Cannabinoid CB2receptor attenuates morphine‐induced inflammatory responses in activated microglial cells

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

Green, L. C., Wagner, D. A., Glogowski, J. A., Skipper, P. L., Wishnok, J. S., & Tannenbaum, S. R. (1982) · Analytical Biochemistry · doi:10.1016/0003-2697(82)90118-x · Cited by 12,089 · see citing works

Guide to receptors and channels (GRAC), 5th edition

Alexander, S., Mathie, A., & Peters, J. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01649_1.x · Cited by 1,947 · see citing works

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2

Pertwee, R. G., Howlett, A. C., Abood, M. E., Alexander, S. P. H., Marzo, V. D., Elphick, M. R., Greasley, P. J., Hansen, H. S., Kunos, G., Mackie, K., et al. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.003004 · Cited by 1,610 · see citing works

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

McGrath, J., Drummond, G., McLachlan, E., Kilkenny, C., & Wainwright, C. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00873.x · Cited by 1,592 · see citing works

A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window

Yrjänheikki, J., Kauppinen, T. M., Keinänen, R., Goldsteins, G., Chan, P. H., & Koıstınaho, J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13496 · Cited by 1,040 · see citing works

Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia

Yrjänheikki, J., Keinänen, R., Pellikka, M., Hökfelt, T., & Koistinaho, J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15769 · Cited by 1,006 · see citing works

MICROGLIA AS MEDIATORS OF INFLAMMATORY AND DEGENERATIVE DISEASES

González-Scarano, F., & Baltuch, G. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.219 · Cited by 984 · see citing works

Beta-caryophyllene is a dietary cannabinoid.

Gertsch, J., Leonti, M., Raduner, S., Racz, I., Chen, J.-Z., Xie, X.-Q., Altmann, K.-H., Karsak, M., & Zimmer, A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803601105 · Cited by 906 · see citing works

GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current

Lauckner, J. E., Jensen, J. B., Chen, H.-Y., Lu, H., Hille, B., & Mackie, K. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711278105 · Cited by 710 · see citing works

The Toll-Like Receptor TLR4 Is Necessary for Lipopolysaccharide-Induced Oligodendrocyte Injury in the CNS

Lehnardt, S., Lachance, C., Patrizi, S., Lefebvre, S., Follett, P. L., Jensen, F. E., Rosenberg, P. A., Volpe, J. J., & Vartanian, T. K. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02478.2002 · Cited by 684 · see citing works

CB2: a cannabinoid receptor with an identity crisis

Atwood, B. K., & Mackie, K. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00729.x · Cited by 633 · see citing works

Cannabinoid and cannabinoid‐like receptors in microglia, astrocytes, and astrocytomas

Stella, N. (2010) · Glia · doi:10.1002/glia.20983 · Cited by 529 · see citing works

The Role of Spinal Neuroimmune Activation in Morphine Tolerance/Hyperalgesia in Neuropathic and Sham-Operated Rats

Vasudeva, R., Rutkowski, M. D., & DeLeo, J. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-22-09980.2002 · Cited by 468 · see citing works

The Endocannabinoid Anandamide Protects Neurons during CNS Inflammation by Induction of MKP-1 in Microglial Cells

Eljaschewitsch, E., Witting, A., Mawrin, C., Lee, T., Schmidt, P. M., Wolf, S., Hoertnagl, H., Raine, C. S., Schneider-Stock, R., Nitsch, R., et al. (2006) · Neuron · doi:10.1016/j.neuron.2005.11.027 · Cited by 445 · see citing works

The involvement of glial cells in the development of morphine tolerance

Song, P., & Zhao, Z.-Q. (2001) · Neuroscience Research · doi:10.1016/s0168-0102(00)00226-1 · Cited by 445 · see citing works

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

Marrs, W., Blankman, J. L., Horne, E. A., Thomazeau, A., Lin, Y. H., Coy, J. W., Bodor, Á. L., Muccioli, G. G., Hu, S. S., Woodruff, G., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2601 · Cited by 442 · see citing works

The “toll” of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia

Watkins, L. R., Hutchinson, M. R., Rice, K. C., & Maier, S. F. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.08.002 · Cited by 438 · see citing works

A Role for Proinflammatory Cytokines and Fractalkine in Analgesia, Tolerance, and Subsequent Pain Facilitation Induced by Chronic Intrathecal Morphine

Johnston, I. N., Milligan, E. D., Wieseler‐Frank, J., Frank, M. G., Zapata, V., Campisi, J., Langer, S. J., Martin, D., Green, P., Fleshner, M., et al. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1850-04.2004 · Cited by 432 · see citing works

Cellular mechanisms of neuropathic pain, morphine tolerance, and their interactions

Mayer, D. J., Mao, J., Holt, J. A., & Price, D. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.7731 · Cited by 423 · see citing works

CB2 cannabinoid receptor-mediated peripheral antinociception

Malan, P. T., Ibrahim, M. M., Deng, H., Liu, Q., Mata, H. P., Vanderah, T., Porreca, F., & Makriyannis, A. (2001) · Pain · doi:10.1016/s0304-3959(01)00321-9 · Cited by 391 · see citing works

Pharmacological and biochemical interactions between opioids and cannabinoids

Manzanares, J., Corchero, J., Romero, J., Fernández‐Ruíz, J., Ramos, J. A., & Fuentes, J. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01339-5 · Cited by 391 · see citing works

Evidence for novel cannabinoid receptors

Begg, M., Pacher, P., Bátkai, S., Osei‐Hyiaman, D., Offertáler, L., Mo, F.-M., LIU, J., & Kunos, G. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.11.005 · Cited by 385 · see citing works

Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation

Ehrhart, J. C., Obregon, D. F., Mori, T., Hou, H., Sun, N., Bai, Y., Klein, T., Fernandez, F., Tan, J., & Shytle, R. D. (2005) · Journal of Neuroinflammation · doi:10.1186/1742-2094-2-29 · Cited by 379 · see citing works

