The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.
Rate of progression of mild cognitive impairment to dementia – meta‐analysis of 41 robust inception cohort studies
Open accessAbstract
Objective: To quantify the risk of developing dementia in those with mild cognitive impairment (MCI). Method: Meta‐analysis of inception cohort studies. Results: Forty‐one robust cohort studies were identified. To avoid heterogeneity clinical studies, population studies and clinical trials were analysed separately. Using Mayo defined MCI at baseline and adjusting for sample size, the cumulative proportion who progressed to dementia, to Alzheimer’s disease (AD) and to vascular dementia (VaD) was 39.2%, 33.6% and 6.2%, respectively in specialist settings and 21.9%, 28.9% and 5.2%, respectively in population studies. The adjusted annual conversion rate (ACR) from Mayo defined MCI to dementia, AD and VaD was 9.6%, 8.1% and 1.9%, respectively in specialist clinical settings and 4.9%, 6.8% and 1.6% in community studies. Figures from non‐Mayo defined MCI and clinical trials are also reported. Conclusion: The ACR is approximately 5–10% and most people with MCI will not progress to dementia even after 10 years of follow‐up.
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“Individuals diagnosed with MCI are a heterogeneous group, with only about 30 % of them developing Alzheimer’s dementia within 3 years after clinical MCI diagnosis [8].”
From Psychotherapeutic interventions in individuals at risk for Alzheimer’s dementia: a systematic review (2022) · cites this paper as [8]
Citations
Cites
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Research works printed but not linked: 1
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Dementia prevention, intervention, and care
Livingston, G., Sommerlad, A., Orgeta, V., Costafreda, S. G., Huntley, J., Ames, D., Ballard, C., Banerjee, S., Burns, A., Cohen-Mansfield, J., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31363-6 · Cited by 6,072
2016 Alzheimer's disease facts and figures
Alzheimer's Association (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.03.001 · Cited by 5,069
“MCI is a condition in which an individual has mild but measurable changes in thinking abilities that are noticeable to the person affected and to family members and friends, but do not affect the individual’s ability to carry out everyday activities.”
Influential2019 Alzheimer’s disease facts and figures.
Alzheimer's Association (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2019.01.010 · Cited by 2,461
“Many (but not all) people with subjective cognitive decline go on to develop MCI and dementia (see Prevalence section).”
Influential2020 Alzheimer's disease facts and figures
(2020) · Alzheimer's & Dementia · doi:10.1002/alz.12068 · Cited by 2,353
2018 Alzheimer's disease facts and figures
Alzheimer's Association (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.02.001 · Cited by 1,912
“A meta-analysis of 41 studies found that among individuals with MCI who were tracked for 5 years or longer, an average of 38 percent developed dementia [18].”
Metadata
- Authors
- Mitchell, A. J., & Shiri‐Feshki, M.
- Affiliations
- University of Leicester (GB)
- Nottinghamshire Healthcare NHS Foundation Trust (GB)
- Corresponding author
- Mitchell, A. J.
- ORCID
- Mitchell, A. J.
- Venue
- Acta Psychiatrica Scandinavica
- Publisher
- Wiley
- Published
- 2009-03-03
- Volume
- 119
- Issue
- 4
- Pages
- 252-265
- ISSN
- 0001-690X (ISSN-L)
- 1600-0447
- OpenAlex
- W2052226124
- Cited by
- 1,659
- References
- 87
- Citations by year
- 2026: 84 · 2025: 98 · 2024: 135 · 2023: 118 · 2022: 129 · 2021: 176 · 2020: 165 · 2019: 115 · 2018: 96 · 2017: 86 · 2016: 88 · 2015: 85 · 2014: 62 · 2013: 75 · 2012: 55
- FWCI
- 5.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Acta Psychiatrica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- mild cognitive impairment, dementia progression, Alzheimer's disease, vascular dementia, Mayo criteria
- MeSH terms
- Aged, Alzheimer Disease, Cognition Disorders, Dementia, Follow-Up Studies, Humans, Middle Aged, Neuropsychological Tests, Severity of Illness Index, Dementia, Vascular, Cohort Studies, Prevalence, Disease Progression
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