Cited by 566T-cell and B-cell ImmunologyImmune cells in cancerCancer, Hypoxia, and Metabolism

The DOI matches its Crossref record; 157 of the 157 references it cites were found in a registry or an index.

Metabolic switching and fuel choice during T‐cell differentiation and memory development

Open access

van der Windt, Gerritje J. W., Pearce, Erika L.·2012·Immunological Reviews

DOI 10.1111/j.1600-065x.2012.01150.xPMC PMC3645891

Open this paper in CoChat — free account Open PDF

Abstract

Summary: Clearance or control of pathogens or tumors usually requires T‐cell‐mediated immunity. As such, understanding the mechanisms that govern the function, maintenance, and persistence of T cells will likely lead to new treatments for controlling disease. During an immune response, T‐cell development is marked by striking changes in metabolism. There is a growing appreciation that these metabolic changes underlie the capacity of T cells to perform particular functions, and this has led to a recent focus on the idea that the manipulation of cellular metabolism can be used to shape adaptive immune responses. Although interest in this area has grown in the last few years, a full understanding of the metabolic control of T‐cell functions, particularly during an immune response in vivo , is still lacking. In this review, we first provide a basic overview of metabolism in T cells, and then we focus on recent studies providing new or updated insights into the regulation of metabolic pathways and how they underpin T‐cell differentiation and memory T‐cell development.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/j.1600-065x.2012.01150.x

Cites

157 of 157 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197
The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088
mTOR: from growth signal integration to cancer, diabetes and ageing
Zoncu, R., Efeyan, A., & Sabatini, D. M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3025 · Cited by 3,941
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766
On Respiratory Impairment in Cancer Cells
Warburg, O. H. (1956) · Science · doi:10.1126/science.124.3215.269 · Cited by 3,472
A C. elegans mutant that lives twice as long as wild type
Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387
mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery
Kim, D., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument‐Bromage, H., Tempst, P., & Sabatini, D. M. (2002) · Cell · doi:10.1016/s0092-8674(02)00808-5 · Cited by 3,051
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
Jäger, S., Handschin, C., St.-Pierre, J., & Spiegelman, B. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705070104 · Cited by 2,491
Ido expression by dendritic cells: tolerance and tryptophan catabolism
Mellor, A. L., & Munn, D. H. (2004) · Nature Reviews Immunology · doi:10.1038/nri1457 · Cited by 2,341

