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What drives bacteria to produce a biofilm?

Kimberly K. Jefferson·2004·FEMS Microbiology Letters
DOI 10.1016/j.femsle.2004.06.005
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Abstract

Nearly 40 years ago, Dr. R.J. Gibbons made the first reports of the clinical relevance of what we now know as bacterial biofilms when he published his observations of the role of polysaccharide glycocalyx formation on teeth by Streptococcus mutans [Sci. Am. 238 (1978) 86]. As the clinical relevance of bacterial biofilm formation became increasingly apparent, interest in the phenomenon exploded. Studies are rapidly shedding light on the biomolecular pathways leading to this sessile mode of growth but many fundamental questions remain. The intent of this review is to consider the reasons why bacteria switch from a free-floating to a biofilm mode of growth. The currently available wealth of data pertaining to the molecular genetics of biofilm formation in commonly studied, clinically relevant, single-species biofilms will be discussed in an effort to decipher the motivation behind the transition from planktonic to sessile growth in the human body. Four potential incentives behind the formation of biofilms by bacteria during infection are considered: (1) protection from harmful conditions in the host (defense), (2) sequestration to a nutrient-rich area (colonization), (3) utilization of cooperative benefits (community), (4) biofilms normally grow as biofilms and planktonic cultures are an in vitro artifact (biofilms as the default mode of growth).

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Metadata

Authors
Jefferson, K. K.
Venue
FEMS Microbiology Letters
Publisher
Oxford University Press (OUP)
Published
2004-07
Volume
236
Issue
2
Pages
163-173
ISSN
  • 0378-1097 (ISSN-L)
  • 1574-6968
DOI
10.1016/j.femsle.2004.06.005
OpenAlex
W4230690150
Cited by
1,059
References
3
FWCI
7.98
Type
journal article
Language
en
Open access
closed

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Jefferson, K. K. (2004). What drives bacteria to produce a biofilm? FEMS Microbiology Letters. https://doi.org/10.1016/j.femsle.2004.06.005

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