The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.
Interleukin‐6, C‐Reactive Protein, and Tumor Necrosis Factor‐Alpha as Predictors of Mortality in Frail, Community‐Living Elderly Individuals
Open accessAbstract
OBJECTIVES: To investigate whether interleukin‐6 (IL‐6), C‐reactive protein (CRP) and tumor necrosis factor‐alpha (TNF‐α) protein levels predict all‐cause mortality in older persons living in the community. DESIGN: Prospective cohort study. SETTING: Data were from the Aging and Longevity Study in the Sirente Geographic Area, a prospective cohort study. PARTICIPANTS: Individuals aged 80 and older living in an Italian mountain community (N=362). MEASUREMENTS: Participants were classified according to the median value of the three inflammation markers (IL‐6, 2.08 pg/mL; TNF‐α, 1.43 pg/mL; CRP, 3.08 mg/L). A composite summary score of inflammation was also created. The main outcome was risk of death after 4 years of follow‐up. RESULTS: One hundred fifty deaths occurred during 4 years of follow‐up. In the unadjusted model, high levels of each of the three markers were associated with greater mortality. After adjusting for potential confounders, high levels of IL‐6 (hazard ratio (HR)=2.18, 95% confidence interval (CI)=1.29–3.69) and CRP (HR=2.58, 95% CI=1.52–4.40) were associated with a significantly greater risk of death, whereas the association between TNF‐α protein levels and mortality was no longer significant (HR=1.26, 95% CI=0.74–2.15). The composite summary score of inflammation was strongly associated with mortality, with the highest risk estimated for individuals with all three inflammatory markers above the median. CONCLUSION: Low levels of inflammatory markers are associated with better survival in older adults, independent of age and other clinical and functional variables.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“those older individuals who are most frail have highest levels of circulating CRP, IL-6 and IL-8 (23).”
From The impact of ageing on monocytes and macrophages (2021) · cites this paper as [23]
In the citing paper
“Inflammation is a strong predictor for frailty, and those older individuals who are most frail have highest levels of circulating CRP, IL-6 and IL-8 (23).”
From The impact of ageing on monocytes and macrophages (2021) · cites this paper as [23]
In the citing paper
“In addition, higher inflammatory activity, measured by plasma or serum interleukin (IL)-6, tumour necrosis factor-α (TNF-α) and C-reactive protein (CRP), has also been associated with shorter survival (Baune et al. 2011; Bruunsgaard et al. 2003; Giovannini et al. 2011).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Giovannini et al. 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
C-reactive protein: a critical update
Pepys, M. B., & Hirschfield, G. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18921 · Cited by 4,694
The Prognostic Value of C-Reactive Protein and Serum Amyloid A Protein in Severe Unstable Angina
Liuzzo, G., Biasucci, L. M., Gallimore, J. R., Grillo, R. L., Rebuzzi, A. G., Pepys, M. B., & Maseri, A. (1994) · New England Journal of Medicine · doi:10.1056/nejm199408183310701 · Cited by 2,354
MDS Cognitive Performance Scale(C)
Morris, J. N., Fries, B. E., Mehr, D. R., Hawes, C., Phillips, C., Mor, V., & Lipsitz, L. A. (1994) · Journal of Gerontology · doi:10.1093/geronj/49.4.m174 · Cited by 1,852
Production of C-reactive protein and risk of coronary events in stable and unstable angina
Haverkate, E., Thompson, S. G., Pyke, S., Gallimore, J. R., & Mark B Pepys Group (1997) · The Lancet · doi:10.1016/s0140-6736(96)07591-5 · Cited by 1,511
Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly
Harris, T. B., Ferrucci, L., Tracy, R. P., Corti, M. C., Wacholder, S., Ettinger, W. H., Heimovitz, H., Cohen, H. J., & Wallace, R. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00066-2 · Cited by 1,488
Torre-Amione, G., Kapadia, S., Benedict, C., Oral, H., Young, J. B., & Mann, D. L. (1996) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00589-7 · Cited by 1,211
Inflammatory markers and loss of muscle mass (sarcopenia) and strength
Schaap, L. A., Pluijm, S. M. F., Deeg, D. J. H., & Visser, M. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.10.049 · Cited by 1,047