Flagged first, then by citations

Show all 157 references

Sorted by citations

Items 101–200 of 566

miR-143 Regulates Memory T Cell Differentiation by Reprogramming T Cell Metabolism
Zhang, T., Zhang, Z., Li, F., Ping, Y., Qin, G., Zhang, C., & Zhang, Y. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800230 · Cited by 81
The role of mitochondria in rheumatic diseases
Becker, Y. L. C., Duvvuri, B., Fortin, P. R., Lood, C., & Boilard, E. (2022) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00834-z · Cited by 81
Regulation of B cell fate, survival, and function by mitochondria and autophagy
Sandoval, H., Kodali, S., & Wang, J. (2017) · Mitochondrion · doi:10.1016/j.mito.2017.11.005 · Cited by 81
Autophagy-related protein PIK3C3/VPS34 controls T cell metabolism and function
Yang, G., Song, W., Postoak, J. L., Chen, J., Martinez, J., Zhang, J., Wu, L., & Kaer, L. V. (2020) · Autophagy · doi:10.1080/15548627.2020.1752979 · Cited by 80
Leukocyte Profiles Differ Between Type 1 and Type 2 Diabetes and Are Associated With Metabolic Phenotypes: Results From the German Diabetes Study (GDS)
Menart, B., RUTTER, R. R., Nowotny, B., Rosenbauer, J., Koliaki, C. C., KAHL, S., Simon, M., Szendroedi, J., Schloot, N. C., Roden, M., et al. (2014) · Diabetes Care · doi:10.2337/dc14-0316 · Cited by 82
Control of Treg cell homeostasis and immune equilibrium by Lkb1 in dendritic cells
Chen, S., Fang, L., Guo, W., Zhou, Y., Yu, G., Li, W., Dong, K., Liu, J., Luo, Y., Wang, B., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07545-8 · Cited by 79
Fine-Tuning of CD8 + T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus
Champagne, D., Hatle, K. M., Fortner, K. A., D’Alessandro, A., Thornton, T. M., Yang, R., Torralba, D., Tomás‐Cortázar, J., Jun, Y. W., Ahn, K. H., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.018 · Cited by 79
Metformin: prevention of genomic instability and cancer: a review
Najafi, M., Cheki, M., Rezapoor, S., Geraily, G., Motevaseli, E., Carnovale, C., Clementi, E., & Shirazi, A. (2018) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2018.01.007 · Cited by 75
TNFα and IFNγ rapidly activate PI3K-AKT signaling to drive glycolysis that confers mesenchymal stem cells enhanced anti-inflammatory property
Xu, C., Feng, C., Huang, P., Li, Y., Liu, R., Liu, C., Han, Y., Chen, L., Ding, Y., Shao, C., et al. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03178-3 · Cited by 79
Engineering Chimeric Antigen Receptor T-Cells for Racing in Solid Tumors: Don’t Forget the Fuel
Irving, M. B., de Silly, R. V., Scholten, K. B. J., Dilek, N., & Coukos, G. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00267 · Cited by 76
The emerging role of immune dysfunction in mitochondrial diseases as a paradigm for understanding immunometabolism
Kapnick, S. M., Pacheco, S. E., & McGuire, P. J. (2017) · Metabolism · doi:10.1016/j.metabol.2017.11.010 · Cited by 76
Exhaust the exhausters: Targeting regulatory T cells in the tumor microenvironment
McRitchie, B., & Akkaya, B. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.940052 · Cited by 79
STING agonism turns human T cells into interferon‐producing cells but impedes their functionality
Kühl, N., Linder, A., Philipp, N., Nixdorf, D., Fischer, H., Veth, S., Kuut, G., Xu, T. T., Theurich, S., Carell, T., et al. (2023) · EMBO Reports · doi:10.15252/embr.202255536 · Cited by 72
Development of Therapeutics That Induce Mitochondrial Biogenesis for the Treatment of Acute and Chronic Degenerative Diseases
Cameron, R. B., Beeson, C., & Schnellmann, R. G. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00669 · Cited by 77
Metabolic plasticity and regulation of T cell exhaustion
Li, F., Liu, H., Zhang, D., Ma, Y., & Zhu, B. (2022) · Immunology · doi:10.1111/imm.13575 · Cited by 73
Mitochondria: A master regulator in macrophage and T cell immunity
Liu, P.-S., & Ho, P. (2017) · Mitochondrion · doi:10.1016/j.mito.2017.11.002 · Cited by 73
Asymmetric Cell Division in T Lymphocyte Fate Diversification
Arsenio, J., Metz, P. J., & Chang, J. T. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.09.004 · Cited by 74
An optimized bicistronic chimeric antigen receptor against GPC2 or CD276 overcomes heterogeneous expression in neuroblastoma
