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Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review

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Madecassoside inhibits estrogen deficiency‐induced osteoporosis by suppressing RANKL ‐induced osteoclastogenesis

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Vitamin C attenuates ERK signalling to inhibit the regulation of collagen production by LL‐37 in human dermal fibroblasts

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An update on cutaneous aging treatment using herbs

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Zeaxanthin-based dietary supplement and topical serum improve hydration and reduce wrinkle count in female subjects

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Carnosol suppresses RANKL‐induced osteoclastogenesis and attenuates titanium particles‐induced osteolysis

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Biomass and centellosides production in two elite Centella asiatica germplasms from India in response to seasonal variation

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Injectable Hydrogel With Glycyrrhizic Acid and Asiaticoside‐Loaded Liposomes for Wound Healing

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Mécano-Stimulation™ of the skin improves sagging score and induces beneficial functional modification of the fibroblasts: clinical, biological, and histological evaluations

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Validation of Medicinal Herbs for Skin Aging

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A review of antioxidant and anti-acetylcholinesterase activities of Centella asiatica (L.) Urb. for the treatment of Alzheimer’s disease

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Electrospun Gelatin Fiber Mats Mixed With C.carandas Extract and its Enhanced Stability and Bioactivity

Rongthong, W., Niamnont, N., Srisuwannaket, C., Paradee, N., & Mingvanish, W. (2020) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2020.12.031 · Cited by 11 · see citing works

Antioxidants with proven efficacy and elastin‐conserving vitamin C—A new approach to free radical defense

Widgerow, A. D., Ziegler, M. E., Garruto, J. A., & Shafiq, F. (2023) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.15999 · Cited by 12 · see citing works

Effectiveness Test of Centella Asiatica Extract on Improvement of Collagen and Hydration in Female White Rat (Rattus Norwegicus Wistar)

Venesia, N. F., Fachrial, E., & Lister, I. N. E. (2020) · American Scientific Research Journal for Engineering, Technology, and Sciences · Cited by 10 · see citing works

Antifaltencremes

Kerscher, M. J., & Buntrock, H. (2011) · Der Hautarzt · doi:10.1007/s00105-011-2137-6 · Cited by 9 · see citing works

Anti-aging activity of tetrahydrocurcumin, Centella asiatica extract, and its mixture

Astuti, I. Y., Yupitawati, A., & Nurulita, N. A. (2021) · Oriental Pharmacy and Experimental Medicine · doi:10.1007/s13596-020-00532-9 · Cited by 9 · see citing works

Simultaneous determination of four active compounds in Centella asiatica by supramolecular solvent-based extraction coupled with high performance liquid chromatography-tandem mass spectrometry

Yuan, Y., Qiao, Y., Zheng, X. X., Yu, X., Dong, Y., Wang, H., & Sun, L. (2023) · Journal of Chromatography A · doi:10.1016/j.chroma.2023.464298 · Cited by 8 · see citing works

Natural Plant-Based Rejuvenating Compositions: Human Study on Astragalus membranaceus and Centella asiatica Saponins for Skin Health

Chan, L., & Liang, C.-H. (2025) · Cosmetics · doi:10.3390/cosmetics12040131 · Cited by 7 · see citing works

Aktivitas pegagan (Centella asiatica) pada dermatologi

Fernenda, L., Ramadani, A. P., & Syukri, Y. (2023) · Jurnal Sains Farmasi & Klinis · doi:10.25077/jsfk.9.3.237-244.2022 · Cited by 7 · see citing works

Prebiotic and panthenol-containing dermocosmetic improves tolerance from artificial daylight photodynamic therapy: A randomized controlled trial in patients with actinic keratosis

Fredman, G. L., Jacobsen, K., Philipsen, P. A., Wiegell, S. R., & Hædersdal, M. (2024) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2024.104394 · Cited by 6 · see citing works

Natural Polymers as Potential Antiaging Constituents

Srivastava, P., & Kalam, S. A. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.80808 · Cited by 5 · see citing works

Synergistic Effect of Madecassoside and Rosmarinic Acid Against Ultraviolet B-Induced Photoaging in Human Skin Fibroblasts

Kim, M., Heo, H., Hong, S., Lee, J., & Lee, H. (2023) · Journal of Medicinal Food · doi:10.1089/jmf.2023.k.0201 · Cited by 5 · see citing works

Asian Medicinal Remedies for Alleviating Aging Effects

Arora, R., Sharma, J., Selvamurthy, W., Shivashankara, A. R., Mathew, N., & Baliga, M. S. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-397155-5.00037-4 · Cited by 4 · see citing works

The Skin Extracellular Matrix as a Target of Environmental Exposure: Molecular Mechanisms, Prevention and Repair

Mellody, K. T., Bell, M., & Sherratt, M. J. (2016) · Springer eBooks · doi:10.1007/978-3-319-43157-4_5 · Cited by 4 · see citing works

Centella asiatica : alternative dry skin therapy in type 2 diabetes mellitus

Legiawati, L. (2021) · Journal of the Medical Sciences (Berkala Ilmu Kedokteran) · doi:10.19106/jmedsci005303202108 · Cited by 3 · see citing works

The Effect of Bee Venom Therapy on Skin Aging

Kim, J.-M., & Kim, Y. (2010) · The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology · Cited by 3 · see citing works

Microbial Transformations of Pentacyclic Triterpenes

Azerad, R. G. (2016) · doi:10.1002/9781118828083.ch28 · Cited by 3 · see citing works

Functional and molecular insights in topical wound healing by ascorbic acid

Jha, B., Majie, A., Roy, K., & Gorain, B. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04180-1 · Cited by 2 · see citing works

Charting the Phytopharmacological Frontier of Centella asiatica: A Quarter-Century Bibliometric Atlas Unlocking Translational Potential

Yang, J., Zhu, H., Zhang, Q., Dai, Y., Yao, Q., & Nie, X. (2026) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-026-00747-y · Cited by 2 · see citing works

Antifaltencremes

Kerscher, M. (2012) · Journal für Ästhetische Chirurgie · doi:10.1007/s12631-011-0144-1 · Cited by 2 · see citing works

Centella asiatica (L.) Urb. and its application in cosmetology

Simka, W. (2023) · Aesthetic Cosmetology and Medicine · doi:10.52336/acm.2023.022 · Cited by 2 · see citing works

Effects of Retinol and Retinyl Palmitate on UV-Induced Skin Ageing and Therapeutic Enhancement

Wang, Y., Nie, X., Zhong, J., Wang, J., Zhang, L., & Shu, P. (2025) · Cosmetics · doi:10.3390/cosmetics12020068 · Cited by 2 · see citing works

Truths and myths about marketed anti-aging skin products: a systematic review

Barnawi, G. M., & Barnawi, A. M. (2021) · International Journal of Research in Medical Sciences · doi:10.18203/2320-6012.ijrms20212796 · Cited by 2 · see citing works

Discontinued dermatological drugs in 2014

Phuong, C., & Maïbach, H. I. (2015) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2015.1081382 · Cited by 2 · see citing works

Lichtschutz – vor und nach IPL-, Laser- und PDT-Behandlungen

Stege, H. (2018) · Springer eBooks · doi:10.1007/978-3-662-56436-3_36 · Cited by 1 · see citing works

Scoping Review: Efek Pegagan (Centella asiatica) dalam Sediaan Topikal terhadap Pencegahan Penuaan Dini

Cahyani, N. A., Sastramihardja, H. S., & Irasanti, S. N. (2022) · Bandung Conference Series Medical Science · doi:10.29313/bcsms.v2i1.574 · Cited by 1 · see citing works

Tolerability and hydrating effects of an anti-aging gynaecological collagen cream in women in menopause

Stefano, A. F. D. D., Radicioni, M. M., Vele, A., Eberhardt, A. M., Caccia, G., Focanti, F., & Salvatori, E. (2014) · Open Journal of Obstetrics and Gynecology · doi:10.4236/ojog.2014.43023 · Cited by 1 · see citing works

Application of Topical Madecassoside Cream in Dogs and Cats with Skin Diseases

Ro, W., Kang, M., Song, D.-W., Kim, H.-S., Lee, G.-W., Kang, H.-M., Kim, J.-W., Park, S.-B., Jeon, J.-H., Keum, J.-S., et al. (2021) · Journal of Veterinary Clinics · doi:10.17555/jvc.2021.04.38.2.56 · Cited by 1 · see citing works