Serum IL‐6 Level and the Development of Disability in Older Persons
Ferrucci, L., Harris, T. B., Guralnik, J. M., Tracy, R. P., Corti, M., Cohen, H. J., Penninx, B., Pahor, M., Wallace, R., & Havlik, R. J. (1999) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1999.tb01583.x · Cited by 809
Self-citationFerrucci, L., Bandinelli, S., Benvenuti, E., Iorio, A. D., Macchi, C., Harris, T. B., & Guralnik, J. M. (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb03873.x · Cited by 797
Age-related inflammatory cytokines and disease
Brüünsgaard, H., & Pedersen, B. K. (2003) · Immunology and Allergy Clinics of North America · doi:10.1016/s0889-8561(02)00056-5 · Cited by 608
Research works printed but not linked: 1
- Morris JN, 1996, RAI – Home Care Assessment Manual
Cited by
Sorted by citations
Thevaranjan, N., Puchta, A., Schulz, C., Naidoo, A., Szamosi, J. C., Verschoor, C. P., Loukov, D., Schenck, L. P., Jury, J., Foley, K. P., et al. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.03.002 · Cited by 1,322
Campbell, J. P., & Turner, J. E. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00648 · Cited by 736
Tenorio, A. R., Zheng, Y., Bosch, R. J., Krishnan, S., Rodriguez, B. A., Hunt, P. W., Plants, J., Seth, A., Wilson, C. C., Deeks, S. G., et al. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu254 · Cited by 551
Inflammaging and Anti-Inflammaging: The Role of Cytokines in Extreme Longevity
Minciullo, P. L., Catalano, A., Mandraffino, G., Casciaro, M., Crucitti, A., Maltese, G., Morabito, N., Lasco, A., Gangemi, S., & Basile, G. (2016) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-015-0377-3 · Cited by 433
Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior study
Puzianowska-Kuźnicka, M., Owczarz, M., Wieczorowska-Tobis, K., Nadrowski, P., Chudek, J., Slusarczyk, P., Skalska, A., Jonas, M., Franek, E., & Mossakowska, M. (2016) · Immunity & Ageing · doi:10.1186/s12979-016-0076-x · Cited by 445
The aging gut microbiome and its impact on host immunity
Bosco, N., & Noti, M. (2021) · Genes and Immunity · doi:10.1038/s41435-021-00126-8 · Cited by 435
Justice, J. N., Ferrucci, L., Newman, A. B., Aroda, V. R., Bahnson, J. L., Divers, J., Espeland, M. A., Marcovina, S., Pollak, M. N., Kritchevsky, S. B., et al. (2018) · GeroScience · doi:10.1007/s11357-018-0042-y · Cited by 359
The impact of ageing on monocytes and macrophages
De Maeyer, R. P. H., & Chambers, E. S. (2021) · Immunology Letters · doi:10.1016/j.imlet.2020.12.003 · Cited by 275
Rasmussen, L. J. H., Petersen, J. E. V., & Eugen‐Olsen, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.780641 · Cited by 261
Pan, F., Zhang, L., Li, M., Hu, Y., Zeng, B., Yuan, H., Zhao, L., & Zhang, C. (2018) · Microbiome · doi:10.1186/s40168-018-0440-5 · Cited by 241
Boakye, D., Rillmann, B., Walter, V., Jansen, L., Hoffmeister, M., & Brenner, H. (2018) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2018.02.003 · Cited by 225
miR-21 and miR-146a: The microRNAs of inflammaging and age-related diseases
Olivieri, F., Prattichizzo, F., Giuliani, A., Matacchione, G., Rippo, M. R., Sabbatinelli, J., & Bonafè, M. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101374 · Cited by 228
Targeting Inflammation and Immunosenescence to Improve Vaccine Responses in the Elderly
Pereira, B. I., Xu, X., & Akbar, A. N. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.583019 · Cited by 190
TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity
Puchta, A., Naidoo, A., Verschoor, C. P., Loukov, D., Thevaranjan, N., Mandur, T. S., Nguyen, P.-S., Jordana, M., Loeb, M. B., Xing, Z., et al. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005368 · Cited by 181
The role of oxidative and inflammatory stress and persistent viral infections in immunosenescence
Bauer, M. E., & la Fuente, M. D. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.01.001 · Cited by 173
Inflammatory Markers Change with Age, but do not Fall Beyond Reported Normal Ranges
Wyczałkowska-Tomasik, A., Czarkowska‐Pączek, B., Zielenkiewicz, M., & Pączek, L. (2015) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-015-0357-7 · Cited by 165
Innate immune responses in the ageing lung.
