Clinical Factors Associated with Quality of Life in Patients with Transient Loss of Consciousness
Abstract
Introduction: Transient loss of consciousness (TLOC) is common and can be lethal. Although the patients with the most prevalent causes of TLOC have a benign prognosis, morbidity is considerable. Aim of this article, therefore, was to compare the generic quality of life (QoL) of patients presenting with TLOC with that of the general population, to compare the disease‐specific QoL with that of an American referral sample, and to examine which sociodemographic and clinical factors are associated with QoL in these patients. Methods: This study was part of the fainting assessment study (FAST), which assessed diagnostic strategies for adult patients presenting with TLOC to the Academic Medical Center Amsterdam, between February 2000 and May 2002. The generic short form‐36 (SF‐36) health survey and the disease‐specific syncope functional status questionnaire (SFSQ) were used to assess QoL. Results: Of 468 included patients, 82% completed the questionnaires. Patients with TLOC scored poorer on all scales of the SF‐36 than the Dutch population, with effect sizes ranging from 0.43 to 1.11 (>0.5 = moderate effect; >0.8 = large effect). The SFSQ indicated mean impairment in 33% of the listed activities (such as driving). Female gender, higher level of comorbidity, shorter duration of complaints, having had more than one syncopal episode, and the presence of presyncopal episodes were associated with poorer QoL. Conclusion: TLOC seriously affects QoL, especially in patients with a recent onset of clinical symptoms and those suffering from both syncopal and presyncopal episodes.
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Those with more frequent syncope have reported poorer quality of life.
“Those with more frequent syncope have reported poorer QoL (726,729,730,732).”
From 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope (2017) · cites this paper as [732]
Quality of life is reduced with recurrent syncope.
“QoL is reduced with recurrent syncope (725–733), as demonstrated in studies that compared patients with and without syncope (727,731).”
From 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope (2017) · cites this paper as [732]
In a hospital-based cohort of patients with a prior episode of syncope, 33% reported syncope-related functional impairments with daily activities, such as driving or working.
“In a hospital-based cohort of patients with a prior episode of syncope, 33% reported syncope-related functional impairments with daily activities, such as driving or working (732).”
From 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope (2017) · cites this paper as [732]
Quality of life is reduced with recurrent syncope, as demonstrated in studies that compared patients with and without syncope.
“QoL is reduced with recurrent syncope (397–405), as demonstrated in studies that compared patients with and without syncope (399,405).”
From 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope: Executive Summary (2017) · cites this paper as [404]
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Symptom Score: A New Instrument to Assess Orthostatic Intolerance in Children and Adolescents
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El síncope: un problema con mayúsculas
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Cardiovascular Conditions in the Observation Unit
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Diagnosis and Management of Syncope
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Reflex vasovagal syncope – Is there a benefit in pacemaker therapy?
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- Authors
- VAN DIJK, N., SPRANGERS, M. A., COLMAN, N., BOER, K. R., WIELING, W., & LINZER, M.
- Affiliations
- Institut für Medizinische Psychologie (DE)
- Amsterdam UMC Location University of Amsterdam (NL)
- University of Wisconsin–Madison (US)
- Venue
- Journal of Cardiovascular Electrophysiology
- Publisher
- Wiley
- Published
- 2006-06-09
- Volume
- 17
- Issue
- 9
- Pages
- 998-1003
- ISSN
- 1045-3873 (ISSN-L)
- 1540-8167
- OpenAlex
- W2103876791
- Cited by
- 125
- References
- 25
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 9 · 2022: 6 · 2021: 6 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 10 · 2016: 6 · 2015: 3 · 2014: 13 · 2013: 7 · 2012: 6
- FWCI
- 8.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cardiovascular Electrophysiology (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Keywords
- transient loss of consciousness, syncope, quality of life, presyncope, syncopal episodes, SF-36, comorbidities, female sex, symptom duration, activities of daily living
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Health Status Indicators, Health Surveys, Humans, Male, Middle Aged, Quality of Life, Syncope, Unconsciousness
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