Light Protection: Before and After IPL, Laser, and PDT Treatments

Stege, H. (2022) · Springer eBooks · doi:10.1007/978-3-030-90680-1_36 · Cited by 1 · see citing works

How to use the monographs

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Development of Natural Cosmeceuticals: Harnessing Asia's Biodiversity

Aziz, A. A., Hamid, M. A., Noor, N. M., Yaakob, H., Hasham, R., & Sarmidi, M. R. (2014) · doi:10.1002/9781118460566.ch30

Desenvolvimento e avaliação clínica dos efeitos de formulações dermocosméticas contendo dimetilaminoetanol ou acetil hexapeptídeo-3

Tadini, K. A. (2009) · doi:10.11606/t.60.2009.tde-30092009-185011

Avaliação in vivo e in vitro da eficácia de um produto com associação de vitamina C, ácido hialurônico fragmentado e manose na prevenção do envelhecimento cutâneo

Sandoval, M. H. L., Caixeta, C. M., & Ribeiro, N. M. (2015) · Surgical & Cosmetic Dermatology

Therapeutic Alternatives for the Treatment of Epidermal Aging

Brohem, C. A., Mambro, V. M. D., & Lorencini, M. (2016) · Springer eBooks · doi:10.1007/978-3-662-47398-6_140

Centella asiatica (Gotu Kola)

Murray, M. T., & Nowicki, J. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-43044-9.00064-9

Cosmeceuticals

Bradley, E., Bell, M., & Draelos, Z. K. (2019) · Royal Society of Chemistry eBooks · doi:10.1039/9781788015981-00315

Topische Dermatokosmetika

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Ästhetische Dermatologie

Ruzicka, T., Wolff, H. J., Thomas, P. T., & Prinz, J. C. (2011) · Fortschritte der praktischen Dermatologie und Venerologie · doi:10.1007/978-3-642-10358-2_6

Therapeutic Alternatives for the Treatment of Epidermal Aging

Brohem, C. A., Mambro, V. M. D., & Lorencini, M. (2015) · Springer eBooks · doi:10.1007/978-3-642-27814-3_140-1

An open‐label, 4‐week, prospective clinical study evaluating the efficacy and safety of a novel targeted skin care line addressing five common skin conditions

Duschek, N., Cajkovsky, M., Prinz, V., Müller, D. S., Hundsamer, A., Baierl, A., Möllhoff, N., Sulovsky, M., & Frank, K. (2022) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.15223

ANTI-AGING ACTIVITY EVALUATION OF GRAMMATOPHYLLUM SPECIOSUM EXTRACT FOR DEVELOPMENT INTO AN ANTI-WRINKLE SERUM

Chowjarean, V., Tengamnuay, P., Nimmannit, U., & Chanvorachote, P. (2017) · doi:10.58837/chula.the.2017.437

MECHANISMS INVOLVED IN ASIATICOSIDE-INDUCED OSTEOGENIC DIFFERENTIATION IN HUMAN PERIODONTAL LIGAMENT CELLS

Fitri, A. R. (2016) · doi:10.58837/chula.the.2016.1741

Potential of herbal remedies in treatment of wounds and scars

Nikolić, J. R., Ristović, M. P. V., & Kladar, N. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33152-7.00014-4

Clinical efficacy of topically applied vitamin C associated with madecassoside on skin aging

(2008) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2007.10.123

Structural evaluation of the long-term effects of topically applied vitamin C associated with madecassoside on intrinsically and actinically aged human skin

(2008) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2007.10.122

Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double‐blind study vs. placebo

Humbert, P. G., Haftek, M., Creidi, P., Lapière, C., Nusgens, B., Richard, A., Schmitt, D., Rougier, A., & Zahouani, H. (2003) · Experimental Dermatology · doi:10.1034/j.1600-0625.2003.00008.x · Cited by 255 · see citing works

5% vitamin C without emulsion in the treatment of skin aging: effects on skin relief

(2005) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2004.10.132

Clinical evaluation of a topical treatment with ascorbyl tetraisopalmitate nanoencapsulated, retinol, and glycolic acid in photoaged human skin

(2014) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2014.01.058