Boe, D. M., Boule, L. A., & Kovacs, E. J. (2016) · Clinical and Experimental Immunology · doi:10.1111/cei.12881 · Cited by 156
Effects of Horticultural Therapy on Asian Older Adults: A Randomized Controlled Trial
Ng, T. K. S., Sia, A., Ng, M. K., Tan, C. T. Y., Chan, H. Y., Tan, C. H., Rawtaer, I., Feng, L., Mahendran, R., Larbi, A., et al. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15081705 · Cited by 156
Association of Lymphopenia With Risk of Mortality Among Adults in the US General Population
Zidar, D. A., Al-Kindi, S. G., Liu, Y., Krieger, N. I., Perzynski, A. T., Osnard, M., Nmai, C., Anthony, D. D., Lederman, M. M., Freeman, M. L., et al. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.16526 · Cited by 128
Altered immune system in frailty: Genetics and diet may influence inflammation
Pansarasa, O., Pistono, C., Davin, A., Bordoni, M., Mimmi, M. C., Guaita, A., & Cereda, C. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100935 · Cited by 122
C-Reactive Protein and Frailty in the Elderly: A Literature Review
Velissaris, D., Pantzaris, N. D., Koniari, I. C., Koutsogiannis, N., Karamouzos, V., Kotroni, I., Skroumpelou, A., & Ellul, J. (2017) · Journal of Clinical Medicine Research · doi:10.14740/jocmr2959w · Cited by 120
Capurso, C. A., Bellanti, F., Buglio, A. L., & Vendemiale, G. (2019) · Nutrients · doi:10.3390/nu12010035 · Cited by 124
Arthur, S. T., & Cooley, I. D. (2012) · International Journal of Biological Sciences · doi:10.7150/ijbs.4262 · Cited by 131
Dental Infection and Resistance—Global Health Consequences
Haque, M., Sartelli, M., & Haque, S. Z. (2019) · Dentistry Journal · doi:10.3390/dj7010022 · Cited by 123
Is immunosenescence influenced by our lifetime “dose” of exercise?
Turner, J. E. (2016) · Biogerontology · doi:10.1007/s10522-016-9642-z · Cited by 112
Marcos-Pérez, D., Sánchez-Flores, M., Maseda, A., Lorenzo‐López, L., Millán-Calentí, J. C., Gostner, J. M., Fuchs, D., Pásaro, E., Laffón, B., & Valdiglesias, V. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01056 · Cited by 107
Intestinal alkaline phosphatase targets the gut barrier to prevent aging
Kühn, F., Adiliaghdam, F., Cavallaro, P. M., Hamarneh, S. R., Tsurumi, A., Hoda, R. S., Munoz, A. R., Dhole, Y., Ramirez, J. M., Liu, E., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.134049 · Cited by 107
Inflammaging markers characteristic of advanced age show similar levels with frailty and dependency
Alberro, A., Iribarren-López, A., Sáenz-Cuesta, M., Matheu, A., Vergara, I., & Otaegui, D. (2021) · Scientific Reports · doi:10.1038/s41598-021-83991-7 · Cited by 102
Ticinesi, A., Meschi, T., Lauretani, F., Felis, G. E., Franchi, F., Pedrolli, C., Barichella, M., Benati, G., Nuzzo, S. D., Ceda, G. P., et al. (2016) · Nutrients · doi:10.3390/nu8040186 · Cited by 104
Age and frailty as risk factors for the development of osteoarthritis
O’Brien, M. S., & McDougall, J. J. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.03.003 · Cited by 97
Inflamm‐aging of the stem cell niche: Breast cancer as a paradigmatic example
Bonafè, M., Storci, G., & Franceschi, C. (2011) · BioEssays · doi:10.1002/bies.201100104 · Cited by 96
Can blocking inflammation enhance immunity during aging?
Chambers, E. S., & Akbar, A. N. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.03.016 · Cited by 92
Fatigue and the prediction of negative health outcomes: A systematic review with meta-analysis
Knoop, V., Cloots, B., Costenoble, A., Debain, A., Azzopardi, R. V., Vermeiren, S., Jansen, B., Scafoglieri, A., Bautmans, I., Bautmans, I., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101261 · Cited by 89
Systemic inflammation and biological aging in the Health and Retirement Study
Meier, H. C. S., Mitchell, C. M., Karadimas, T., & Faul, J. D. (2023) · GeroScience · doi:10.1007/s11357-023-00880-9 · Cited by 93
Inflamm-ageing: How cytokines and nutrition shape the trajectory of ageing
Coperchini, F., Greco, A., Teliti, M., Croce, L., Chytiris, S., Magri, F., Gaetano, C., & Rotondi, M. (2024) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2024.08.004 · Cited by 95
Motta, F., Sica, A., & Selmi, C. F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.576134 · Cited by 92
The hormetic and hermetic role of IL-6
Forcina, L., Franceschi, C., & Musarò, A. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101697 · Cited by 85
Pallis, A. G., Hatse, S., Brouwers, B. A. H., Pawelec, G., Falandry, C., Wedding, U., Lago, L. D., Repetto, L., Ring, A. E., & Wildiers, H. P. M. W. (2013) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2013.09.001 · Cited by 84
Davis, J. C., Bryan, S., LI, L. C., Best, J. R., Hsu, C. L., Gomez, C., Vertes, K. A., & Liu-Ambrose, T. Y. L. (2015) · BMC Geriatrics · doi:10.1186/s12877-015-0076-2 · Cited by 88
Cole, S. W., Shanahan, M. J., Gaydosh, L. M., & Harris, K. M. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1821367117 · Cited by 81
Hohman, L. S., & Osborne, L. C. (2022) · Aging Cell · doi:10.1111/acel.13700 · Cited by 89
Li, H., Liu, W., & Xie, J. (2017) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2017.08.007 · Cited by 76
Berglundh, S., Malmgren, L., Luthman, H., McGuigan, F. E., & Åkesson, K. (2014) · Osteoporosis International · doi:10.1007/s00198-014-2951-7 · Cited by 73
Ansari, M. M., Ahmad, A., Mishra, R. K., Raza, S. S., & Khan, R. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b00427 · Cited by 73
Kapétanovic, R., Bokil, N. J., & Sweet, M. J. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.02.005 · Cited by 70
Biomarkers of the ageing immune system and their association with frailty – A systematic review
Hoi, E. T. V., de Glas, N. A., Portielje, J. E. A., van Heemst, D., van den Bos, F., Jochems, S. P., & Mooijaart, S. P. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112163 · Cited by 72
Lee, J. S., Kim, C. G., Seo, T. B., Kim, H. G., & Yoon, S. J. (2014) · Aging Clinical and Experimental Research · doi:10.1007/s40520-014-0257-4 · Cited by 69
Frailty assessment: from clinical to radiological tools
Bentov, I., Kaplan, S. J., Pham, T. N., & Reed, M. J. (2019) · British Journal of Anaesthesia · doi:10.1016/j.bja.2019.03.034 · Cited by 72
Forti, L. N., Njemini, R., Beyer, I., Eelbode, E., Meeusen, R., Mets, T., & Bautmans, I. (2014) · AGE · doi:10.1007/s11357-014-9704-6 · Cited by 67
Ansari, M. M., Ahmad, A., Kumar, A., Alam, P., Khan, T. H., Jayamurugan, G., Raza, S. S., & Khan, R. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.117600 · Cited by 68
Hussien, H., Nastasa, A., Apetrii, M., Nistor, I., Petrović, M., & Covic, A. C. (2021) · BMC Geriatrics · doi:10.1186/s12877-021-02316-5 · Cited by 70
Cudjoe, T., Selvakumar, S., Chung, S.-E., Latkin, C. A., Roth, D. L., Thorpe, R. J., & Boyd, C. M. (2021) · Journal of the American Geriatrics Society · doi:10.1111/jgs.17518 · Cited by 71
Turner, J. E., & Brum, P. C. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/4234765 · Cited by 66
Ligon, M. M., Wang, C., Jennings, Z., Schulz, C., DeJong, E. N., Lowder, J. L., Bowdish, D. M. E., & Mysorekar, I. U. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-0290-x · Cited by 64
Effects of Long-Term Exercise on Age-Related Hearing Loss in Mice
Han, C. J., Ding, D., Lopez, M.-C., Manohar, S., Zhang, Y., Kim, M., Park, H., White, K., Kim, Y. H., Linser, P. J., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2493-16.2016 · Cited by 64
Lacina, L., Kolář, M., Pfeiferová, L., Gál, P., & Smetana, K. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1403570 · Cited by 69
Smorenberg, A., Peters, E. J. G., van Daele, P. L. A., Nossent, E. J., & Muller, M. (2020) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2020.11.024 · Cited by 63
Meade, R. D., Notley, S. R., Akerman, A. P., McCormick, J. J., King, K. E., Sigal, R. J., & Kenny, G. P. (2023) · Environmental Health Perspectives · doi:10.1289/ehp11651 · Cited by 67
Biological ageing and frailty markers in breast cancer patients
Brouwers, B. A. H., Dalmasso, B., Hatse, S., Laenen, A., Kenis, C., Swerts, E., Neven, P., Smeets, A., Schöffski, P., & Wildiers, H. P. M. W. (2015) · Aging · doi:10.18632/aging.100745 · Cited by 59
Lavin, K. M., Coen, P. M., Baptista, L. C. P., Bell, M. B., Drummer, D. J., Harper, S. A., Lixandrão, M. E., McAdam, J. S., O’Bryan, S. M., Ramos, S. V., et al. (2022) · Comprehensive physiology · doi:10.1002/cphy.c200033 · Cited by 78
Soy Food Intake and Circulating Levels of Inflammatory Markers in Chinese Women
Wu, S., Shu, X. O., Chow, W., Xiang, Y., Zhang, X., Li, H., Cai, Q., Ji, B., Cai, H., Rothman, N., et al. (2012) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2012.04.001 · Cited by 56
Age-related changes in the immune system and challenges for the development of age-specific vaccines
Doherty, M. T., Weinberger, B., Didierlaurent, A. M., & Lambert, P. (2025) · Annals of Medicine · doi:10.1080/07853890.2025.2477300 · Cited by 69
Nie, Y., Yan, Z., Yin, H. Y., Shan, L., Wang, J., & Wu, Q. (2022) · BMC Geriatrics · doi:10.1186/s12877-022-03225-x · Cited by 55
McFarland, K. N., & Chakrabarty, P. (2022) · Neurotherapeutics · doi:10.1007/s13311-021-01179-3 · Cited by 48
Adriaensen, W. J., Matheï, C., Vaes, B., Pottelbergh, G. V., Wallemacq, P. E., & Degryse, J. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.06.005 · Cited by 47
Rolland, T., Boutroy, S., Vilayphiou, N., Blaizot, S., Chapurlat, R. D., & Szulc, P. (2012) · Calcified Tissue International · doi:10.1007/s00223-012-9598-1 · Cited by 47
A Comprehensive Analysis of Cytokine Network in Centenarians
Pinti, M., Gibellini, L., Tartaro, D. L., Biasi, S. D., Nasi, M., Borella, R., Fidanza, L., Neroni, A., Troiano, L., Franceschi, C., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032719 · Cited by 48
Genetic background, epigenetic factors and dietary interventions which influence human longevity
Costa, D., Scognamiglio, M., Fiorito, C., Benincasa, G., & Claudio Napoli, A. (2019) · Biogerontology · doi:10.1007/s10522-019-09824-3 · Cited by 47
The effects of weight cycling on lifespan in male C57BL/6J mice
List, E. O., Berryman, D. E., Wright‐Piekarski, J., Jara, A., Funk, K. M., & Kopchick, J. J. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.203 · Cited by 44
The Association of Anti-Inflammatory Diet Ingredients and Lifestyle Exercise with Inflammaging
Wawrzyniak-Gramacka, E., Hertmanowska, N., Tylutka, A., Morawin, B., Wacka, E., Gutowicz, M., & Zembroń-Łacny, A. (2021) · Nutrients · doi:10.3390/nu13113696 · Cited by 48
Hesseberg, K., Tangen, G. G., Pripp, A. H., & Bergland, A. (2020) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000510382 · Cited by 43
Are aging biomarkers clinically relevant in oncogeriatrics?
