z. I., Ridgway, I. D., Philipp, E. E. R., Campbell, C. M., McQuary, P. R., Chow, T., Coelho, M., Didier, E. S., Gelino, S., Holmbeck, M. A., et al. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr044 · Cited by 106
Mitochondrial dysfunction and its association with age-related disorders
Somasundaram, I., Jain, S. M., Blot‐Chabaud, M., Pathak, S., Banerjee, A., Rawat, S. J., Sharma, N. R., & Duttaroy, A. K. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1384966 · Cited by 125
MECHANISMS IN ENDOCRINOLOGY: Aging and anti-aging: a Combo-Endocrinology overview
Diamanti‐Kandarakis, E., Dattilo, M., Μacut, D., Duntas, L. H., Gonos, E. S., Goulis, D. G., Kanaka‐Gantenbein, C., Καπετάνου, Μ., Koukkou, E. G., Lambrinoudaki, I. V., et al. (2017) · European Journal of Endocrinology · doi:10.1530/eje-16-1061 · Cited by 105
Rapamycin and quasi-programmed aging: Four years later
Blagosklonny, M. V. (2010) · Cell Cycle · doi:10.4161/cc.9.10.11872 · Cited by 106
Cardiovascular Aging and Longevity
Pietri, P. G., & Stefanadis, C. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.11.023 · Cited by 106
Reversal of the Mitochondrial Phenotype and Slow Development of Oxidative Biomarkers of Aging in Long-lived Mclk1+/− Mice
Lapointe, J., Stepanyan, Z., Bigras, E., & Hekimi, S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.006569 · Cited by 91
The Idea of Electronic Democracy: Origins, Visions and Questions
Vedel, T. (2006) · Parliamentary Affairs · doi:10.1093/pa/gsl005 · Cited by 92
The Role of Autophagy, Mitophagy and Lysosomal Functions in Modulating Bioenergetics and Survival in the Context of Redox and Proteotoxic Damage: Implications for Neurodegenerative Diseases
Redmann, M., Darley-Usmar, V. M., & Zhang, J. (2016) · Aging and Disease · doi:10.14336/ad.2015.0820 · Cited by 93
The microenvironment of naked mole‐rat burrows in East Africa
Holtze, S., Braude, S. H., Lemma, A., Koch, R., Morhart, M., Szafranski, K., Platzer, M., Alemayehu, F., Göritz, F., & Hildebrandt, T. B. (2017) · African Journal of Ecology · doi:10.1111/aje.12448 · Cited by 93
Metallothionein and the biology of aging
Swindell, W. R. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2010.09.007 · Cited by 89
A midlife crisis for the mitochondrial free radical theory of aging
Stuart, J. A., Maddalena, L. A., Merilovich, M., & Robb, E. L. (2014) · Longevity & Healthspan · doi:10.1186/2046-2395-3-4 · Cited by 84
Mitochondrial ROS and the Effectors of the Intrinsic Apoptotic Pathway in Aging Cells: The Discerning Killers!
Hekimi, S., Wang, Y., & Noë, A. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00161 · Cited by 83
Use of Saccharomyces cerevisiae and Caenorhabditis elegans as Model Organisms To Study the Effect of Cocoa Polyphenols in the Resistance to Oxidative Stress
Martorell, P., Forment, J. V., de Llanos, R., Montón, F., Llopis, S., González, N., Genovés, S., Cienfuegos, E., Monzó, H., & Ramón, D. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf104217g · Cited by 84
The Effect of Long Term Calorie Restriction on in Vivo Hepatic Proteostatis: A Novel Combination of Dynamic and Quantitative Proteomics
Price, J. C., Khambatta, C. F., Li, K. W., Bruss, M. D., Shankaran, M., Dalidd, M., Floreani, N. A., Roberts, L. S., Turner, S., Holmes, W. E., et al. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.021204 · Cited by 87
Pro‐ and Antioxidant Functions of the Peroxisome‐Mitochondria Connection and Its Impact on Aging and Disease
Pascual‐Ahuir, A., Manzanares‐Estreder, S., & Proft, M. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/9860841 · Cited by 87
Urgent needs of caregiving in ageing populations with Alzheimer’s disease and other chronic conditions: Support our loved ones
Culberson, J. W., Kopel, J. J., Sehar, U., & Reddy, P. H. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102001 · Cited by 95
Mitochondrial uncoupling and longevity – A role for mitokines?
Klaus, S., & Ost, M. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110796 · Cited by 80
Antiaging effects of bioactive molecules isolated from plants and fungi
Martel, J., Ojcius, D. M., Ko, Y., Chang, C., & Young, J. D. (2019) · Medicinal Research Reviews · doi:10.1002/med.21559 · Cited by 79
An Evolutionary Genome Scan for Longevity-Related Natural Selection in Mammals
Jobson, R. W., Nabholz, B., & Galtier, N. (2009) · Molecular Biology and Evolution · doi:10.1093/molbev/msp293 · Cited by 72
Caloric restriction: is mammalian life extension linked to p53?
Tucci, P. (2012) · Aging · doi:10.18632/aging.100481 · Cited by 70
Pharmacological lifespan extension of invertebrates
Lucanic, M., Lithgow, G. J., & Alavez, S. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.06.006 · Cited by 70

Authors: Pérez, V. I., Van Remmen, H., Bokov, A., Epstein, C. J., Vijg, J., & Richardson, A.
Affiliations: The University of Texas at San Antonio Health Science Center (US)
University of California, San Francisco (US)
Albert Einstein College of Medicine (US)
South Texas Veterans Health Care System (US)
Corresponding author: Richardson, Arlan
ORCID: Bokov, Alex
Epstein, Charles J.
Vijg, Jan
Richardson, Arlan
Venue: Aging Cell
Publisher: Wiley
Published: 2009-01-28
Volume: 8
Issue: 1
Pages: 73-75
ISSN: 1474-9718 (ISSN-L)
1474-9726
DOI: 10.1111/j.1474-9726.2008.00449.x
PMC: PMC2667893
OpenAlex: W2005586848
Cited by: 353
References: 19
Citations by year: 2026: 5 · 2025: 9 · 2024: 16 · 2023: 16 · 2022: 18 · 2021: 13 · 2020: 13 · 2019: 18 · 2018: 21 · 2017: 20 · 2016: 20 · 2015: 14 · 2014: 27 · 2013: 25 · 2012: 31
FWCI: 8.45
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Aging Cell (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (1P30- AG13319, P01 AG19316, R37AG026557, P01AG019316, P30AG013319)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: antioxidant enzymes, lifespan extension, superoxide dismutase, catalase, manganese superoxide dismutase, copper-zinc superoxide dismutase, transgenic mice, oxidative stress, aging, mitochondrial superoxide
MeSH terms: Animals, Catalase, Disease Models, Animal, Humans, Hydrogen Peroxide, Longevity, Mice, Inbred C57BL, Mice, Transgenic, Superoxide Dismutase, Oxidative Stress, Reverse Transcriptase Polymerase Chain Reaction, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks