Influence of red wine polyphenols and ethanol on the gut microbiota ecology and biochemical biomarkers
Open accessAbstract
Background Few studies have investigated the effect of dietary polyphenols on the complex human gut microbiota, and they focused mainly on single polyphenol molecules and select bacterial populations.Objective The objective was to evaluate the effect of a moderate intake of red wine polyphenols on select gut microbial groups implicated in host health benefits.Design Ten healthy male volunteers underwent a randomized, crossover, controlled intervention study. After a washout period, all of the subjects received red wine, the equivalent amount of de-alcoholized red wine, or gin for 20 d each. Total fecal DNA was submitted to polymerase chain reaction(PCR)-denaturing gradient gel electrophoresis and real-time quantitative PCR to monitor and quantify changes in fecal microbiota. Several biochemical markers were measured.Results The dominant bacterial composition did not remain constant over the different intake periods. Compared with baseline, the daily consumption of red wine polyphenol for 4 wk significantly increased the number of Enterococcus, Prevotella, Bacteroides, Bifidobacterium, Bacteroides uniformis, Eggerthella lenta, and Blautia coccoides-Eubacterium rectale groups (P < 0.05). In parallel, systolic and diastolic blood pressures and triglyceride, total cholesterol, HDL cholesterol, and C-reactive protein concentrations decreased significantly (P < 0.05). Moreover, changes in cholesterol and C-reactive protein concentrations were linked to changes in the bifidobacteria number.Conclusion This study showed that red wine consumption can significantly modulate the growth of select gut microbiota in humans, which suggests possible prebiotic benefits associated with the inclusion of red wine polyphenols in the diet. This trial was registered at controlled-trials.com as ISRCTN88720134.
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Changes in gut microbiota composition may occur after dietary interventions.
“Recent research indicates that changes in gut microbiota composition may occur after dietary interventions [13–15].”
From Intestinal Microbiota Is Influenced by Gender and Body Mass Index (2016) · cites this paper as [14]
Resveratrol consumption can significantly modulate the growth of certain gut microbiota in vivo, including increasing the Bacteroidetes-to-Firmicutes ratio and the growth of Bacteroides, Lactobacillus, and Bifidobacterium.
“Moreover, it has been found that RSV consumption can significantly modulate the growth of certain gut microbiota in vivo, including increasing the Bacteroidetes-to-Firmicutes ratios, and the growth of Bacteroides, Lactobacillus, and Bifidobacterium (18–22).”
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Self-citationDoes consumption of fermented foods modify the human gut microbiota?
Stiemsma, L. T., Nakamura, R. E., Nguyen, J. G., & Michels, K. B. (2020) · The Journal of Nutrition · doi:10.1093/jn/nxaa077 · Cited by 144 · see citing works
The interaction between gut microbiota and age-related changes in immune function and inflammation
Magrone, T., & Jirillo, E. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-31 · Cited by 124 · see citing works
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Assessing the in vivo data on low/no-calorie sweeteners and the gut microbiota
Lobach, A. R., Roberts, A., & Rowland, I. R. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.12.005 · Cited by 104 · see citing works
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Dietary Regulation of Gut-Brain Axis in Alzheimer’s Disease: Importance of Microbiota Metabolites
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Gut Microbiota: A Pivotal Hub for Polyphenols as Antidepressants
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- Authors
- Queipo-Ortuño, M. I., Boto-Ordóñez, M., Murri, M., Gomez-Zumaquero, J. M., Clemente-Postigo, M., Estruch, R., Cardona Diaz, F., Andrés-Lacueva, C., & Tinahones, F. J.
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 95
- Issue
- 6
- Pages
- 1323-1334
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2109759565
- Cited by
- 671
- References
- 56
- Citations by year
- 2026: 23 · 2025: 43 · 2024: 43 · 2023: 47 · 2022: 56 · 2021: 73 · 2020: 62 · 2019: 66 · 2018: 54 · 2017: 39 · 2016: 42 · 2015: 48 · 2014: 40 · 2013: 29 · 2012: 5
- FWCI
- 15.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Repositorio Institucional de la Universidad de Málaga (University of Málaga) (acceptedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Life Sciences › Agricultural and Biological Sciences › Food Science › Fermentation and Sensory Analysis
- Keywords
- red wine polyphenols, gut microbiota, ethanol, Bifidobacterium, Bacteroides, Enterococcus, Prevotella, blood pressure, triglycerides, cholesterol, C-reactive protein, prebiotic activity, dietary polyphenols
- MeSH terms
- Ethanol, Bacteria, Bifidobacterium, Blood Pressure, C-Reactive Protein, Energy Intake, Diet, Ecology, Feces, Humans, Lipids, Male, Middle Aged, Wine, Biomarkers, Cross-Over Studies, Vitis, Gastrointestinal Tract, Metagenome, Polyphenols
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