Cited by 199Oral microbiology and periodontitis researchAntioxidant Activity and Oxidative StressDental Health and Care Utilization

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Micronutritional approaches to periodontal therapy

Van der Velden, U., Kuzmanova, D., Chapple, I. L. C.·2011·Journal of Clinical Periodontology

DOI 10.1111/j.1600-051x.2010.01663.x

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Abstract

Van der Velden U, Kuzmanova D, Chapple ILC. Micronutritional approaches to periodontal therapy. J Clin Periodontol 2011; 38 (Suppl. 11): 142–158. doi: 10.1111/j.1600‐051X.2010.01663.x. Aim: Periodontitis results from the loss of a delicate balance between microbial virulence factors and a proportionate host response. Nutritional factors have been implicated in several chronic inflammatory diseases that are associated with periodontitis. This manuscript reviews the evidence for nutritional exposures in the etiology and therapeutic management of periodontitis, and makes recommendations for daily nutritional intake for vitamin C (ascorbic acid), vitamin D, calcium, and antioxidants. Results and conclusion: Periodontitis is associated with low serum/plasma micronutrient levels, which may result from dietary and/or life‐style factors as well as nutrigenetic characteristics. Early evidence suggests beneficial outcomes from nutritional interventions; supporting the contention that daily intake of certain nutrients should be at the higher end of recommended daily allowances. For prevention and treatment of periodontitis daily nutrition should include sufficient antioxidants, vitamin D, and calcium. Inadequate antioxidant levels may be managed by higher intake of vegetables, berries, and fruits (e.g. kiwi fruit), or by phytonutrient supplementation. Current evidence is insufficient to support recommendations of mono‐antioxidant vitamin supplements and randomised controlled double‐blind intervention studies are needed to provide evidence to underpin future recommendations. Inadequate supply of vitamin D and calcium may be addressed by implementing changes in diet/life style or by supplements.

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Authors: Van der Velden, U., Kuzmanova, D., & Chapple, I. L. C.
Affiliations: Academic Center for Dentistry Amsterdam (NL)
University of Birmingham (GB)
ORCID: Chapple, I. L. C.
Venue: Journal of Clinical Periodontology
Publisher: Wiley
Published: 2011-02-16
Volume: 38
Issue: s11
Pages: 142-158
ISSN: 0303-6979 (ISSN-L)
1600-051X
DOI: 10.1111/j.1600-051x.2010.01663.x
OpenAlex: W2159104664
Cited by: 199
References: 179
Citations by year: 2026: 6 · 2025: 16 · 2024: 7 · 2023: 13 · 2022: 18 · 2021: 21 · 2020: 14 · 2019: 14 · 2018: 13 · 2017: 13 · 2016: 18 · 2015: 7 · 2014: 15 · 2013: 11 · 2012: 5
FWCI: 1.99
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal Of Clinical Periodontology (publishedVersion)
PubMed (publishedVersion)
UvA-DARE (University of Amsterdam) (publishedVersion)
VU Research Portal (publishedVersion)
UvA-DARE (University of Amsterdam) (submittedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Dentistry › General Dentistry › Dental Health and Care Utilization
Keywords: periodontitis, micronutrient nutrition, vitamin C, vitamin D, calcium, antioxidants, phytochemicals, dietary supplementation, nutrigenetics, chronic inflammation, dietary recommendations
MeSH terms: Antioxidants, Ascorbic Acid, Calcium, Dietary, Diet, Fatty Acids, Unsaturated, Humans, Periodontitis, Vitamin D, Vitamins, Micronutrients, Dietary Supplements, Nutrigenomics

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