Tian, M., Cheuk, A., Wei, J. S., Abdelmaksoud, A. A., Chou, H.-C., Milewski, D., Kelly, M. C., Song, Y., Dower, C. M., Li, N., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci155621 · Cited by 70
Human Plasma-like Medium Improves T Lymphocyte Activation
Leney-Greene, M. A., Boddapati, A. K., Su, H. C., Cantor, J. R., & Lenardo, M. J. (2019) · iScience · doi:10.1016/j.isci.2019.100759 · Cited by 70
Targeting Drp1 and mitochondrial fission for therapeutic immune modulation
Simula, L., Campanella, M., & Campello, S. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104317 · Cited by 66
Survival of Effector CD8+ T Cells during Influenza Infection Is Dependent on Autophagy
Schlie, K., Westerback, A., DeVorkin, L., Hughson, L. R. K., Brandon, J. M., MacPherson, S., Gadawski, I., Townsend, K. N., Poon, V. I., Elrick, M. A., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402571 · Cited by 68
T cell metabolic reprogramming and plasticity
Slack, M. A., Wang, T., & Wang, R. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.07.036 · Cited by 70
Regulation of Dendritic Cell Immune Function and Metabolism by Cellular Nutrient Sensor Mammalian Target of Rapamycin (mTOR)
Snyder, J. P., & Amiel, E. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03145 · Cited by 68
Metabolism and autophagy in the immune system: immunometabolism comes of age
Rathmell, J. C. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01158.x · Cited by 69
Multiplex and Genome-Wide Analyses Reveal Distinctive Properties of KIR+ and CD56+ T Cells in Human Blood
Chan, W. K., Rujkijyanont, P., Neale, G. A. M., Yang, J., Bari, R., Gupta, N., Holladay, M. S., Rooney, B., & Leung, W. H. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300111 · Cited by 67
Interactions of IDO and the Kynurenine Pathway with Cell Transduction Systems and Metabolism at the Inflammation–Cancer Interface
Stone, T. W., & Williams, R. O. (2023) · Cancers · doi:10.3390/cancers15112895 · Cited by 67
Dissecting the heterogeneity of DENV vaccine-elicited cellular immunity using single-cell RNA sequencing and metabolic profiling
Waickman, A. T., Victor, K., Li, T., Hatch, K., Rutvisuttinunt, W., Medin, C. L., Gabriel, B., Jarman, R. G., Friberg, H., & Currier, J. R. (2019) · Nature Communications · doi:10.1038/s41467-019-11634-7 · Cited by 67
24-Norursodeoxycholic acid reshapes immunometabolism in CD8(+) T cells and alleviates hepatic inflammation
Zhu, C., Boucheron, N., Müller, A. C., Májek, P., Claudel, T., Halilbasic, E., Baazim, H., Lercher, A., Viczenczova, C., Hainberger, D., et al. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.06.036 · Cited by 65
Early Effector CD8 T Cells Display Plasticity in Populating the Short-Lived Effector and Memory-Precursor Pools Following Bacterial or Viral Infection
Plumlee, C. R., Obar, J. J., Colpitts, S. L., Jellison, E. R., Haining, W. N., Lefrançois, L., & Khanna, K. M. (2015) · Scientific Reports · doi:10.1038/srep12264 · Cited by 66
T-cell immunometabolism against cancer
Jiang, S., & Yan, W. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.09.003 · Cited by 66
Altered chromatin landscape in circulating T follicular helper and regulatory cells following grass pollen subcutaneous and sublingual immunotherapy
Sharif, H., Acharya, S., Dhondalay, G. K., Varricchi, G., Krasner-Macleod, S., Laisuan, W., Switzer, A., Lenormand, M. M., Kashe, E., Parkin, R. V., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.10.035 · Cited by 64
Targeting PIM Kinase with PD1 Inhibition Improves Immunotherapeutic Antitumor T-cell Response
Chatterjee, S., Chakraborty, P., Daenthanasanmak, A., Iamsawat, S., Andrejeva, G., Luevano, L. A., Wolf, M. M., Baliga, U. K., Krieg, C., Beeson, C., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-0706 · Cited by 66
Glycolysis inhibition induces anti-tumor central memory CD8+T cell differentiation upon combination with microwave ablation therapy
Tang, X., Mao, X., Ling, P., Yu, M., Pan, H., Wang, J., Liu, M., Pan, H., Qiu, W., Che, N., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49059-6 · Cited by 67
Improved Expansion and In Vivo Function of Patient T Cells by a Serum-free Medium
Medvec, A. R., Ecker, C., Kong, H., Winters, E. A., Glover, J. A., Varela‐Rohena, A., & Riley, J. L. (2017) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2017.11.001 · Cited by 64
