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The natural course of social anxiety disorder among adolescents and young adults
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Beesdo‐Baum K, Knappe S, Fehm L, Höfler M, Lieb R, Hofmann SG, Wittchen H‐U. The natural course of social anxiety disorder among adolescents and young adults. Objective: To examine the natural course of social anxiety disorder (SAD) in the community and to explore predictors for adverse long‐term outcomes. Method: A community sample of N = 3021 subjects aged 14–24 was followed‐up over 10 years using the DSM‐IV/M‐CIDI. Persistence of SAD is based on a composite score reflecting the proportion of years affected since onset. Diagnostic stability is the proportion of SAD subjects still affected at follow‐up. Results: SAD reveals considerable persistence with more than half of the years observed since onset spent with symptoms. 56.7% of SAD cases revealed stability with at least symptomatic expressions at follow‐up; 15.5% met SAD threshold criteria again. 15.1% were completely remitted (no SAD symptoms and no other mental disorders during follow‐up). Several clinical features (early onset, generalized subtype, more anxiety cognitions, severe avoidance and impairment, co‐occurring panic) and vulnerability characteristics (parental SAD and depression, behavioural inhibition, harm avoidance) predicted higher SAD persistence and – less impressively – diagnostic stability. Conclusion: A persistent course with a considerable degree of fluctuations in symptom severity is characteristic for SAD. Both consistently meeting full threshold diagnostic criteria and complete remissions are rare. Vulnerability and clinical severity indicators predict poor prognosis and might be helpful markers for intervention needs.
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“and tend to have a chronic and unremitting course (Beesdo-Baum et al., 2012; Steinert et al., 2013)”
From Psychological inflexibility explains social anxiety over time: a mediation analyses with a clinical adolescent sample (2024) · cites this paper as Beesdo-Baum et al., 2012
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Cites
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.593 · Cited by 20,391
Wittchen, H.-U. (1994) · Journal of Psychiatric Research · doi:10.1016/0022-3956(94)90036-1 · Cited by 2,348
Pine, D. S., Cohen, P., Gurley, D., Brook, J., & Ma, Y. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.1.56 · Cited by 1,753
Agoraphobia, simple phobia, and social phobia in the National Comorbidity Survey
Magee, W. J. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830020077009 · Cited by 996
Social fears and social phobia in the USA: results from the National Comorbidity survey replication
Ruscio, A. M., Brown, T. A., Chiu, W. T., Sareen, J., Stein, M. B., & Kessler, R. C. (2008) · Psychological Medicine · doi:10.1017/s0033291707001699 · Cited by 835
WITTCHEN, H.-U., STEIN, M. B., & KESSLER, R. C. (1999) · Psychological Medicine · doi:10.1017/s0033291798008174 · Cited by 745
What do childhood anxiety disorders predict?
Bittner, A., Egger, H. L., Erkanli, A., Jane Costello, E., Foley, D. L., & Angold, A. (2007) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2007.01812.x · Cited by 733
Beesdo, K., Bittner, A., Pine, D. S., Stein, M. B., Höfler, M., Lieb, R., & Wittchen, H.-U. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.8.903 · Cited by 731
Self-citationThe etiology of social phobia: empirical evidence and an initial model
Rapee, R. M., & Spence, S. H. (2004) · Clinical Psychology Review · doi:10.1016/j.cpr.2004.06.004 · Cited by 693
Wittchen, H.-U., Lachner, G., Wunderlich, U., & Pfister, H. (1998) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s001270050095 · Cited by 668
Model Robust Confidence Intervals Using Maximum Likelihood Estimators
Royall, R. M. (1986) · International Statistical Review · doi:10.2307/1403146 · Cited by 579
Stein, M. B., Fuetsch, M., Müller, N., Höfler, M., Lieb, R., & Wittchen, H.-U. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.3.251 · Cited by 573
Self-citationSocial anxiety disorder: questions and answers for the DSM-V
Bögels, S. M., Alden, L., Beidel, D. C., Clark, L. A., Pine, D. S., Stein, M. B., & Voncken, M. (2010) · Depression and Anxiety · doi:10.1002/da.20670 · Cited by 526
Lieb, R., Wittchen, H.-U., Höfler, M., Fuetsch, M., Stein, M. B., & Merikangas, K. R. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.9.859 · Cited by 501
Self-citationBeesdo, K., Pine, D. S., Lieb, R., & Wittchen, H.-U. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.177 · Cited by 494
Self-citationStable behavioral inhibition and its association with anxiety disorder
HIRSHFELD, D. R., ROSENBAUM, J. F., BIEDERMAN, J., BOLDUC, E. A., FARAONE, S. V., SNIDMAN, N., REZNICK, J. S., & KAGAN, J. (1992) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199201000-00016 · Cited by 491
Ernst, C., & Angst, J. (1992) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02190257 · Cited by 450
Size and burden of social phobia in Europe
Fehm, L., Pélissolo, A., Furmark, T., & Wïttchen, H. (2005) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2005.04.002 · Cited by 413
Self-citationYonkers, K., Bruce, S., Dyck, I. R., & Keller, M. B. (2003) · Depression and Anxiety · doi:10.1002/da.10106 · Cited by 400
Epidemiology and natural course of social fears and social phobia
Wïttchen, H., & Fehm, L. (2003) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.108.s417.1.x · Cited by 394
Self-citationEssau, C. A., Conradt, J., & Petermann, F. (1999) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(98)00179-x · Cited by 392
A Prospective Study of Childhood Anxiety Disorders
Last, C. G., Perrin, S. G., Hersen, M., & Kazdin, A. E. (1996) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199611000-00019 · Cited by 390
Fehm, L., Beesdo, K., Jacobi, F., & Fiedler, A. (2008) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-007-0299-4 · Cited by 338
Self-citationThe impairments caused by social phobia in the general population: implications for intervention
Kessler, R. C. (2003) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.108.s417.2.x · Cited by 322
Reed, V., Gander, F., Pfister, H., Steiger, A., Sonntag, H., Trenkwalder, C., Sonntag, A., Hundt, W., & Wittchen, H. (1998) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.44 · Cited by 278
What Characteristics of Primary Anxiety Disorders Predict Subsequent Major Depressive Disorder?
Bittner, A., Goodwin, R. D., Wittchen, H.-U., Beesdo, K., Höfler, M., & Lieb, R. (2004) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v65n0505 · Cited by 272
Self-citationBELZER, K., & SCHNEIER, F. R. (2004) · Journal of Psychiatric Practice · doi:10.1097/00131746-200409000-00003 · Cited by 235 · cited 1×
“SAD typically has its onset in adolescence (2-9) and is associated with high comorbidity (1, 3-5, 9-12), substantial impairment and disability in psychosocial functioning (4, 11-15).”