Falandry, C., Gilson, É., & Rudolph, K. L. (2012) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2012.08.004 · Cited by 39
Zuliani, G., Morieri, M. L., Volpato, S., Maggio, M. G., Cherubini, A., Francesconi, D., Bandinelli, S., Paolisso, G., Guralnik, J. M., & Ferrucci, L. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.05.959 · Cited by 36
Iron deficiency and biomarkers of inflammation: a 3-year prospective analysis of the DO-HEALTH trial
Wieczorek, M., Schwarz, F., Sadlon, A., Abderhalden, L. A., Molino, C. D. G. R. C., Spahn, D. R., Schaer, D. J., Orav, E. J., Egli, A., & Bischoff-Ferrari, H. A. (2021) · Aging Clinical and Experimental Research · doi:10.1007/s40520-021-01955-3 · Cited by 36
Age-Related Differences in Biomarkers of Acute Inflammation During Hospitalization for Sepsis
Ginde, A. A., Blatchford, P. J., Trzeciak, S., Hollander, J. E., Birkhahn, R., Otero, R., Osborn, T. M., Moretti, E., Nguyen, H. T., Gunnerson, K. J., et al. (2014) · Shock · doi:10.1097/shk.0000000000000182 · Cited by 35
Association of serum glycine levels with metabolic syndrome in an elderly Chinese population
Li, X., Sun, L., Zhang, W., Li, H., Wang, S., Mu, H., Zhou, Q., Zhang, Y., Tang, Y., Wang, Y., et al. (2018) · Nutrition & Metabolism · doi:10.1186/s12986-018-0325-4 · Cited by 35
Risk Factors for Frailty and Cardiovascular Diseases: Are They the Same?
Piotrowicz, K., & Gąsowski, J. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-33330-0_5 · Cited by 36
Uchio, R., Kawasaki, K., Okuda-Hanafusa, C., Saji, R., Muroyama, K., Murosaki, S., Yamamoto, Y., & Hirose, Y. (2021) · Nutrition Journal · doi:10.1186/s12937-021-00748-8 · Cited by 42
Advances in Osteoimmunology: Pathophysiologic Concepts and Treatment Opportunities
Rauner, M., Sipos, W., Thiele, S., & Pietschmann, P. (2012) · International Archives of Allergy and Immunology · doi:10.1159/000342426 · Cited by 34
Adriaensen, W. J., Matheï, C., Pottelbergh, G. V., Vaes, B., Legrand, D., Wallemacq, P. E., & Degryse, J. (2013) · AGE · doi:10.1007/s11357-013-9558-3 · Cited by 33
Pathophysiology and emerging biomarkers of cardiovascular-renal-hepato-metabolic syndrome
Nzobokela, J., Muchaili, L., Mwambungu, A., Masenga, S. K., & Kirabo, A. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1661563 · Cited by 36
Extermann, M., Leeuwenburgh, C., Samiian, L., Sehovic, M., Xu, J., Cubitt, C. L., Jacobsen, P. B., Pahor, M., Grobmyer, S. R., & Manini, T. M. (2016) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2016.09.004 · Cited by 34
Self-citationUrsin, M. H., Bergland, A., Fure, B., Thommessen, B., Hagberg, G., Øksengård, A. R., & Ihle‐Hansen, H. (2018) · Physiotherapy · doi:10.1016/j.physio.2018.07.007 · Cited by 35
Inflammation-related genes are associated with epigenetic aging in HIV
the HNRP Group, Sundermann, E. E., Hussain, M., Moore, D. J., Horvath, S., Lin, D. T. S., Kobor, M. S., & Levine, A. J. (2019) · Journal of NeuroVirology · doi:10.1007/s13365-019-00777-4 · Cited by 32
Nouvenne, A., Ticinesi, A., Lauretani, F., Maggio, M. G., Lippi, G., Prati, B., Borghi, L., & Meschi, T. (2015) · The journal of nutrition health & aging · doi:10.1007/s12603-015-0626-5 · Cited by 31
Elevated Systolic Blood Pressure in Male GH Transgenic Mice Is Age Dependent
Jara, A., Benner, C. M., Sim, D., Liu, X., List, E. O., Householder, L. A., Berryman, D. E., & Kopchick, J. J. (2014) · Endocrinology · doi:10.1210/en.2013-1899 · Cited by 30
Proctor, A. S., Barth, A., & Holt‐Lunstad, J. (2023) · Lifestyle Medicine · doi:10.1002/lim2.91 · Cited by 35
Siegel, G., Ermilov, E. A., Knes, O., & Rodríguez, M. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.10.023 · Cited by 29