Lactate and Lactate Transporters as Key Players in the Maintenance of the Warburg Effect
Pereira‐Nunes, A., Afonso, J., Granja, S., & Baltazar, F. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-34025-4_3 · Cited by 63
Fatty acid oxidation in immune function
Kemp, F., Braverman, E. L., & Byersdorfer, C. A. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1420336 · Cited by 62
Immune checkpoint blockade in pancreatic cancer: Trudging through the immune desert
Li, X., Gulati, M., Larson, A. C., Solheim, J. C., Jain, M., Sushil Kumar, K., & Batra, S. K. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.08.009 · Cited by 56
Transcriptomes and metabolism define mouse and human MAIT cell populations
Chandra, S., Ascui, G., Riffelmacher, T., Chawla, A., Ramírez-Suástegui, C., Castelan, V. O. C., Seumois, G., Simon, H. A., Murray, M. P., Seo, G., et al. (2023) · Science Immunology · doi:10.1126/sciimmunol.abn8531 · Cited by 63
Molecular characterization of HCMV‐specific immune responses: Parallels between CD8+ T cells, CD4+ T cells, and NK cells
Braga, F. A. V., Hertoghs, K. M. L., van Lier, R. A. W., & van Gisbergen, K. P. J. M. (2015) · European Journal of Immunology · doi:10.1002/eji.201545495 · Cited by 56
Metabolic regulation of T cells in the tumor microenvironment by nutrient availability and diet
Zhao, S., Peralta, R. M., Avina-Ochoa, N., Delgoffe, G. M., & Kaech, S. M. (2021) · Seminars in Immunology · doi:10.1016/j.smim.2021.101485 · Cited by 58
Oncometabolites at the crossroads of genetic, epigenetic and ecological alterations in cancer
Lanzetti, L. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01402-6 · Cited by 57
Differential Impact of CD27 and 4-1BB Costimulation on Effector and Memory CD8 T Cell Generation following Peptide Immunization
Willoughby, J. E., Kerr, J. P., Rogel, A., Taraban, V. Y., Buchan, S. L., Johnson, P., & Al‐Shamkhani, A. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301217 · Cited by 54
Naïve CD8+ T-Cells Engage a Versatile Metabolic Program Upon Activation in Humans and Differ Energetically From Memory CD8+ T-Cells
Nicoli, F., Papagno, L., Frere, J. J., Cabral-Piccin, M. P., Clave, E., Emma Gostick, D., Toubert, A., Price, D. A., Caputo, A., & Appay, V. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02736 · Cited by 57
Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality
Quinn, K. M., Hussain, T., Kraus, F., Formosa, L. E., Lam, W. K., Dagley, M. J., Saunders, E. C., Assmus, L. M., Wynne-Jones, E., Loh, L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16633-7 · Cited by 56
Interplay between bile acids, gut microbiota, and the tumor immune microenvironment: mechanistic insights and therapeutic strategies
Tong, Y., & Lou, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1638352 · Cited by 64
Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification
Widjaja, C. E., Olvera, J. G., Metz, P. J., Phan, A. T., Savas, J. N., de Bruin, G., Leestemaker, Y., Berkers, C. R., de Jong, A., Florea, B. I., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90895 · Cited by 56
Re-establishing immune tolerance in multiple sclerosis: focusing on novel mechanisms of mesenchymal stem cell regulation of Th17/Treg balance
Hu, H., Li, H., Li, R., Liu, P., & Liu, H. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05450-x · Cited by 56
DUSP6 mediates T cell receptor-engaged glycolysis and restrains T FH cell differentiation
Hsu, W.-C., Chen, M.-Y., Hsu, S.-C., Huang, L.-R., Kao, C., Cheng, W., Pan, C.-H., Wu, M.-S., Yu, G., Hung, M., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1800076115 · Cited by 56
Increased Mitochondrial Biogenesis and Reactive Oxygen Species Production Accompany Prolonged CD4+ T Cell Activation
Akkaya, B., Roesler, A. S., Miozzo, P., Theall, B. P., Souz, J. A. A., Smelkinson, M. G., Kabát, J., Traba, J., Sack, M. N., Brzostowski, J. A., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800753 · Cited by 52
Single-cell multiomics dissection of basal and antigen-specific activation states of CD19-targeted CAR T cells
Bai, Z., Lundh, S. M., Kim, D., Woodhouse, S., Barrett, D. M., Myers, R. M., Grupp, S. A., Maus, M. V., June, C. H., Cámara, P. G., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-002328 · Cited by 57
Regulation of activated T cell survival in rheumatic autoimmune diseases
Rosetti, F., Madera-Salcedo, I. K., Rodríguez‐Rodríguez, N., & Crispín, J. C. (2022) · Nature Reviews Rheumatology · doi:10.1038/s41584-021-00741-9 · Cited by 54
LKB1 and Tumor Metabolism: The Interplay of Immune and Angiogenic Microenvironment in Lung Cancer
Bonanno, L., Zulato, E., Pavan, A., Attili, I., Pasello, G., Conte, P., & Indraccolo, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081874 · Cited by 53
Genomic and Single-Cell Landscape Reveals Novel Drivers and Therapeutic Vulnerabilities of Transformed Cutaneous T-cell Lymphoma
Song, X., Chang, S., Seminario‐Vidal, L., Pulido, Á. D. M., Tordesillas, L., Song, X., Reed, R. A., Harkins, A., Whiddon, S., Nguyen, J. V., et al. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-1207 · Cited by 52
Mitochondrial functionality and metabolism in T cells from progressive multiple sclerosis patients
Biasi, S. D., Simone, A. M., Bianchini, E., Tartaro, D. L., Pecorini, S., Nasi, M., Patergnani, S., Carnevale, G., Gibellini, L., Ferraro, D., et al. (2019) · European Journal of Immunology · doi:10.1002/eji.201948223 · Cited by 51
Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1+ progenitor CD8+ T cells to improve immunotherapy
Markowitz, G. J., Ban, Y., Tavarez, D. A., Yoffe, L., Podaza, E., He, Y., Martin, M. T., Crowley, M. J. P., Sandoval, T. A., Gao, D., et al. (2024) · Nature Immunology · doi:10.1038/s41590-024-01963-1 · Cited by 60
T cells display mitochondria hyperpolarization in human type 1 diabetes
Chen, J., Chernatynskaya, A., Li, J.-W., Kimbrell, M. R., Cassidy, R. J., Perry, D. J., MUIR, A. B., Atkinson, M. A., Brusko, T. M., & Mathews, C. E. (2017) · Scientific Reports · doi:10.1038/s41598-017-11056-9 · Cited by 52
CD8+ T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation
Fernández-García, J., Franco, F., Parik, S., Altea‐Manzano, P., Pane, A. A., Broekaert, D., Elsen, J. V., Conza, G. D., Vermeire, I., Schalley, T., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111639 · Cited by 53
The Impact of Glycolysis and Its Inhibitors on the Immune Response to Inflammation and Autoimmunity
Pająk, B., Zielinski, R. J., & Priebe, W. (2024) · Molecules · doi:10.3390/molecules29061298 · Cited by 51
Targeting metabolism to reverse T‐cell exhaustion in chronic viral infections
Sears, J. D., Waldron, K. J., Wei, J. N., & Chang, C. (2020) · Immunology · doi:10.1111/imm.13238 · Cited by 51
CD4 + T cell activation and concomitant mTOR metabolic inhibition can ablate microbiota-specific memory cells and prevent colitis
Zhao, Q. S., Duck, L. W., Huang, F., Alexander, K. L., Maynard, C. L., Mannon, P., & Elson, C. O. (2020) · Science Immunology · doi:10.1126/sciimmunol.abc6373 · Cited by 49
The role of mitochondria in the resistance of melanoma to PD-1 inhibitors
Du, F., Yang, L.-H., Liu, J., Wang, J., Fan, L., Duangmano, S., Liu, H., Liu, M., Wang, J., Zhong, X., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04200-9 · Cited by 47
Metabolic engineering for optimized CAR-T cell therapy
McPhedran, S. J., Carleton, G. A., & Lum, J. J. (2024) · Nature Metabolism · doi:10.1038/s42255-024-00976-2 · Cited by 51
Evolving Perspectives of mTOR Complexes in Immunity and Transplantation
Fantus, D., & Thomson, A. W. (2015) · American Journal of Transplantation · doi:10.1111/ajt.13151 · Cited by 47
Merger of dynamic two-photon and phosphorescence lifetime microscopy reveals dependence of lymphocyte motility on oxygen in solid and hematological tumors
Rytelewski, M., Haryutyunan, K., Nwajei, F., Shanmugasundaram, M., Wspanialy, P., Zal, M. A., Chen, C.-H., Khatib, M. E., Plunkett, S., Vinogradov, S. A., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0543-y · Cited by 49
CD73 Ectonucleotidase Restrains CD8+ T Cell Metabolic Fitness and Anti-tumoral Activity
Briceño, P., Rivas-Yáñez, E., Rosemblatt, M. V., Parra-Tello, B., Farías, P., Vargas, L., Simon, V., Cárdenas, C., Lladser, Á., Salazar‐Onfray, F., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.638037 · Cited by 49
Regulation of GVHD and GVL Activity via PD-L1 Interaction With PD-1 and CD80
Cassady, K. M., Martin, P. J., & Zeng, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03061 · Cited by 48
A Regulator of Metabolic Reprogramming: MicroRNA Let-7
Jiang, S. (2019) · Translational Oncology · doi:10.1016/j.tranon.2019.04.013 · Cited by 49
Manipulating the Metabolism to Improve the Efficacy of CAR T-Cell Immunotherapy
Pellegrino, M., Bufalo, F. D., Angelis, B. D., Quintarelli, C., Caruana, I., & de Billy, E. (2020) · Cells · doi:10.3390/cells10010014 · Cited by 48
Redirecting glucose flux during in vitro expansion generates epigenetically and metabolically superior T cells for cancer immunotherapy
Frisch, A. T., Wang, Y., Xie, B., Yang, A., Ford, B. R., Joshi, S. K., Kedziora, K. M., Peralta, R. M., Wilfahrt, D. N., Mullett, S. J., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2024.12.007 · Cited by 50
Age-associated nicotinamide adenine dinucleotide decline drives CAR-T cell failure
Hope, H. C., de Sostoa, J., Ginefra, P., Andreatta, M., Chiang, Y.-H., Ronet, C., Pich-Bavastro, C., Corría-Osorio, J., Kuonen, F., Auwerx, J. H., et al. (2025) · Nature Cancer · doi:10.1038/s43018-025-00982-7 · Cited by 50
Resveratrol stimulates the metabolic reprogramming of human CD4 + T cells to enhance effector function
Craveiro, M., Cretenet, G., Mongellaz, C., Matias, M. I., Caron, O., de Lima, M. C. P., Zimmermann, V. S., Solary, É., Dardalhon, V., Dulić, V., et al. (2017) · Science Signaling · doi:10.1126/scisignal.aal3024 · Cited by 48
“Immune TOR-opathies,” a Novel Disease Entity in Clinical Immunology
Jung, S., Gámez-Díaz, L. Y., Proietti, M., & Grimbacher, B. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00966 · Cited by 46
Pathogenic CD8+ Epidermis-Resident Memory T Cells Displace Dendritic Epidermal T Cells in Allergic Dermatitis
Gadsbøll, A.-S. Ø., Jee, M. H., Funch, A. B., Alhede, M., Mraz, V., Weber, J. F., Callender, L. A., Carroll, E. C., Bjarnsholt, T., Woetmann, A., et al. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2019.07.722 · Cited by 46
LDHA as a regulator of T cell fate and its mechanisms in disease
Dai, M., Wang, L., Yang, J., Chen, J., Dou, X., Chen, R., Ge, Y., & Lin, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114164 · Cited by 50
Supplementation with EPA and DHA omega-3 fatty acids improves peripheral immune cell mitochondrial dysfunction and inflammation in subjects with obesity
Borja-Magno, A. I., Furuzawa‐Carballeda, J., Guevara‐Cruz, M., Arias, C., Granados, J., Bourges, H., Tovar, A. R., Sears, B., Noriega, L. G., & Gómez, F. E. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109415 · Cited by 45
Metabolic plasticity and hematopoietic stem cell biology
Hsu, P., & Qu, C. (2013) · Current Opinion in Hematology · doi:10.1097/moh.0b013e328360ab4d · Cited by 47
Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol
Cameron, R. B., Peterson, Y. K., Beeson, C. C., & Schnellmann, R. G. (2017) · Scientific Reports · doi:10.1038/s41598-017-11030-5 · Cited by 44
The transcriptional repressor HIC1 regulates intestinal immune homeostasis
Burrows, K., Antignano, F., Bramhall, M., Chenery, A., Scheer, S., Kořínek, V., Underhill, T. M., & Zaph, C. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.17 · Cited by 45
Strategies to overcome HBV-specific T cell exhaustion: checkpoint inhibitors and metabolic re-programming
Fisicaro, P., Boni, C., Barili, V., Laccabue, D., & Ferrari, C. I. (2018) · Current Opinion in Virology · doi:10.1016/j.coviro.2018.01.003 · Cited by 44
Demonstrating the Manufacture of Human CAR‐T Cells in an Automated Stirred‐Tank Bioreactor
Costariol, E., Rotondi, M. C., Amini, A., Hewitt, C. J., Nienow, A. W., Heathman, T. R. J., & Rafiq, Q. A. (2020) · Biotechnology Journal · doi:10.1002/biot.202000177 · Cited by 49
The role of gut microbial metabolites in the T cell lifecycle
Tran, M. T., Huh, J. R., & Devlin, A. S. (2025) · Nature Immunology · doi:10.1038/s41590-025-02227-2 · Cited by 54
The Immune System in Obesity: Developing Paradigms Amidst Inconvenient Truths
Agrawal, M., Kern, P. A., & Nikolajczyk, B. S. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0917-9 · Cited by 45
The role of metabolic reprogramming in T cell fate and function.
Patsoukis, N., Bardhan, K., Weaver, J. D., Herbel, C., Seth, P., Li, L., & Boussiotis, V. A. (2016) · PubMed · Cited by 47
Blockade of N -Glycosylation Promotes Antitumor Immune Response of T Cells
Sasawatari, S., Okamoto, Y., Kumanogoh, A., & Toyofuku, T. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1900937 · Cited by 42
A metabolic switch to memory CAR T cells: Implications for cancer treatment