Spinal cord glia: new players in pain

Watkins, L. R., Milligan, E. D., & Maier, S. F. (2001) · Pain · doi:10.1016/s0304-3959(01)00359-1 · Cited by 350 · see citing works

CB2receptors in the brain: role in central immune function

Cabral, G. A., Raborn, E. S., Griffin, L., Dennis, J., & Marciano‐Cabral, F. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707584 · Cited by 346 · see citing works

Differential expression of the CB2 cannabinoid receptor by rodent macrophages and macrophage-like cells in relation to cell activation

Carlisle, S. J., Marciano‐Cabral, F., Staab, A., LUDWICK, C., & Cabral, G. A. (2002) · International Immunopharmacology · doi:10.1016/s1567-5769(01)00147-3 · Cited by 344 · see citing works

Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-α inhibitor and an effective neuroprotectant

Shohami, E., Gallily, R., Mechoulam, R., Bass, R., & Ben‐Hur, T. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(96)00181-6 · Cited by 337 · see citing works

Glia as the “bad guys”: Implications for improving clinical pain control and the clinical utility of opioids

Watkins, L. R., Hutchinson, M. R., Ledeboer, A., Wieseler‐Frank, J., Milligan, E. D., & Maier, S. F. (2006) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.10.011 · Cited by 327 · see citing works

Glia: novel counter-regulators of opioid analgesia

Watkins, L. R., Hutchinson, M. R., Johnston, I. N., & Maier, S. F. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.10.001 · Cited by 327 · see citing works

Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain.

Watkins, L. R., Milligan, E. D., & Maier, S. F. (2003) · PubMed · Cited by 314 · see citing works

Synergistic interactions between cannabinoid and opioid analgesics

Cichewicz, D. L. (2004) · Life Sciences · doi:10.1016/j.lfs.2003.09.038 · Cited by 305 · see citing works

Cannabinoid CB 2 receptors in human brain inflammation

Benito, C., Tolón, R. M., Pazos, M. R., Núñez, E., Castillo, A. I., & Romero, J. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707505 · Cited by 293 · see citing works

Cannabinoids ablate release of TNFα in rat microglial cells stimulated with lypopolysaccharide

Facchinetti, F., Giudice, E. D., Furegato, S., Passarotto, M., & Leon, A. (2002) · Glia · doi:10.1002/glia.10177 · Cited by 275 · see citing works

Attenuation of morphine tolerance, withdrawal-induced hyperalgesia, and associated spinal inflammatory immune responses by propentofylline in rats

Raghavendra, V., Tanga, F. Y., & DeLeo, J. A. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300315 · Cited by 263 · see citing works

Molecular pharmacology of the opioid receptors

Satoh, M., & Minami, M. (1995) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(95)02011-x · Cited by 257 · see citing works

Inhibition of MAP Kinase Kinase Prevents Cytokine and Prostaglandin E2 Production in Lipopolysaccharide-Stimulated Monocytes

Scherle, P., Jones, E. A., Favata, M. F., Daulerio, A. J., Covington, M. B., Nurnberg, S., Magolda, R. L., & Trzăskos, J. M. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.10.5681 · Cited by 256 · see citing works

Synthetic cannabinoid WIN55,212‐2 inhibits generation of inflammatory mediators by IL‐1β‐stimulated human astrocytes

Sheng, W. S., Hu, S., Min, X. M., Cabral, G. A., Lokensgard, J. R., & Peterson, P. K. (2004) · Glia · doi:10.1002/glia.20108 · Cited by 246 · see citing works

Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid‐type CB2 receptor

Klegeris, A., Bissonnette, C. J., & McGeer, P. L. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705304 · Cited by 244 · see citing works

The endocannabinoid system as a target for the treatment of motor dysfunction

Fernández‐Ruíz, J. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00088.x · Cited by 218 · see citing works

The Cannabinoid System and Cytokine Network

Klein, T., Lane, B., Newton, C. A., & Friedman, H. P. (2000) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.2000.22501.x · Cited by 216 · see citing works

GPR55 ligands promote receptor coupling to multiple signalling pathways

Henstridge, C. M., Balenga, N. A. B., Schröder, R. J., Kargl, J., Platzer, W., Martini, L., Arthur, J. S. C., Penman, J., Whistler, J. L., Kostenis, E., et al. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00625.x · Cited by 209 · see citing works

Role of Mitogen-Activated Protein Kinase Cascades in Mediating Lipopolysaccharide-Stimulated Induction of Cyclooxygenase-2 and IL-1β in RAW264 Macrophages

Caivano, M., & Cohen, P. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.6.3018 · Cited by 204 · see citing works

Morphine peripheral analgesia depends on activation of the PI3Kγ/AKT/nNOS/NO/K ATP signaling pathway

Cunha, T. M., Roman‐Campos, D., Lotufo, C. M. D. C., Duarte, H. L., de Souza, G. R., Verri, W. A., Jr., Funez, M. I., Dias, Q. M., Schivo, I. R. S., Domingues, A. C., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914733107 · Cited by 202 · see citing works

Endogenous Interleukin-1 Receptor Antagonist Mediates Anti-Inflammatory and Neuroprotective Actions of Cannabinoids in Neurons and Glia

Molina‐Holgado, F., Pinteaux, E., Moore, J. D., Molina‐Holgado, E., Guaza, C., Gibson, R. M., & Rothwell, N. J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-16-06470.2003 · Cited by 192 · see citing works

Anandamide enhances IL‐10 production in activated microglia by targeting CB2receptors: Roles of ERK1/2, JNK, and NF‐κB

Correa, F., Hernangómez, M., Mestre, L., Loría, F., Spagnolo, A., Docagne, F., Marzo, V. D., & Guaza, C. (2009) · Glia · doi:10.1002/glia.20907 · Cited by 183 · see citing works

Pro-inflammatory cytokines induce the transcription factors C/EBP? and C/EBP? in astrocytes

Cardinaux, J., Allaman, I., & Magistretti, P. J. (2000) · Glia · doi:10.1002/(sici)1098-1136(20000101)29:1 · Cited by 183 · see citing works

Activation of p38 mitogen-activated protein kinase in spinal microglia mediates morphine antinociceptive tolerance

Cui, Y., Chen, Y., Zhi, J., Guo, R., Feng, J., & Chen, P. (2006) · Brain Research · doi:10.1016/j.brainres.2005.11.066 · Cited by 173 · see citing works

CANnabinoid Receptor Type 2 Activation Induces a Microglial Anti-Inflammatory Phenotype and Reduces Migration via MKP Induction and ERK Dephosphorylation

Romero-Sandoval, E. A., Horvath, R. J., Landry, R. P., & DeLeo, J. A. (2009) · Molecular Pain · doi:10.1186/1744-8069-5-25 · Cited by 159 · see citing works

Caffeine Inhibits Adenosine-Induced Accumulation of Hypoxia-Inducible Factor-1α, Vascular Endothelial Growth Factor, and Interleukin-8 Expression in Hypoxic Human Colon Cancer Cells

Merighi, S., Benini, A., Mirandola, P., Gessi, S., Varani, K., Simioni, C., Leung, E., Maclennan, S., Baraldi, P. G., & Borea, P. A. (2007) · Molecular Pharmacology · doi:10.1124/mol.106.032920 · Cited by 156 · see citing works

Modulation of l-α-Lysophosphatidylinositol/GPR55 Mitogen-activated Protein Kinase (MAPK) Signaling by Cannabinoids

Anavi‐Goffer, S., Baillie, G. L., Irving, A. J., Gertsch, J., Greig, I. R., Pertwee, R. G., & Ross, R. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.296020 · Cited by 151 · see citing works

Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide‐induced nitric oxide release in astrocyte cultures

Molina‐Holgado, F., Molina‐Holgado, E., Guaza, C., & Rothwell, N. J. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10165 · Cited by 148 · see citing works

Neuroimmune interactions and pain: focus on glial-modulating targets.

Romero-Sandoval, E. A., Horvath, R. J., & DeLeo, J. A. (2008) · PubMed · Cited by 140 · see citing works

Central and peripheral sites of action for CB ₂ receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats

Hsieh, G. C., Pai, M., Chandran, P., Hooker, B. A., Zhu, C. Z., Salyers, A. K., Wensink, E. J., Zhan, C., Carroll, W. A., Dart, M. J., et al. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01046.x · Cited by 139 · cited 1× · see citing works

Activation of cannabinoid CB2 receptor negatively regulates IL‐12p40 production in murine macrophages: role of IL‐10 and ERK1/2 kinase signaling

Correa, F., Mestre, L., Docagne, F., & Guaza, C. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706215 · Cited by 131 · see citing works

A Differential Role for the Mitogen-activated Protein Kinases in Lipopolysaccharide Signaling

Watters, J. J., Sommer, J. A., Pfeiffer, Z. A., Prabhu, U., Guerra, A. N., & Bertics, P. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m104385200 · Cited by 127 · see citing works

A3 Adenosine Receptor Activation Inhibits Cell Proliferation via Phosphatidylinositol 3-Kinase/Akt-dependent Inhibition of the Extracellular Signal-regulated Kinase 1/2 Phosphorylation in A375 Human Melanoma Cells

Merighi, S., Benini, A., Mirandola, P., Gessi, S., Varani, K., Leung, E., MacLennan, S., & Borea, P. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413772200 · Cited by 124 · see citing works

Prospects for cannabinoid therapies in basal ganglia disorders

Fernández‐Ruíz, J., Moreno‐Martet, M., Rodríguez‐Cueto, C., Palomo‐Garo, C., Gómez‐Cañas, M., Valdeolivas, S., Guaza, C., Romero, J., Guzmán, M., Mechoulam, R., et al. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01365.x · Cited by 123 · see citing works

Anandamide suppresses nitric oxide and TNF-α responses to Theilerʼs virus or endotoxin in astrocytes

Molina‐Holgado, F., Lledó, A., & Guaza, C. (1997) · Neuroreport · doi:10.1097/00001756-199705260-00027 · Cited by 110 · see citing works

Cannabinoids modulate pain by multiple mechanisms of action

Richardson, J. D. (2000) · The Journal of Pain · doi:10.1016/s1526-5900(00)90082-8 · Cited by 109 · see citing works

Cilostazol is anti‐inflammatory in BV2 microglial cells by inactivating nuclear factor‐kappaB and inhibiting mitogen‐activated protein kinases

Jung, W., Lee, D., Park, C., Choi, Y. H., Choi, I., Park, S., Seo, S., Lee, S., Yea, S. S., Ahn, S., et al. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00615.x · Cited by 104 · see citing works

Priming effect of morphine on the production of tumor necrosis factor-alpha by microglia: implications in respiratory burst activity and human immunodeficiency virus-1 expression.

Chao, C. C., Gekker, G., Sheng, W., Hu, S., Tsang, M., & Peterson, P. K. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38683-0 · Cited by 101 · see citing works

Cell‐type specific activation of p38 and ERK mediates calcitonin gene‐related peptide involvement in tolerance to morphine‐induced analgesia

Wang, Z., Ma, W., Chabot, J., & Quirion, R. (2009) · The FASEB Journal · doi:10.1096/fj.08-128348 · Cited by 99 · see citing works

A role for CB2 receptors in anandamide signalling pathways involved in the regulation of IL-12 and IL-23 in microglial cells

Correa, F., Docagne, F., Mestre, L., Clemente, D., Hernangómez, M., Loría, F., & Guaza, C. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.09.014 · Cited by 98 · see citing works

Effect of anandamide uptake inhibition in the production of nitric oxide and in the release of cytokines in astrocyte cultures

Ortega‐Gutiérrez, S., Molina‐Holgado, E., & Guaza, C. (2005) · Glia · doi:10.1002/glia.20229 · Cited by 93 · see citing works

Comparative effects of cyclo‐oxygenase and nitric oxide synthase inhibition on the development and reversal of spinal opioid tolerance

Powell, K. J., Hosokawa, A., Bell, A. H., Sutak, M., Milne, B., Quirion, R., & Jhamandas, K. H. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702587 · Cited by 92 · see citing works