Imbrechts, M., Avau, A., Vandenhaute, J., Malengier‐Devlies, B., Put, K., Mitera, T., Berghmans, N., Burton, O. T., Junius, S., Liston, A., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800468 · Cited by 28
An old problem with new solutions: Strategies to improve vaccine efficacy in the elderly
Bell, M. R., & Kutzler, M. A. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114175 · Cited by 29
Inflammatory Markers Associated with Physical Frailty and Cognitive Impairment
Pan, Y., & Ma, L. (2024) · Aging and Disease · doi:10.14336/ad.2024.0258 · Cited by 29
Aging and immunotherapies: New horizons for the golden ages
Hamilton, J. A. G., & Henry, C. J. (2020) · Aging and Cancer · doi:10.1002/aac2.12014 · Cited by 28
Theabrownin modulates the gut microbiome and serum metabolome in aging mice induced by D-galactose
Lei, S., Zhang, Z., Xie, G., Zhao, C., Miao, Y., Chen, D., Zhang, G., Liu, H., Peng, C., Hou, Y., et al. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.104941 · Cited by 27
Circulating biomarkers of inflammaging as potential predictors of COVID-19 severe outcomes
Sabbatinelli, J., Matacchione, G., Giuliani, A., Ramini, D., Rippo, M. R., Procopio, A. D., Bonafè, M., & Olivieri, F. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111667 · Cited by 28
Sgro, M., Kodila, Z. N., Brady, R. D., Reichelt, A. C., Mychasiuk, R., & Yamakawa, G. R. (2021) · SLEEP · doi:10.1093/sleep/zsab268 · Cited by 25
Recent clinical trials with stem cells to slow or reverse normal aging processes
Garay, R. P. (2023) · Frontiers in Aging · doi:10.3389/fragi.2023.1148926 · Cited by 27
O’Doherty, M. G., Jørgensen, T., Borglykke, A., Brenner, H., Schöttker, B., Wilsgaard, T., Siganos, G., Kavousi, M., Hughes, M., Müezzinler, A., et al. (2014) · European Journal of Epidemiology · doi:10.1007/s10654-014-9954-8 · Cited by 25
Redox Regulation in Aging Lungs and Therapeutic Implications of Antioxidants in COPD
Kiyokawa, H., Hoshino, Y., Sakaguchi, K., Muro, S., & Yodoi, J. (2021) · Antioxidants · doi:10.3390/antiox10091429 · Cited by 25
From reactive to proactive: Continuous protein monitoring for preventive health care
Donnelly, J. M., Neff, R. A., Sedlack, A. J. H., Juska, V. B., Ayala‐Cardona, L. F., Bass, J. T., McNally, E. M., Shah, S. J., Alshurafa, N. I., Kimchi, E. Y., et al. (2025) · Science · doi:10.1126/science.ady6497 · Cited by 26
Beleigoli, A. M. R., Boersma, E. H., Diniz, M. D. F. H. S., Vidigal, P. G., Lima‐Costa, M. F., & Ribeiro, A. L. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075809 · Cited by 24
Metadata
- Authors
- Giovannini, S., Onder, G., Liperoti, R., Russo, A., Carter, C., Capoluongo, E., Pahor, M., Bernabei, R., & Landi, F.
- Affiliations
- Università Cattolica del Sacro Cuore (IT)
- ORCID
- Venue
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Published
- 2011-08-24
- Volume
- 59
- Issue
- 9
- Pages
- 1679-1685
- ISSN
- 0002-8614 (ISSN-L)
- 1532-5415
- PMC
- PMC4321727
- OpenAlex
- W1562509057
- Cited by
- 249
- References
- 31
- Citations by year
- 2026: 11 · 2025: 39 · 2024: 23 · 2023: 22 · 2022: 20 · 2021: 30 · 2020: 21 · 2019: 18 · 2018: 15 · 2017: 6 · 2016: 11 · 2015: 9 · 2014: 10 · 2013: 6 · 2012: 6
- FWCI
- 3.66
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of the American Geriatrics Society (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG017994, R01AG021042, P30AG028740)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Keywords
- interleukin-6, C-reactive protein, TNF-α, inflammatory markers, all-cause mortality, frail elderly, community-dwelling older adults
- MeSH terms
- Aged, 80 and over, C-Reactive Protein, Female, Humans, Inflammation, Male, Mortality, Predictive Value of Tests, Prognosis, Prospective Studies, Residence Characteristics, Tumor Necrosis Factor-alpha, Biomarkers, Interleukin-6, Frail Elderly
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