Rostamian, H., Fallah-Mehrjardi, K., Khakpoor-Koosheh, M., Pawelek, J. M., Hadjati, J., Brown, C. E., & Mirzaei, H. R. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.12.004 · Cited by 44
Targeting age‐specific changes in CD4+ T cell metabolism ameliorates alloimmune responses and prolongs graft survival
Nian, Y., Iske, J., Maenosono, R., Minami, K., Heinbokel, T., Quante, M., Yang, L., Azuma, H., Yang, J., Abdi, R., et al. (2021) · Aging Cell · doi:10.1111/acel.13299 · Cited by 42
Phosphoinositide acyl chain saturation drives CD8+ effector T cell signaling and function
Edwards-Hicks, J., Apostolova, P., Buescher, J. M., Maib, H., Stanczak, M. A., Corrado, M., Geltink, R. I. K., Maccari, M. E., Villa, M., Carrizo, G., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01419-y · Cited by 43
Self-citation
Alterations of lipid metabolism provide serologic biomarkers for the detection of asymptomatic versus symptomatic COVID-19 patients
Janneh, A. H., Kassir, M. F., Dwyer, C. J., Chakraborty, P., Pierce, J. S., Flume, P. A., Li, H., Nadig, S. N., Mehrotra, S., & Öğretmen, B. (2021) · Scientific Reports · doi:10.1038/s41598-021-93857-7 · Cited by 41
Metabolic dynamics instruct CD8 + T‐cell differentiation and functions
Bevilacqua, A., Li, Z., & Ho, P. (2022) · European Journal of Immunology · doi:10.1002/eji.202149486 · Cited by 41
The role of eIF4F-driven mRNA translation in regulating the tumour microenvironment
Bartish, M., Abraham, M. J., Gonçalves, C., Larsson, O. S., Rolny, C., & Rincon, S. V. D. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-023-00567-5 · Cited by 42
α‐Ketoglutarate –Dependent KDM6 Histone Demethylases and Interferon‐Stimulated Gene Expression in Lupus
Montano, E. N., Bose, M., Huo, L., Tumurkhuu, G., Santos, G. D. L., Simental, B., Stotland, A. B., Wei, J., Merz, C. N. B., Suda, J., et al. (2023) · Arthritis & Rheumatology · doi:10.1002/art.42724 · Cited by 40
Glycolysis: A fork in the path of normal and pathological pregnancy
Gou, R., & Zhang, X. (2023) · The FASEB Journal · doi:10.1096/fj.202301230r · Cited by 43
mTOR Inhibitor Everolimus in Regulatory T Cell Expansion for Clinical Application in Transplantation
Gedaly, R., Stefano, F. D., Turcios, L. M., Hill, M., Hidalgo, G. E., Mitov, M. I., Alstott, M. C., Butterfield, D. A., Mitchel, H., Hart, J., et al. (2018) · Transplantation · doi:10.1097/tp.0000000000002495 · Cited by 41
Mitochondrial Dysfunction is Associated With an Immune Paralysis Phenotype in Pediatric Sepsis
Weiss, S. L., Zhang, D. “., Bush, J., Graham, K., Starr, J. P., Murray, J. B., Tuluc, F., Henrickson, S. E., Deutschman, C. S., Becker, L. B., et al. (2019) · Shock · doi:10.1097/shk.0000000000001486 · Cited by 44
How Non-invasive in vivo Cell Tracking Supports the Development and Translation of Cancer Immunotherapies
Iafrate, M., & Fruhwirth, G. O. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00154 · Cited by 41
Therapeutic mTOR blockade in systemic autoimmunity: Implications for antiviral immunity and extension of lifespan
Geier, C., & Perl, A. (2021) · Autoimmunity Reviews · doi:10.1016/j.autrev.2021.102984 · Cited by 40
Mitochondria determine response to anti-programmed cell death protein-1 (anti-PD-1) immunotherapy: An evidence-based hypothesis
Akbari, H., Taghizadeh‐Hesary, F., & Bahadori, M. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.12.001 · Cited by 38
Metabolic priming of GD2 TRAC-CAR T cells during manufacturing promotes memory phenotypes while enhancing persistence
Cappabianca, D., Pham, D. L., Forsberg, M. H., Bugel, M., Tommasi, A. M., Lauer, A. C., Vidugirienė, J., Hrdlicka, B., McHale, A., Sodji, Q. H., et al. (2024) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2024.101249 · Cited by 37
Mitochondrial Superoxide Signaling Contributes to Norepinephrine-Mediated T-Lymphocyte Cytokine Profiles
Case, A. J., Roessner, C. T., Tian, J., & Zimmerman, M. C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164609 · Cited by 38
Label-free Analysis of CD8+ T Cell Subset Proteomes Supports a Progressive Differentiation Model of Human-Virus-Specific T Cells
van Aalderen, M. C., van den Biggelaar, M., Remmerswaal, E. B. M., van Alphen, F. P. J., Meijer, A. B., ten Berge, I. J. M., & van Lier, R. A. W. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.04.014 · Cited by 38