Early Developmental Stages of Psychopathology Study (EDSP): Objectives and Design
Wïttchen, H., Perkonigg, A., Lachner, G., & Nelson, C. B. (1998) · European Addiction Research · doi:10.1159/000018921 · Cited by 232
Davidson, J. R. T. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950120047008 · Cited by 222
The Early Developmental Stages of Psychopathology Study (EDSP): A Methodological Update
Lieb, R., Isensee, B., von Sydow, K., & Wïttchen, H. (2000) · European Addiction Research · doi:10.1159/000052043 · Cited by 208
Self-citationThe nature and expression of social phobia: Toward a new classification
Hofmann, S. G., Heinrichs, N., & Moscovitch, D. A. (2004) · Clinical Psychology Review · doi:10.1016/j.cpr.2004.07.004 · Cited by 202
Self-citationThe spectrum of social phobia in the zurich cohort study of young adults
Merikangas, K. R., Avenevoli, S., Acharyya, S., Zhang, H., & Angst, J. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01309-9 · Cited by 189
Early anxious/withdrawn behaviours predict later internalising disorders
Goodwin, R. D., Fergusson, D. M., & Horwood, L. J. (2004) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2004.00279.x · Cited by 189
Course and outcome of anxiety disorders in adolescents
Essau, C. A., Conradt, J., & Petermann, F. (2002) · Journal of Anxiety Disorders · doi:10.1016/s0887-6185(01)00091-3 · Cited by 177
The lifelong course of social anxiety disorder: a clinical perspective
Keller, M. B. (2003) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.108.s417.6.x · Cited by 165
Reznick, J. S., Hegeman, I. M., Kaufman, E. R., Woods, S. W., & Jacobs, M. (1992) · Development and Psychopathology · doi:10.1017/s095457940000016x · Cited by 163
Panic Attack as a Risk Factor for Severe Psychopathology
Goodwin, R. D., Lieb, R., Hoefler, M., Pfister, H., Bittner, A., Beesdo‐Baum, K., & Wïttchen, H. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.12.2207 · Cited by 151
Self-citationMassion, A. O., Dyck, I. R., Shea, M. T., Phillips, K. A., Warshaw, M. G., & Keller, M. B. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.5.434 · Cited by 149 · cited 1×
“With regard to clinical characteristics as predictors of course, many studies merely refer to anxiety disorders in general, with early age of onset (42), degree of impairment (43), or comorbidities (17-19) being associated with an unfavourable outcome.”
Acartürk, C., de Graaf, R., van Straten, A., ten Have, M., & Cuijpers, P. J. (2008) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-008-0309-1 · Cited by 143
Wïttchen, H., Lieb, R., Pfister, H., & Schuster, P. (2000) · Comprehensive Psychiatry · doi:10.1016/s0010-440x(00)80018-8 · Cited by 136
Self-citationvan Beljouw, I. M., Verhaak, P. F., Cuijpers, P., van Marwijk, H. W., & Penninx, B. W. (2010) · BMC Psychiatry · doi:10.1186/1471-244x-10-86 · Cited by 128
Economic costs of social phobia: A population-based study
Acartürk, C., Smit, F., de Graaf, R., van Straten, A., ten Have, M., & Cuijpers, P. J. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.10.008 · Cited by 125
Knappe, S., Lieb, R., Beesdo‐Baum, K., Fehm, L., Low, N. C. P., Gloster, A. T., & Wïttchen, H. (2008) · Depression and Anxiety · doi:10.1002/da.20527 · Cited by 117
Self-citationKnappe, S., Beesdo-Baum, K., Fehm, L., Stein, M. B., Lieb, R., & Wittchen, H.-U. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.05.002 · Cited by 113
Kessler, R. C. (1999) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1999.tb05378.x · Cited by 106
Childhood Onset of “Adult” Psychopathology: Clinical and Research Advances
Kazdin, A. E. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.1.152 · Cited by 89
Knappe, S., Beesdo‐Baum, K., Fehm, L., Lieb, R., & Wïttchen, H. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-008-0118-4 · Cited by 88
Self-citationSocial anxiety disorder: what are we losing with the current diagnostic criteria?
Filho, A. S., Hetem, L. A. B., Ferrari, M. C. F., Trzesniak, C., Martín‐Santos, R., Borduqui, T., De Lima Osório, F., Loureiro, S. R., Busatto Filho, G., Zuardi, A. W., et al. (2010) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2009.01459.x · Cited by 87
A prospective follow-along study of the course of social phobia
Reich, J. H., Goldenberg, I. M., Vasile, R. G., Goisman, R. M., & Keller, M. B. (1994) · Psychiatry Research · doi:10.1016/0165-1781(94)90019-1 · Cited by 84
Degonda, M., & Angst, J. (1993) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02191571 · Cited by 82
When is onset? Investigations into early developmental stages of anxiety and depressive disorders.