The Role of Mitogen-Activated Protein Kinase (MAPK) in Morphine Tolerance and Dependence

Chen, Y., & Sommer, C. (2009) · Molecular Neurobiology · doi:10.1007/s12035-009-8074-z · Cited by 85 · see citing works

Cellular Mechanisms Underlying the Interaction between Cannabinoid and Opioid System

Parolaro, D., Rubino, T., Viganò, D., Massi, P., Guidali, C., & Realini, N. (2010) · Current Drug Targets · doi:10.2174/138945010790980367 · Cited by 85 · see citing works

The μ‐opioid receptor agonist morphine, but not agonists at δ‐ or κ‐opioid receptors, induces peripheral antinociception mediated by cannabinoid receptors

Da Fonseca Pacheco, D., Klein, A., De Castro Perez, A., Da Fonseca Pacheco, C. M., De Francischi, J. N., & Duarte, I. D. G. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.175 · Cited by 81 · cited 2× · see citing works

Signaling pathway of morphine induced acute thermal hyperalgesia in mice

Galeotti, N., Stefano, G. B., Guarna, M., Bianchi, E., & Ghelardini, C. (2006) · Pain · doi:10.1016/j.pain.2006.03.008 · Cited by 76 · see citing works

A2B and A3 Adenosine Receptors Modulate Vascular Endothelial Growth Factor and Interleukin-8 Expression in Human Melanoma Cells Treated with Etoposide and Doxorubicin

Merighi, S., Simioni, C., Gessi, S., Varani, K., Mirandola, P., Tabrizi, M. A., Baraldi, P. G., & Borea, P. A. (2009) · Neoplasia · doi:10.1593/neo.09768 · Cited by 75 · see citing works

A comparative study of morphine stimulation and biphalin inhibition of human glioblastoma T98G cell proliferation in vitro

Łazarczyk, M., Matyja, E., & Lipkowski, A. W. (2010) · Peptides · doi:10.1016/j.peptides.2010.05.002 · Cited by 62 · see citing works

Cannabinoid-mediated Inhibition of Inducible Nitric Oxide Production by Rat Microglial Cells: Evidence for CB1 Receptor Participation

Cabral, G. A., Harmon, K. W. N., & Carlisle, S. J. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-47611-8_24 · Cited by 61 · see citing works

Repeated cannabinoid injections into the rat periaqueductal gray enhance subsequent morphine antinociception

Wilson, A. R., Maher, L., & Morgan, M. M. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.038 · Cited by 52 · see citing works

Flow cytometry detection of serotonin content and release in resting and activated platelets

Gobbi, G., Mirandola, P., Tazzari, P. L., Ricci, F., Caimi, L., Cacchioli, A., Papa, S., Conte, R., & Vitale, M. (2003) · British Journal of Haematology · doi:10.1046/j.1365-2141.2003.04369.x · Cited by 52 · see citing works

Therapeutic Potential of Cannabinoid-Based Drugs

Klein, T., & Newton, C. A. (2007) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-72005-0_43 · Cited by 49 · see citing works

The Cannabinoid System and Cytokine Network

Klein, T., Lane, B., Newton, C. A., & Friedman, H. P. (2000) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1111/j.1525-1373.2000.22501.x · Cited by 46 · see citing works

Anandamide inhibits IL-12p40 production by acting on the promoter repressor element GA-12: possible involvement of the COX-2 metabolite prostamide E2

Correa, F., Docagne, F., Clemente, D., Mestre, L., Becker, C., & Guaza, C. (2008) · Biochemical Journal · doi:10.1042/bj20071329 · Cited by 41 · see citing works

Adolescent Exposure to Chronic Delta-9-Tetrahydrocannabinol Blocks Opiate Dependence in Maternally Deprived Rats

Morel, L. J., Bruno Giros, A., & Daugé, V. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.70 · Cited by 37 · see citing works

Binding thermodynamics at the human cannabinoid CB1 and CB2 receptors

Merighi, S., Simioni, C., Gessi, S., Varani, K., & Borea, P. A. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.09.009 · Cited by 24 · see citing works

Human gliomas contain morphine.

Olsen, P., Rasmussen, M., Zhu, W. M., Tønnesen, E., & Stefano, G. B. (2005) · PubMed · Cited by 11 · see citing works

The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain

Donvito, G., Nass, S. R., Wilkerson, J. L., Curry, Z. A., Schurman, L. D., Kinsey, S. G., & Lichtman, A. H. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.204 · Cited by 301 · see citing works

An overview of the cannabinoid type 2 receptor system and its therapeutic potential

Bie, B., Wu, J., Foss, J. F., & Naguib, M. (2018) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000616 · Cited by 208 · see citing works

Morphine mediates a proinflammatory phenotype via μ-opioid receptor–PKCɛ–Akt–ERK1/2 signaling pathway in activated microglial cells

Merighi, S., Gessi, S., Varani, K., Fazzi, D., Stefanelli, A., & Borea, P. A. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.05.027 · Cited by 112 · see citing works

Medicinal Chemistry, Pharmacology, and Potential Therapeutic Benefits of Cannabinoid CB2Receptor Agonists

Tabrizi, M. A., Baraldi, P. G., Borea, P. A., & Varani, K. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00411 · Cited by 110 · see citing works

Endogenous opiates and behavior: 2012

Bodnar, R. J. (2013) · Peptides · doi:10.1016/j.peptides.2013.10.001 · Cited by 98 · see citing works

Synergistic attenuation of chronic pain using mu opioid and cannabinoid receptor 2 agonists

Grenald, S. A., Young, M. A., Wang, Y., Ossipov, M. H., Ibrahim, M. M., Largent-Milnes, T. M., & Vanderah, T. W. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.12.008 · Cited by 97 · see citing works

Slowly Signaling G Protein–Biased CB2 Cannabinoid Receptor Agonist LY2828360 Suppresses Neuropathic Pain with Sustained Efficacy and Attenuates Morphine Tolerance and Dependence

Lin, X., Dhopeshwarkar, A., Huibregtse, M. E., Mackie, K., & Hohmann, A. G. (2017) · Molecular Pharmacology · doi:10.1124/mol.117.109355 · Cited by 91 · see citing works

The endocannabinoid hydrolysis inhibitor SA-57: intrinsic antinociceptive effects, augmented morphine-induced antinociception, and attenuated heroin seeking behavior in mice

Wilkerson, J. L., Ghosh, S., Mustafa, M., Abdullah, R. A., Niphakis, M. J., Cabrera, R., Maldonado, R. L., Cravatt, B. F., & Lichtman, A. H. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.11.015 · Cited by 78 · see citing works

Microglia Express Mu Opioid Receptor: Insights From Transcriptomics and Fluorescent Reporter Mice

Maduna, T., Audouard, E., Dembélé, D., Mouzaoui, N., Reiss, D. J., Massotte, D., & Gavériaux‐Ruff, C. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00726 · Cited by 75 · see citing works

Endocannabinoids and neuropathic pain: focus on neuron–glia and endocannabinoid–neurotrophin interactions

Luongo, L., Maione, S., & Marzo, V. D. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12440 · Cited by 69 · see citing works

Cannabinoid CB2 Agonist AM1710 Differentially Suppresses Distinct Pathological Pain States and Attenuates Morphine Tolerance and Withdrawal

Li, A.-L., Lin, X., Dhopeshwarkar, A., Thomaz, A. C., Carey, L. M., Liu, Y., Nikas, S. P., Makriyannis, A., Mackie, K., & Hohmann, A. G. (2018) · Molecular Pharmacology · doi:10.1124/mol.118.113233 · Cited by 69 · see citing works

The Selective Monoacylglycerol Lipase Inhibitor MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model

Wilkerson, J. L., Niphakis, M. J., Grim, T. W., Mustafa, M. A., Abdullah, R. A., Poklis, J. L., Dewey, W. L., Akbarali, H. I., Banks, M. L., Wise, L. E., et al. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.115.229971 · Cited by 67 · see citing works

Mu opioid receptor in microglia contributes to morphine analgesic tolerance, hyperalgesia, and withdrawal in mice

Reiss, D. J., Maduna, T., Maurin, H., Audouard, E., & Gavériaux‐Ruff, C. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24626 · Cited by 62 · see citing works

Mu-opioid receptor and delta-opioid receptor differentially regulate microglial inflammatory response to control proopiomelanocortin neuronal apoptosis in the hypothalamus: effects of neonatal alcohol

Shrivastava, P., Cabrera, M. A., Chastain, L. G., Boyadjieva, N. I., Jabbar, S., Franklin, T., & Sarkar, D. K. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0844-3 · Cited by 60 · see citing works

The cannabinoid CB2 receptor agonist LY2828360 synergizes with morphine to suppress neuropathic nociception and attenuates morphine reward and physical dependence

Iyer, V., Slivicki, R. A., Thomaz, A. C., Crystal, J. D., Mackie, K., & Hohmann, A. G. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173544 · Cited by 48 · see citing works

Anti-nociceptive interactions between opioids and a cannabinoid receptor 2 agonist in inflammatory pain

Yuill, M. B., Hale, D. E., Guindon, J., & Morgan, D. J. (2017) · Molecular Pain · doi:10.1177/1744806917728227 · Cited by 49 · see citing works

Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase: New Targets for Future Antidepressants

Ogawa, S., & Kunugi, H. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150612225212 · Cited by 48 · see citing works

Activation of cannabinoid receptor 2 attenuates mechanical allodynia and neuroinflammatory responses in a chronic post‐ischemic pain model of complex regional pain syndrome type I in rats

Xu, J. J., Tang, Y., Xie, M., Bie, B., Wu, J., Yang, H., Foss, J. F., Yang, B., Rosenquist, R. W., & Naguib, M. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13414 · Cited by 46 · see citing works

Localization and production of peptide endocannabinoids in the rodent CNS and adrenal medulla

Hofer, S. C., Ralvenius, W. T., Gachet, M. S., Fritschy, J., Zeilhofer, H. U., & Gertsch, J. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.03.021 · Cited by 45 · see citing works

Delay of Morphine Tolerance by Palmitoylethanolamide

Mannelli, L. D. C., Corti, F., Micheli, L., Zanardelli, M., & Ghelardini, C. (2015) · BioMed Research International · doi:10.1155/2015/894732 · Cited by 46 · see citing works

The endocannabinoidome in neuropsychiatry: Opportunities and potential risks

Morris, G., Walder, K. R., Kloiber, S. M., Amminger, G. P., Berk, M., Bortolasci, C. C., Maes, M. H. J., Puri, B. K., & Carvalho, A. F. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105729 · Cited by 47 · see citing works

A2a and a2b adenosine receptors affect HIF‐1α signaling in activated primary microglial cells

Merighi, S., Borea, P. A., Stefanelli, A., Bencivenni, S., Castillo, C. A., Varani, K., & Gessi, S. (2015) · Glia · doi:10.1002/glia.22861 · Cited by 44 · see citing works

The effects of anaesthetics and sedatives on brain inflammation

Dominguini, D., Steckert, A. V., Michels, M., Borges, M. S., Ritter, C., Barichello, T., Thompson, J. P., & Dal‐Pizzol, F. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.05.009 · Cited by 44 · see citing works

Discovery of a fluorinated 4‐oxo‐quinoline derivative as a potential positron emission tomography radiotracer for imaging cannabinoid receptor type 2

Slavik, R., Herde, A. M., Haider, A., Krämer, S. D., Weber, M., Schibli, R., Ametamey, S. M., & Mu, L. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13716 · Cited by 39 · see citing works

Methamphetamine modulates the production of interleukin-6 and tumor necrosis factor-alpha via the cAMP/PKA/CREB signaling pathway in lipopolysaccharide-activated microglia

Wang, B., Chen, T., Wang, J., Jia, Y., Ren, H., Wu, F., Hu, M., & Chen, Y. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.01.024 · Cited by 39 · see citing works

Arsenic trioxide mediates HAPI microglia inflammatory response and the secretion of inflammatory cytokine IL-6 via Akt/NF-κB signaling pathway

Chen, G., Mao, J., Zhao, J., Zhang, Y., Li, T., Wang, C., Xu, L., Hu, Q., Wang, X., Jiang, S., et al. (2016) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2016.09.027 · Cited by 36 · see citing works

CB2 Receptor Activation Inhibits Melanoma Cell Transmigration through the Blood-Brain Barrier

Haskó, J., Fazakas, C., Molnár, J., Nyúl‐Tóth, Á., Herman, H., Hermenean, A. O., Wilhelm, I., Persidsky, Y., & Krizbai, I. A. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15058063 · Cited by 35 · see citing works

Low-Dose Cannabinoid Type 2 Receptor Agonist Attenuates Tolerance to Repeated Morphine Administration via Regulating μ-Opioid Receptor Expression in Walker 256 Tumor-Bearing Rats

Zhang, M., Wang, K., Ma, M., Tian, S., Wei, N., & Wang, G. (2015) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000001129 · Cited by 33 · see citing works

TLR4 Receptor Induces 2-AG–Dependent Tolerance to Lipopolysaccharide and Trafficking of CB2 Receptor in Mast Cells

Espinosa‐Riquer, Z. P., Ibarra-Sánchez, A., Vibhushan, S., Bratti, M., Charles, N., Blank, U., Rodrı́guez–Manzo, G., & González‐Espinosa, C. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1800997 · Cited by 31 · see citing works

The CB2-preferring agonist JWH015 also potently and efficaciously activates CB1 in autaptic hippocampal neurons

Murataeva, N., Mackie, K., & Straiker, A. J. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.08.002 · Cited by 31 · see citing works

Neuroinflammation as a possible link between cannabinoids and addiction

Rodrigues, L. C. M., Gobira, P. H., de Oliveira, A. C., Pelição, R., Teixeira, A. L., Moreira, F. A., & Campos, A. C. (2013) · Acta Neuropsychiatrica · doi:10.1017/neu.2014.24 · Cited by 29 · see citing works

Effects of Cannabinoid Type 2 Receptor Agonist AM1241 on Morphine-Induced Antinociception, Acute and Chronic Tolerance, and Dependence in Mice

Zhang, M., Dong, L., Zou, H., Li, J., Li, Q., Wang, G., & Li, H. (2018) · Journal of Pain · doi:10.1016/j.jpain.2018.04.009 · Cited by 26 · see citing works

Involvement of Spinal Cannabinoid CB2 Receptors in Exercise-Induced Antinociception

dos Santos, R. S., Sorgi, C. A., Peti, A. P. F., Veras, F. P., Faccioli, L. H., & Galdino, G. S. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.08.041 · Cited by 27 · see citing works

A comprehensive review of the multifaceted role of cannabinoid receptor type 2 in neurodegenerative and neuropsychiatric disorders

García‐Gutiérrez, M. S., Torregrosa, A. B., Navarrete, F., Navarro, D., & Manzanares, J. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107657 · Cited by 27 · see citing works

The Effect of Preoperative Marijuana Use on Surgical Outcomes, Patient-Reported Outcomes, and Opioid Consumption Following Lumbar Fusion

D’Antonio, N. D., Lambrechts, M. J., Heard, J. C., Siegel, N. M., Karamian, B. A., Huang, A., Canseco, J. A., Woods, B. I., Kaye, I. D., Hilibrand, A. S., et al. (2022) · Global Spine Journal · doi:10.1177/21925682221116819 · Cited by 26 · see citing works

Neuroinflammation in the Central Nervous System: Exploring the Evolving Influence of Endocannabinoid System

Rathod, S., Agrawal, Y. O., Nakhate, K. T., Meeran, M. F. N., Ojha, S. K., & Goyal, S. N. (2023) · Biomedicines · doi:10.3390/biomedicines11102642 · Cited by 25 · see citing works

Cannabinoid receptor 2 selective agonists and Alzheimer's disease: An insight into the therapeutic potentials

Varshini, M. S., Krishnamurthy, P. T., Shaji, N., Mani, L., & Balasubramanian, S. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24933 · Cited by 23 · see citing works

Blockade of CB1 or Activation of CB2 Cannabinoid Receptors Is Differentially Efficacious in the Treatment of the Early Pathological Events in Streptozotocin-Induced Diabetic Rats

Spyridakos, D., Mastrodimou, N., Vemuri, K. V., Ho, T. C., Nikas, S. P., Makriyannis, A., & Thermos, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010240 · Cited by 23 · see citing works

Allodynia Lowering Induced by Cannabinoids and Endocannabinoids (ALICE)

Luongo, L., Starowicz, K., Maione, S., & Marzo, V. D. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.02.019 · Cited by 23 · see citing works

Naltrexone prevents delayed encephalopathy in rats poisoned with the sarin analogue diisopropylflurophosphate

Brewer, K. L., Troendle, M. M., Pekman, L., & Meggs, W. J. (2013) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2012.12.003 · Cited by 20 · see citing works

Involvement of neuronal TGF ‐ β activated kinase 1 in the development of tolerance to morphine‐induced antinociception in rat spinal cord

Xu, H., Xu, T., Ma, X., & Jiang, W. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13094 · Cited by 19 · see citing works

Morphine consumption during pregnancy exacerbates neonatal hypoxia‐ischemia injury in rats

Bornavard, M., Fanaei, H., Mirshekar, M. A., Mashhadi, F. F., & Atashpanjeh, A. (2020) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10008 · Cited by 19 · see citing works

Transcriptional and epigenetic regulation of microglia in substance use disorders

Vilca, S. J., Margetts, A. V., Pollock, T. A., & Tuesta, L. M. (2023) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2023.103838 · Cited by 19 · see citing works

Microglia in morphine tolerance: cellular and molecular mechanisms and therapeutic potential

Zhang, X., Jin, T., Wang, H., Han, S., & Liang, Y. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1499799 · Cited by 17 · see citing works

Opioid tolerance and opioid-induced hyperalgesia: Is TrkB modulation a potential pharmacological solution?

Lim, S. Y., & Cengiz, P. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109260 · Cited by 16 · see citing works

Type 2 cannabinoid receptor expression on microglial cells regulates neuroinflammation during graft-versus-host disease

Moe, A. B., Rayasam, A., Sauber, G., Shah, R. K., Doherty, A., Yuan, C.-Y., Szabó, A., Moore, B. M., II, Colonna, M., Cui, W., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci175205 · Cited by 16 · see citing works

Anandamide rescues retinal barrier properties in Müller glia through nitric oxide regulation

Krishnan, G., & Chatterjee, N. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.10.020 · Cited by 16 · see citing works

The cannabinoid CB2 agonist LY2828360 suppresses neuropathic pain behavior and attenuates morphine tolerance and conditioned place preference in rats

Guenther, K. G., Wirt, J. L., Oliva, I., Saberi, S. A., Crystal, J. D., & Hohmann, A. G. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110257 · Cited by 15 · see citing works

The endocannabinoid system and breathing

Wiese, B. M., Reyes, A. A., Vanderah, T. W., & Largent‐Milnes, T. M. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1126004 · Cited by 12 · see citing works

Intertwined associations between oxidative and nitrosative stress and endocannabinoid system pathways: Relevance for neuropsychiatric disorders

Morris, G., Walder, K. R., Berk, M., Carvalho, A. F., Marx, W., Bortolasci, C. C., Yung, A. R., Puri, B. K., & Maes, M. H. J. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110481 · Cited by 12 · see citing works

Brain Penetrant, but not Peripherally Restricted, Synthetic Cannabinoid 1 Receptor Agonists Promote Morphine-Mediated Respiratory Depression

Wiese, B. M., Liktor‐Busa, E., Couture, S. A., Nikas, S. P., Ji, L., Liu, Y., Makriyannis, A., Spigelman, I., Vanderah, T. W., & Largent‐Milnes, T. M. (2021) · Cannabis and Cannabinoid Research · doi:10.1089/can.2021.0090 · Cited by 11 · see citing works

Non-Psychoactive Cannabinoid Modulation of Nociception and Inflammation Associated with a Rat Model of Pulpitis

Laks, E. Y., Li, H., & Ward, S. J. (2023) · Biomolecules · doi:10.3390/biom13050846 · Cited by 12 · see citing works

Cannabinoid Receptor Type 2 Agonist Reduces Morphine Tolerance via Mitogen Activated Protein Kinase Phosphatase Induction and Mitogen Activated Protein Kinase Dephosphorylation

Kong, Q., Tian, S., Ma, C., Wang, G., & Zhang, M. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.11.007 · Cited by 12 · see citing works

Cannabinoid CB2 receptors in primary sensory neurons are implicated in CB2 agonist-mediated suppression of paclitaxel-induced neuropathic nociception and sexually-dimorphic sparing of morphine tolerance

Guenther, K. G., Lin, X., Xu, Z., Makriyannis, A., Romero, J., Hillard, C. J., Mackie, K., & Hohmann, A. G. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116879 · Cited by 11 · see citing works

Cannabinoid type 2 receptor agonist JWH133 decreases blood pressure of spontaneously hypertensive rats through relieving inflammation in the rostral ventrolateral medulla of the brain

Shi, H., Guo, H., Liu, H.-Y., Zhang, Z.-L., Hu, M., Zhang, Y., & Li, Q. (2020) · Journal of Hypertension · doi:10.1097/hjh.0000000000002342 · Cited by 10 · see citing works

Chronic exposure to methadone induces activated microglia and astrocyte and cell death in the cerebellum of adult male rats

Zamani, N., Osgoei, L. T., Aliaghaei, A., Zamani, N., & Hassanian‐Moghaddam, H. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-01108-z · Cited by 7 · see citing works

Broad and Region-Specific Impacts of the Synthetic Cannabinoid CP 55,940 in Adolescent and Adult Female Mouse Brains

Leishman, E., Murphy, M. N., Murphy, M. I., Mackie, K., & Bradshaw, H. B. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00436 · Cited by 7 · see citing works

Cannabinoid CB 2 Receptor Activation Attenuates Fentanyl-Induced Respiratory Depression

Zavala, C. A., Thomaz, A. C., Iyer, V., Mackie, K., & Hohmann, A. G. (2020) · Cannabis and Cannabinoid Research · doi:10.1089/can.2020.0059 · Cited by 7 · see citing works

The effect of cannabinoid type 2 receptor agonist on morphine tolerance

Cui, D., Zhang, Y., & Zhang, M. (2023) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2023.11.005 · Cited by 6 · see citing works

Disrupted neuregulin 1-ErbB4 signaling: Consequences of prenatal morphine exposure in rat pups and molecular gateway to neurological impairment

Khayat, S., Fanaei, H., Hafezinouri, H., Ghanbarzehi, A., Parsi-Moud, A., & Mirzaei, I. (2024) · Toxicology Reports · doi:10.1016/j.toxrep.2024.101687 · Cited by 5 · see citing works

Involvement of CXCL12/CXCR4 in CB2 receptor agonist-attenuated morphine tolerance in Walker 256 tumor-bearing rats with cancer pain

Liu, D., Zhang, M., Xu, X., Zhong, X., Ma, C., Zheng, X., Wu, X., & Wang, G. (2024) · European journal of medical research · doi:10.1186/s40001-024-02207-6 · Cited by 4 · see citing works

Iatrogenic Angiogenesis

Gupta, K. (2012) · Springer eBooks · doi:10.1007/978-94-007-5678-6_5 · Cited by 4 · see citing works

EXPRESS: CB2 receptor agonist AM1241 regulating the polarization of microglia reduces morphine tolerance through IL-4/STAT6 pathway

Cui, D., Yang, C., Zhang, Y., Kong, Q., Wang, G., & Zhang, M. (2025) · Molecular Pain · doi:10.1177/17448069251374281 · Cited by 3 · see citing works

Class A GPCRs: Cannabinoid and Opioid Receptor Heteromers

Sierra, S., Gomes, I., & Devi, L. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-60174-8_7 · Cited by 3 · see citing works