Authors: van der Windt, G. J. W., & Pearce, E. L.
Affiliations: Department of Pathology & Immunology Washington University School of Medicine St. Louis MO USA
Washington University in St. Louis (US)
Corresponding author: Pearce, Erika L.
ORCID: Pearce, Erika L.
Venue: Immunological Reviews
Publisher: Wiley
Published: 2012-08-14
Volume: 249
Issue: 1
Pages: 27-42
ISSN: 0105-2896 (ISSN-L)
1600-065X
DOI: 10.1111/j.1600-065x.2012.01150.x
PMC: PMC3645891
OpenAlex: W1999195849
Cited by: 563
References: 157
Citations by year: 2026: 38 · 2025: 52 · 2024: 44 · 2023: 55 · 2022: 58 · 2021: 53 · 2020: 54 · 2019: 44 · 2018: 41 · 2017: 35 · 2016: 22 · 2015: 26 · 2014: 23 · 2013: 14 · 2012: 3
FWCI: 1.95
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Immunological Reviews (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
Funders: Emerald Foundation
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
National Institutes of Health
National Cancer Institute (R21CA158823)
National Institute of Allergy and Infectious Diseases (R01AI091965)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Keywords: T cell metabolism, metabolic switch, fuel selection, T cell differentiation, memory T cells, metabolic reprogramming, adaptive immune response, T cell immunity
MeSH terms: Animals, Cell Differentiation, Energy Metabolism, Humans, Immunity, Cellular, Immunologic Memory, Lymphocyte Activation, Mitochondria, T-Lymphocytes, Cell Proliferation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Metabolic switching and fuel choice during T‐cell differentiation and memory development

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks