Sleep deprivation amplifies striatal activation to monetary reward
Open accessAbstract
Background: Sleep loss produces abnormal increases in reward seeking but the mechanisms underlying this phenomenon are poorly understood. The present study examined the influence of one night of sleep deprivation on neural responses to a monetary reward task in a sample of late adolescents/young adults. Method: Using a within-subjects crossover design, 27 healthy, right-handed late adolescents/young adults (16 females, 11 males; mean age 23.1 years) underwent functional magnetic resonance imaging (fMRI) following a night of sleep deprivation and following a night of normal sleep. Participants' recent sleep history was monitored using actigraphy for 1 week prior to each sleep condition. Results: Following sleep deprivation, participants exhibited increased activity in the ventral striatum (VS) and reduced deactivation in the medial prefrontal cortex (mPFC) during the winning of monetary reward, relative to the same task following normal sleep conditions. Shorter total sleep time over the five nights before the sleep-deprived testing condition was associated with reduced deactivation in the mPFC during reward. Conclusions: These findings support the hypothesis that sleep loss produces aberrant functioning in reward neural circuitry, increasing the salience of positively reinforcing stimuli. Aberrant reward functioning related to insufficient sleep may contribute to the development and maintenance of reward dysfunction-related disorders, such as compulsive gambling, eating, substance abuse and mood disorders.
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A single night of total sleep deprivation leads to decreases in mPFC activity and increases in VS activity in response to rewarding stimuli in young adults aged 18-25 years.
“a single night of total sleep deprivation leads to decreases in mPFC activity and increases in VS activity in response to rewarding stimuli in young adults (aged 18–25 years)180”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [180]
Sleep deprivation disrupts reward neural circuitry, usually enhancing brain reactivity to positive experiences.
“Sleep deprivation also disrupts reward neural circuitry, usually enhancing brain reactivity to positive experiences.”
From Impact of Sleep and Circadian Rhythms on Addiction Vulnerability in Adolescents (2018) · cites this paper as [86]
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- Authors
- Mullin, B. C., Phillips, M. L., Siegle, G. J., Buysse, D. J., Forbes, E. E., & Franzen, P. L.
- Affiliations
- Children's Hospital Colorado (US)
- University of Pittsburgh (US)
- Corresponding author
- Franzen, P. L.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2013-01-04
- Volume
- 43
- Issue
- 10
- Pages
- 2215-2225
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- PMC
- PMC3742668
- OpenAlex
- W2015859900
- Cited by
- 120
- References
- 56
- Citations by year
- 2026: 13 · 2025: 13 · 2024: 9 · 2023: 8 · 2022: 9 · 2021: 6 · 2020: 14 · 2019: 12 · 2018: 8 · 2017: 3 · 2016: 11 · 2015: 8 · 2014: 4 · 2013: 2
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Funders
- National Institutes of Health (UL1TR000005)
- National Heart, Lung, and Blood Institute (R24HL076852, R24HL076858, T32HL082610)
- National Institute of Mental Health (K01MH077106, R01MH076961)
- National Center for Research Resources (UL1RR024153)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- sleep deprivation, monetary rewards, ventral striatum, medial prefrontal cortex, reward processing, neural deactivation, total sleep time, adolescents and young adults, gambling addiction, substance abuse
- MeSH terms
- Adolescent, Adult, Corpus Striatum, Female, Humans, Magnetic Resonance Imaging, Male, Reward, Sleep, Sleep Deprivation, Prefrontal Cortex, Cross-Over Studies, Young Adult, Actigraphy, Functional Neuroimaging
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