Wïttchen, H., Lieb, R., Schuster, P., & Oldehinkel, T. (1999) · Max Planck Institute for Plasma Physics · Cited by 81
Self-citationDell’Osso, L., Rucci, P., Ducci, F., Ciapparelli, A., Vivarelli, L., Carlini, M., Ramacciotti, C., & Cassano, G. B. (2003) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-003-0442-5 · Cited by 77
Incidence of social phobia and identification of its risk indicators: a model for prevention
Acartürk, C., Smit, F., de Graaf, R., van Straten, A., ten Have, M., & Cuijpers, P. J. (2008) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2008.01275.x · Cited by 76
Family and high‐risk studies of social anxiety disorder
Merikangas, K. R., Lieb, R., Wïttchen, H., & Avenevoli, S. (2003) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.108.s417.5.x · Cited by 71
Self-citationKnappe, S., Beesdo‐Baum, K., Fehm, L., Höfler, M., Lieb, R., & Wïttchen, H. (2009) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2009.06.010 · Cited by 65
Self-citationThe prognosis and incidence of social phobia in an elderly population. A 5‐year follow‐up
Karlsson, B., Sigström, R., Wærn, M., Östling, S., Gustafson, D., & Skoog, I. G. (2010) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2010.01559.x · Cited by 62
Vriends, N., Becker, E. S., Meyer, A., Williams, S. L., Lutz, R., & Margraf, J. (2007) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2006.06.005 · Cited by 58
Krebs, H., Weyers, P., & Janke, W. (1998) · Personality and Individual Differences · doi:10.1016/s0191-8869(98)00008-7 · Cited by 55
Lépine, J., Wïttchen, H., & Essau, C. A. (1993) · Max Planck Institute for Plasma Physics · Cited by 44
Windle, M. T., & Windle, R. C. (2006) · Personality and Individual Differences · doi:10.1016/j.paid.2006.01.005 · Cited by 44
Beard, C., Moitra, E., Weisberg, R. B., & Keller, M. B. (2010) · Depression and Anxiety · doi:10.1002/da.20676 · Cited by 33
Becker, E. S., Türke, V., Neumer, S., Soeder, U., Krause, P. R., & Margraf, J. (2000) · Radboud Repository (Radboud University) · Cited by 29
Rohrbacher, H., Hoyer, J., Beesdo‐Baum, K., Höfler, M., Bittner, A., Lieb, R., & Wïttchen, H. (2008) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.233 · Cited by 28
Self-citationRunge, A. J., Beesdo‐Baum, K., Lieb, R., & Wittchen, H.-U. (2008) · Verhaltenstherapie · doi:10.1159/000113890 · Cited by 26
Self-citationCox, B. J., Turnbull, D. L., Robinson, J. A., Grant, B. F., & Stein, M. B. (2011) · Depression and Anxiety · doi:10.1002/da.20787 · Cited by 22
Early-onset social anxiety disorder in adults: clinical and therapeutic features
de Menezes, G. B., Fontenelle, L. F., & Versiani, M. (2005) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462005000100009 · Cited by 21
Possible inhibition of early PTSD symptoms by alcohol intoxication
Mellman, T. A., Ramos, J., David, D., Williams, L. D., & Augenstein, J. S. (1998) · Depression and Anxiety · doi:10.1002/(sici)1520-6394(1998)7:3 · Cited by 14
Bullenkamp, J., Salize, H., Hansson, L., McCabe, R., Priebe, S., Wulf Rössler, A., Torres‐González, F., & Wiersma, D. (2004) · Acta Psychiatrica Scandinavica · doi:10.1111/j.0001-690x.2004.0352a.x · Cited by 1
Research works printed but not linked: 5
- Bobes J, 1999, Social anxiety disorder/social phobia – the course of illness prior treatment, Int J Psychiatr Clin Pract, 3, 21
- Becker ES, 2000, Public Health Research and Practice: Report of the Public Health Reserach Association Saxony, 259
- Bittner A, 2004, Behavioral inhibition in childhood and the development of anxiety disorders and depression in adolescence and young adulthood, Acta Psychiatr Scand Suppl, 110, 9
- Wittchen HU, 1997, DIA‐X‐Interviews: Manual für Screening Verfahren und Interview; Interviewheft Längsschnittuntersuchung (DIA‐X‐Lifetime); Ergänzungsheft (DIA‐X‐Lifetime); Interviewheft Querschnittsuntersuchung (DIA‐X‐12 Monate); Ergänzungsheft (DIA‐X‐12 Monate); PC‐Programm zur Durchführung des Interviews (Längs‐ und Querschnittsuntersuchung); Auswertungsprogramm
- STATACORP, 2007, Stata Statistical Software: Release 10
Cited by
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“In fact, SAD is one of the more chronic and persistent of the mental disorders across the lifespan although it is more likely to have a waxing and waning course than a stable one (Beesdo-Baum et al., 2012; Bruce et al., 2005).”