The actions of morphine on microglia and the underlying effects on associated adverse effects

Wu, W., Li, Q., & Yang, F. (2025) · Psychopharmacology · doi:10.1007/s00213-025-06956-y · Cited by 2 · see citing works

Exploring β-caryophyllene: a non-psychotropic cannabinoid's potential in mitigating cognitive impairment induced by sleep deprivation

Lim, C. R., Ogawa, S., & Kumari, Y. (2024) · Archives of Pharmacal Research · doi:10.1007/s12272-024-01523-z · Cited by 2 · see citing works

Evaluation of the effect of mesenchymal stem cells injection in the nucleus accumbens on the morphine reinstatement behavior in a conditioned place preference model in Wistar rat: Expression changes of NMDA receptor subunits and NT-3

Kataj, P. D., Vousooghi, N., Hadjighassem, M., Farahmandfar, M., & Ebrahimi‐Barough, S. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114360 · Cited by 2 · see citing works

Differential opioid receptor expression and biochemical coupling profiles on glia

Kadhim, S., McDonald, J. F., Bird, M. F., Guerrini, R., Calò, G., & Lambert, D. G. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117559 · Cited by 1 · see citing works

Rescue of astrocytic ASCT1 expression and d-serine uptake attenuates remifentanil-induced hyperalgesia

Chen, C., Shi, Y., Wan, Y., Zhu, Z., Feng, Y., Song, M., 李兴玉, & Shi, J. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.153944 · Cited by 1 · see citing works

Endocannabinoid System: behavioral modulation in murine models by Cannabinoids type 2 receptors

Monteiro, R. F. M., Nascimento, M. V. L., Lima, K. T., Almeida, J. R. G., Ávila, P. E. S., & Bastos, G. D. N. T. (2021) · Research Society and Development · doi:10.33448/rsd-v10i13.21491 · Cited by 1 · see citing works

Effect of hydroalcoholic extract of Ferula szowitsiana DC. on paw edema in rat

Saghravanian, S. J., Fereidoni, M., & Asadollahi, A. (2016) · KAUMS Journal · Cited by 1 · see citing works

Cannabinoids in Opioid Addiction Treatment: Pharmacological Mechanisms

Zuo, Q., Tam, K. L., Bekker, A., Zuo, W., & Ye, J.-H. (2019) · doi:10.35248/2329-6488.19.7.325 · Cited by 1 · see citing works

Activation of cannabinoid receptor 2 inhibits LPS-induced neuroinflammation via PI3K/Akt signaling pathway in micePreprint

Wang, B., denghan, 邓., Sui, Y., Liu, X., Ren, Y., & Ma, Z. (2024) · Research Square · doi:10.21203/rs.3.rs-3733804/v1 · Cited by 1 · see citing works

Syntheses and Evaluation of Novel Cannabinoid Type 2 Receptors Tracers for PET Imaging

Slavik, R. (2015) · Repository for Publications and Research Data (ETH Zurich) · doi:10.3929/ethz-a-010349745

MICROGLIAL CELL EXPRESSION OF THE TYPE 2 CANNABINOID RECEPTOR REGULATES IMMUNE-MEDIATED NEUROINFLAMMATIONPreprint

Moe, A. B., Rayasam, A., Sauber, G., Shah, R. K., Yuan, C.-Y., Szabó, A., Moore, B. M., Colonna, M., Cui, W., Romero, J., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.10.552854

From Computational Prediction to Experimental Validation: Linoleoylethanolamide Combats Ulcerative Colitis Via Suppressing Nf-Κb P65 Nuclear TranslocationPreprint

Shi, Z., Wen, H., Bao, Y., Qin, Y., Wan, J., & Zhong, X. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5348501

Insulin-Regulated Amino Peptidase (IRAP) controls FcR-mediated signaling and inflammatory responses

Bratti, M. (2021) · doi:10.70675/cbdb8b72zd1adz47d8z8825ze4395bdc852f

Endocannabinoid system, inflammation, and mental well-being

Iqbal, A. Z., Wu, S., Yaseen, M., Suwindi, P. M., Chang, J. P., & Su, K. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-28842-5.00023-5

PM289, a synthetic CB2 in vitro receptor agonist, modulates morphine-induced antinociceptive effect and withdrawal syndrome in an animal model of osteoarthritic pain

Martínez-García, M. Á., Paniagua, N., Morales, P., Rodríguez‐Rivera, C., Sánchez-Robles, E., Pascual, D., Herradón, E., Goicoechea, C., Jagerovic, N., & Girón, R. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.111090

CANNABINOID CB2 AND μ-OPIOID RECEPTORS SIGNALLING IN MICROGLIAL CELLS: POTENTIAL TARGETS TO INCREASE CLINICAL EFFICACY OF OPIOIDS

Fazzi, D. (2015) · Institutional Research Information System University of Ferrara (University of Ferrara)

CANNABINOID CB2 AND μ-OPIOID RECEPTORS \nSIGNALLING IN MICROGLIAL CELLS: POTENTIAL \nTARGETS TO INCREASE CLINICAL EFFICACY OF \nOPIOIDS

Fazzi, D. (2015) · EprintsUnife

Cannabinoid CB2 receptor modulates microglial cell activation: role of ERK-1/2 Kinase signaling.

MERIGHI, S., Gessi, S., VARANI, K., Fazzi, D., Stefanelli, A., Mirandola, P., & Borea*, P. A. (2011) · Institutional Research Information System University of Ferrara (University of Ferrara)

Morphine mediates a proinflammatory phenotype via μ-opioid receptor–PKCɛ–Akt–ERK1/2 signaling pathway in activated microglial cells

Merighi, S., Gessi, S., Varani, K., Fazzi, D., Stefanelli, A., & Borea, P. A. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.05.027 · Cited by 112 · see citing works

The effect of cannabinoid type 2 receptor agonist on morphine tolerance

Cui, D., Zhang, Y., & Zhang, M. (2023) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2023.11.005 · Cited by 6 · see citing works