BackgroundInfluentialDevelopmental epidemiology of anxiety disorders
Beesdo-Baum, K., & Knappe, S. (2012) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2012.05.001 · Cited by 330
Self-citationLeigh, E., & Clark, D. M. (2018) · Clinical Child and Family Psychology Review · doi:10.1007/s10567-018-0258-5 · Cited by 260
“A 10-year prospective community study with over 3000 German adolescents and young adults (aged 14–24 years) (Beesdo-Baum et al. 2012) found that 57% of those with social anxiety disorder at the start of the study were still reporting at least symptomatic social anxiety at follow-up and higher persistence of social anx…”
BackgroundExtrahypothalamic oxytocin neurons drive stress-induced social vigilance and avoidance
Duque-Wilckens, N., Torres, L. Y., Yokoyama, S., Minie, V. A., Tran, A. M., Petkova, S. P., Hao, R., Ramos-Maciel, S., Rios, R. A., Jackson, K., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2011890117 · Cited by 139
Asselmann, E., Wittchen, H. ‐., Lieb, R., & Beesdo‐Baum, K. (2018) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12792 · Cited by 112
Self-citation
Metadata
- Authors
- Beesdo‐Baum, K., Knappe, S., Fehm, L., Höfler, M., Lieb, R., Hofmann, S. G., & Wittchen, H. ‐.
- Affiliations
- Technische Universität Dresden (DE)
- Humboldt-Universität zu Berlin (DE)
- University of Basel (CH)
- Boston University (US)
- Corresponding author
- Beesdo‐Baum, K.
- Venue
- Acta Psychiatrica Scandinavica
- Publisher
- Wiley
- Published
- 2012-05-26
- Volume
- 126
- Issue
- 6
- Pages
- 411-425
- ISSN
- 0001-690X (ISSN-L)
- 1600-0447
- OpenAlex
- W1602079716
- Cited by
- 167
- References
- 69
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 14 · 2023: 20 · 2022: 14 · 2021: 15 · 2020: 16 · 2019: 15 · 2018: 11 · 2017: 11 · 2016: 13 · 2015: 6 · 2014: 9 · 2013: 5 · 2012: 1
- FWCI
- 9.00
- Type
- journal article
- Language
- en
- Open access
- green
- tud.qucosa.de
- Licence
- Locations
- Acta Psychiatrica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Qucosa (Saxon State and University Library Dresden) (submittedVersion, other-oa)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Keywords
- social anxiety disorder, natural course, adolescents, young adults, symptom persistence, diagnostic stability, remission, early onset, generalized social anxiety, avoidance, impairment, parental depression, behavioral inhibition, harm avoidance, vulnerability factors, prognosis
- MeSH terms
- Adolescent, Adult, Female, Humans, Male, Phobic Disorders, Registries, Severity of Illness Index, Diagnostic and Statistical Manual of Mental Disorders, Young Adult
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